Works by Kriwacki, Richard W

Results: 42

TERT c.3150 G > C (p.K1050N): a founder Ashkenazi Jewish variant associated with telomere biology disorders.

Published in:

NPJ Genomic Medicine, 2025, v. 10, n. 1, p. 1, doi. 10.1038/s41525-025-00501-8

By:

de Andrade, Kelvin César;
Pinto, Emilia M.;
Zhao, Tianna;
Zeigler, Logan P.;
Kim, Jung;
Giri, Neelam;
Haley, Jeremy S.;
McReynolds, Lisa J.;
Florez-Vargas, Oscar;
Phillips, Aaron H.;
Kriwacki, Richard W.;
Akinniyi, Sherifa A.;
Cohen, Scott B.;
Emerson, Matthew R.;
Smelser, Diane T.;
Urban, Gretchen M.;
Fridman, Cintia;
Zambetti, Gerard P.;
Bryan, Tracy M.;
Carey, David J.

Publication type:

Article

The DNA-binding domain mediates both nuclear and cytosolic functions of p53.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 6, p. 535, doi. 10.1038/nsmb.2829

By:

Follis, Ariele Viacava;
Llambi, Fabien;
Ou, Li;
Baran, Katherine;
Green, Douglas R;
Kriwacki, Richard W

Publication type:

Article

Electron microscopy structure of human APC/CCDH1-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 7, p. 827, doi. 10.1038/nsmb.2593

By:

Frye, Jeremiah J;
Brown, Nicholas G;
Petzold, Georg;
Watson, Edmond R;
Grace, Christy R R;
Nourse, Amanda;
Jarvis, Marc A;
Kriwacki, Richard W;
Peters, Jan-Michael;
Stark, Holger;
Schulman, Brenda A

Publication type:

Article

BID-induced structural changes in BAK promote apoptosis.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 5, p. 589, doi. 10.1038/nsmb.2563

By:

Moldoveanu, Tudor;
Grace, Christy R;
Llambi, Fabien;
Nourse, Amanda;
Fitzgerald, Patrick;
Gehring, Kalle;
Kriwacki, Richard W;
Green, Douglas R

Publication type:

Article

A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 8, p. 947, doi. 10.1038/nsmb.2086

By:

Calabrese, Matthew F.;
Scott, Daniel C.;
Duda, David M.;
Grace, Christy R. R.;
Kurinov, Igor;
Kriwacki, Richard W.;
Schulman, Brenda A.

Publication type:

Article

Asymmetric Modulation of Protein Order-Disorder Transitions by Phosphorylation and Partner Binding.

Published in:

Angewandte Chemie, 2016, v. 128, n. 5, p. 1707, doi. 10.1002/ange.201507728

By:

Banerjee, Priya R.;
Mitrea, Diana M.;
Kriwacki, Richard W.;
Deniz, Ashok A.

Publication type:

Article

Amidomethylation of indoles and cyclisations to spiro[pyrrolo[4,3,2- de]isoquinoline-3,4′-piperidines].

Published in:

Journal of Heterocyclic Chemistry, 1987, v. 24, n. 2, p. 387, doi. 10.1002/jhet.5570240218

By:

Carter, Christine;
Freter, Kurt R.;
Kriwacki, Richard W.;
Leonard, Scott F.;
Phil Pitner, T.

Publication type:

Article

Peptide design and structural characterization of a GPCR loop mimetic.

Published in:

Biopolymers, 2007, v. 86, n. 4, p. 298, doi. 10.1002/bip.20745

By:

Pham, Truc-Chi T.;
Kriwacki, Richard W.;
Parrill, Abby L.

Publication type:

Article

8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0124423

By:

Pettersson, Mariell;
Bliman, David;
Jacobsson, Jimmy;
Nilsson, Jesper R.;
Min, Jaeki;
Iconaru, Luigi;
Guy, R. Kiplin;
Kriwacki, Richard W.;
Andréasson, Joakim;
Grøtli, Morten

Publication type:

Article

p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 4, p. 358, doi. 10.1038/nsmb746

By:

Lacy, Eilyn R.;
Filippov, Igor;
Lewis, William S.;
Otieno, Steve;
Xiao, Limin;
Weiss, Sonja;
Hengst, Ludger;
Kriwacki, Richard W.

