Works by Kordasiewicz, Holly B

Results: 20

MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models.

Published in:

Journal of Neuroscience, 2017, v. 37, n. 22, p. 5574, doi. 10.1523/JNEUROSCI.3582-16.2017

By:

Hoye, Mariah L.;
Koval, Erica D.;
Wegener, Amy J.;
Hyman, Theodore S.;
Chengran Yang;
O'Brien, David R.;
Miller, Rebecca L.;
Cole, Tracy;
Schoch, Kathleen M.;
Tao Shen;
Tomonori Kunikata;
Richard, Jean-Philippe;
Gutmann, David H.;
Maragakis, Nicholas J.;
Kordasiewicz, Holly B.;
Dougherty, Joseph D.;
Miller, Timothy M.

Publication type:

Article

Antisense‐mediated APP suppression as potential therapeutic for Down Syndrome Alzheimer's Disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S6, p. 1, doi. 10.1002/alz.092628

By:

Zhao, Hien T;
Chen, Xu‐Qiao;
Das, Utpal;
Zuo, Xinxin;
Ford, Brittany T;
Kordasiewicz, Holly B;
Mobley, William C.

Publication type:

Article

Huntingtin-Lowering Therapies for Huntington Disease: A Review of the Evidence of Potential Benefits and Risks.

Published in:

JAMA Neurology, 2020, v. 77, n. 6, p. 764, doi. 10.1001/jamaneurol.2020.0299

By:

Leavitt, Blair R.;
Kordasiewicz, Holly B.;
Schobel, Scott A.

Publication type:

Article

Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models.

Published in:

2018

By:

McCampbell, Alex;
Cole, Tracy;
Wegener, Amy J.;
Tomassy, Giulio S.;
Setnicka, Amy;
Farley, Brandon J.;
Schoch, Kathleen M.;
Hoye, Mariah L.;
Shabsovich, Mark;
Linhong Sun;
Yi Luo;
Mingdi Zhang;
Sai Thankamony;
Salzman, David W.;
Cudkowicz, Merit;
Graham, Danielle L.;
Bennett, C. Frank;
Kordasiewicz, Holly B.;
Swayze, Eric E.;
Miller, Timothy M.

Publication type:

journal article

PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models.

Published in:

2018

By:

Hien Tran Zhao;
Damle, Sagar;
Ikeda-Lee, Karli;
Kuntz, Steven;
Jian Li;
Mohan, Apoorva;
Kim, Aneeza;
Hung, Gene;
Scheideler, Mark A.;
Scherer, Steven S.;
Svaren, John;
Swayze, Eric E.;
Kordasiewicz, Holly B.;
Zhao, Hien Tran;
Li, Jian

Publication type:

journal article

Antisense oligonucleotide–mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC–derived striatal neurons.

Published in:

Science Translational Medicine, 2025, v. 17, n. 785, p. 1, doi. 10.1126/scitranslmed.adn4600

By:

Bunting, Emma L.;
Donaldson, Jasmine;
Cumming, Sarah A.;
Olive, Jessica;
Broom, Elizabeth;
Miclăuș, Mihai;
Hamilton, Joseph;
Tegtmeyer, Matthew;
Zhao, Hien T.;
Brenton, Jonathan;
Lee, Won-Seok;
Handsaker, Robert E.;
Li, Susan;
Ford, Brittany;
Ryten, Mina;
McCarroll, Steven A.;
Kordasiewicz, Holly B.;
Monckton, Darren G.;
Balmus, Gabriel;
Flower, Michael

Publication type:

Article

C-termini of P/Q-type Ca2+ channel α1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity.

Published in:

Human Molecular Genetics, 2006, v. 15, n. 10, p. 1587, doi. 10.1093/hmg/ddl080

By:

Kordasiewicz, Holly B.;
Thompson, Randall M.;
Clark, H. Brent;
Gomez, Christopher M.

