Works by Kool, Jeroen

Results: 58

The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms.

Published in:

Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0039-1

By:

Ainsworth, Stuart;
Slagboom, Julien;
Alomran, Nessrin;
Pla, Davinia;
Alhamdi, Yasir;
King, Sarah I.;
Bolton, Fiona M. S.;
Gutiérrez, José María;
Vonk, Freek J.;
Toh, Cheng-Hock;
Calvete, Juan J.;
Kool, Jeroen;
Harrison, Robert A.;
Casewell, Nicholas R.

Publication type:

Article

A novel microplate reader-based high-throughput assay for estrogen receptor binding.

Published in:

International Journal of Environmental Analytical Chemistry, 2005, v. 85, n. 3, p. 149, doi. 10.1080/03067310500042236

By:

Gurer-Orhan, Hande;
Kool, Jeroen;
Vermeulen, Nico P. E.;
Meerman, John H. N.

Publication type:

Article

Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2023.1331224

By:

Albulescu, Laura-Oana;
Westhorpe, Adam;
Clare, Rachel H.;
Woodley, Christopher M.;
James, Nivya;
Kool, Jeroen;
Berry, Neil G.;
O'Neill, Paul M.;
Casewell, Nicholas R.

Publication type:

Article

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2023.1328950

By:

Clare, Rachel H.;
Dawson, Charlotte A.;
Westhorpe, Adam;
Albulescu, Laura-Oana;
Woodley, Christopher M.;
Mosallam, Nada;
Chong, Daniel J. W.;
Kool, Jeroen;
Berry, Neil G.;
O'Neill, Paul M.;
Casewell, Nicholas R.

Publication type:

Article

The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32174-7

By:

Nys, Mieke;
Zarkadas, Eleftherios;
Brams, Marijke;
Mehregan, Aujan;
Kambara, Kumiko;
Kool, Jeroen;
Casewell, Nicholas R.;
Bertrand, Daniel;
Baenziger, John E.;
Nury, Hugues;
Ulens, Chris

Publication type:

Article

Aligning Post-Column ESI-MS, MALDI-MS, and Coagulation Bioassay Data of Naja spp., Ophiophagus hannah , and Pseudonaja textillis Venoms Chromatographically to Assess MALDI-MS and ESI-MS Complementarity with Correlation of Bioactive Toxins to Mass Spectrometric Data

Published in:

Toxins, 2024, v. 16, n. 9, p. 379, doi. 10.3390/toxins16090379

By:

Xu, Haifeng;
El-Asal, Susan;
Zakri, Hafsa;
Mutlaq, Rama;
Krikke, Natascha T. B.;
Casewell, Nicholas R.;
Slagboom, Julien;
Kool, Jeroen

Publication type:

Article

Nanofractionation Analytics for Comparing MALDI-MS and ESI-MS Data of Viperidae Snake Venom Toxins.

Published in:

Toxins, 2024, v. 16, n. 8, p. 370, doi. 10.3390/toxins16080370

By:

Xu, Haifeng;
Mastenbroek, Jesse;
Krikke, Natascha T. B.;
El-Asal, Susan;
Mutlaq, Rama;
Casewell, Nicholas R.;
Slagboom, Julien;
Kool, Jeroen

Publication type:

Article

Qualitative Profiling of Venom Toxins in the Venoms of Several Bothrops Species Using High-Throughput Venomics and Coagulation Bioassaying.

Published in:

Toxins, 2024, v. 16, n. 7, p. 300, doi. 10.3390/toxins16070300

By:

Weekers, Dimoetsha J. C.;
Alonso, Luis L.;
Verstegen, Anniek X.;
Slagboom, Julien;
Kool, Jeroen

Publication type:

Article

Studying Venom Toxin Variation Using Accurate Masses from Liquid Chromatography–Mass Spectrometry Coupled with Bioinformatic Tools.

Published in:

Toxins, 2024, v. 16, n. 4, p. 181, doi. 10.3390/toxins16040181

By:

Alonso, Luis L.;
van Thiel, Jory;
Slagboom, Julien;
Dunstan, Nathan;
Modahl, Cassandra M.;
Jackson, Timothy N. W.;
Samanipour, Saer;
Kool, Jeroen

Publication type:

Article

Analytical Size Exclusion Chromatography Coupled with Mass Spectrometry in Parallel with High-Throughput Venomics and Bioassaying for Venom Profiling.

