Works by Konvalinka, Jan

Results: 43

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus.

Published in:

Viruses (1999-4915), 2018, v. 10, n. 7, p. 339, doi. 10.3390/v10070339

By:

Pokorná, Jana;
Pachl, Petr;
Karlukova, Elena;
Hejdánek, Jakub;
Řezáčová, Pavlína;
Machara, Aleš;
Hudlický, Jason;
Konvalinka, Jan;
Kožíšek, Milan

Publication type:

Article

Expression and distribution of ‘high affinity’ glutamate transporters GLT1, GLAST, EAAC1 and of GCPII in the rat peripheral nervous system.

Published in:

Journal of Anatomy, 2008, v. 213, n. 5, p. 539, doi. 10.1111/j.1469-7580.2008.00984.x

By:

Carozzi, Valentina Alda;
Canta, Annalisa;
Oggioni, Norberto;
Ceresa, Cecilia;
Marmiroli, Paola;
Konvalinka, Jan;
Zoia, Chiara;
Bossi, Mario;
Ferrarese, Carlo;
Tredici, Giovanni;
Cavaletti, Guido

Publication type:

Article

Tris-(Nitrilotriacetic Acid)-Decorated Polymer Conjugates as Tools for Immobilization and Visualization of His-Tagged Proteins.

Published in:

Catalysts (2073-4344), 2019, v. 9, n. 12, p. 1011, doi. 10.3390/catal9121011

By:

Beranová, Jana;
Knedlík, Tomáš;
Šimková, Adéla;
Šubr, Vladimír;
Kostka, Libor;
Etrych, Tomáš;
Šácha, Pavel;
Konvalinka, Jan

Publication type:

Article

Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases.

Published in:

FEBS Journal, 2014, v. 281, n. 7, p. 1834, doi. 10.1111/febs.12743

By:

Kožíšek, Milan;
Lepšík, Martin;
Grantz Šašková, Klára;
Brynda, Jiří;
Konvalinka, Jan;
Řezáčová, Pavlína

Publication type:

Article

Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.

Published in:

FEBS Journal, 2009, v. 276, n. 16, p. 4448, doi. 10.1111/j.1742-4658.2009.07152.x

By:

Hlouchova, Klara;
Barinka, Cyril;
Konvalinka, Jan;
Lubkowski, Jacek

Publication type:

Article

Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis.

Published in:

FEBS Journal, 2007, v. 274, n. 18, p. 4731, doi. 10.1111/j.1742-4658.2007.06021.x

By:

Mlčochov, Petra;
Plechanovov, Anna;
Bařinka, Cyril;
Mahadevan, Daruka;
Saldanha, Jose W.;
Rulíšek, Lubomír;
Konvalinka&, Jan

Publication type:

Article

Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors.

Published in:

Biological Chemistry, 2005, v. 386, n. 4, p. 339, doi. 10.1515/BC.2005.041

By:

Caffrey, Conor R.;
Placha, Lenka;
Barinka, Cyril;
Hradilek, Martin;
Dostal, Jiř;í;
Sajid, Mohammed;
McKerrow, James H.;
Majer, Pavel;
Konvalinka, Jan;
Vondrášek, Jiří

Publication type:

Article

A Novel Substrate-Based HIV-1 Protease Inhibitor Drug Resistance Mechanism.

Published in:

PLoS Medicine, 2007, v. 4, n. 1, p. 152, doi. 10.1371/journal.pmed.0040036

By:

Nijhuis, Monique;
van Maarseveen, Noortje M.;
Lastere, Stephane;
Schipper, Pauline;
Coakley, Eoin;
Glass, Bä rbel;
Rovenska, Mirka;
de Jong, Dorien;
Chappey, Colombe;
Goedegebuure, Irma W.;
Heilek-Snyder, Gabrielle;
Dulude, Dominic;
Cammack, Nick;
Brakier-Gingras, Lea;
Konvalinka, Jan;
Parkin, Neil;
Kräusslich, Hans-Georg;
Brun-Vezinet, Francoise;
Boucher, Charles A. B.

