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Influence of Fatigue Loading and Bone Turnover on Bone Strength and Pattern of Experimental Fractures of the Tibia in Mice.
Published in:
2016
By:
- Bonnet, Nicolas;
- Gerbaix, Maude;
- Ominsky, Michael;
- Ammann, Patrick;
- Kostenuik, Paul;
- Ferrari, Serge;
- Kostenuik, Paul J;
- Ferrari, Serge L
Publication type:
journal article
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab.
Published in:
Nature Reviews Drug Discovery, 2012, v. 11, n. 5, p. 401, doi. 10.1038/nrd3705
By:
- Lacey, David L.;
- Boyle, William J.;
- Simonet, W. Scott;
- Kostenuik, Paul J.;
- Dougall, William C.;
- Sullivan, John K.;
- Martin, Javier San;
- Dansey, Roger
Publication type:
Article
Advances in Osteoporosis Therapy: Focus on Osteoanabolic Agents, Secondary Fracture Prevention, and Perioperative Bone Health.
Published in:
Current Osteoporosis Reports, 2023, v. 21, n. 4, p. 386, doi. 10.1007/s11914-023-00793-8
By:
- Kostenuik, Paul J.;
- Binkley, Neil;
- Anderson, Paul A.
Publication type:
Article
Immobilization of Denosumab on Titanium Affects Osteoclastogenesis of Human Peripheral Blood Monocytes.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 5, p. 1002, doi. 10.3390/ijms20051002
By:
- Beck, Felicitas;
- Hartmann, Eliza S.;
- Koehler, Miriam I.;
- Redeker, Julia I.;
- Schluessel, Sabine;
- Schmitt, Baerbel;
- Fottner, Andreas;
- Unger, Marina;
- van Griensven, Martijn;
- Michael, Jan;
- Summer, Burkhard;
- Kunzelmann, Karl-Heinz;
- Beutner, Rene;
- Scharnweber, Dieter;
- Kostenuik, Paul J.;
- Mayer-Wagner, Susanne
Publication type:
Article
Matrix Metalloproteinase- Driven Endochondral Fracture Union Proceeds Independently of Osteoclast Activity.
Published in:
Journal of Bone & Mineral Research, 2013, v. 28, n. 7, p. 1550, doi. 10.1002/jbmr.1889
By:
- McDonald, Michelle M;
- Morse, Alyson;
- Mikulec, Kathy;
- Peacock, Lauren;
- Baldock, Paul A;
- Kostenuik, Paul J;
- Little, David G
Publication type:
Article
Inhibition of Sclerostin by Monoclonal Antibody Increases Bone Formation, Bone Mass, and Bone Strength in Aged Male Rats.
Published in:
Journal of Bone & Mineral Research, 2010, v. 25, n. 12, p. 2371, doi. 10.1002/jbmr.182
By:
- Xiaodong Li;
- Warmington, Kelly S.;
- Qing-Tian Niu;
- Asuncion, Franklin J.;
- Barrero, Mauricio;
- Grisanti, Mario;
- Dwyer, Denise;
- Stouch, Brian;
- Thway, Theingi M.;
- Stolina, Marina;
- Ominsky, Michael S.;
- Kostenuik, Paul J.;
- Simonet, William S.;
- Paszty, Chris;
- Hua Zhu Ke
Publication type:
Article
One Year of Transgenic Overexpression of Osteoprotegerin in Rats Suppressed Bone Resorption and Increased Vertebra Bone Volume, Density, and Strength.
Published in:
Journal of Bone & Mineral Research, 2009, v. 24, n. 7, p. 1234, doi. 10.1359/JBMR.090215
By:
- Ominsky, Michael S.;
- Stolina, Marina;
- Xiaodong Li;
- Corbin, Timothy J.;
- Asuncion, Franklin J.;
- Barrero, Mauricio;
- Qing-Tian Niu;
- Dwyer, Denise;
- Adamu, Steven;
- Warmington, Kelly S.;
- Grisanti, Mario;
- Tan, Hong L.;
- Ke, Hua Z.;
- Simonet, William S.;
- Kostenuik, Paul J.
Publication type:
Article
Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis.
