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Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells.
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2016, v. 39, n. 6, p. 2110, doi. 10.1159/000447907
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- Publication type:
- Article
NSC23766, a Known Inhibitor of Tiam1- Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model.
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2016, v. 39, n. 2, p. 760, doi. 10.1159/000445666
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- Publication type:
- Article
A lack of 'glue' misplaces Rab27A to cause islet dysfunction in diabetes.
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- Journal of Pathology, 2016, v. 238, n. 3, p. 375, doi. 10.1002/path.4671
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- Article
Kinome Profiling Reveals Abnormal Activity of Kinases in Skeletal Muscle From Adults With Obesity and Insulin Resistance.
- Published in:
- 2019
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- Publication type:
- journal article
Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation.
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- Cellular Physiology & Biochemistry (Karger AG), 2015, v. 36, n. 1, p. 208, doi. 10.1159/000374065
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- Publication type:
- Article
Nm23-H1 Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells via Arf6-Rac1 Signaling Axis.
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- Cellular Physiology & Biochemistry (Karger AG), 2013, v. 32, n. 3, p. 533, doi. 10.1159/000354457
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- Publication type:
- Article
Phagocytic NADPH Oxidase Links ARNO-Arf6 Signaling Pathway in Glucose-Stimulated Insulin Secretion from the Pancreatic β-Cell.
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- Cellular Physiology & Biochemistry (Karger AG), 2012, v. 30, n. 6, p. 1351, doi. 10.1159/000343324
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- Publication type:
- Article
L-threo-C<sub>6</sub>-pyridinium-ceramide Bromide, a Novel Cationic Ceramide, Induces NADPH Oxidase Activation, Mitochondrial Dysfunction and Loss in Cell Viability in INS 832/13 β-cells.
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2012, v. 30, n. 4, p. 1051, doi. 10.1159/000341481
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- Publication type:
- Article
Oxidative Stress in Cytokine-Induced Dysfunction of the Pancreatic Beta Cell: Known Knowns and Known Unknowns.
- Published in:
- Metabolites (2218-1989), 2020, v. 10, n. 12, p. 480, doi. 10.3390/metabo10120480
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- Publication type:
- Article
VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.
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- Diabetologia, 2015, v. 58, n. 11, p. 2573, doi. 10.1007/s00125-015-3707-4
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- Publication type:
- Article
TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy.
- Published in:
- Diabetologia, 2014, v. 57, n. 5, p. 1047, doi. 10.1007/s00125-014-3194-z
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- Publication type:
- Article
Role of G-proteins in islet function in health and diabetes.
- Published in:
- Diabetes, Obesity & Metabolism, 2017, v. 19, p. 63, doi. 10.1111/dom.13011
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- Publication type:
- Article
Calcium-Calmodulin-Dependent Myosin Phosphorylation by Pancreatic Islets.
- Published in:
- Diabetes, 1982, v. 31, n. 6, p. 566, doi. 10.2337/diab.31.6.566
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- Publication type:
- Article
Enzymes of phospholipid metabolism in rat pancreatic islets: Subcellular distribution and the effect of glucose and calcium.
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- Journal of Cellular Biochemistry, 1986, v. 32, n. 2, p. 143, doi. 10.1002/jcb.240320206
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- Publication type:
- Article
Protein histidine [de]phosphorylation in insulin secretion: abnormalities in models of impaired insulin secretion.
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- Naunyn-Schmiedeberg's Archives of Pharmacology, 2011, v. 384, n. 4/5, p. 383, doi. 10.1007/s00210-011-0616-z
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- Publication type:
- Article
A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells.
- Published in:
- Journal of Cellular & Molecular Medicine, 2009, v. 13, n. 8b, p. 1877, doi. 10.1111/j.1582-4934.2008.00672.x
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- Publication type:
- Article
Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet β-cell.
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- Journal of Cellular & Molecular Medicine, 2008, v. 12, n. 5b, p. 1885, doi. 10.1111/j.1582-4934.2008.00330.x
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- Publication type:
- Article
Protein prenylation in glucose-induced insulin secretion from the pancreatic islet β cell: a perspective.
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- Journal of Cellular & Molecular Medicine, 2008, v. 12, n. 1, p. 164, doi. 10.1111/j.1582-4934.2007.00168.x
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- Publication type:
- Article
CARD9 Mediates Glucose‐Stimulated Insulin Secretion in Pancreatic‐β Cells.
- Published in:
- FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.05201
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- Publication type:
- Article
CARD9 Accelerates Rac1‐p38MAPK Axis in Pancreatic‐β Cells Under the Duress of Chronic Hyperglycemia.
- Published in:
- FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.05202
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- Publication type:
- Article
Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants.
- Published in:
- Journal of Diabetes Research, 2021, p. 1, doi. 10.1155/2021/9979234
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- Publication type:
- Article
Dominant-Negative α-Subunit of Farnesyl- and Geranyltransferase Inhibits Glucose-Stimulated, but Not KCl-Stimulated, Insulin Secretion in INS 832/13 Cells.