Publication type:

Article

Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 14, p. 7735, doi. 10.3390/ijms22147735

By:

Reiberger, Robert;
Radilová, Kateřina;
Kráľ, Michal;
Zima, Václav;
Majer, Pavel;
Brynda, Jiří;
Dračínský, Martin;
Konvalinka, Jan;
Kožíšek, Milan;
Machara, Aleš

Publication type:

Article

Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.

Published in:

2019

By:

Walle, Lieselotte Vande;
Stowe, Irma B.;
Šácha, Pavel;
Lee, Bettina L.;
Demon, Dieter;
Fossoul, Amelie;
Van Hauwermeiren, Filip;
Saavedra, Pedro H. V.;
Šimon, Petr;
Šubr, Vladimír;
Kostka, Libor;
Stivala, Craig E.;
Pham, Victoria C.;
Staben, Steven T.;
Yamazoe, Sayumi;
Konvalinka, Jan;
Kayagaki, Nobuhiko;
Lamkanfi, Mohamed

Publication type:

Correction Notice

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.

Published in:

PLoS Biology, 2019, v. 17, n. 9, p. 1, doi. 10.1371/journal.pbio.3000354

By:

Vande Walle, Lieselotte;
Stowe, Irma B.;
Šácha, Pavel;
Lee, Bettina L.;
Demon, Dieter;
Fossoul, Amelie;
Van Hauwermeiren, Filip;
Saavedra, Pedro H. V.;
Šimon, Petr;
Šubrt, Vladimír;
Kostka, Libor;
Stivala, Craig E.;
Pham, Victoria C.;
Staben, Steven T.;
Yamazoe, Sayumi;
Konvalinka, Jan;
Kayagaki, Nobuhiko;
Lamkanfi, Mohamed

Publication type:

Article

The calcium‐binding site of human glutamate carboxypeptidase II is critical for dimerization, thermal stability, and enzymatic activity.

Published in:

Protein Science: A Publication of the Protein Society, 2018, v. 27, n. 9, p. 1575, doi. 10.1002/pro.3460

By:

Ptacek, Jakub;
Nedvedova, Jana;
Navratil, Michal;
Havlinova, Barbora;
Konvalinka, Jan;
Barinka, Cyril

Publication type:

Article

Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir.

Published in:

Protein Science: A Publication of the Protein Society, 2008, v. 17, n. 9, p. 1555, doi. 10.1110/ps.036079.108

By:

Šašková, Klára Grantz;
Kožíšek, Milan;
Lepšík, Martin;
Brynda, Jiří;
Řezáčová, Pavlína;
Václavíková, Jana;
Kagan, Ron M.;
Machala, Ladislav;
Konvalinka, Jan

Publication type:

Article

Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.

Published in:

Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 6, p. 1627, doi. 10.1110/ps.04622104

By:

Barinka, Cyril;
Šácha, Pavel;
Sklenář, Jan;
Man, Petr;
Bezouška, Karel;
Slusher, Barbara S.;
Konvalinka, Jan

Publication type:

Article

Kinetics of the dimerization of retroviral proteases: The 'fireman's grip' and dimerization.

Published in:

Protein Science: A Publication of the Protein Society, 2003, v. 12, n. 10, p. 2173, doi. 10.1110/ps.03171903

By:

Ingr, Marek;
Uhlíková, Tat'ána;
Str̆ís̆ovský, Kvido;
Majerová, Eva;
Konvalinka, Jan

Publication type:

Article

A novel PSMA/GCPII‐deficient mouse model shows enlarged seminal vesicles upon aging.

Published in:

Prostate, 2019, v. 79, n. 2, p. 126, doi. 10.1002/pros.23717

By:

Vorlová, Barbora;
Sedlák, František;
Kašpárek, Petr;
Šrámková, Karolína;
Malý, Marek;
Zámečník, Josef;
Šácha, Pavel;
Konvalinka, Jan

Publication type:

Article

Detection and quantitation of glutamate carboxypeptidase II in human blood.