Published in:
Journal of Bone & Mineral Research, 2009, v. 24, n. 4, p. 578, doi. 10.1359/jbmr.081206
By:
- Xiaodong Li;
- Ominsky, Michael S.;
- Warmington, Kelly S.;
- Morony, Sean;
- Gong, Jianhua;
- Jin Cao;
- Yongming Gao;
- Shalhoub, Victoria;
- Tipton, Barbara;
- Haldankar, Raj;
- Chen, Qing;
- Winters, Aaron;
- Boone, Tom;
- Zhaopo Geng;
- Niu, Qing-Tian;
- Hua Zhu Ke;
- Kostenuik, Paul J.;
- Simonet, W. Scott;
- Lacey, David L.;
- Paszty, Chris
Publication type:
Article
Comparison of Effects of the Bisphosphonate Alendronate Versus the RANKL Inhibitor Denosumab on Murine Fracture Healing.
Published in:
Journal of Bone & Mineral Research, 2009, v. 24, n. 2, p. 196, doi. 10.1359/jbmr.081113
By:
- Gerstenfeld, Louis C.;
- Sacks, Daniel J.;
- Pelis, Megan;
- Mason, Zachary D.;
- Graves, Dana T.;
- Barrero, Mauricio;
- Ominsky, Michael S.;
- Kostenuik, Paul J.;
- Morgan, Elise F.;
- Einhorn, Thomas A.
Publication type:
Article
Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock-In Mice That Express Chimeric (Murine/Human) RANKL.
Published in:
Journal of Bone & Mineral Research, 2009, v. 24, n. 2, p. 182, doi. 10.1359/jbmr.081112
By:
- Kostenuik, Paul J.;
- Nguyen, Hung Q.;
- McCabe, James;
- Warmington, Kelly S.;
- Kurahara, Carol;
- Ning Sun;
- Ching Chen;
- Li, Luke;
- Cattley, Russ C.;
- Van, Gwyneth;
- Scully, Shelia;
- Elliott, Robin;
- Grisanti, Mario;
- Morony, Sean;
- Hong Lin Tan;
- Asuncion, Frank;
- Xiaodong Li;
- Ominsky, Michael S.;
- Stolina, Marina;
- Dwyer, Denise
Publication type:
Article
Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength.
Published in:
Journal of Bone & Mineral Research, 2008, v. 23, n. 6, p. 860, doi. 10.1359/jbmr.080216
By:
- Xiaodong Li;
- Ominsky, Michael S.;
- Qing-Tian Niu;
- Ning Sun;
- Daugherty, Betsy;
- D'Agostin, Diane;
- Kurahara, Carole;
- Yongming Gao;
- Jin Cao;
- Jianhua Gong;
- Asuncion, Frank;
- Barrero, Mauricio;
- Warmington, Kelly;
- Dwyer, Denise;
- Stolina, Marina;
- Morony, Sean;
- Sarosi, Ildiko;
- Kostenuik, Paul J.;
- Lacey, David L.;
- Simonet, W. Scott
Publication type:
Article
RANKL Inhibition With Osteoprotegerin Increases Bone Strength by Improving Cortical and Trabecular Bone Architecture in Ovariectomized Rats.
Published in:
Journal of Bone & Mineral Research, 2008, v. 23, n. 5, p. 672, doi. 10.1359/JBMR.080109
By:
- Ominsky, Michael S.;
- Xiaodong Li;
- Asuncion, Frank J.;
- Barrero, Mauricio;
- Warmington, Kelly S.;
- Dwyer, Denise;
- Stolina, Marina;
- Zhaopo Geng;
- Grisanti, Mario;
- Hony-Lin Tan;
- Corbin, Timothy;
- McCabe, James;
- Simonet, William S.;
- Ke, Hua Z.;
- Kostenuik, Paul J.
Publication type:
Article
Infrequent Delivery of a Long-Acting PTH-Fc Fusion Protein Has Potent Anabolic Effects on Cortical and Cancellous Bone.
Published in:
Journal of Bone & Mineral Research, 2007, v. 22, n. 10, p. 1534, doi. 10.1359/JBMR.070616
By:
- Kostenuik, Paul J.;
- Ferrari, Serge;
- Pierroz, Dominique;
- Bouxsein, Mary;
- Morony, Sean;
- Warmington, Kelly S.;
- Adamu, Steven;
- Geng, Zhaopo;
- Grisanti, Mario;
- Shalhoub, Victoria;
- Martin, Steve;
- Biddlecome, Gloria;
- Shimamoto, Grant;
- Boone, Tom;
- Shen, Victor;
- Lacey, David
Publication type:
Article
RANKL is a Marker and Mediator of Local and Systemic Bone Loss in Two Rat Models of Inflammatory Arthritis.