Published in:

Toxins, 2023, v. 15, n. 9, p. 552, doi. 10.3390/toxins15090552

By:

Terzioglu, Sedef;
Bittenbinder, Mátyás A.;
Slagboom, Julien;
van de Velde, Bas;
Casewell, Nicholas R.;
Kool, Jeroen

Publication type:

Article

Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins.

Published in:

Toxins, 2023, v. 15, n. 4, p. 294, doi. 10.3390/toxins15040294

By:

Wachtel, Eric;
Bittenbinder, Matyas A.;
van de Velde, Bas;
Slagboom, Julien;
de Monts de Savasse, Axel;
Alonso, Luis L.;
Casewell, Nicholas R.;
Vonk, Freek J.;
Kool, Jeroen

Publication type:

Article

Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools.

Published in:

Toxins, 2023, v. 15, n. 2, p. 161, doi. 10.3390/toxins15020161

By:

Alonso, Luis L.;
Slagboom, Julien;
Casewell, Nicholas R.;
Samanipour, Saer;
Kool, Jeroen

Publication type:

Article

Highly Evolvable: Investigating Interspecific and Intraspecific Venom Variation in Taipans (Oxyuranus spp.) and Brown Snakes (Pseudonaja spp.).

Published in:

Toxins, 2023, v. 15, n. 1, p. 74, doi. 10.3390/toxins15010074

By:

van Thiel, Jory;
Alonso, Luis L.;
Slagboom, Julien;
Dunstan, Nathan;
Wouters, Roel M.;
Modahl, Cassandra M.;
Vonk, Freek J.;
Jackson, Timothy N. W.;
Kool, Jeroen

Publication type:

Article

A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib.

Published in:

Toxins, 2022, v. 14, n. 11, p. 736, doi. 10.3390/toxins14110736

By:

Arrahman, Arif;
Kazandjian, Taline D.;
Still, Kristina B. M.;
Slagboom, Julien;
Somsen, Govert W.;
Vonk, Freek J.;
Casewell, Nicholas R.;
Kool, Jeroen

Publication type:

Article

Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib.

Published in:

Toxins, 2021, v. 13, n. 5, p. 302, doi. 10.3390/toxins13050302

By:

Kazandjian, Taline D.;
Arrahman, Arif;
Still, Kristina B. M.;
Somsen, Govert W.;
Vonk, Freek J.;
Casewell, Nicholas R.;
Wilkinson, Mark C.;
Kool, Jeroen

Publication type:

Article

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics.

Published in:

Toxins, 2020, v. 12, n. 1, p. 53, doi. 10.3390/toxins12010053

By:

Xie, Chunfang;
Slagboom, Julien;
Albulescu, Laura-Oana;
Bruyneel, Ben;
Still, Kristina B. M.;
Vonk, Freek J.;
Somsen, Govert W.;
Casewell, Nicholas R.;
Kool, Jeroen

Publication type:

Article

Multipurpose HTS Coagulation Analysis: Assay Development and Assessment of Coagulopathic Snake Venoms.

Published in:

Toxins, 2017, v. 9, n. 12, p. 382, doi. 10.3390/toxins9120382

By:

Still, Kristina B. M.;
Nandlal, Randjana S. S.;
Slagboom, Julien;
Somsen, Govert W.;
Casewell, Nicholas R.;
Kool, Jeroen

Publication type:

Article

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.

Published in:

Toxins, 2015, v. 7, n. 7, p. 2336, doi. 10.3390/toxins7072336

By:

Otvos, Reka A.;
Iyer, Janaki Krishnamoorthy;
van Elk, René;
Ulens, Chris;
Niessen, Wilfried M. A.;
Somsen, Govert W.;
Kini, R. Manjunatha;
Smit, August B.;
Kool, Jeroen

Publication type:

Article

PHARMACEUTICAL PROPERTIES OF VENOM TOXINS AND THEIR POTENTIAL IN DRUG DISCOVERY.

Published in:

Indonesian Journal of Pharmacy / Majalah Farmasi Indonesia, 2016, v. 27, n. 1, p. 1, doi. 10.14499/indonesianjpharm27iss1pp1

By:

Kool, Jeroen

Publication type:

Article

Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite.

