Works by Krüger, Achim

Results: 40

Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer.

Published in:

2018

By:

Prokopchuk, Olga;
Grünwald, Barbara;
Nitsche, Ulrich;
Jäger, Carsten;
Prokopchuk, Oleksii L.;
Schubert, Elaine C.;
Friess, Helmut;
Martignoni, Marc E.;
Krüger, Achim;
Grünwald, Barbara;
Jäger, Carsten;
Krüger, Achim

Publication type:

journal article

Oncogenic Linear Collagen VI of Invasive Breast Cancer Is Induced by CCL5.

Published in:

Journal of Clinical Medicine, 2020, v. 9, n. 4, p. 991, doi. 10.3390/jcm9040991

By:

Brett, Elizabeth;
Sauter, Matthias;
Timmins, Éadaoin;
Azimzadeh, Omid;
Rosemann, Michael;
Merl-Pham, Juliane;
Hauck, Stefanie M.;
Nelson, Peter J.;
Becker, Karl Friedrich;
Schunn, Ilse;
Lowery, Aoife;
Kerin, Michael J.;
Atkinson, Michael;
Krüger, Achim;
Machens, Hans-Günther;
Duscher, Dominik

Publication type:

Article

Molecular targets and pathways involved in liver metastasis of colorectal cancer.

Published in:

Clinical & Experimental Metastasis, 2015, v. 32, n. 6, p. 623, doi. 10.1007/s10585-015-9732-3

By:

Weidle, Ulrich;
Birzele, Fabian;
Krüger, Achim

Publication type:

Article

Role of L1 cell adhesion molecule (L1CAM) in the metastatic cascade: promotion of dissemination, colonization, and metastatic growth.

Published in:

Clinical & Experimental Metastasis, 2014, v. 31, n. 1, p. 87, doi. 10.1007/s10585-013-9613-6

By:

Weinspach, Dirk;
Seubert, Bastian;
Schaten, Susanne;
Honert, Katja;
Sebens, Susanne;
Altevogt, Peter;
Krüger, Achim

Publication type:

Article

Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10.

Published in:

Clinical & Experimental Metastasis, 2011, v. 28, n. 8, p. 793, doi. 10.1007/s10585-011-9410-z

By:

Schelter, Florian;
Grandl, Martina;
Seubert, Bastian;
Schaten, Susanne;
Hauser, Stephanie;
Gerg, Michael;
Boccaccio, Carla;
Comoglio, Paolo;
Krüger, Achim

Publication type:

Article

Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by hypoxia-inducible factor-1α.

Published in:

Clinical & Experimental Metastasis, 2011, v. 28, n. 2, p. 91, doi. 10.1007/s10585-010-9360-x

By:

Schelter, Florian;
Halbgewachs, Birgit;
Bäumler, Petra;
Neu, Caroline;
Görlach, Agnes;
Schrötzlmair, Florian;
Krüger, Achim

Publication type:

Article

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes.

Published in:

Biological Chemistry, 2012, v. 393, n. 12, p. 1449, doi. 10.1515/hsz-2012-0206

By:

Grismayer, Bettina;
Sato, Sumito;
Kopitz, Charlotte;
Ries, Christian;
Soelch, Susanne;
Schmitt, Manfred;
Baretton, Gustavo;
Krüger, Achim;
Luther, Thomas;
Kotzsch, Matthias;
Magdolen, Viktor

Publication type:

Article

Placental expression of proteases and their inhibitors in patients with HELLP syndrome.

Published in:

Biological Chemistry, 2009, v. 390, n. 11, p. 1199, doi. 10.1515/BC.2009.123

By:

Von Steinburg, Stephanie Pildner;
Krüger, Achim;
Fischer, Thorsten;
Schneider, Karl-Theodor Mario;
Schmitt, Manfred

Publication type:

Article

Functional genetic mouse models: promising tools for investigation of the proteolytic internet.

Published in:

Biological Chemistry, 2009, v. 390, n. 2, p. 91, doi. 10.1515/BC.2009.015

By:

Krüger, Achim

Publication type:

Article

Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells.