Publication type:

Article

NMR assignment of the R2 domain of pneumococcal choline binding protein A (CbpA).

Published in:

Journal of Biomolecular NMR, 2005, v. 32, n. 1, p. 93, doi. 10.1007/s10858-005-3657-0

By:

Luo, Rensheng;
Mann, Beth;
Tuomanen, Elaine;
Kriwacki, Richard W.

Publication type:

Article

Letter to the Editor: Assignments of the 1H, 13C, and 15N resonances of the winged helix domain of the proto-oncoprotein cQin (FoxG1B).

Published in:

Journal of Biomolecular NMR, 2002, v. 23, n. 3, p. 243, doi. 10.1023/A:1019890330593

By:

Jayawardene, Dhammika S.;
Liu, Junmin;
Zhang, Weixing;
Kriwacki, Richard W.

Publication type:

Article

Letter to the Editor: Assignment of 1H, 13C and 15N resonances of the I-domain of human leukocyte function associated antigen-1.

Published in:

Journal of Biomolecular NMR, 2000, v. 16, n. 3, p. 271, doi. 10.1023/A:1008358912334

By:

Kriwacki, Richard W.;
Legge, Glen B.;
Hommel, Ulrich;
Ramage, Paul;
Chung, John;
Tennant, Linda L.;
Wright, Peter E.;
Dyson, H. Jane

Publication type:

Article

Discovery of Small Molecules that Inhibit the Disordered Protein, p27Kip1.

Published in:

Scientific Reports, 2015, p. 15686, doi. 10.1038/srep15686

By:

Iconaru, Luigi I.;
Ban, David;
Bharatham, Kavitha;
Ramanathan, Arvind;
Zhang, Weixing;
Shelat, Anang A.;
Zuo, Jian;
Kriwacki, Richard W.

Publication type:

Article

Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07530-1

By:

Ferrolino, Mylene C.;
Mitrea, Diana M.;
Michael, J. Robert;
Kriwacki, Richard W.

Publication type:

Article

On the relationship status for Arf and NPM1 – it's complicated.

Published in:

FEBS Journal, 2018, v. 285, n. 5, p. 828, doi. 10.1111/febs.14407

By:

Mitrea, Diana M.;
Kriwacki, Richard W.

Publication type:

Article

Negative Regulation of ASK1 by p21Cip1 Involves a Small Domain That Includes Serine 98 That Is Phosphorylated by ASK1 In Vivo.

Published in:

Molecular & Cellular Biology, 2007, v. 27, n. 9, p. 24, doi. 10.1128/MCB.00086-06

By:

Jun Zhan;
Easton, John B.;
Shile Huang;
Mishra, Ashutosh;
Limin Xiao;
Lacy, Eilyn R.;
Kriwacki, Richard W.;
Houghton, Peter J.

Publication type:

Article

Solution NMR Studies of an Intrinsically Unstructured Protein within a Dilute, 75 kDa Eukaryotic Protein Assembly; Probing the Practical Limits for Efficiently Assigning Polypeptide Backbone Resonances.

Published in:

ChemBioChem, 2005, v. 6, n. 12, p. 2242, doi. 10.1002/cbic.200500260

By:

Yuefeng Wang;
Igor Filippov;
Christian Richter;
Rensheng Luo;
Richard W. Kriwacki

Publication type:

Article

Cell cycle regulation by the intrinsically disordered proteins p21 and p27.

Published in:

Biochemical Society Transactions, 2012, v. 40, n. 5, p. 981, doi. 10.1042/BST20120092

By:

Mi-Kyung Yoon;
Mitrea, Diana M.;
Li Ou;
Kriwacki, Richard W.

Publication type:

Article

A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer.

Published in:

Nature Structural Biology, 2002, v. 9, n. 1, p. 12, doi. 10.1038/nsb730

By:

DiGiammarino, Enrico L.;
Lee, Amanda S.;
Cadwell, Craig;
Zhang, Weixing;
Bothner, Brian;
Ribeiro, Raul C.;
Zambetti, Gerard;
Kriwacki, Richard W.

Publication type:

Article

A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes.

