Works matching AU Kontro, Mika

Results: 21

CLEVER-1 targeting antibody, bexmarilimab, supports HLA-DR expression and alters ex vivo responsiveness to azacitidine and venetoclax in myeloid malignancies.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41598-025-01675-y

By:

Aakko, Sofia;
Ylitalo, Arno;
Kuusanmäki, Heikki;
Rannikko, Jenna H.;
Björkman, Mari;
Mandelin, Jami;
Heckman, Caroline A.;
Kontro, Mika;
Hollmén, Maija

Publication type:

Article

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry.

Published in:

Human Mutation, 2017, v. 38, n. 3, p. 269, doi. 10.1002/humu.23157

By:

Heikkinen, Tuomas;
Kämpjärvi, Kati;
Keskitalo, Salla;
von Nandelstadh, Pernilla;
Liu, Xiaonan;
Rantanen, Ville;
Pitkänen, Esa;
Kinnunen, Matias;
Kuusanmäki, Heikki;
Kontro, Mika;
Turunen, Mikko;
Mäkinen, Netta;
Taipale, Jussi;
Heckman, Caroline;
Lehti, Kaisa;
Mustjoki, Satu;
Varjosalo, Markku;
Vahteristo, Pia

Publication type:

Article

Capillary Sampling Enables Venetoclax Concentration Measurement in Acute Myeloid Leukaemia Within Academic Multicentre Trial.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2025, v. 136, n. 6, p. 1, doi. 10.1111/bcpt.70041

By:

Kytölä, Sari;
Kurkela, Mika;
Kiiski, Johanna I.;
Vänttinen, Ida;
Ruokoranta, Tanja;
Partanen, Anu;
Holopainen, Annasofia;
Pyörälä, Marja;
Kuusisto, Milla E. L.;
Siitonen, Timo;
Koskela, Sirpa;
Rimpiläinen, Johanna;
Ettala, Pia;
Kuusanmäki, Heikki;
Niemi, Mikko;
Backman, Janne T.;
Kontro, Mika

Publication type:

Article

Multiple myeloma of cranium with external ear canal swelling and occipital mass: A rare case report.

Published in:

2022

By:

Kellberg, Salla;
Kurdo, Goran;
Kontro, Mika;
Sinkkonen, Saku T.

Publication type:

Case Study

FLT3-ITD allelic ratio and HLF expression predict FLT3 inhibitor efficacy in adult AML.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-03010-7

By:

Kivioja, Jarno;
Malani, Disha;
Kumar, Ashwini;
Kontro, Mika;
Parsons, Alun;
Kallioniemi, Olli;
Heckman, Caroline A.

Publication type:

Article

Venetoclax triggers sublethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine.

Published in:

Cell Death & Disease, 2024, v. 15, n. 10, p. 1, doi. 10.1038/s41419-024-07140-4

By:

Tambe, Mahesh;
Unterberger, Sarah;
Kriegbaum, Mette C.;
Vänttinen, Ida;
Olgac, Ezgi June;
Vähä-Koskela, Markus;
Kontro, Mika;
Wennerberg, Krister;
Heckman, Caroline A.

Publication type:

Article

MDS-420: Sabatolimab Plus Hypomethylating Agents (HMAs) in Patients with High-/Very High-risk Myelodysplastic Syndrome (HR/vHR-MDS) and Newly Diagnosed Acute Myeloid Leukemia (ND-AML): Subgroup Analysis of a Phase 1 Study.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S350, doi. 10.1016/S2152-2650(21)01811-5

By:

Garcia-Manero, Guillermo;
Wei, Andrew H.;
Porkka, Kimmo;
Knapper, Steve;
Traer, Elie;
Scholl, Sebastian;
Vey, Norbert;
Wermke, Martin;
Janssen, Jeroen;
Narayan, Rupa;
Sun Loo;
Tovar, Natalia;
Kontro, Mika;
Ottmann, Oliver;
Naidu, Purushotham;
Orlando, Elena;
Patei, Nidhi;
Makofske, Jessica;
Fei Ma;
Na Zhang

Publication type:

Article

MDS-404: Population Pharmacokinetics Modeling and Evaluation of Clinical Efficacy and Safety of Sabatolimab: Dose Selection and Dose-Response Analysis.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S349, doi. 10.1016/S2152-2650(21)01810-3

By:

Garcia-Manero, Guillermo;
Wei, Andrew H.;
Porkka, Kimmo;
Knapper, Steve;
Vey, Norbert;
Scholl, Sebastian;
Wermke, Martin;
Janssen, Jeroen;
Traer, Elie;
Sun Loo;
Narayan, Rupa;
Tovar, Natalia;
Kontro, Mika;
Ottmann, Oliver;
Siyan Xu;
Lewandowski, Andrew;
Stein, Andrew;
Naidu, Purushotham;
Na Zhang;
Mohammed, Anisa