Published in:

Prostate, 2014, v. 74, n. 7, p. 768, doi. 10.1002/pros.22796

By:

Knedlík, Tomáš;
Navrátil, Václav;
Vik, Viktor;
Pacík, Dalibor;
Šácha, Pavel;
Konvalinka, Jan

Publication type:

Article

Prostate-specific membrane antigen and its truncated form PSM′.

Published in:

Prostate, 2009, v. 69, n. 5, p. 471, doi. 10.1002/pros.20894

By:

Mlčochová, Petra;
Bařinka, Cyril;
Tykvart, Jan;
Šácha, Pavel;
Konvalinka, Jan

Publication type:

Article

Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs.

Published in:

Prostate, 2008, v. 68, n. 2, p. 171, doi. 10.1002/pros.20676

By:

Rovenská, Miroslava;
Hlouchová, Klára;
Šácha, Pavel;
Mlčochová, Petra;
Horák, Vratislav;
Zámečník, Josef;
Bařinka, Cyril;
Konvalinka, Jan

Publication type:

Article

Proteinases of betaretroviruses bind single-stranded nucleic acids through a novel interaction module, the G-patch

Published in:

FEBS Letters, 2004, v. 576, n. 1/2, p. 271, doi. 10.1016/j.febslet.2004.09.010

By:

Švec, Martin;
Bauerová, Helena;
Pichová, Iva;
Konvalinka, Jan;
Stříšovský, Kvido

Publication type:

Article

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor.

Published in:

Nature Communications, 2015, v. 6, n. 3, p. 6461, doi. 10.1038/ncomms7461

By:

Schimer, Jiří;
Pávová, Marcela;
Anders, Maria;
Pachl, Petr;
Šácha, Pavel;
Cígler, Petr;
Weber, Jan;
Majer, Pavel;
Řezáčová, Pavlína;
Kräusslich, Hans-Georg;
Müller, Barbara;
Konvalinka, Jan

Publication type:

Article

iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties.

Published in:

Angewandte Chemie, 2016, v. 128, n. 7, p. 2402, doi. 10.1002/ange.201508642

By:

Šácha, Pavel;
Knedlík, Tomáš;
Schimer, Jiří;
Tykvart, Jan;
Parolek, Jan;
Navrátil, Václav;
Dvořáková, Petra;
Sedlák, František;
Ulbrich, Karel;
Strohalm, Jiří;
Majer, Pavel;
Šubr, Vladimír;
Konvalinka, Jan

Publication type:

Article

Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances.

Published in:

Pure & Applied Chemistry, 2012, v. 84, n. 11, p. 2243

By:

Grüner, Bohumír;
Švec, Petr;
Hájková, Zuzana;
Císarová, Ivana;
Pokorná, Jana;
Konvalinka, Jan

Publication type:

Article

Mouse glutamate carboxypeptidase II ( GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII.

Published in:

FEBS Open Bio, 2017, v. 7, n. 9, p. 1362, doi. 10.1002/2211-5463.12276

By:

Knedlík, Tomáš;
Vorlová, Barbora;
Navrátil, Václav;
Tykvart, Jan;
Sedlák, František;
Vaculín, Šimon;
Franěk, Miloslav;
Šácha, Pavel;
Konvalinka, Jan

Publication type:

Article

DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening.

Published in:

Nucleic Acids Research, 2017, v. 45, n. 2, p. 1, doi. 10.1093/nar/gkw853

By:

Navrátil, Václav;
Schimer, Jiří;
Tykvart, Jan;
Knedlík, Tomáš;
Vik, Viktor;
Majer, Pavel;
Konvalinka, Jan;
Šácha, Pavel

Publication type:

Article

Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

Published in:

EMBO Journal, 2006, v. 25, n. 6, p. 1375, doi. 10.1038/sj.emboj.7600969

By:

Mesters, Jeroen R.;
Barinka, Cyril;
Weixing Li;
Tsukamoto, Takashi;
Majer, Pavel;
Slusher, Barbara S.;
Konvalinka, Jan;
Hilgenfeld, Rolf

Publication type:

Article

Glutamate carboxypeptidase II does not process amyloid-β peptide.

