Works by Krekels, Elke H. J.

Results: 43

Correction to: Population pharmacokinetics‑pharmacodynamics of fondaparinux in dialysis‑dependent chronic kidney disease patients undergoing chronic renal replacement therapy.

Published in:

2022

By:

Michaličková, Danica;
Hartinger, Jan Miroslav;
Hladinová, Zuzana;
Bednářová, Vladimíra;
Szonowská, Barbora;
Polakovič, Vladimír;
Matthios, Andreas;
Tesař, Vladimír;
Slanař, Ondřej;
Krekels, Elke H. J.

Publication type:

Correction Notice

Population pharmacokinetics-pharmacodynamics of fondaparinux in dialysis-dependent chronic kidney disease patients undergoing chronic renal replacement therapy.

Published in:

European Journal of Clinical Pharmacology, 2022, v. 78, n. 1, p. 89, doi. 10.1007/s00228-021-03201-1

By:

Michaličková, Danica;
Hartinger, Jan Miroslav;
Hladinová, Zuzana;
Bednářová, Vladimíra;
Szonowská, Barbora;
Polakovič, Vladimír;
Matthios, Andreas;
Tesař, Vladimír;
Slanař, Ondřej;
Krekels, Elke H. J.

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Posaconazole.

Published in:

Drugs, 2020, v. 80, n. 7, p. 671, doi. 10.1007/s40265-020-01306-y

By:

Chen, Lu;
Krekels, Elke H. J.;
Verweij, Paul. E.;
Buil, Jochem B.;
Knibbe, Catherijne A. J.;
Brüggemann, Roger J. M.

Publication type:

Article

First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 6, p. 374, doi. 10.1002/psp4.12295

By:

Brussee, Janneke M.;
Yu, Huixin;
Krekels, Elke H. J.;
de Roos, Berend;
Brill, Margreke J. E.;
van den Anker, Johannes N.;
Rostami‐Hodjegan, Amin;
de Wildt, Saskia N.;
Knibbe, Catherijne A. J.

Publication type:

Article

Outside‐In Systems Pharmacology Combines Innovative Computational Methods With High‐Throughput Whole Vertebrate Studies.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 5, p. 285, doi. 10.1002/psp4.12297

By:

Schulthess, Pascal;
van Wijk, Rob C.;
Krekels, Elke H. J.;
Yates, James W. T.;
Spaink, Herman P.;
van der Graaf, Piet H.

Publication type:

Article

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 3, p. 175, doi. 10.1002/psp4.12273

By:

Calvier, Elisa A. M.;
Krekels, Elke H. J.;
Yu, Huixin;
Välitalo, Pyry A. J.;
Johnson, Trevor N.;
Rostami‐Hodjegan, Amin;
Tibboel, Dick;
van der Graaf, Piet H.;
Danhof, Meindert;
Knibbe, Catherijne A. J.

Publication type:

Article

Total bodyweight and sex both drive pharmacokinetic variability of fluconazole in obese adults.

Published in:

2022

By:

Chen, Lu;
Rhee, Koen P van;
Wasmann, Roeland E;
Krekels, Elke H J;
Wiezer, Marinus J;
Dongen, Eric P A van;
Verweij, Paul E;
Linden, Paul D van der;
Brüggemann, Roger J;
Knibbe, Catherijne A J;
van Rhee, Koen P;
van Dongen, Eric P A;
van der Linden, Paul D

Publication type:

journal article

The Oral Bioavailability and Metabolism of Midazolam in Stable Critically Ill Children: A Pharmacokinetic Microtracing Study.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 140, doi. 10.1002/cpt.1890

By:

Groen, Bianca D.;
Krekels, Elke H. J.;
Mooij, Miriam G.;
Duijn, Esther;
Vaes, Wouter H. J.;
Windhorst, Albert D.;
Rosmalen, Joost;
Hartman, Stan J. F.;
Hendrikse, N. Harry;
Koch, Birgit C. P.;
Allegaert, Karel;
Tibboel, Dick;
Knibbe, Catherijne A. J.;
Wildt, Saskia N.

