Works by Kontermann, Roland E.

Results: 65

A fusogenic dengue virus-derived peptide enhances antitumor efficacy of an antibody–ribonuclease fusion protein targeting the EGF receptor.

Published in:

PEDS: Protein Engineering, Design & Selection, 2014, v. 27, n. 10, p. 331, doi. 10.1093/protein/gzu040

By:

Kiesgen, Stefan;
Liebers, Nora;
Cremer, Martin;
Arnold, Ulrich;
Weber, Tobias;
Keller, Armin;
Herold-Mende, Christel;
Dyckhoff, Gerhard;
Jäger, Dirk;
Kontermann, Roland E.;
Arndt, Michaela A. E.;
Krauss, Jürgen

Publication type:

Article

An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action.

Published in:

PEDS: Protein Engineering, Design & Selection, 2013, v. 26, n. 10, p. 581, doi. 10.1093/protein/gzt044

By:

Berger, Verena;
Richter, Fabian;
Zettlitz, Kirstin;
Unverdorben, Felix;
Scheurich, Peter;
Herrmann, Andreas;
Pfizenmaier, Klaus;
Kontermann, Roland E.

Publication type:

Article

The IgM CH2 domain as covalently linked homodimerization module for the generation of fusion proteins with dual specificity.

Published in:

PEDS: Protein Engineering, Design & Selection, 2012, v. 25, n. 10, p. 603, doi. 10.1093/protein/gzs059

By:

Seifert, Oliver;
Plappert, Aline;
Heidel, Nadine;
Fellermeier, Sina;
Messerschmidt, Sylvia K.E.;
Richter, Fabian;
Kontermann, Roland E.

Publication type:

Article

Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A.

Published in:

PEDS: Protein Engineering, Design & Selection, 2012, v. 25, n. 2, p. 81, doi. 10.1093/protein/gzr061

By:

Unverdorben, Felix;
Färber-Schwarz, Aline;
Richter, Fabian;
Hutt, Meike;
Kontermann, Roland E.

Publication type:

Article

The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein.

Published in:

PEDS: Protein Engineering, Design & Selection, 2010, v. 23, n. 11, p. 827, doi. 10.1093/protein/gzq058

By:

Hopp, Jonas;
Hornig, Nora;
Zettlitz, Kirstin A.;
Schwarz, Aline;
Fuß, Nadine;
Müller, Dafne;
Kontermann, Roland E.

Publication type:

Article

A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G.

Published in:

PEDS: Protein Engineering, Design & Selection, 2007, v. 20, n. 11, p. 569, doi. 10.1093/protein/gzm061

By:

Roland Stork;
Dafne Müller;
Roland E. Kontermann

Publication type:

Article

Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells.

Published in:

PEDS: Protein Engineering, Design & Selection, 2004, v. 17, n. 5, p. 433, doi. 10.1093/protein/gzh055

By:

Peter Hölig;
Miriam Bach;
Tina Völkel;
Thomas Nahde;
Sven Hoffmann;
Rolf Müller;
Roland E. Kontermann

Publication type:

Article

Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02785-y

By:

Pegoretti, Valentina;
Bauer, Jan;
Fischer, Roman;
Paro, Iskra;
Douwenga, Wanda;
Kontermann, Roland E.;
Pfizenmaier, Klaus;
Houben, Evelien;
Broux, Bieke;
Hellings, Niels;
Baron, Wia;
Laman, Jon D.;
Eisel, Ulrich L. M.

Publication type:

Article

Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02784-z

By:

Fiedler, Timon;
Fairless, Richard;
Pichi, Kira;
Fischer, Roman;
Richter, Fabian;
Kontermann, Roland E.;
Pfizenmaier, Klaus;
Diem, Ricarda;
Williams, Sarah K.

Publication type:

Article

Transcytosis of payloads that are non-covalently complexed to bispecific antibodies across the hCMEC/D3 blood-brain barrier model.