Published in:

FASEB Journal, 2013, v. 27, n. 7, p. 2626, doi. 10.1096/fj.12-225094

By:

Sedlák, František;
Šácha, Pavel;
Blechová, Miroslava;
Březinová, Anna;
Šafařík, Martin;
Šebestík, Jaroslav;
Konvalinka, Jan

Publication type:

Article

Biochemical characterization of human glutamate carboxypeptidase III.

Published in:

Journal of Neurochemistry, 2007, v. 101, n. 3, p. 682, doi. 10.1111/j.1471-4159.2006.04341.x

By:

Hlouchová, Klára;
Bařinka, Cyril;
Klusák, Vojtěch;
Šácha, Pavel;
Mlčochová, Petra;
Majer, Pavel;
RulíŠek, Lubomír;
Konvalinka, Jan

Publication type:

Article

Capillary electrophoresis method for determination of D-serine and its application for monitoring of serine racemase activity.

Published in:

Electrophoresis, 2006, v. 27, n. 13, p. 2558, doi. 10.1002/elps.200500946

By:

Dušan Koval;
Jana Jirásková;
Kvido Stříšovský;
Jan Konvalinka;
Václav Kašička

Publication type:

Article

DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors.

Published in:

Biochemical Journal, 2018, v. 475, n. 23, p. 3847, doi. 10.1042/BCJ20180764

By:

Kožíšek, Milan;
Navrátil, Václav;
na Rojíková, Katerǐ;
Pokorná, Jana;
Albiñana, Carlos Berenguer;
Pachl, Petr;
Zemanová, Jitka;
Machara, Aleš;
Šácha, Pavel;
Hudlický, Jason;
Císarǒ vá, Ivana;
Řezáčová, Pavlína;
Konvalinka, Jan

Publication type:

Article

Inhibitor and Substrate Binding Induced Stability of HIV-1 Protease against Sequential Dissociation and Unfolding Revealed by High Pressure Spectroscopy and Kinetics.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0119099

By:

Ingr, Marek;
Lange, Reinhard;
Halabalová, Věra;
Yehya, Alaa;
Hrnčiřík, Josef;
Chevalier-Lucia, Dominique;
Palmade, Laetitia;
Blayo, Claire;
Konvalinka, Jan;
Dumay, Eliane

Publication type:

Article

Czech bibliometric system fosters mediocre research.

Published in:

2009

By:

Konvalinka, Jan;
Illnerová, Helena;
Hobza, Pavel;
Hořejší, Václav;
Holý, Antonín;
Jungwirth, Pavel;
Pačes, Václav;
Martásek, Pavel;
Zlatuška, Jiří

Publication type:

Letter

Peptide inhibitors of HIV-1 and HIV-2 proteases: a comparative study.

Published in:

Leukemia (08876924), 1997, v. 11, p. 120

By:

PICHOVÁ, Iva;
WEBER, Jan;
LITERA, Jaroslav;
KONVALINKA, Jan;
VONDRÁSEK, JiřI;
SOUČEK, Milan;
STROP, Petr;
MAJER, Pavel;
HEUSER, Anke M.;
KRAEUSSLICH, Hans-Georg

Publication type:

Article

Current and Novel Inhibitors of HIV Protease.

Published in:

Viruses (1999-4915), 2009, v. 1, n. 3, p. 1209, doi. 10.3390/v1031209

By:

Pokorná, Jana;
Machala, Ladislav;
Rezácová, Pavlína;
Konvalinka, Jan

Publication type:

Article

Front Cover: 3'‐Dehydroxypurpurogallin‐4‐Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure‐Activity Relationship Analysis, and Structural Characterization of Protein Complex (ChemMedChem 3/2025).