Published in:

Biological Chemistry, 2006, v. 387, n. 6, p. 807, doi. 10.1515/BC.2006.102

By:

Prezas, Panagiotis;
Arlt, Matthias J. E.;
Viktorov, Petar;
Soosaipillai, Antoninus;
Holzscheiter, Leon;
Schmitt, Manfred;
Talieri, Maroulio;
Diamandis, Eleftherios P.;
Krüger, Achim;
Magdolen, Viktor

Publication type:

Article

Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2021, v. 12, n. 5, p. 1333, doi. 10.1002/jcsm.12758

By:

Morigny, Pauline;
Kaltenecker, Doris;
Zuber, Julia;
Machado, Juliano;
Mehr, Lisa;
Tsokanos, Foivos‐Filippos;
Kuzi, Hanna;
Hermann, Chris D.;
Voelkl, Michael;
Monogarov, German;
Springfeld, Christoph;
Laurent, Victor;
Engelmann, Bernd;
Friess, Helmut;
Zörnig, Inka;
Krüger, Achim;
Krijgsveld, Jeroen;
Prokopchuk, Olga;
Fisker Schmidt, Søren;
Rohm, Maria

Publication type:

Article

A novel tissue inhibitor of metalloproteinases‐1/liver/cachexia score predicts prognosis of gastrointestinal cancer patients.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2021, v. 12, n. 2, p. 378, doi. 10.1002/jcsm.12680

By:

Prokopchuk, Olga;
Hermann, Chris D.;
Schoeps, Benjamin;
Nitsche, Ulrich;
Prokopchuk, Oleksii L.;
Knolle, Percy;
Friess, Helmut;
Martignoni, Marc E.;
Krüger, Achim

Publication type:

Article

Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by host-derived urokinase-type plasminogen activator.

Published in:

Journal of Cellular & Molecular Medicine, 2010, v. 14, n. 12, p. 2760, doi. 10.1111/j.1582-4934.2009.00951.x

By:

Schrötzlmair, Florian;
Kopitz, Charlotte;
Halbgewachs, Birgit;
Lu, Fei;
Algül, Hana;
Brünner, Nils;
Gänsbacher, Bernd;
Krüger, Achim

Publication type:

Article

TNF promotes metastasis by impairing natural killer cell activity.

Published in:

International Journal of Cancer, 1996, v. 66, n. 3, p. 388, doi. 10.1002/(SICI)1097-0215(19960503)66:3<388::AID-IJC20>3.0.CO;2-6

By:

Hafner, Michael;
Orosz, Peter;
Krüger, Achim;
Männel, Daniela N.

Publication type:

Article

Liver endothelial cells participate in T-cell-dependent host resistance to lymphoma metastasis by production of nitric oxide in vivo.

Published in:

International Journal of Cancer, 1995, v. 63, n. 3, p. 405, doi. 10.1002/ijc.2910630318

By:

Rocha, Marian;
Krüger, Achim;
Van Rooijen, Nico;
Schirrmacher, Volker;
Umansky, Victor

Publication type:

Article

Promotion of experimental liver metastasis by tumor necrosis factor.

Published in:

International Journal of Cancer, 1995, v. 60, n. 6, p. 867, doi. 10.1002/ijc.2910600624

By:

Orosz, Peter;
Krüger, Achim;
Hubbe, Marcus;
Rüschoff, Josef;
Hoegen, Paul Von;
N. Männel, Daniela

Publication type:

Article

Scattered micrometastases visualized at the single-cell level: Detection and re-isolation of lacZ-labeled metastasized lymphoma cells.

Published in:

International Journal of Cancer, 1994, v. 58, n. 2, p. 275, doi. 10.1002/ijc.2910580222

By:

Krüger, Achim;
Schirrmacher, Volker;
Hoegen, Paul Von

Publication type:

Article

Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells.

Published in:

Molecular Cancer, 2012, v. 11, n. 1, p. 62, doi. 10.1186/1476-4598-11-62

By:

Grismayer, Bettina;
Sölch, Susanne;
Seubert, Bastian;
Kirchner, Thomas;
Schäfer, Sonja;
Baretton, Gustavo;
Schmitt, Manfred;
Luther, Thomas;
Krüger, Achim;
Kotzsch, Matthias;
Magdolen, Viktor

Publication type:

Article

Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo.

Published in:

Breast Cancer Research & Treatment, 2011, v. 127, n. 3, p. 649, doi. 10.1007/s10549-010-1042-5

By:

Sato, Sumito;
Kopitz, Charlotte;
Grismayer, Bettina;
Beaufort, Nathalie;
Reuning, Ute;
Schmitt, Manfred;
Luther, Thomas;
Kotzsch, Matthias;
Krüger, Achim;
Magdolen, Viktor

Publication type:

Article

O-(2-[[sup 18] F]Fluoroethyl)-L-tyrosine (FET): a tracer for differentiation of tumour from inflammation in murine lymph nodes.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2002, v. 29, n. 8, p. 1039, doi. 10.1007/s00259-002-0821-6

By:

Rau, Friederike C.;
Weber, Wolfgang A.;
Wester, Hans-Jürgen;
Herz, Michael;
Becker, Ingrid;
Krüger, Achim;
Schwaiger, Markus;
Senekowitsch-Schmidtke, Reingard

Publication type:

Article

Host TIMP-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell line.