Publication type:

Article

Huntingtin suppression restores cognitive function in a mouse model of Huntington disease.

Published in:

Science Translational Medicine, 2018, v. 10, n. 461, p. 1, doi. 10.1126/scitranslmed.aar3959

By:

Southwell, Amber L.;
Kordasiewicz, Holly B.;
Langbehn, Douglas;
Skotte, Niels H.;
Parsons, Matthew P.;
Villanueva, Erika B.;
Caron, Nicholas S.;
Østergaard, Michael E.;
Anderson, Lisa M.;
Xie, Yuanyun;
Cengio, Louisa Dal;
Findlay-Black, Hailey;
Doty, Crystal N.;
Fitsimmons, Bethany;
Swayze, Eric E.;
Seth, Punit P.;
Raymond, Lynn A.;
Frank Bennett, C.;
Hayden, Michael R.

Publication type:

Article

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.

Published in:

Science Translational Medicine, 2017, v. 9, n. 374, p. 1, doi. 10.1126/scitranslmed.aag0481

By:

DeVos, Sarah L.;
Miller, Rebecca L.;
Schoch, Kathleen M.;
Holmes, Brandon B.;
Kebodeaux, Carey S.;
Wegener, Amy J.;
Guo Chen;
Tao Shen;
Tran, Hien;
Nichols, Brandon;
Zanardi, Tom A.;
Kordasiewicz, Holly B.;
Swayze, Eric E.;
Bennett, C. Frank;
Diamond, Marc I.;
Miller, Timothy M.

Publication type:

Article

Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.Htt<sup>Q111/+</sup> mouse model of Huntington’s disease.

Published in:

PLoS ONE, 2017, v. 12, n. 4, p. 1, doi. 10.1371/journal.pone.0175968

By:

Coffey, Sydney R.;
Bragg, Robert M.;
Minnig, Shawn;
Ament, Seth A.;
Cantle, Jeffrey P.;
Glickenhaus, Anne;
Shelnut, Daniel;
Carrillo, José M.;
Shuttleworth, Dominic D.;
Rodier, Julie-Anne;
Noguchi, Kimihiro;
Bennett, C. Frank;
Price, Nathan D.;
Kordasiewicz, Holly B.;
Carroll, Jeffrey B.

Publication type:

Article

In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides.

Published in:

Molecular Therapy, 2014, v. 22, n. 12, p. 2093, doi. 10.1038/mt.2014.153

By:

Southwell, Amber L;
Skotte, Niels H;
Kordasiewicz, Holly B;
Østergaard, Michael E;
Watt, Andrew T;
Carroll, Jeffrey B;
Doty, Crystal N;
Villanueva, Erika B;
Petoukhov, Eugenia;
Vaid, Kuljeet;
Xie, Yuanyun;
Freier, Susan M;
Swayze, Eric E;
Seth, Punit P;
Bennett, Clarence Frank;
Hayden, Michael R

Publication type:

Article

Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides.

Published in:

Biomolecules (2218-273X), 2020, v. 10, n. 1, p. 1, doi. 10.3390/biom10010001

By:

Reidenbach, Andrew G.;
Minikel, Eric Vallabh;
Zhao, Hien T.;
Guzman, Stacy G.;
Leed, Alison J.;
Mesleh, Michael F.;
Kordasiewicz, Holly B.;
Schreiber, Stuart L.;
Vallabh, Sonia M.

Publication type:

Article

A single-cell map of antisense oligonucleotide activity in the brain.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 14, p. 7109, doi. 10.1093/nar/gkad371

By:

Mortberg, Meredith A;
Gentile, Juliana E;
Nadaf, Naeem M;
Vanderburg, Charles;
Simmons, Sean;
Dubinsky, Dan;
Slamin, Adam;
Maldonado, Salome;
Petersen, Caroline L;
Jones, Nichole;
Kordasiewicz, Holly B;
Zhao, Hien T;
Vallabh, Sonia M;
Minikel, Eric Vallabh

Publication type:

Article

Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics.