Published in:

Biological Chemistry, 2018, v. 399, n. 7, p. 711, doi. 10.1515/hsz-2017-0311

By:

Schmid, Daniela;
Buntz, Annette;
Thi Ngoc Hanh Phan;
Mayer, Klaus;
Hoffmann, Eike;
Thorey, Irmgard;
Niewöhner, Jens;
Vasters, Katrin;
Sircar, Ranjan;
Mundigl, Olaf;
Kontermann, Roland E.;
Brinkmann, Ulrich

Publication type:

Article

GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments.

Published in:

Molecules, 2022, v. 27, n. 10, p. 3272, doi. 10.3390/molecules27103272

By:

Seifert, Oliver;
Kontermann, Roland E.

Publication type:

Article

Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma.

Published in:

Molecules, 2021, v. 26, n. 24, p. 7582, doi. 10.3390/molecules26247582

By:

Krishna Moorthy, Nivetha;
Seifert, Oliver;
Eisler, Stephan;
Weirich, Sara;
Kontermann, Roland E.;
Rehm, Markus;
Fullstone, Gavin

Publication type:

Article

A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-93351-0

By:

Aschmoneit, Nadine;
Steinlein, Sophia;
Kühl, Lennart;
Seifert, Oliver;
Kontermann, Roland E.

Publication type:

Article

Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma.

Published in:

Cell Death & Disease, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41419-022-04502-8

By:

Del Mistro, Greta;
Riemann, Shamala;
Schindler, Sebastian;
Beissert, Stefan;
Kontermann, Roland E.;
Ginolhac, Aurelien;
Halder, Rashi;
Presta, Luana;
Sinkkonen, Lasse;
Sauter, Thomas;
Kulms, Dagmar

Publication type:

Article

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice.

Published in:

Cell Death & Disease, 2020, v. 11, n. 3, p. 1, doi. 10.1038/s41419-020-2411-6

By:

Wandrer, Franziska;
Liebig, Stephanie;
Marhenke, Silke;
Vogel, Arndt;
John, Katharina;
Manns, Michael P.;
Teufel, Andreas;
Itzel, Timo;
Longerich, Thomas;
Maier, Olaf;
Fischer, Roman;
Kontermann, Roland E.;
Pfizenmaier, Klaus;
Schulze-Osthoff, Klaus;
Bantel, Heike

Publication type:

Article

Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism.

Published in:

Cell Death & Disease, 2018, v. 9, n. 11, p. 1, doi. 10.1038/s41419-018-1160-2

By:

Lincoln, Frank A.;
Imig, Dirke;
Boccellato, Chiara;
Juric, Viktorija;
Noonan, Janis;
Kontermann, Roland E.;
Allgöwer, Frank;
Murphy, Brona M.;
Rehm, Markus

Publication type:

Article

Antibody phage display technologies with special reference to angiogenesis.

Published in:

FASEB Journal, 2005, v. 19, n. 3, p. 331, doi. 10.1096/fj.04-2863rev

By:

Smith, Julia;
Kontermann, Roland E.;
Embleton, Jim;
Kumar, Shant

Publication type:

Article

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice.

Published in:

2021

By:

Papazian, Irini;
Tsoukala, Eleni;
Boutou, Athena;
Karamita, Maria;
Kambas, Konstantinos;
Iliopoulou, Lida;
Fischer, Roman;
Kontermann, Roland E.;
Denis, Maria C.;
Kollias, George;
Lassmann, Hans;
Probert, Lesley

Publication type:

journal article

Inhibition of cell proliferation and induction of apoptosis by novel tetravalent peptides inhibiting DNA binding of E2F.

Published in:

Oncogene, 2003, v. 22, n. 32, p. 4943, doi. 10.1038/sj.onc.1206495

By:

Montigiani, Silvia;
Müller, Rolf;
Kontermann, Roland E

Publication type:

Article

Bispecific Antibodies for Cancer Immunotherapy.