Published in:

Oncogene, 1998, v. 16, n. 18, p. 2419, doi. 10.1038/sj.onc.1201774

By:

Krüger, Achim;
Sanchez-Sweatman, Otto H;
Martin, David C;
Fata, Jimmie E;
Ho, Andrew T;
Orr, F William;
Rüther, Ulrich;
Khokha, Rama

Publication type:

Article

Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis.

Published in:

Journal of Gene Medicine, 2004, v. 6, n. 11, p. 1228, doi. 10.1002/jgm.637

By:

Elezkurtaj, Sefer;
Kopitz, Charlotte;
Baker, Andrew H.;
Perez-Cantó, Alejandra;
Arlt, Matthias J. E.;
Khokha, Rama;
Gansbacher, Bernd;
Anton, Martina;
Brand, Karsten;
Krüger, Achim

Publication type:

Article

The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib.

Published in:

Cancer Immunology, Immunotherapy, 2016, v. 65, n. 3, p. 273, doi. 10.1007/s00262-015-1790-5

By:

Heine, Annkristin;
Schilling, Judith;
Grünwald, Barbara;
Krüger, Achim;
Gevensleben, Heidrun;
Held, Stefanie;
Garbi, Natalio;
Kurts, Christian;
Brossart, Peter;
Knolle, Percy;
Diehl, Linda;
Höchst, Bastian

Publication type:

Article

TIMP-1 is a novel ligand of Amyloid Precursor Protein and triggers a proinflammatory phenotype in human monocytes.

Published in:

Journal of Cell Biology, 2023, v. 222, n. 2, p. 1, doi. 10.1083/jcb.202206095

By:

Eckfeld, Celina;
Schoeps, Benjamin;
Häußler, Daniel;
Frädrich, Julian;
Bayerl, Felix;
Böttcher, Jan Philipp;
Knolle, Percy;
Heisz, Simone;
Prokopchuk, Olga;
Hauner, Hans;
Munkhbaatar, Enkhtsetseg;
Demir, Ihsan Ekin;
Hermann, Chris D.;
Krüger, Achim

Publication type:

Article

Tetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization.

Published in:

International Journal of Cancer, 2015, v. 136, n. 10, p. 2304, doi. 10.1002/ijc.29296

By:

Seubert, Bastian;
Cui, Haissi;
Simonavicius, Nicole;
Honert, Katja;
Schäfer, Sandra;
Reuning, Ute;
Heikenwalder, Mathias;
Mari, Bernard;
Krüger, Achim

Publication type:

Article

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.

Published in:

International Journal of Cancer, 2015, v. 136, n. 4, p. E14, doi. 10.1002/ijc.29129

By:

Kelwick, Richard;
Wagstaff, Laura;
Decock, Julie;
Roghi, Christian;
Cooley, Lindsay S.;
Robinson, Stephen D.;
Arnold, Hugh;
Gavrilović, Jelena;
Jaworski, Diane M.;
Yamamoto, Kazuhiro;
Nagase, Hideaki;
Seubert, Bastian;
Krüger, Achim;
Edwards, Dylan R.

Publication type:

Article

Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation.

Published in:

ChemMedChem, 2015, v. 10, n. 12, p. 1969, doi. 10.1002/cmdc.201500449

By:

Beck, Philipp;
Cui, Haissi;
Hegemann, Julian D.;
Marahiel, Mohammed A.;
Krüger, Achim;
Groll, Michael

Publication type:

Article

Selektive Inhibition des Immunoproteasoms durch ligandeninduzierte Vernetzung des katalytischen Zentrums.

Published in:

Angewandte Chemie, 2014, v. 126, n. 44, p. 12163, doi. 10.1002/ange.201406964

By:

Dubiella, Christian;
Cui, Haissi;
Gersch, Malte;
Brouwer, Arwin J.;
Sieber, Stephan A.;
Krüger, Achim;
Liskamp, Rob M. J.;
Groll, Michael

Publication type:

Article

Ein systematischer Vergleich peptidischer Proteasominhibitoren unterstreicht α-Ketoamid als vielversprechende elektrophile Leitstruktur.

Published in:

Angewandte Chemie, 2014, v. 126, n. 6, p. 1705, doi. 10.1002/ange.201308984

By:

Stein, Martin L.;
Cui, Haissi;
Beck, Philipp;
Dubiella, Christian;
Voss, Constantin;
Krüger, Achim;
Schmidt, Boris;
Groll, Michael

Publication type:

Article

Premetastatic niche formation in the liver: emerging mechanisms and mouse models.

Published in:

Journal of Molecular Medicine, 2015, v. 93, n. 11, p. 1193, doi. 10.1007/s00109-015-1342-7

By:

Krüger, Achim

Publication type:

Article

Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill.