Published in:

Science Translational Medicine, 2020, v. 12, n. 542, p. 1, doi. 10.1126/scitranslmed.aay8314

By:

Albulescu, Laura-Oana;
Hale, Melissa S.;
Ainsworth, Stuart;
Alsolaiss, Jaffer;
Crittenden, Edouard;
Calvete, Juan J.;
Evans, Chloe;
Wilkinson, Mark C.;
Harrison, Robert A.;
Kool, Jeroen;
Casewell, Nicholas R.

Publication type:

Article

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches.

Published in:

PLoS Neglected Tropical Diseases, 2020, v. 14, n. 4, p. 1, doi. 10.1371/journal.pntd.0007802

By:

Slagboom, Julien;
Mladić, Marija;
Xie, Chunfang;
Kazandjian, Taline D.;
Vonk, Freek;
Somsen, Govert W.;
Casewell, Nicholas R.;
Kool, Jeroen

Publication type:

Article

Activity assay based on the immobilized enzyme kallikrein and mass spectrometry.

Published in:

Frontiers in Analytical Science, 2022, p. 1, doi. 10.3389/frans.2022.1018115

By:

Romano De Carvalho, Daniella;
Barbosa Laurentino, Bruna;
Loreta Rocha, Camila;
Kool, Jeroen;
Somsen, Govert;
Amstalden van Hove, Erika;
Lúcia Cardoso, Carmen

Publication type:

Article

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins.

Published in:

Biomedicines, 2020, v. 8, n. 9, p. 297, doi. 10.3390/biomedicines8090297

By:

Xie, Chunfang;
Albulescu, Laura-Oana;
Bittenbinder, Mátyás A.;
Somsen, Govert W.;
Vonk, Freek J.;
Casewell, Nicholas R.;
Kool, Jeroen

Publication type:

Article

Varespladib Inhibits the Phospholipase A2 and Coagulopathic Activities of Venom Components from Hemotoxic Snakes.

Published in:

Biomedicines, 2020, v. 8, n. 6, p. 165, doi. 10.3390/biomedicines8060165

By:

Xie, Chunfang;
Albulescu, Laura-Oana;
Still, Kristina B. M.;
Slagboom, Julien;
Zhao, Yumei;
Jiang, Zhengjin;
Somsen, Govert W.;
Vonk, Freek J.;
Casewell, Nicholas R.;
Kool, Jeroen

Publication type:

Article

Novel Analytical Methods for the Discovery and Trace Analysis of Biochemically Active Compounds.

Published in:

LC-GC Europe, 2009, v. 22, n. 6, p. 292

By:

Kool, Jeroen;
Lingeman, Henk;
Niessen, Wilfried;
Irth, Hubertus

Publication type:

Article

Monitoring Snake Venom-Induced Extracellular Matrix Degradation and Identifying Proteolytically Active Venom Toxins Using Fluorescently Labeled Substrates.

Published in:

Biology (2079-7737), 2023, v. 12, n. 6, p. 765, doi. 10.3390/biology12060765

By:

Bittenbinder, Mátyás A.;
Bergkamp, Nick D.;
Slagboom, Julien;
Bebelman, Jan Paul M.;
Casewell, Nicholas R.;
Siderius, Marco H.;
Smit, Martine J.;
Kool, Jeroen;
Vonk, Freek J.

Publication type:

Article

Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail.

Published in:

Biology (2079-7737), 2014, v. 3, n. 1, p. 139, doi. 10.3390/biology3010139

By:

Heus, Ferry;
Otvos, Reka A.;
Aspers, Ruud L. E. G.;
van Elk, Rene;
Halff, Jenny I.;
Ehlers, Andreas W.;
Dutertre, Sébastien;
Lewis, Richard J.;
Wijmenga, Sybren;
Smit, August B.;
Niessen, Wilfried M. A.;
Kool, Jeroen

Publication type:

Article

Author Correction: A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite.

Published in:

2021

By:

Albulescu, Laura-Oana;
Xie, Chunfang;
Ainsworth, Stuart;
Alsolaiss, Jaffer;
Crittenden, Edouard;
Dawson, Charlotte A.;
Softley, Rowan;
Bartlett, Keirah E.;
Harrison, Robert A.;
Kool, Jeroen;
Casewell, Nicholas R.

Publication type:

Correction Notice

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-19981-6

By:

Albulescu, Laura-Oana;
Xie, Chunfang;
Ainsworth, Stuart;
Alsolaiss, Jaffer;
Crittenden, Edouard;
Dawson, Charlotte A.;
Softley, Rowan;
Bartlett, Keirah E.;
Harrison, Robert A.;
Kool, Jeroen;
Casewell, Nicholas R.