Published in:
Journal of Bone & Mineral Research, 2005, v. 20, n. 10, p. 1756, doi. 10.1359/JBMR.050601
By:
- Stolina, Marina;
- Adamu, Stephen;
- Ominsky, Mike;
- Dwyer, Denise;
- Asuncion, Frank;
- Geng, Zhaopo;
- Middleton, Scot;
- Brown, Heather;
- Pretorius, Jim;
- Schett, Georg;
- Bolon, Brad;
- Feige, Ulrich;
- Zack, Debra;
- Kostenuik, Paul J
Publication type:
Article
Sustained Antiresorptive Effects After a Single Treatment With Human Recombinant Osteoprotegerin (OPG): A Pharmacodynamic and Pharmacokinetic Analysis in Rats.
Published in:
Journal of Bone & Mineral Research, 2003, v. 18, n. 5, p. 852, doi. 10.1359/jbmr.2003.18.5.852
By:
- Capparelli, Charles;
- Morony, Sean;
- Warmington, Kelly;
- Adamu, Stephen;
- Lacey, David;
- Dunstan, Colin R;
- Stouch, Brian;
- Martin, Steven;
- Kostenuik, Paul J
Publication type:
Article
Growth Factor Regulation of Fracture Repair.
Published in:
Journal of Bone & Mineral Research, 1999, v. 14, n. 11, p. 1805, doi. 10.1359/jbmr.1999.14.11.1805
By:
- Barnes, George L.;
- Kostenuik, Paul J.;
- Gerstenfeld, Louis C.;
- Einhorn, Thomas A.
Publication type:
Article
Skeletal Unloading Causes Resistance of Osteoprogenitor Cells to Parathyroid Hormone and to Insulin-like Growth Factor-I.
Published in:
Journal of Bone & Mineral Research, 1999, v. 14, n. 1, p. 21, doi. 10.1359/jbmr.1999.14.1.21
By:
- Kostenuik, Paul J.;
- Harris, Jonathan;
- Halloran, Bernard P.;
- Turner, Russell T.;
- Morey-Holton, Emily R.;
- Bikle, Daniel D.
Publication type:
Article
The development of denosumab for the treatment of diseases of bone loss and cancer-induced bone destruction.
Published in:
Annals of the New York Academy of Sciences, 2012, v. 1263, n. 1, p. 29, doi. 10.1111/j.1749-6632.2012.06674.x
By:
- Goessl, Carsten;
- Katz, Leonid;
- Dougall, William C.;
- Kostenuik, Paul J.;
- Zoog, Holly Brenza;
- Braun, Ada;
- Dansey, Roger;
- Wagman, Rachel B.
Publication type:
Article
Why is hypercholesterolaemia so prevalent? A view from evolutionary medicine.
Published in:
European Heart Journal, 2019, v. 40, n. 33, p. 2825, doi. 10.1093/eurheartj/ehy479
By:
- Laufs, Ulrich;
- Dent, Ricardo;
- Kostenuik, Paul J;
- Toth, Peter P;
- Catapano, Alberico Luigi;
- Chapman, M John
Publication type:
Article
Transient muscle paralysis degrades bone via rapid osteoclastogenesis.
Published in:
FASEB Journal, 2012, v. 26, n. 3, p. 1110, doi. 10.1096/fj.11-196642
By:
- Aliprantis, Antonios O.;
- Stolina, Marina;
- Kostenuik, Paul J.;
- Poliachik, Sandra L.;
- Warner, Sarah E.;
- Bain, Steven D.;
- Gross, Ted S.
Publication type:
Article
RANKL Inhibition Through Osteoprotegerin Blocks Bone Loss in Experimental Periodontitis.
Published in:
Journal of Periodontology, 2007, v. 78, n. 7, p. 1300, doi. 10.1902/jop.2007.070073
By:
- Qiming Jin;
- Cirelli, Joni A.;
- Chan Ha Park;
- Sugai, James V.;
- Taba Jr., Maria;
- Kostenuik, Paul J.;
- Giannobile, William V.