Publication type:

Article

Higher Plasma Levels of Endocannabinoids and Analogues Correlate With a Worse Cardiometabolic Profile in Young Adults.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2024, v. 109, n. 5, p. 1351, doi. 10.1210/clinem/dgad668

By:

Di, Xinyu;
Martinez-Tellez, Borja;
Krekels, Elke H J;
Jurado-Fasoli, Lucas;
Osuna-Prieto, Francisco J;
Ortiz-Alvarez, Lourdes;
Hankemeier, Thomas;
Rensen, Patrick C N;
Ruiz, Jonatan R;
Kohler, Isabelle

Publication type:

Article

Predicting CYP3A‐mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure.

Published in:

British Journal of Clinical Pharmacology, 2018, v. 84, n. 2, p. 358, doi. 10.1111/bcp.13459

By:

Brussee, Janneke M.;
Vet, Nienke J.;
Krekels, Elke H. J.;
Valkenburg, Abraham J.;
Jacqz‐Aigrain, Evelyne;
van Gerven, Joop M. A.;
Swart, Eleonora L.;
van den Anker, Johannes N.;
Tibboel, Dick;
de Hoog, Matthijs;
de Wildt, Saskia N.;
Knibbe, Catherijne A. J.

Publication type:

Article

Population pharmacokinetics of edoxaban in patients with symptomatic deep-vein thrombosis and/or pulmonary embolism--the Hokusai-VTE phase 3 study.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 80, n. 6, p. 1374, doi. 10.1111/bcp.12727

By:

Niebecker, Ronald;
Jönsson, Siv;
Karlsson, Mats O.;
Miller, Raymond;
Nyberg, Joakim;
Krekels, Elke H. J.;
Simonsson, Ulrika S. H.

Publication type:

Article

Population pharmacokinetics of riociguat and its metabolite in patients with chronic thromboembolic pulmonary hypertension from routine clinical practice.

Published in:

Pulmonary Circulation, 2020, v. 10, n. 1, p. 1, doi. 10.1177/2045894019898031

By:

Michaličková, Danica;
Jansa, Pavel;
Bursová, Miroslava;
Hložek, Tomáš;
Čabala, Radomír;
Hartinger, Jan Miroslav;
Ambrož, David;
Aschermann, Michael;
Lindner, Jaroslav;
Linhart, Aleš;
Slanař, Ondřej;
Krekels, Elke H. J.

Publication type:

Article

The Drug Titration Paradox in the Presence of Intra-Individual Variation: Can we Estimate the True Concentration-Effect Relationship?

Published in:

AAPS Journal, 2025, v. 27, n. 3, p. 1, doi. 10.1208/s12248-025-01055-4

By:

Goulooze, Sebastiaan C.;
Krekels, Elke H. J.;
Knibbe, Catherijne A. J.;
van Noort, Martijn

Publication type:

Article

Impact of Obesity on Hepatic Drug Clearance: What are the Influential Variables?

Published in:

AAPS Journal, 2024, v. 26, n. 3, p. 1, doi. 10.1208/s12248-024-00929-3

By:

Zhang, Tan;
Calvier, Elisa A. M.;
Krekels, Elke H. J.;
Knibbe, Catherijne A. J.

Publication type:

Article

Prediction of glomerular filtration rate maturation across preterm and term neonates and young infants using inulin as marker.

Published in:

AAPS Journal, 2022, v. 24, n. 2, p. 1, doi. 10.1208/s12248-022-00688-z

By:

Wu, Yunjiao;
Allegaert, Karel;
Flint, Robert B.;
Simons, Sinno H. P.;
Krekels, Elke H. J.;
Knibbe, Catherijne A. J.;
Völler, Swantje

Publication type:

Article

Towards Evidence-Based Weaning: a Mechanism-Based Pharmacometric Model to Characterize Iatrogenic Withdrawal Syndrome in Critically Ill Children.

Published in:

AAPS Journal, 2021, v. 23, n. 4, p. 1, doi. 10.1208/s12248-021-00586-w

By:

Goulooze, Sebastiaan C.;
Ista, Erwin;
van Dijk, Monique;
Tibboel, Dick;
Krekels, Elke H. J.;
Knibbe, Catherijne A. J.

Publication type:

Article

Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00595-9

By:

Cristea, Sînziana;
Krekels, Elke H. J.;
Allegaert, Karel;
De Paepe, Peter;
de Jaeger, Annick;
De Cock, Pieter;
Knibbe, Catherijne A. J.