Published in:

Autophagy, 2012, v. 8, n. 9, p. 1325, doi. 10.4161/auto.20764

By:

Ji Zhang;
Loyd, Melanie R.;
Randall, Mindy S.;
Waddell, M. Brett;
Kriwacki, Richard W.;
Ney, Paul A.

Publication type:

Article

Regulated unfolding of proteins in signaling.

Published in:

FEBS Letters, 2013, v. 587, n. 8, p. 1081, doi. 10.1016/j.febslet.2013.02.024

By:

Mitrea, Diana M.;
Kriwacki, Richard W.

Publication type:

Article

Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A.

Published in:

Angewandte Chemie, 2019, v. 131, n. 10, p. 3146, doi. 10.1002/ange.201812697

By:

Beveridge, Rebecca;
Migas, Lukasz G.;
Kriwacki, Richard W.;
Barran, Perdita E.

Publication type:

Article

Real-Time Analysis of Folding upon Binding of a Disordered Protein by Using Dissolution DNP NMR Spectroscopy.

Published in:

Angewandte Chemie, 2017, v. 129, n. 25, p. 7176, doi. 10.1002/ange.201700464

By:

Ragavan, Mukundan;
Iconaru, Luigi I.;
Park, Cheon ‐ Gil;
Kriwacki, Richard W.;
Hilty, Christian

Publication type:

Article

Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0137867

By:

Pettersson, Mariell;
Quant, Maria;
Min, Jaeki;
Iconaru, Luigi;
Kriwacki, Richard W.;
Waddell, M. Brett;
Guy, R. Kiplin;
Luthman, Kristina;
Grøtli, Morten

Publication type:

Article

Erratum: Protein dynamics: Tuning disorder propensity in p53.

Published in:

Nature Chemical Biology, 2015, v. 11, n. 2, p. 172, doi. 10.1038/nchembio0215-172b

By:

Kriwacki, Richard W

Publication type:

Article

Protein dynamics: Tuning disorder propensity in p53.

Published in:

Nature Chemical Biology, 2014, v. 10, n. 12, p. 987, doi. 10.1038/nchembio.1692

By:

Kriwacki, Richard W

Publication type:

Article

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.

Published in:

Nature Chemical Biology, 2013, v. 9, n. 3, p. 163, doi. 10.1038/nchembio.1166

By:

Follis, Ariele Viacava;
Chipuk, Jerry E;
Fisher, John C;
Yun, Mi-Kyung;
Grace, Christy R;
Nourse, Amanda;
Baran, Katherine;
Ou, Li;
Min, Lie;
White, Stephen W;
Green, Douglas R;
Kriwacki, Richard W

Publication type:

Article

Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21.

Published in:

Nature Chemical Biology, 2011, v. 7, n. 4, p. 214, doi. 10.1038/nchembio.536

By:

Yuefeng Wang;
Fisher, John C.;
Mathew, Rose;
Li Ou;
Otieno, Steve;
Sublet, Jack;
Limin Xiao;
Jianhan Chen;
Roussel, Martine F.;
Kriwacki, Richard W.

Publication type:

Article

Phase separation in biology; functional organization of a higher order.

Published in:

Cell Communication & Signaling, 2016, v. 14, p. 1, doi. 10.1186/s12964-015-0125-7

By:

Mitrea, Diana M.;
Kriwacki, Richard W.

Publication type:

Article

Discoveries and controversies in BCL-2 protein-mediated apoptosis.

Published in:

FEBS Journal, 2016, v. 283, n. 14, p. 2690, doi. 10.1111/febs.13527

By:

Zheng, Janet H.;
Viacava Follis, Ariele;
Kriwacki, Richard W.;
Moldoveanu, Tudor

Publication type:

Article

Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 10, p. 3114, doi. 10.1002/anie.201812697

By:

Beveridge, Rebecca;
Migas, Lukasz G.;
Kriwacki, Richard W.;
Barran, Perdita E.

Publication type:

Article

Real-Time Analysis of Folding upon Binding of a Disordered Protein by Using Dissolution DNP NMR Spectroscopy.

