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Insulin resistance due to nutrient excess.
Published in:
Cell Cycle, 2011, v. 10, n. 20, p. 3447, doi. 10.4161/cc.10.20.17886
By:
- Saha, Asish K.;
- Xu, X. Julia;
- Balon, Thomas W.;
- Brandon, Amanda;
- Kraegen, Edward W.;
- Ruderman, Neil B.
Publication type:
Article
A semi‐closed loop computer‐assisted insulin infusion system Hospital use for control of diabetes in patients.
Published in:
Medical Journal of Australia, 1984, v. 141, n. 12/13, p. 784, doi. 10.5694/j.1326-5377.1984.tb132950.x
By:
- Chisholm, Donald J.;
- Kraegen, Edward W.;
- Bell, David J.;
- Chipps, David R.
Publication type:
Article
PATHOGENESIS OF THE INSULIN RESISTANCE SYNDROME (SYNDROME X).
Published in:
Clinical & Experimental Pharmacology & Physiology, 1997, v. 24, n. 9/10, p. 782, doi. 10.1111/j.1440-1681.1997.tb02132.x
By:
- Chisholm, Donald J.;
- Campbell, Lesley V.;
- Kraegen, Edward W.
Publication type:
Article
ROUTINE USE OF LOW‐DOSE INTRAVENOUS INSULIN INFUSION IN SEVERE HYPERGLYCAEMIA∗.
Published in:
Medical Journal of Australia, 1976, v. 2, n. 14, p. 519, doi. 10.5694/j.1326-5377.1976.tb128205.x
By:
- Campbell, Lesley V.;
- Lazarus, Leslie;
- Casey, John H.;
- Kraegen, Edward W.
Publication type:
Article
Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats.
Published in:
PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0127388
By:
- Coughlan, Kimberly A.;
- Balon, Thomas W.;
- Valentine, Rudy J.;
- Petrocelli, Robert;
- Schultz, Vera;
- Brandon, Amanda;
- Cooney, Gregory J.;
- Kraegen, Edward W.;
- Ruderman, Neil B.;
- Saha, Asish K.
Publication type:
Article
Overexpression of SIRT1 in Rat Skeletal Muscle Does Not Alter Glucose Induced Insulin Resistance.
Published in:
PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0121959
By:
- Brandon, Amanda E.;
- Tid-Ang, Jennifer;
- Wright, Lauren E.;
- Stuart, Ella;
- Suryana, Eurwin;
- Bentley, Nicholas;
- Turner, Nigel;
- Cooney, Gregory J.;
- Ruderman, Neil B.;
- Kraegen, Edward W.
Publication type:
Article
Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKβ.
Published in:
PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062309
By:
- Iseli, Tristan J.;
- Turner, Nigel;
- Zeng, Xiao-Yi;
- Cooney, Gregory J.;
- Kraegen, Edward W.;
- Yao, Sheng;
- Ye, Yang;
- James, David E.;
- Ye, Ji-Ming
Publication type:
Article
Oleanolic Acid Reduces Hyperglycemia beyond Treatment Period with Akt/FoxO1-Induced Suppression of Hepatic Gluconeogenesis in Type-2 Diabetic Mice.
Published in:
PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0042115
By:
- Xiao-Yi Zeng;
- Yi-Ping Wang;
- James Cantley;
- Iseli, Tristan J.;
- Molero, Juan Carlos;
- Hegarty, Bronwyn D.;
- Kraegen, Edward W.;
- Yang Ye;
- Ji-Ming Ye
Publication type:
Article
Differing Endoplasmic Reticulum Stress Response to Excess Lipogenesis versus Lipid Oversupply in Relation to Hepatic Steatosis and Insulin Resistance.
Published in:
PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0030816
By:
- Lu-Ping Ren;
- Chan, Stanley M. H.;
- Xiao-Yi Zeng;
- Laybutt, D. Ross;
- Iseli, Tristan J.;
- Ruo-Qiong Sun;
- Kraegen, Edward W.;
- Cooney, Gregory J.;
- Turner, Nigel;
- Ji-Ming Ye
Publication type:
Article
Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle.
Published in:
Diabetes, 2010, v. 59, n. 10, p. 2426, doi. 10.2337/db09-1870
By:
- Saha, Asish K.;
- Xu, X. Julia;
- Lawson, Ebony;
- Deoliveira, Rosangela;
- Brandon, Amanda E.;
- Kraegen, Edward W.;
- Ruderman, Neff B.