- Published in:
- Diabetes, 2007, v. 56, n. 1, p. 204, doi. 10.2337/db06-0668
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- Publication type:
- Article
Rho guanosine diphosphate-dissociation inhibitor plays a negative modulatory role in glucose-stimulated insulin secretion.
- Published in:
- 2005
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- Publication type:
- journal article
Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+.
- Published in:
- 2005
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- Publication type:
- journal article
Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats.
- Published in:
- 2004
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- Publication type:
- journal article
Activation of acetyl-CoA carboxylase by a glutamate- and magnesium-sensitive protein phosphatase in the islet beta-cell.
- Published in:
- 2001
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- Publication type:
- journal article
A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.
- Published in:
- 1999
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- Publication type:
- journal article
Hyperglycemic Conditions Promote Rac1-Mediated Serine536 Phosphorylation of p65 Subunit of NFκB (RelA) in Pancreatic Beta Cells.
- Published in:
- Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2022, v. 56, n. 4, p. 367, doi. 10.33594/000000557
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- Publication type:
- Article
CARD9 Mediates Pancreatic Islet Beta-Cell Dysfunction Under the Duress of Hyperglycemic Stress.
- Published in:
- Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2022, v. 56, n. 2, p. 120, doi. 10.33594/000000508
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- Publication type:
- Article
P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic β-Cells.
- Published in:
- Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2021, v. 55, n. 6, p. 1218, doi. 10.33594/000000310
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- Publication type:
- Article
RhoG-Rac1 Signaling Pathway Mediates Metabolic Dysfunction of the Pancreatic Beta-Cells Under Chronic Hyperglycemic Conditions.
- Published in:
- Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2021, v. 55, n. 2, p. 180, doi. 10.33594/000000354
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- Publication type:
- Article
P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic β-Cells.
- Published in:
- Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2020, v. 54, n. 6, p. 1218, doi. 10.33594/000000310
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- Publication type:
- Article
Hyperglycemic Stress Induces Expression, Degradation, and Nuclear Association of Rho GDP Dissociation Inhibitor 2 (RhoGDIβ) in Pancreatic β-Cells.
- Published in:
- Cells (2073-4409), 2024, v. 13, n. 3, p. 272, doi. 10.3390/cells13030272
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- Publication type:
- Article
Glucotoxicity promotes aberrant activation and mislocalization of Ras-related C3 botulinum toxin substrate 1 [Rac1] and metabolic dysfunction in pancreatic islet β-cells: reversal of such metabolic defects by metformin.
- Published in:
- Apoptosis, 2017, v. 22, n. 11, p. 1380, doi. 10.1007/s10495-017-1409-8
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- Publication type:
- Article
Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells.
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- Apoptosis, 2017, v. 22, n. 5, p. 597, doi. 10.1007/s10495-017-1354-6
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- Publication type:
- Article
Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells.
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- Apoptosis, 2014, v. 19, n. 12, p. 1691, doi. 10.1007/s10495-014-1038-4
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- Publication type:
- Article
Nifedipine prevents etoposide-induced caspase-3 activation, prenyl transferase degradation and loss in cell viability in pancreatic β-cells.
- Published in:
- Apoptosis, 2013, v. 18, n. 1, p. 1, doi. 10.1007/s10495-012-0763-9
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- Publication type:
- Article
Localization of a nuclear serine/threonine protein phosphatase in insulin-secreting INS-1 cells: potential regulation by IL-1β.
- Published in:
- Apoptosis, 2006, v. 11, n. 8, p. 1401, doi. 10.1007/s10495-006-8371-1
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- Publication type:
- Article
Phospholipid N-methylation in diabetic erythrocytes: Effects on membrane Na<sup>+</sup>, K<sup>+</sup> ATPase activity.
- Published in:
- Cell Biochemistry & Function, 1992, v. 10, n. 2, p. 95, doi. 10.1002/cbf.290100205
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- Publication type:
- Article
Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-Cells.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 21, p. 15994, doi. 10.3390/ijms242115994
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- Publication type:
- Article
Depletion of the catalytic subunit of protein phosphatase-2A (PP2Ac) markedly attenuates glucose-stimulated insulin secretion in pancreatic β-cells.
- Published in:
- Endocrine (1355008X), 2007, v. 31, n. 3, p. 248, doi. 10.1007/s12020-007-0046-3
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- Publication type:
- Article
Deoxysphingolipids: β-Cell, Beware of These New Kids on the Block.
- Published in:
- 2014
- By:
- Publication type:
- Opinion
Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.
- Published in:
- 2011
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- Publication type:
- journal article
Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets.
- Published in:
- Diabetes, 2011, v. 60, n. 11, p. 2843, doi. 10.2337/db11-0809
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- Publication type:
- Article
Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
- Published in:
- 2010
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- Publication type:
- journal article
Protein Farnesylation--Dependent Raf/Extracellular Signal--Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells.
- Published in:
- Diabetes, 2010, v. 59, n. 4, p. 967, doi. 10.2337/db09-1334
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- Publication type:
- Article