Publication type:

Article

High-Resolution Bioassay Profiling with Complemented Sensitivity and Resolution for Pancreatic Lipase Inhibitor Screening.

Published in:

Molecules, 2022, v. 27, n. 20, p. 6923, doi. 10.3390/molecules27206923

By:

Jian, Jingyi;
Yuan, Jiaming;
Fan, Yu;
Wang, Jincai;
Zhang, Tingting;
Kool, Jeroen;
Jiang, Zhengjin

Publication type:

Article

Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06019-6

By:

Bittenbinder, Mátyás A.;
van Thiel, Jory;
Cardoso, Fernanda C.;
Casewell, Nicholas R.;
Gutiérrez, José-María;
Kool, Jeroen;
Vonk, Freek J.

Publication type:

Article

Author Correction: Using organ-on-a-chip technology to study haemorrhagic activities of snake venoms on endothelial tubules.

Published in:

2024

By:

Bittenbinder, Mátyás A.;
Bonanini, Flavio;
Kurek, Dorota;
Vulto, Paul;
Kool, Jeroen;
Vonk, Freek J.

Publication type:

Correction Notice

Using organ-on-a-chip technology to study haemorrhagic activities of snake venoms on endothelial tubules.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-60282-5

By:

Bittenbinder, Mátyás A.;
Bonanini, Flavio;
Kurek, Dorota;
Vulto, Paul;
Kool, Jeroen;
Vonk, Freek J.

Publication type:

Article

Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise.

Published in:

British Journal of Haematology, 2017, v. 177, n. 6, p. 947, doi. 10.1111/bjh.14591

By:

Slagboom, Julien;
Kool, Jeroen;
Harrison, Robert A.;
Casewell, Nicholas R.

Publication type:

Article

In vitro metabolism of cathinone positional isomers: does sex matter?

Published in:

Analytical & Bioanalytical Chemistry, 2023, v. 415, n. 22, p. 5403, doi. 10.1007/s00216-023-04815-3

By:

Che, Peng;
Davidson, J. Tyler;
Still, Kristina;
Kool, Jeroen;
Kohler, Isabelle

Publication type:

Article

Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing.

Published in:

Analytical & Bioanalytical Chemistry, 2018, v. 410, n. 30, p. 7837, doi. 10.1007/s00216-018-1414-y

By:

Lakayan, Dina;
Haselberg, Rob;
Gahoual, Rabah;
Somsen, Govert W.;
Kool, Jeroen

Publication type:

Article

Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms.

Published in:

Analytical & Bioanalytical Chemistry, 2018, v. 410, n. 23, p. 5751, doi. 10.1007/s00216-018-1253-x

By:

Zietek, Barbara M.;
Mayar, Morwarid;
Slagboom, Julien;
Bruyneel, Ben;
Vonk, Freek J.;
Somsen, Govert W.;
Casewell, Nicholas R.;
Kool, Jeroen

Publication type:

Article

Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS.

Published in:

Analytical & Bioanalytical Chemistry, 2017, v. 409, n. 25, p. 5987, doi. 10.1007/s00216-017-0531-3

By:

Mladic, Marija;
Waal, Tessa;
Burggraaff, Lindsey;
Slagboom, Julien;
Somsen, Govert;
Niessen, Wilfried;
Manjunatha Kini, R.;
Kool, Jeroen

Publication type:

Article

Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment.

Published in:

Analytical & Bioanalytical Chemistry, 2015, v. 407, n. 23, p. 7067, doi. 10.1007/s00216-015-8867-z

By:

Mladic, Marija;
Scholten, Danny;
Wijtmans, Maikel;
Falck, David;
Leurs, Rob;
Niessen, Wilfried;
Smit, Martine;
Kool, Jeroen

Publication type:

Article

A high-throughput sample preparation method for cellular proteomics using 96-well filter plates.

Published in:

Proteomics, 2013, v. 13, n. 20, p. 2980, doi. 10.1002/pmic.201300080

By:

Switzar, Linda;
Angeren, Jordy;
Pinkse, Martijn;
Kool, Jeroen;
Niessen, Wilfried M. A.

Publication type:

Article

Suction blister fluid as potential body fluid for biomarker proteins.