Publication type:
Article
Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent.
Published in:
Diabetes, 2009, v. 58, n. 11, p. 2547, doi. 10.2337/db09-0784
By:
- Turner, Nigel;
- Hariharan, Krit;
- TidAng, Jennifer;
- Frangioudakis, Georgia;
- Beale, Susan M.;
- Wright, Lauren E.;
- Xiao Yi Zeng;
- Leslie, Simon J.;
- Jing-Ya Li;
- Kraegen, Edward W.;
- Cooney, Gregory J.;
- Ji-Ming Ye
Publication type:
Article
Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet-Induced Insulin Resistance.
Published in:
Diabetes, 2009, v. 58, n. 3, p. 550, doi. 10.2337/db08-1078
By:
- Bruce, Clinton R.;
- Hoy, Andrew J.;
- Turner, Nigel;
- Watt, Matthew J.;
- Allen, Tamara L.;
- Carpenter, Kevin;
- Cooney, Gregory J.;
- Febbraio, Mark A.;
- Kraegen, Edward W.
Publication type:
Article
Fat partitioning and insulin sensitivity: robbing Peter to pay Paul?
Published in:
2009
By:
- Watt MJ;
- Kraegen EW;
- Watt, Matthew J;
- Kraegen, Edward W
Publication type:
journal article
Fat Partitioning and Insulin Sensitivity.
Published in:
2009
By:
- Watt, Matthew J.;
- Kraegen, Edward W.
Publication type:
Editorial
Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I.
Published in:
Diabetes, 2008, v. 57, n. 5, p. 1414, doi. 10.2337/db07-1552
By:
- Turner, Nigel;
- Jing-Ya Li;
- Gosby, Alison;
- To, Sabrina W. C.;
- Zhe Cheng;
- Miyoshi, Hiroyuki;
- Taketo, Makoto M.;
- Cooney, Gregory J.;
- Kraegen, Edward W.;
- James, David E.;
- Li-Hong Hu;
- Jia Li;
- Ye, Ji-Ming
Publication type:
Article
Insulin Resistance in Rat Skeletal Muscle Induced by Acute Glucose Infusion Is Not Dependent on Oxidative Stress.
Published in:
Diabetes, 2007, v. 56, p. A341
By:
- Hoy, Andrew J.;
- Bruce, Clinton R.;
- Turner, Nigel;
- James, David E.;
- Cooney, Gregory J.;
- Kraegen, Edward W.
Publication type:
Article
Acute Glucose Infusion-Induced Insulin Resistance Occurs Independent of Defects in Insulin Signaling in Skeletal Muscle.
Published in:
Diabetes, 2007, v. 56, p. A341
By:
- Hoy, Andrew J.;
- Bruce, Clinton R.;
- Cederberg, Anna;
- Turner, Nigel;
- James, David E.;
- Cooney, Gregory J.;
- Kraegen, Edward W.
Publication type:
Article
Berberine Activates AMPK in L6 Myotubes by a Mechanism Other Than Via Changes in ATP Levels.
Published in:
Diabetes, 2007, v. 56, p. A164
By:
- Turner, Nigel;
- To, Sabrina;
- Gosby, Alison;
- Kraegen, Edward W.;
- James, David E.;
- Cooney, Gregory J.
Publication type:
Article
Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States.
Published in:
Diabetes, 2006, v. 55, n. 8, p. 2256, doi. 10.2337/db06-0006
By:
- Lee, Yun S.;
- Kim, Woo S.;
- Kim, Kang H.;
- Yoon, Myung J.;
- Cho, Hye J.;
- Shen, Yun;
- Ye, Ji-Ming;
- Lee, Chul H.;
- Oh, Won K.;
- Kim, Chul T.;
- Hohnen-Behrens, Cordula;
- Gosby, Alison;
- Kraegen, Edward W.;
- James, David E.;
- Kim, Jae B.
Publication type:
Article
Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes.
Published in:
2005
By:
- Cleasby, Mark E.;
- Davey, Jonathan R.;
- Reinten, Tracie A.;
- Graham, Michael W.;
- James, David E.;
- Kraegen, Edward W.;
- Cooney, Gregory J.
Publication type:
journal article
Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms.