Publication type:

Article

A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0351-9

By:

Brussee, Janneke M.;
Krekels, Elke H. J.;
Calvier, Elisa A. M.;
Palić, Semra;
Rostami-Hodjegan, Amin;
Danhof, Meindert;
Barrett, Jeffrey S.;
de Wildt, Saskia N.;
Knibbe, Catherijne A. J.

Publication type:

Article

Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools.

Published in:

AAPS Journal, 2019, v. 21, n. 1, p. 1, doi. 10.1208/s12248-018-0278-6

By:

Goulooze, Sebastiaan C.;
Krekels, Elke H. J.;
Hankemeier, Thomas;
Knibbe, Catherijne A. J.

Publication type:

Article

Kernel-Based Visual Hazard Comparison (kbVHC): a Simulation-Free Diagnostic for Parametric Repeated Time-to-Event Models.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0162-9

By:

Goulooze, Sebastiaan C.;
Välitalo, Pyry A. J.;
Knibbe, Catherijne A. J.;
Krekels, Elke H. J.

Publication type:

Article

When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers?

Published in:

Pharmaceutical Research, 2024, v. 41, n. 4, p. 637, doi. 10.1007/s11095-024-03677-3

By:

Wu, Yunjiao;
Allegaert, Karel;
Flint, Robert B.;
Goulooze, Sebastiaan C.;
Välitalo, Pyry A. J.;
de Hoog, Matthijs;
Mulla, Hussain;
Sherwin, Catherine M. T.;
Simons, Sinno H. P.;
Krekels, Elke H. J.;
Knibbe, Catherijne A. J.;
Völler, Swantje

Publication type:

Article

Maturation of Paracetamol Elimination Routes in Preterm Neonates Born Below 32 Weeks of Gestation.

Published in:

Pharmaceutical Research, 2023, v. 40, n. 9, p. 2155, doi. 10.1007/s11095-023-03580-3

By:

Wu, Yunjiao;
Völler, Swantje;
Krekels, Elke H. J.;
Roofthooft, Daniëlla W. E.;
Simons, Sinno H. P.;
Tibboel, Dick;
Flint, Robert B.;
Knibbe, Catherijne A. J.

Publication type:

Article

Midazolam Infusion and Disease Severity Affect the Level of Sedation in Children: A Parametric Time-to-Event Analysis.

Published in:

Pharmaceutical Research, 2021, v. 38, n. 10, p. 1711, doi. 10.1007/s11095-021-03113-w

By:

Upadhyay, Parth J.;
Vet, Nienke J.;
Goulooze, Sebastiaan C.;
Krekels, Elke H. J.;
de Wildt, Saskia N.;
Knibbe, Catherijne A. J.

Publication type:

Article

Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory.

Published in:

Pharmaceutical Research, 2018, v. 35, n. 11, p. 1, doi. 10.1007/s11095-018-2487-1

By:

Calvier, Elisa A. M.;
Nguyen, Thu Thuy;
Johnson, Trevor N.;
Rostami-Hodjegan, Amin;
Tibboel, Dick;
Krekels, Elke H. J.;
Knibbe, Catherijne A. J.

Publication type:

Article

Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach.

Published in:

Pharmaceutical Research, 2018, v. 35, n. 9, p. 1, doi. 10.1007/s11095-018-2458-6

By:

Brussee, Janneke M.;
Yu, Huixin;
Krekels, Elke H. J.;
Palić, Semra;
Brill, Margreke J. E.;
Barrett, Jeffrey S.;
Rostami-Hodjegan, Amin;
de Wildt, Saskia N.;
Knibbe, Catherijne A. J.

Publication type:

Article

Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 12, p. 5420, doi. 10.1111/bcp.15476

By:

Liu, Feiyan;
Aulin, Linda B. S.;
Guo, Tingjie;
Krekels, Elke H. J.;
Moerland, Matthijs;
van der Graaf, Piet H.;
van Hasselt, Johan G. C.

Publication type:

Article

An Integrated Population Pharmacokinetic Analysis for Posaconazole Oral Suspension, Delayed-Release Tablet, and Intravenous Infusion in Healthy Volunteers.