Publication type:

Article

Poster: MDS-404: Population Pharmacokinetics Modeling and Evaluation of Clinical Efficacy and Safety of Sabatolimab: Dose Selection and Dose-Response Analysis.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S230, doi. 10.1016/S2152-2650(21)01448-8

By:

Garcia-Manero, Guillermo;
Wei, Andrew H.;
Porkka, Kimmo;
Knapper, Steve;
Vey, Norbert;
Scholl, Sebastian;
Wermke, Martin;
Janssen, Jeroen;
Traer, Elie;
Sun Loo;
Narayan, Rupa;
Tovar, Natalia;
Kontro, Mika;
Ottmann, Oliver;
Siyan Xu;
Lewandowski, Andrew;
Stein, Andrew;
Naidu, Purushotham;
Na Zhang;
Mohammed, Anisa

Publication type:

Article

Poster: MDS-420: Sabatolimab Plus Hypomethylating Agents (HMAs) in Patients with High-/Very High-risk Myelodysplastic Syndrome (HR/vHR-MDS) and Newly Diagnosed Acute Myeloid Leukemia (ND-AML): Subgroup Analysis of a Phase 1 Study.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S230, doi. 10.1016/S2152-2650(21)01447-6

By:

Garcia-Manero, Guillermo;
Wei, Andrew H.;
Porkka, Kimmo;
Knapper, Steve;
Traer, Elie;
Scholl, Sebastian;
Vey, Norbert;
Wermke, Martin;
Janssen, Jeroen;
Narayan, Rupa;
Sun Loo;
Tovar, Natalia;
Kontro, Mika;
Ottmann, Oliver;
Naidu, Purushotham;
Orlando, Elena;
Patel, Nidhi;
Makofske, Jessica;
Fei Ma;
Na Zhang

Publication type:

Article

Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52980-5

By:

Ianevski, Aleksandr;
Nader, Kristen;
Driva, Kyriaki;
Senkowski, Wojciech;
Bulanova, Daria;
Moyano-Galceran, Lidia;
Ruokoranta, Tanja;
Kuusanmäki, Heikki;
Ikonen, Nemo;
Sergeev, Philipp;
Vähä-Koskela, Markus;
Giri, Anil K.;
Vähärautio, Anna;
Kontro, Mika;
Porkka, Kimmo;
Pitkänen, Esa;
Heckman, Caroline A.;
Wennerberg, Krister;
Aittokallio, Tero

Publication type:

Article

Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep05193

By:

Yadav, Bhagwan;
Pemovska, Tea;
Szwajda, Agnieszka;
Kulesskiy, Evgeny;
Kontro, Mika;
Karjalainen, Riikka;
Mamun Majumder, Muntasir;
Malani, Disha;
Murumägi, Astrid;
Knowles, Jonathan;
Porkka, Kimmo;
Heckman, Caroline;
Kallioniemi, Olli;
Wennerberg, Krister;
Aittokallio, Tero

Publication type:

Article

Age-specific survival in acute myeloid leukemia in the Nordic countries through a half century.

Published in:

Blood Cancer Journal, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41408-024-01033-7

By:

Hemminki, Kari;
Zitricky, Frantisek;
Försti, Asta;
Kontro, Mika;
Gjertsen, Bjorn T.;
Severinsen, Marianne Tang;
Juliusson, Gunnar

Publication type:

Article

Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-48167-4

By:

Batcha, Aarif M. N.;
Bamopoulos, Stefanos A.;
Kerbs, Paul;
Kumar, Ashwini;
Jurinovic, Vindi;
Rothenberg-Thurley, Maja;
Ksienzyk, Bianka;
Philippou-Massier, Julia;
Krebs, Stefan;
Blum, Helmut;
Schneider, Stephanie;
Konstandin, Nikola;
Bohlander, Stefan K.;
Heckman, Caroline;
Kontro, Mika;
Hiddemann, Wolfgang;
Spiekermann, Karsten;
Braess, Jan;
Metzeler, Klaus H.;
Greif, Philipp A.

Publication type:

Article

Somatic MED12 Mutations in Prostate Cancer and Uterine Leiomyomas Promote Tumorigenesis Through Distinct Mechanisms.