Published in:
2004
By:
- Cleasby, Mark E.;
- Dzamko, Nicolas;
- Hegarty, Bronwyn D.;
- Cooney, Gregory J.;
- Kraegen, Edward W.;
- Ye, Ji-Ming
Publication type:
journal article
AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo.
Published in:
2004
By:
- Iglesias, Miguel A.;
- Furler, Stuart M.;
- Cooney, Gregory J.;
- Kraegen, Edward W.;
- Ji-Ming Ye;
- Ye, Ji-Ming
Publication type:
journal article
Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy.
Published in:
2002
By:
- Gan, Seng Khee;
- Samaras, Katherine;
- Thompson, Campbell H.;
- Kraegen, Edward W.;
- Carr, Andrew;
- Cooper, David A.;
- Chisholm, Donald J.
Publication type:
journal article
AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.
Published in:
2002
By:
- Iglesias, Miguel A.;
- Ye, Ji-Ming;
- Frangioudakis, Georgia;
- Saha, Asish K.;
- Tomas, Eva;
- Ruderman, Neil B.;
- Cooney, Gregory J.;
- Kraegen, Edward W.
Publication type:
journal article
Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats.
Published in:
2002
By:
- Hegarty, Bronwyn D;
- Cooney, Gregory J.;
- Kraegen, Edward W.;
- Furler, Stuart M.
Publication type:
journal article
Chronic central melanocortin-4 receptor antagonism and central neuropeptide-Y infusion in rats produce increased adiposity by divergent pathways.
Published in:
2002
By:
- Baran, Katherine;
- Preston, Elaine;
- Wilks, Donna;
- Cooney, Gregory J.;
- Kraegen, Edward W.;
- Sainsbury, Amanda
Publication type:
journal article
Alteration in Phosphorylation of P20 Is Associated With Insulin Resistance.
Published in:
Diabetes, 2001, v. 50, n. 8, p. 1821, doi. 10.2337/diabetes.50.8.1821
By:
- Yu Wang;
- Aimin Xu;
- Jiming Ye;
- Kraegen, Edward W.;
- Tse, Cynthia A.;
- Cooper, Garth J.S.
Publication type:
Article
Peroxisome Proliferator-Activated Receptor (PPAR)-α Activation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat-Fed Rats.
Published in:
Diabetes, 2001, v. 50, n. 2, p. 411
By:
- Ji-Ming Ye;
- Doyle, Patrick J.;
- Iglesias, Miguel A.;
- Watson, David G.;
- Cooney, Gregory J.;
- Kraegen, Edward W.
Publication type:
Article
Local factors modulate tissue-specific NEFA utilization: assessment in rats using 3H-(R)-2-bromopalmitate.
Published in:
2000
By:
- Furler, Stuart M.;
- Cooney, Gregory J.;
- Hegarty, Bronwyn D.;
- Lim-Fraser, Megan Y.;
- Kraegen, Edward W.;
- Oakes, Nicholas D.;
- Furler, S M;
- Cooney, G J;
- Hegarty, B D;
- Lim-Fraser, M Y;
- Kraegen, E W;
- Oakes, N D
Publication type:
journal article
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Published in:
1999
By:
- Griffin, Margaret E.;
- Marcucci, Melissa J.;
- Cline, Gary W.;
- Bell, Kim;
- Barucci, Nicole;
- Lee, Dennis;
- Goodyear, Laurie J.;
- Kraegen, Edward W.;
- White, Morris F.;
- Shulman, Gerald I.;
- Griffin, M E;
- Marcucci, M J;
- Cline, G W;
- Bell, K;
- Barucci, N;
- Lee, D;
- Goodyear, L J;
- Kraegen, E W;
- White, M F;
- Shulman, G I
Publication type:
journal article
Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA.
Published in:
1997
By:
- Oakes, Nicholas D.;
- Bell, Kiln S.;
- Furler, Stuart M.;
- Camilleri, Souad;
- Saha, Asish K.;
- Ruderman, Neff B.;
- Chisholm, Donald J.;
- Kraegen, Edward W.;
- Oakes, N D;
- Bell, K S;
- Furler, S M;
- Camilleri, S;
- Saha, A K;
- Ruderman, N B;
- Chisholm, D J;
- Kraegen, E W
Publication type:
journal article
Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding.