Published in:

Cancers, 2021, v. 13, n. 7, p. 1679, doi. 10.3390/cancers13071679

By:

Mohan, Vishnu;
Gaffney, Jean P.;
Solomonov, Inna;
Levin, Maxim;
Klepfish, Mordehay;
Akbareian, Sophia;
Grünwald, Barbara;
Dym, Orly;
Eisenstein, Miriam;
Yu, Kenneth H.;
Kelsen, David P.;
Krüger, Achim;
Edwards, Dylan R.;
Sagi, Irit;
Mohammad, Ramzi M.

Publication type:

Article

Full-Length L1CAM and Not Its Δ2Δ27 Splice Variant Promotes Metastasis through Induction of Gelatinase Expression.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018989

By:

Hauser, Stephanie;
Bickel, Laura;
Weinspach, Dirk;
Gerg, Michael;
Schäfer, Michael K.;
Pfeifer, Marco;
Hazin, John;
Schelter, Florian;
Weidle, Ulrich H.;
Ramser, Juliane;
Volkmann, Juliane;
Meindl, Alfons;
Schmitt, Manfred;
Schrötzlmair, Florian;
Altevogt, Peter;
Krüger, Achim

Publication type:

Article

Reduction of breast carcinoma tumor growth and lung colonization by overexpression of the soluble urokinase-type plasminogen activator receptor (CD87).

Published in:

Cancer Gene Therapy, 2000, v. 7, n. 2, p. 292, doi. 10.1038/sj.cgt.7700144

By:

Krüger, Achim;
Soeltl, Rita;
Lutz, Verena;
Wilhelm, Olaf G;
Magdolen, Viktor;
Rojo, Elena E;
Hantzopoulos, Petros A;
Graeff, Henner;
Gänsbacher, Bernd;
Schmitt, Manfred

Publication type:

Article

Functional disparities within the TIMP family in cancer: hints from molecular divergence.

Published in:

Cancer & Metastasis Reviews, 2019, v. 38, n. 3, p. 469, doi. 10.1007/s10555-019-09812-6

By:

Eckfeld, Celina;
Häußler, Daniel;
Schoeps, Benjamin;
Hermann, Chris D.;
Krüger, Achim

Publication type:

Article

Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 44, p. 11969, doi. 10.1002/anie.201406964

By:

Dubiella, Christian;
Cui, Haissi;
Gersch, Malte;
Brouwer, Arwin J.;
Sieber, Stephan A.;
Krüger, Achim;
Liskamp, Rob M. J.;
Groll, Michael

Publication type:

Article

Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the α-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 6, p. 1679, doi. 10.1002/anie.201308984

By:

Stein, Martin L.;
Cui, Haissi;
Beck, Philipp;
Dubiella, Christian;
Voss, Constantin;
Krüger, Achim;
Schmidt, Boris;
Groll, Michael

Publication type:

Article

High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread

Published in:

FEBS Letters, 2002, v. 528, n. 1-3, p. 212, doi. 10.1016/S0014-5793(02)03311-2

By:

Sato, Sumito;
Kopitz, Charlotte;
Schmalix, Wolfgang A.;
Muehlenweg, Bernd;
Kessler, Horst;
Schmitt, Manfred;
Krüger, Achim;
Magdolen, Viktor

Publication type:

Article

Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine.

Published in:

Cell Biochemistry & Function, 2011, v. 29, n. 8, p. 651, doi. 10.1002/cbf.1801

By:

Ari, Ferda;
Napieralski, Rudolf;
Ulukaya, Engin;
Dere, Egemen;
Colling, Christoph;
Honert, Katja;
Krüger, Achim;
Kiechle, Marion;
Schmitt, Manfred

Publication type:

Article

Increase of Anti-Metastatic Efficacy by Selectivity-But Not Affinity-Optimization of Synthetic Serine Protease Inhibitors.

Published in:

Biological Chemistry, 2003, v. 384, n. 10/11, p. 1515, doi. 10.1515/BC.2003.168

By:

Banke, Ingo J.;
Arlt, Matthias J. E.;
Pennington, Caroline;
Kopitz, Charlotte;
Steinmetzer, Torsten;
Schweinitz, Andrea;
Gansbacher, Bernd;
Quigley, James P.;
Edwards, Dylan R.;
Stürzebecher, Jörg;
Krüger, Achim

Publication type:

Article

Inhibition of Intraperitoneal Tumor Growth of Human Ovarian Cancer Cells by Bi- and Trifunctional Inhibitors of Tumor-Associated Proteolytic Systems.

Published in:

Biological Chemistry, 2003, v. 384, n. 7, p. 1097, doi. 10.1515/BC.2003.122

By:

Krol, Janna;
Kopitz, Charlotte;
Kirschenhofer, Angela;
Schmitt, Manfred;
Magdolen, Ulla;
Krüger, Achim;
Magdolen, Viktor

Publication type:

Article