Publication type:
Article
Sclerostin antibody stimulates periodontal regeneration in large alveolar bone defects.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-73026-y
By:
- Yao, Yao;
- Kauffmann, Frederic;
- Maekawa, Shogo;
- Sarment, Lea V.;
- Sugai, James V.;
- Schmiedeler, Caroline A.;
- Doherty, Edward J.;
- Holdsworth, Gill;
- Kostenuik, Paul J.;
- Giannobile, William V.
Publication type:
Article
Selective inhibition of receptor activator of NF-κB ligand (RANKL) in hematopoietic cells improves outcome after experimental myocardial infarction.
Published in:
Journal of Molecular Medicine, 2018, v. 96, n. 6, p. 559, doi. 10.1007/s00109-018-1641-x
By:
- Slavic, Svetlana;
- Andrukhova, Olena;
- Ford, Kristopher;
- Handschuh, Stephan;
- Latic, Nejla;
- Reichart, Ursula;
- Sasgary, Soleman;
- Bergow, Claudia;
- Hofbauer, Lorenz C.;
- Kostenuik, Paul J.;
- Erben, Reinhold G.
Publication type:
Article
Twelve Months of Denosumab and/or Alendronate Is Associated With Improved Bone Fatigue Life, Microarchitecture, and Density in Ovariectomized Cynomolgus Monkeys.
Published in:
Journal of Bone & Mineral Research, 2023, v. 38, n. 3, p. 403, doi. 10.1002/jbmr.4758
By:
- Haider, Ifaz T.;
- Loundagin, Lindsay L.;
- Sawatsky, Andrew;
- Kostenuik, Paul J.;
- Boyd, Steven K.;
- Edwards, W. Brent
Publication type:
Article
Finite Element Analysis of Denosumab Treatment Effects on Vertebral Strength in Ovariectomized Cynomolgus Monkeys.
Published in:
Journal of Bone & Mineral Research, 2016, v. 31, n. 8, p. 1586, doi. 10.1002/jbmr.2830
By:
- Lee, David C;
- Varela, Aurore;
- Kostenuik, Paul J;
- Ominsky, Michael S;
- Keaveny, Tony M
Publication type:
Article
Sustained Modeling-Based Bone Formation During Adulthood in Cynomolgus Monkeys May Contribute to Continuous BMD Gains With Denosumab.
Published in:
Journal of Bone & Mineral Research, 2015, v. 30, n. 7, p. 1280, doi. 10.1002/jbmr.2480
By:
- Ominsky, Michael S;
- Libanati, Cesar;
- Niu, Qing-Tian;
- Boyce, Rogely W;
- Kostenuik, Paul J;
- Wagman, Rachel B;
- Baron, Roland;
- Dempster, David W
Publication type:
Article
Journal of Bone and Mineral Research: Volume 30, Issue 5, May 2015, Frontmatter page ii.
Published in:
Journal of Bone & Mineral Research, 2015, v. 30, n. 7, p. 1347, doi. 10.1002/jbmr.2543
By:
- Ominsky, Michael S;
- Libanati, Cesar;
- Niu, Qing-Tian;
- Boyce, Rogely W;
- Kostenuik, Paul J;
- Wagman, Rachel B;
- Baron, Roland;
- Dempster, David W
Publication type:
Article
Effects of Denosumab, Alendronate, or Denosumab Following Alendronate on Bone Turnover, Calcium Homeostasis, Bone Mass and Bone Strength in Ovariectomized Cynomolgus Monkeys.
Published in:
Journal of Bone & Mineral Research, 2015, v. 30, n. 4, p. 657, doi. 10.1002/jbmr.2401
By:
- Kostenuik, Paul J;
- Smith, Susan Y;
- Samadfam, Rana;
- Jolette, Jacquelin;
- Zhou, Lei;
- Ominsky, Michael S
Publication type:
Article
Integrin α(v)β₃ as a PET imaging biomarker for osteoclast number in mouse models of negative and positive osteoclast regulation.
Published in:
2012
By:
- Zheleznyak A;
- Wadas TJ;
- Sherman CD;
- Wilson JM;
- Kostenuik PJ;
- Weilbaecher KN;
- Anderson CJ;
- Zheleznyak, Alexander;
- Wadas, Thaddeus J;
- Sherman, Christopher D;
- Wilson, Jessica M;
- Kostenuik, Paul J;
- Weilbaecher, Katherine N;
- Anderson, Carolyn J
Publication type:
journal article

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