Published in:

Drugs, 2023, v. 83, n. 1, p. 75, doi. 10.1007/s40265-022-01819-8

By:

Chen, Lu;
Krekels, Elke H. J.;
Heijnen, Anne R.;
Knibbe, Catherijne A. J.;
Brüggemann, Roger J.

Publication type:

Article

Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-38530-w

By:

van Wijk, Rob C.;
Krekels, Elke H. J.;
Kantae, Vasudev;
Harms, Amy C.;
Hankemeier, Thomas;
van der Graaf, Piet H.;
Spaink, Herman P.

Publication type:

Article

Intraperitoneally Administered Vancomycin in Patients with Peritoneal Dialysis-Associated Peritonitis: Population Pharmacokinetics and Dosing Implications.

Published in:

Pharmaceutics, 2023, v. 15, n. 5, p. 1394, doi. 10.3390/pharmaceutics15051394

By:

Hartinger, Jan Miroslav;
Michaličková, Danica;
Dvořáčková, Eliška;
Hronová, Karolína;
Krekels, Elke H. J.;
Szonowská, Barbora;
Bednářová, Vladimíra;
Benáková, Hana;
Kroneislová, Gabriela;
Závora, Jan;
Tesař, Vladimír;
Slanař, Ondřej

Publication type:

Article

The Effect of Ibuprofen Exposure and Patient Characteristics on the Closure of the Patent Ductus Arteriosus in Preterm Infants.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 2, p. 307, doi. 10.1002/cpt.2616

By:

Engbers, Aline G. J.;
Völler, Swantje;
Flint, Robert B.;
Goulooze, Sebastiaan C.;
de Klerk, Johan;
Krekels, Elke H. J.;
van Dijk, Monique;
Willemsen, Sten P.;
Reiss, Irwin K. M.;
Knibbe, Catherijne A. J.;
Simons, Sinno H. P.

Publication type:

Article

All You Need to Know About Allometric Scaling: An Integrative Review on the Theoretical Basis, Empirical Evidence, and Application in Human Pharmacology: Theoretical Allometry for Human Pharmacology, a Theoretical and Empirical Overview: D. W. van Valkengoed et al

Published in:

Clinical Pharmacokinetics, 2025, v. 64, n. 2, p. 173, doi. 10.1007/s40262-024-01444-6

By:

van Valkengoed, Daan W.;
Krekels, Elke H. J.;
Knibbe, Catherijne A. J.

Publication type:

Article

Changes in Plasma Clearance of CYP450 Probe Drugs May Not be Specific for Altered In Vivo Enzyme Activity Under (Patho)Physiological Conditions: How to Interpret Findings of Probe Cocktail Studies.

Published in:

Clinical Pharmacokinetics, 2024, v. 63, n. 11, p. 1585, doi. 10.1007/s40262-024-01426-8

By:

de Jong, Laura M.;
van de Kreeke, Marinda;
Ahmadi, Mariam;
Swen, Jesse J.;
Knibbe, Catherijne A. J.;
van Hasselt, J. G. Coen;
Manson, Martijn L.;
Krekels, Elke H. J.

Publication type:

Article

How to Dose Vancomycin in Overweight and Obese Patients with Varying Renal (Dys)function in the Novel Era of AUC 400–600 mg·h/L-Targeted Dosing.

Published in:

Clinical Pharmacokinetics, 2024, v. 63, n. 1, p. 79, doi. 10.1007/s40262-023-01324-5

By:

Zhang, Tan;
Krekels, Elke H. J.;
Smit, Cornelis;
van Dongen, Eric P. A.;
Brüggemann, Roger J. M.;
Knibbe, Catherijne A. J.

Publication type:

Article

Vancomycin Clearance in Obese Adults is not Predictive of Clearance in Obese Adolescents.

Published in:

Clinical Pharmacokinetics, 2023, v. 62, n. 5, p. 749, doi. 10.1007/s40262-023-01227-5

By:

Zhang, Tan;
Smit, Cornelis;
Sherwin, Catherine M. T.;
Knibbe, Catherijne A. J.;
Krekels, Elke H. J.

Publication type:

Article

Ciprofloxacin Pharmacokinetics After Oral and Intravenous Administration in (Morbidly) Obese and Non-obese Individuals: A Prospective Clinical Study.