Published in:

Prostate, 2016, v. 76, n. 1, p. 22, doi. 10.1002/pros.23092

By:

Kämpjärvi, Kati;
Kim, Nam Hee;
Keskitalo, Salla;
Clark, Alison D.;
von Nandelstadh, Pernilla;
Turunen, Mikko;
Heikkinen, Tuomas;
Park, Min Ju;
Mäkinen, Netta;
Kivinummi, Kati;
Lintula, Susanna;
Hotakainen, Kristina;
Nevanlinna, Heli;
Hokland, Peter;
Böhling, Tom;
Bützow, Ralf;
Böhm, Jan;
Mecklin, Jukka‐Pekka;
Järvinen, Heikki;
Kontro, Mika

Publication type:

Article

8‐chloro‐adenosine activity in FLT3‐ITD acute myeloid leukemia.

Published in:

Journal of Cellular Physiology, 2019, v. 234, n. 9, p. 16295, doi. 10.1002/jcp.28294

By:

Buettner, Ralf;
Nguyen, Le Xuan Truong;
Kumar, Bijender;
Morales, Corey;
Liu, Chao;
Chen, Lisa S.;
Pemovska, Tea;
Synold, Timothy W.;
Palmer, Joycelynne;
Thompson, Ryan;
Li, Ling;
Hoang, Dinh Hoa;
Zhang, Bin;
Ghoda, Lucy;
Kowolik, Claudia;
Kontro, Mika;
Leitch, Calum;
Wennerberg, Krister;
Yu, Xiaochun;
Chen, Ching‐Cheng

Publication type:

Article

Phase Ib study of sabatolimab (MBG453), a novel immunotherapy targeting TIM‐3 antibody, in combination with decitabine or azacitidine in high‐ or very high‐risk myelodysplastic syndromes.

Published in:

American Journal of Hematology, 2024, v. 99, n. 2, p. E32, doi. 10.1002/ajh.27161

By:

Brunner, Andrew M.;
Esteve, Jordi;
Porkka, Kimmo;
Knapper, Steve;
Traer, Elie;
Scholl, Sebastian;
Garcia‐Manero, Guillermo;
Vey, Norbert;
Wermke, Martin;
Janssen, Jeroen J. W. M.;
Narayan, Rupa;
Fleming, Shaun;
Loo, Sun;
Tovar, Natalia;
Kontro, Mika;
Ottmann, Oliver G.;
Naidu, Purushotham;
Sun, Haiying;
Han, May;
White, Roisin

Publication type:

Article

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation.

Published in:

Nature, 2015, v. 519, n. 7541, p. 102, doi. 10.1038/nature14119

By:

Pemovska, Tea;
Johnson, Eric;
Kontro, Mika;
Repasky, Gretchen A.;
Chen, Jeffrey;
Wells, Peter;
Cronin, Ciarán N.;
McTigue, Michele;
Kallioniemi, Olli;
Porkka, Kimmo;
Murray, Brion W.;
Wennerberg, Krister

Publication type:

Article

Case studies investigating genetic heterogeneity between anatomically distinct bone marrow compartments in acute myeloid leukemia.

Published in:

Leukemia & Lymphoma, 2018, v. 59, n. 12, p. 3002, doi. 10.1080/10428194.2018.1453067

By:

Ojamies, Poojitha N.;
Kontro, Mika;
Edgren, Henrik;
Ellonen, Pekka;
Heckman, Caroline;
Porkka, Kimmo;
Wolf, Maija;
Kallioniemi, Olli

Publication type:

Article

Chimeric NUP98-NSD1 transcripts from the cryptic t(5;11)(q35.2;p15.4) in adult de novo acute myeloid leukemia.

Published in:

Leukemia & Lymphoma, 2018, v. 59, n. 3, p. 725, doi. 10.1080/10428194.2017.1357174

By:

Kivioja, Jarno L.;
Lopez Martí, Jesus M.;
Kumar, Ashwini;
Kontro, Mika;
Edgren, Henrik;
Parsons, Alun;
Lundán, Tuija;
Wolf, Maija;
Porkka, Kimmo;
Heckman, Caroline A.

Publication type:

Article

Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation.

Published in:

Cellular & Molecular Life Sciences, 2021, v. 78, n. 23, p. 7851, doi. 10.1007/s00018-021-03977-6

By:

Iftakhar-e-Khuda, Imtiaz;
Pessia, Alberto;
Zheng, Shuyu;
Kankainen, Matti;
Kontro, Mika;
Karikoski, Marika;
Laurila, Juha;
Gerke, Heidi;
Tadayon, Sina;
Hollmén, Maija;
Tang, Jing;
Imhof, Beat A.;
Salmi, Marko;
Jalkanen, Sirpa

Publication type:

Article