Published in:

Brain: A Journal of Neurology, 2022, v. 145, n. 12, p. 4409, doi. 10.1093/brain/awac241

By:

Fienko, Sandra;
Landles, Christian;
Sathasivam, Kirupa;
McAteer, Sean J;
Milton, Rebecca E;
Osborne, Georgina F;
Smith, Edward J;
Jones, Samuel T;
Bondulich, Marie K;
Danby, Emily C E;
Phillips, Jemima;
Taxy, Bridget A;
Kordasiewicz, Holly B;
Bates, Gillian P

Publication type:

Article

Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice.

Published in:

2018

By:

Mcloughlin, Hayley S.;
Moore, Lauren R.;
Chopra, Ravi;
Komlo, Robert;
Mckenzie, Megan;
Blumenstein, Kate G.;
Zhao, Hien;
Kordasiewicz, Holly B.;
Shakkottai, Vikram G.;
Paulson, Henry L.

Publication type:

journal article

Protein production is an early biomarker for RNA‐targeted therapies.

Published in:

Annals of Clinical & Translational Neurology, 2018, v. 5, n. 12, p. 1492, doi. 10.1002/acn3.657

By:

Self, Wade K.;
Schoch, Kathleen M.;
Alex, Jacob;
Barthélemy, Nicolas;
Bollinger, James G.;
Sato, Chihiro;
Cole, Tracy;
Kordasiewicz, Holly B.;
Swayze, Eric;
Bateman, Randall J.;
Miller, Timothy M.

Publication type:

Article

Results of the first‐in‐human, randomized, double‐blind, placebo‐controlled phase 1b study of lumbar intrathecal bolus administrations of antisense oligonucleotide (ISIS 814907; BIIB080) targeting tau mRNA in patients with mild Alzheimer's disease

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.051871

By:

Mummery, Catherine J;
Junge, Candice;
Kordasiewicz, Holly B;
Mignon, Laurence;
Moore, Katrina M;
Yun, Chris;
Baumann, Tiffany L;
Li, Dan;
Norris, Daniel A;
Crean, Rebecca;
Graham, Danielle;
Huang, Ellen;
Ratti, Elena;
Lane, Roger M

Publication type:

Article

DISCOVERY AND EARLY CLINICAL DEVELOPMENT OF IONIS-MAPTRX, THE FIRST TAU-LOWERING ANTISENSE OLIGONUCLEOTIDE, IN PATIENTS WITH MILD AD.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P600, doi. 10.1016/j.jalz.2017.07.242

By:

Lane, Roger M.;
Kordasiewicz, Holly B.;
Smith, Anne;
Mignon, Laurence;
Miller, Timothy M.;
Mummery, Catherine J.;
Andreasen, Niels;
Narayanan, Padma;
Swayze, Eric;
Norris, Daniel A.;
Fitzsimmons, Bethany;
Bennett, C Frank

Publication type:

Article

A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 6, p. 1115, doi. 10.1093/hmg/ddx021

By:

Southwell, Amber L.;
Skotte, Niels H.;
Villanueva, Erika B.;
Østergaard, Michael E.;
Xiaofeng Gu;
Kordasiewicz, Holly B.;
Kay, Chris;
Cheung, Daphne;
Yuanyun Xie;
Waltl, Sabine;
Dal Cengio, Louisa;
Findlay-Black, Hailey;
Doty, Crystal N.;
Petoukhov, Eugenia;
Iworima, Diepiriye;
Slama, Ramy;
Ooi, Jolene;
Pouladi, Mahmoud A.;
Yang, X. William;
Swayze, Eric E.

Publication type:

Article

Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia.

Published in:

Human Molecular Genetics, 2016, v. 25, n. R1, p. R53, doi. 10.1093/hmg/ddv442

By:

Keiser, Megan S.;
Kordasiewicz, Holly B.;
McBride, Jodi L.

Publication type:

Article