Published in:

Clinical Pharmacokinetics, 2022, v. 61, n. 8, p. 1167, doi. 10.1007/s40262-022-01130-5

By:

van Rhee, Koen P.;
Smit, Cornelis;
Wasmann, Roeland E.;
van der Linden, Paul D.;
Wiezer, Rene;
Van Dongen, Eric P. A.;
Krekels, Elke H. J.;
Brüggemann, Roger J. M.;
Knibbe, Catherijne A. J.

Publication type:

Article

The Predictive Value of Glomerular Filtration Rate-Based Scaling of Pediatric Clearance and Doses for Drugs Eliminated by Glomerular Filtration with Varying Protein-Binding Properties.

Published in:

2020

By:

Cristea, Sinziana;
Krekels, Elke H. J.;
Allegaert, Karel;
Knibbe, Catherijne A. J.

Publication type:

journal article

The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models.

Published in:

2019

By:

Goulooze, Sebastiaan C.;
Völler, Swantje;
Välitalo, Pyry A. J.;
Calvier, Elisa A. M.;
Aarons, Leon;
Krekels, Elke H. J.;
Knibbe, Catherijne A. J.

Publication type:

journal article

Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?

Published in:

2017

By:

Calvier, Elisa;
Krekels, Elke;
Välitalo, Pyry;
Rostami-Hodjegan, Amin;
Tibboel, Dick;
Danhof, Meindert;
Knibbe, Catherijne;
Calvier, Elisa A M;
Krekels, Elke H J;
Välitalo, Pyry A J;
Knibbe, Catherijne A J

Publication type:

journal article

Population Pharmacokinetics of Edoxaban in Patients with Non-Valvular Atrial Fibrillation in the ENGAGE AF-TIMI 48 Study, a Phase III Clinical Trial.

Published in:

2016

By:

Krekels, Elke;
Niebecker, Ronald;
Karlsson, Mats;
Miller, Raymond;
Shimizu, Takako;
Karlsson, Kristin;
Ruff, Christian;
Simonsson, Ulrika;
Jönsson, Siv;
Krekels, Elke H J;
Karlsson, Mats O;
Karlsson, Kristin E;
Ruff, Christian T;
Simonsson, Ulrika S H;
Jönsson, Siv

Publication type:

journal article

Prediction of morphine clearance in the paediatric population : how accurate are the available pharmacokinetic models?

Published in:

2012

By:

Krekels EH;
Tibboel D;
Danhof M;
Knibbe CA;
Krekels, Elke H J;
Tibboel, Dick;
Danhof, Meindert;
Knibbe, Catherijne A J

Publication type:

journal article

Prediction of Morphine Clearance in the Paediatric Population.

Published in:

Clinical Pharmacokinetics, 2012, v. 51, n. 11, p. 695, doi. 10.1007/s40262-012-0006-9

By:

Krekels, Elke H. J.;
Tibboel, Dick;
Danhof, Meindert;
Knibbe, Catherijne A. J.

Publication type:

Article

Morphine Glucuronidation in Preterm Neonates, Infants and Children Younger than 3 Years.

Published in:

Clinical Pharmacokinetics, 2009, v. 48, n. 6, p. 371, doi. 10.2165/00003088-200948060-00003

By:

Knibbe, Catherijne A. J.;
Krekels, Elke H. J.;
van den Anker, Johannes N.;
DeJongh, Joost;
Santen, Gijs W. E.;
van Dijk, Monique;
Simons, Sinno H. P.;
van Lingen, Richard A.;
Jacqz-Aigrain, Evelyne M.;
Danhof, Meindert;
Tibboel, Dick

Publication type:

Article

Children in clinical trials: towards evidence-based pediatric pharmacotherapy using pharmacokinetic-pharmacodynamic modeling.

Published in:

Expert Review of Clinical Pharmacology, 2016, v. 9, n. 9, p. 1235, doi. 10.1080/17512433.2016.1198256

By:

Brussee, Janneke M.;
Calvier, Elisa A. M.;
Krekels, Elke H. J.;
Välitalo, Pyry A. J.;
Tibboel, Dick;
Allegaert, Karel;
Knibbe, Catherijne A. J.

Publication type:

Article