Published in:

Angewandte Chemie International Edition, 2017, v. 56, n. 25, p. 7070, doi. 10.1002/anie.201700464

By:

Ragavan, Mukundan;
Iconaru, Luigi I.;
Park, Cheon‐Gil;
Kriwacki, Richard W.;
Hilty, Christian

Publication type:

Article

Asymmetric Modulation of Protein Order-Disorder Transitions by Phosphorylation and Partner Binding.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 5, p. 1675, doi. 10.1002/anie.201507728

By:

Banerjee, Priya R.;
Mitrea, Diana M.;
Kriwacki, Richard W.;
Deniz, Ashok A.

Publication type:

Article

Assembly of mTORC3 Involves Binding of ETV7 to Two Separate Sequences in the mTOR Kinase Domain.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 18, p. 10042, doi. 10.3390/ijms251810042

By:

Zhan, Jun;
Harwood, Frank;
Have, Sara Ten;
Lamond, Angus;
Phillips, Aaron H.;
Kriwacki, Richard W.;
Halder, Priyanka;
Cardone, Monica;
Grosveld, Gerard C.

Publication type:

Article

Clinical and functional analysis of the germline TP53 p.K164E acetylation site variant.

Published in:

Cold Spring Harbor Molecular Case Studies, 2023, v. 9, n. 4, p. 1, doi. 10.1101/mcs.a006290

By:

Pinto, Emilia Modolo;
Ribeiro, Enilze M. S. F.;
Jinling Wang;
Phillips, Aaron H.;
Kriwacki, Richard W.;
Zambetti, Gerard P.

Publication type:

Article

Biomolecular condensates form spatially inhomogeneous network fluids.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-47602-z

By:

Dar, Furqan;
Cohen, Samuel R.;
Mitrea, Diana M.;
Phillips, Aaron H.;
Nagy, Gergely;
Leite, Wellington C.;
Stanley, Christopher B.;
Choi, Jeong-Mo;
Kriwacki, Richard W.;
Pappu, Rohit V.

Publication type:

Article

Disruption of an intermonomer salt bridge in the p53 tetramerization domain results in an increased propensity to form amyloid fibrils.

Published in:

Protein Science: A Publication of the Protein Society, 2005, v. 14, n. 12, p. 2993, doi. 10.1110/ps.051622005

By:

Galea, Charles;
Bowman, Prentice;
Kriwacki, Richard W.

Publication type:

Article

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.13571

By:

Mitrea, Diana M.;
Cika, Jaclyn A.;
Guy, Clifford S.;
Ban, David;
Banerjee, Priya R.;
Stanley, Christopher B.;
Nourse, Amanda;
Deniz, Ashok A.;
Kriwacki, Richard W.

Publication type:

Article

pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins.

Published in:

Nucleic Acids Research, 2014, v. 42, n. D1, p. D326, doi. 10.1093/nar/gkt960

By:

Varadi, Mihaly;
Kosol, Simone;
Lebrun, Pierre;
Valentini, Erica;
Blackledge, Martin;
Dunker, A. Keith;
Felli, Isabella C.;
Forman-Kay, Julie D.;
Kriwacki, Richard W.;
Pierattelli, Roberta;
Sussman, Joel;
Svergun, Dmitri I.;
Uversky, Vladimir N.;
Vendruscolo, Michele;
Wishart, David;
Wright, Peter E.;
Tompa, Peter

Publication type:

Article

Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae.

Published in:

EMBO Journal, 2005, v. 24, n. 1, p. 34, doi. 10.1038/sj.emboj.7600490

By:

Luo, Rensheng;
Mann, Beth;
Lewis, William S.;
Rowe, Arthur;
Heath, Richard;
Stewart, Michael L.;
Hamburger, Agnes E.;
Sivakolundu, Siva;
Lacy, Eilyn R.;
Bjorkman, Pamela J.;
Tuomanen, Elaine;
Kriwacki, Richard W.

Publication type:

Article

Disorder-function relationships for the cell cycle regulatory proteins p21 and p27.

Published in:

Biological Chemistry, 2012, v. 393, n. 4, p. 259, doi. 10.1515/hsz-2011-0254

By:

Mitrea, Diana M.;
Yoon, Mi-Kyung;
Ou, Li;
Kriwacki, Richard W.

Publication type:

Article