Published in:

ChemMedChem, 2025, v. 20, n. 3, p. 1, doi. 10.1002/cmdc.202580301

By:

Kráľ, Michal;
Kotačka, Tomáš;
Reiberger, Róbert;
Panýrková, Gabriela;
Radilová, Kateřina;
Osifová, Zuzana;
Flieger, Miroslav;
Konvalinka, Jan;
Majer, Pavel;
Kožíšek, Milan;
Machara, Aleš

Publication type:

Article

3'‐Dehydroxypurpurogallin‐4‐Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure‐Activity Relationship Analysis, and Structural Characterization of Protein Complex.

Published in:

ChemMedChem, 2025, v. 20, n. 3, p. 1, doi. 10.1002/cmdc.202400577

By:

Kráľ, Michal;
Kotačka, Tomáš;
Reiberger, Róbert;
Panýrková, Gabriela;
Radilová, Kateřina;
Osifová, Zuzana;
Flieger, Miroslav;
Konvalinka, Jan;
Majer, Pavel;
Kožíšek, Milan;
Machara, Aleš

Publication type:

Article

iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 7, p. 2356, doi. 10.1002/anie.201508642

By:

Šácha, Pavel;
Knedlík, Tomáš;
Schimer, Jiří;
Tykvart, Jan;
Parolek, Jan;
Navrátil, Václav;
Dvořáková, Petra;
Sedlák, František;
Ulbrich, Karel;
Strohalm, Jiří;
Majer, Pavel;
Šubr, Vladimír;
Konvalinka, Jan

Publication type:

Article

Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate

Published in:

FEBS Letters, 2003, v. 535, n. 1-3, p. 44, doi. 10.1016/S0014-5793(02)03855-3

By:

Střıšovský, Kvido;
Jirásková, Jana;
Bařinka, Cyril;
Majer, Pavel;
Rojas, Camilo;
Slusher, Barbara S.;
Konvalinka, Jan

Publication type:

Article

Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase †.

Published in:

Molecules, 2021, v. 26, n. 4, p. 1007, doi. 10.3390/molecules26041007

By:

Gregor, Jiří;
Radilová, Kateřina;
Brynda, Jiří;
Fanfrlík, Jindřich;
Konvalinka, Jan;
Kožíšek, Milan;
Collina, Simona

Publication type:

Article

Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family.

Published in:

Scientific Reports, 2016, p. 33671, doi. 10.1038/srep33671

By:

Trempe, Jean-François;
Šašková, Klára Grantz;
Sivá, Monika;
Ratcliffe, Colin D. H.;
Veverka, Václav;
Hoegl, Annabelle;
Ménade, Marie;
Feng, Xin;
Shenker, Solomon;
Svoboda, Michal;
Kožíšek, Milan;
Konvalinka, Jan;
Gehring, Kalle

Publication type:

Article

Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog.

Published in:

Scientific Reports, 2016, p. 30443, doi. 10.1038/srep30443

By:

Sivá, Monika;
Svoboda, Michal;
Veverka, Václav;
Trempe, Jean-François;
Hofmann, Kay;
Kožíšek, Milan;
Hexnerová, Rozálie;
Sedlák, František;
Belza, Jan;
Brynda, Jiří;
Šácha, Pavel;
Hubálek, Martin;
Starková, Jana;
Flaisigová, Iva;
Konvalinka, Jan;
Šašková, Klára Grantz

Publication type:

Article

Comparison of human glutamate carboxypeptidases II and III reveals their divergent substrate specificities.

Published in:

FEBS Journal, 2016, v. 283, n. 13, p. 2528, doi. 10.1111/febs.13761

By:

Navrátil, Michal;
Tykvart, Jan;
Schimer, Jiří;
Pachl, Petr;
Navrátil, Václav;
Rokob, Tibor András;
Hlouchová, Klára;
Rulíšek, Lubomír;
Konvalinka, Jan

Publication type:

Article

Structural and biochemical characterization of the folyl-poly-γ- l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.

Published in:

FEBS Journal, 2014, v. 281, n. 14, p. 3228, doi. 10.1111/febs.12857

By:

Navrátil, Michal;
Ptáček, Jakub;
Šácha, Pavel;
Starková, Jana;
Lubkowski, Jacek;
Bařinka, Cyril;
Konvalinka, Jan

Publication type:

Article