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Interferons induce tyrosine phosphorylation of the eIF2α kinase PKR through activation of Jak1 and Tyk2.
- Published in:
- EMBO Reports, 2007, v. 8, n. 3, p. 265, doi. 10.1038/sj.embor.7400891
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- Article
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24661-0
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- Article
Development of transgenic mice expressing a conditionally active form of the eIF2α kinase PKR.
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- Genesis: The Journal of Genetics & Development, 2011, v. 49, n. 9, p. 743, doi. 10.1002/dvg.20749
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- Article
Protein Tyrosine Phosphatase 1B Deficiency Potentiates PERK/eIF2α Signaling in Brown Adipocytes.
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- PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0034412
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- Article
Stat1 Phosphorylation Determines Ras Oncogenicity by Regulating p27<sup>Kip1</sup>.
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- PLoS ONE, 2008, v. 3, n. 10, p. 1, doi. 10.1371/journal.pone.0003476
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- Article
Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival.
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- Oncogene, 2003, v. 22, n. 24, p. 3721, doi. 10.1038/sj.onc.1206490
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- Article
An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy.
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- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10138-8
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- Article
Activation of the IκBα kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR.
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- Oncogene, 2001, v. 20, n. 15, p. 1900, doi. 10.1038/sj.onc.1204267
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- Article
The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-α.
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- Oncogene, 1999, v. 18, n. 42, p. 5727, doi. 10.1038/sj.onc.1202960
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- Article
The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro.
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- Oncogene, 1999, v. 18, n. 17, p. 2690, doi. 10.1038/sj.onc.1202620
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- Article
The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.
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- Nature Communications, 2017, v. 8, n. 3, p. 14638, doi. 10.1038/ncomms14638
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- Article
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.
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- Nature Communications, 2016, v. 7, n. 4, p. 11127, doi. 10.1038/ncomms11127
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- Article
The existence of ornithine decarboxylase-antizyme complex in germinated barley seeds.
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- Physiologia Plantarum, 1988, v. 72, n. 4, p. 718, doi. 10.1111/j.1399-3054.1988.tb06371.x
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- Article
Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.
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- Cell Death & Disease, 2018, v. 9, n. 3, p. 1, doi. 10.1038/s41419-018-0326-2
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- Article
Akt Determines Cell Fate Through Inhibition of the PERK-eIF2α Phosphorylation Pathway.
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- Science Signaling, 2011, v. 4, n. 192, p. 1, doi. 10.1126/scisignal.2001630
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- Article
Tumor Suppression by PTEN Requires the Activation of the PKR-elF2α Phosphorylation Pathway.
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- Science Signaling, 2009, v. 2, n. 102, p. 1, doi. 10.1126/scisignal.2000389
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- Article