Published in:
1997
By:
- Oakes, Nicholas D.;
- Cooney, Gregory J.;
- Camilleri, Souad;
- Chisholm, Donald J.;
- Kraegen, Edward W.;
- Oakes, N D;
- Cooney, G J;
- Camilleri, S;
- Chisholm, D J;
- Kraegen, E W
Publication type:
journal article
Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.
Published in:
1997
By:
- Schmitz-Peiffer, Carsten;
- Browne, Carol L.;
- Oakes, Nicholas D.;
- Watkinson, Allan;
- Chisholm, Donald J.;
- Kraegen, Edward W.;
- Biden, Trevor J.;
- Schmitz-Peiffer, C;
- Browne, C L;
- Oakes, N D;
- Watkinson, A;
- Chisholm, D J;
- Kraegen, E W;
- Biden, T J
Publication type:
journal article
Growth hormone-induced insulin resistance and its relationship to lipid availability in the rat.
Published in:
1996
By:
- Hettiarachchi, Manthinda;
- Watkinson, Allan;
- Jenkins, Arthur B.;
- Theos, Vicki;
- Ho, Ken K.Y.;
- Kraegen, Edward W.;
- Hettiarachchi, M;
- Watkinson, A;
- Jenkins, A B;
- Theos, V;
- Ho, K K;
- Kraegen, E W
Publication type:
journal article
A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat.
Published in:
1994
By:
- Oakes, Nicholas D.;
- Kennedy, Catherine J.;
- Jenkins, Arthur B.;
- Laybutt, D. Ross;
- Chisholm, Donald J.;
- Kraegen, Edward W.;
- Oakes, N D;
- Kennedy, C J;
- Jenkins, A B;
- Laybutt, D R;
- Chisholm, D J;
- Kraegen, E W
Publication type:
journal article
Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats.
Published in:
1991
By:
- Kraegen, Edward W.;
- Clark, Peter W.;
- Jenkins, Arthur B.;
- Daley, Eugene A.;
- Chisholm, Donald J.;
- Storlien, Leonard H.;
- Kraegen, E W;
- Clark, P W;
- Jenkins, A B;
- Daley, E A;
- Chisholm, D J;
- Storlien, L H
Publication type:
journal article
Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid.
Published in:
1991
By:
- Storlien, Leonard H.;
- Jenkins, Arthur B.;
- Chisholm, Donald J.;
- Pascoe, Wendy S.;
- Khouri, Sue;
- Kraegen, Edward W.;
- Storlien, L H;
- Jenkins, A B;
- Chisholm, D J;
- Pascoe, W S;
- Khouri, S;
- Kraegen, E W
Publication type:
journal article
Effects of exercise training and dietary manipulation on insulin-regulatable glucose-transporter mRNA in rat muscle.
Published in:
1991
By:
- Wake, Samantha A.;
- Sowden, Judith A.;
- Storlien, Leonard H.;
- James, David E.;
- Clark, Peter W.;
- Shine, John;
- Chisholm, Donald J.;
- Kraegen, Edward W.;
- Wake, S A;
- Sowden, J A;
- Storlien, L H;
- James, D E;
- Clark, P W;
- Shine, J;
- Chisholm, D J;
- Kraegen, E W
Publication type:
journal article
Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM.
Published in:
1989
By:
- Borkman, Mark;
- Chisholm, Donald J.;
- Furler, Stuart M.;
- Storlien, Leonard H.;
- Kraegen, Edward W.;
- Simon, Leon A.;
- Chesterman, Colin N.;
- Borkman, M;
- Chisholm, D J;
- Furler, S M;
- Storlien, L H;
- Kraegen, E W;
- Simons, L A;
- Chesterman, C N
Publication type:
journal article
Effect of d-fenfluramine on basal glucose turnover and fat-feeding-induced insulin resistance in rats.
Published in:
1989
By:
- Storlien, Leonard H.;
- Thorburn, Anne W.;
- Smythe, George A.;
- Jenkins, Arthur B.;
- Chisholm, Donald J.;
- Kraegen, Edward W.;
- Storlien, L H;
- Thorburn, A W;
- Smythe, G A;
- Jenkins, A B;
- Chisholm, D J;
- Kraegen, E W
Publication type:
journal article
Physiological importance of deficiency in early prandial insulin secretion in non-insulin-dependent diabetes.