Published in:

Proteomics, 2007, v. 7, n. 20, p. 3638, doi. 10.1002/pmic.200600938

By:

Kool, Jeroen;
Reubsaet, Léon;
Wesseldijk, Feikje;
Maravilha, Raquel T.;
Pinkse, Martijn W.;
D'Santos, Clive S.;
van Hilten, Jacobus J.;
Zijlstra, Freek J.;
Heck, Albert J. R.

Publication type:

Article

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite.

Published in:

Frontiers in Pharmacology, 2019, p. 1, doi. 10.3389/fphar.2019.00848

By:

Albulescu, Laura-Oana;
Kazandjian, Taline;
Slagboom, Julien;
Bruyneel, Ben;
Ainsworth, Stuart;
Alsolaiss, Jaffer;
Wagstaff, Simon C.;
Whiteley, Gareth;
Harrison, Robert A.;
Ulens, Chris;
Kool, Jeroen;
Casewell, Nicholas R.

Publication type:

Article

Terrestrial venomous animals, the envenomings they cause, and treatment perspectives in the Middle East and North Africa.

Published in:

PLoS Neglected Tropical Diseases, 2021, v. 15, n. 12, p. 1, doi. 10.1371/journal.pntd.0009880

By:

Jenkins, Timothy P.;
Ahmadi, Shirin;
Bittenbinder, Matyas A.;
Stewart, Trenton K.;
Akgun, Dilber E.;
Hale, Melissa;
Nasrabadi, Nafiseh N.;
Wolff, Darian S.;
Vonk, Freek J.;
Kool, Jeroen;
Laustsen, Andreas H.

Publication type:

Article

Acetylcholine-Binding Protein Affinity Profiling of Neurotoxins in Snake Venoms with Parallel Toxin Identification.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 23, p. 16769, doi. 10.3390/ijms242316769

By:

Palermo, Giulia;
Schouten, Wietse M.;
Alonso, Luis Lago;
Ulens, Chris;
Kool, Jeroen;
Slagboom, Julien

Publication type:

Article

On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors.

Published in:

Analytical & Bioanalytical Chemistry, 2012, v. 403, n. 2, p. 367, doi. 10.1007/s00216-011-5663-2

By:

Falck, David;
Vlieger, Jon;
Giera, Martin;
Honing, Maarten;
Irth, Hubertus;
Niessen, Wilfried;
Kool, Jeroen

Publication type:

Article

Studying protein-protein affinity and immobilized ligand-protein affinity interactions using MS-based methods.

Published in:

Analytical & Bioanalytical Chemistry, 2011, v. 401, n. 4, p. 1109, doi. 10.1007/s00216-011-5207-9

By:

Kool, Jeroen;
Jonker, Niels;
Irth, Hubertus;
Niessen, Wilfried

Publication type:

Article

Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures.

Published in:

Analytical & Bioanalytical Chemistry, 2011, v. 399, n. 8, p. 2655, doi. 10.1007/s00216-010-4406-0

By:

Kool, Jeroen;
Giera, Martin;
Irth, Hubertus;
Niessen, Wilfried M. A.

Publication type:

Article

Recent developments in protein-ligand affinity mass spectrometry.

Published in:

Analytical & Bioanalytical Chemistry, 2011, v. 399, n. 8, p. 2669, doi. 10.1007/s00216-010-4350-z

By:

Jonker, Niels;
Kool, Jeroen;
Irth, Hubertus;
Niessen, Wilfried M. A.

Publication type:

Article

Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays.

Published in:

Analytical & Bioanalytical Chemistry, 2010, v. 398, n. 7/8, p. 3023, doi. 10.1007/s00216-010-4210-x

By:

Heus, Ferry;
Giera, Martin;
de Kloe, Gerdien E.;
van Iperen, Dick;
Buijs, Joost;
Nahar, Tariq T.;
Smit, August B.;
Lingeman, Henk;
de Esch, Iwan J. P.;
Niessen, Wilfried M. A.;
Irth, Hubertus;
Kool, Jeroen

Publication type:

Article

Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC-HR-MS.

Published in:

Analytical & Bioanalytical Chemistry, 2010, v. 398, n. 4, p. 1771, doi. 10.1007/s00216-010-4087-8

By:

Falck, David;
De Vlieger, Jon S. B.;
Niessen, Wilfried M. A.;
Kool, Jeroen;
Honing, Maarten;
Giera, Martin;
Irth, Hubertus

Publication type:

Article