Published in:
1988
By:
- Bruce, David G.;
- Chisholm, Donald J.;
- Storlien, Leonard H.;
- Kraegen, Edward W.;
- Bruce, D G;
- Chisholm, D J;
- Storlien, L H;
- Kraegen, E W
Publication type:
journal article
Insulin Action, Regional Fat, and Myocyte Lipid: Altered Relationships with Increased Adiposity.
Published in:
Obesity (19307381), 2003, v. 11, n. 11, p. 1295, doi. 10.1038/oby.2003.176
By:
- Gan, Seng Khee;
- Kriketos, Adamandia D.;
- Poynten, Ann M.;
- Furler, Stuart M.;
- Thompson, Campbell H.;
- Kraegen, Edward W.;
- Campbell, Lesley V.;
- Chisholm, Donald J.
Publication type:
Article
Independent Influences of Central Fat and Skeletal Muscle Lipids on Insulin Sensitivity.
Published in:
Obesity (19307381), 2001, v. 9, n. 9, p. 535, doi. 10.1038/oby.2001.70
By:
- Furler, Stuart M.;
- Poynten, Ann M.;
- Kriketos, Adamandia D.;
- Lowy, Andrew J.;
- Ellis, Bronwyn A.;
- Maclean, Elizabeth L.;
- Courtenay, Brett G.;
- Kraegen, Edward W.;
- Campbell, Lesley V.;
- Chisholm, Donald J.
Publication type:
Article
The effect of hyperinsulinemia on glucose homeostasis during moderate exercise in man.
Published in:
1982
By:
- Chisholm, Donald J.;
- Jenkins, Arthur B.;
- James, David E.;
- Kraegen, Edward W.;
- Chisholm, D J;
- Jenkins, A B;
- James, D E;
- Kraegen, E W
Publication type:
journal article
PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle.
Published in:
2011
By:
- Ye, Ji-Ming;
- Tid-Ang, Jennifer;
- Turner, Nigel;
- Zeng, Xiao-Yi;
- Li, Hai-Yan;
- Cooney, Gregory J.;
- Wulff, Erik Max;
- Sauerberg, Per;
- Kraegen, Edward W.
Publication type:
journal article
Changes in Aerobic Capacity and Visceral Fat but not Myocyte Lipid Levels Predict Increased Insulin Action After Exercise in Overweight and Obese Men.
Published in:
Diabetes Care, 2003, v. 26, n. 6, p. 1706, doi. 10.2337/diacare.26.6.1706
By:
- Seng Khee Gan;
- Kriketos, Adamandia D.;
- Ellis, Bronwyn A.;
- Thompson, Campbell H.;
- Kraegen, Edward W.;
- Chisholm, Donald J.
Publication type:
Article
The Determinants of Glycemic Responses to Diet Restriction and Weight Loss in Obesity and NIDDM.
Published in:
Diabetes Care, 1998, v. 21, n. 5, p. 687, doi. 10.2337/diacare.21.5.687
By:
- Markovic, Tania P.;
- Jenkins, Arthur B.;
- Campbell, Lesley V.;
- Furler, Stuart M.;
- Kraegen, Edward W.;
- Chisholm, Donald J.
Publication type:
Article
Assessment of experts' approach to insulin therapy and development of a simulator for diabetes insulin adjustment.
Published in:
1992
By:
- Hauser, Thomas;
- Kraegen, Edward W.;
- Campbell, Lesley V.;
- Compton, Paul J.;
- Sammut, Claude;
- Chisholm, Donald J.;
- Hauser, T;
- Kraegen, E W;
- Campbell, L V;
- Compton, P J;
- Sammut, C;
- Chisholm, D J
Publication type:
journal article
Blood glucose control by intermittent loop closure in the basal mode: computer simulation studies with a diabetic model.
Published in:
1985
By:
- Furler, Stuart M.;
- Kraegen, Edward W.;
- Smallwood, Robert H.;
- Chisholm, Donald J.;
- Furler, S M;
- Kraegen, E W;
- Smallwood, R H;
- Chisholm, D J
Publication type:
journal article
Comparison of plateau insulin levels achieved by intravenous or subcutaneous insulin infusion: evidence for low rates of subcutaneous degradation.
Published in:
1983
By:
- KRAEGEN, EDWARD W.;
- CHISHOLM, DONALD J.;
- HEWETT, MARGOT J.;
- Kraegen, E W;
- Chisholm, D J;
- Hewett, M J
Publication type:
journal article

Found: 51