Published in:

BioDrugs, 2010, v. 24, n. 2, p. 89, doi. 10.2165/11530960-000000000-00000

By:

Müller, Dafne;
Kontermann, Roland E.

Publication type:

Article

Strategies to Extend Plasma Half-Lives of Recombinant Antibodies.

Published in:

BioDrugs, 2009, v. 23, n. 2, p. 93, doi. 10.2165/00063030-200923020-00003

By:

Kontermann, Roland E.

Publication type:

Article

Retargeting of adenoviral infection to melanoma: Combining genetic ablation of native tropism with a recombinant bispecific single-chain diabody (scDb) adapter that binds to fiber knob and HMWMAA.

Published in:

International Journal of Cancer, 2004, v. 108, n. 1, p. 136, doi. 10.1002/ijc.11563

By:

Dirk M. Nettelbeck;
Angel A. Rivera;
Jörg Kupsch;
Detlef Dieckmann;
Joanne T. Douglas;
Roland E. Kontermann;
Ramon Alemany;
David T. Curiel

Publication type:

Article

Recombinant bispecific antibodies for cancer therapy.

Published in:

Acta Pharmacologica Sinica, 2005, v. 26, n. 1, p. 1, doi. 10.1111/j.1745-7254.2005.00008.x

By:

Kontermann, Roland E.

Publication type:

Article

Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma.

Published in:

NPJ Systems Biology & Applications, 2018, v. 4, n. 1, p. N.PAG, doi. 10.1038/s41540-018-0075-y

By:

Del Mistro, Greta;
Lucarelli, Philippe;
Müller, Ines;
De Landtsheer, Sébastien;
Zinoveva, Anna;
Hutt, Meike;
Siegemund, Martin;
Kontermann, Roland E.;
Beissert, Stefan;
Sauter, Thomas;
Kulms, Dagmar

Publication type:

Article

A fast and effective determination of the biodistribution and subcellular localization of fluorescent immunoliposomes in freshly excised animal organs.

Published in:

BMC Biotechnology, 2017, v. 18, p. 1, doi. 10.1186/s12896-017-0327-8

By:

Tansi, Felista L.;
Rüger, Ronny;
Kollmeier, Ansgar M.;
Böhm, Claudia;
Kontermann, Roland E.;
Teichgraebe, Ulf K.;
Fahr, Alfred;
Hilger, Ingrid

Publication type:

Article

Back-to-Germline (B2G) Procedure for Antibody Devolution.

Published in:

Antibodies (2073-4468), 2019, v. 8, n. 3, p. 45, doi. 10.3390/antib8030045

By:

Schrade, Anja;
Bujotzek, Alexander;
Spick, Christian;
Wagner, Martina;
Goerl, Johannes;
Wezler, Xenia;
Georges, Guy;
Kontermann, Roland E.;
Brinkmann, Ulrich

Publication type:

Article

Targeting sTNF/TNFR1 Signaling as a New Therapeutic Strategy.

Published in:

Antibodies (2073-4468), 2015, v. 4, n. 1, p. 48, doi. 10.3390/antib4010048

By:

Fischer, Roman;
Kontermann, Roland E.;
Maier, Olaf

Publication type:

Article

Dual Targeting of Tumor Cells with Bispecific Single-Chain Fv-Immunoliposomes.

Published in:

Antibodies (2073-4468), 2012, v. 1, n. 2, p. 199, doi. 10.3390/antib1020199

By:

Mack, Katharina;
Rüger, Ronny;
Fellermeier, Sina;
Seifert, Oliver;
Kontermann, Roland E.

Publication type:

Article

Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.759337

By:

Siegemund, Martin;
Oak, Prajakta;
Hansbauer, Eva-Maria;
Allersdorfer, Andrea;
Utschick, Karoline;
Winter, Alexandra;
Grasmüller, Christina;
Galler, Gunther;
Mayer, Jan-Peter;
Weiche, Benjamin;
Prassler, Josef;
Kontermann, Roland E.;
Rothe, Christine

Publication type:

Article

eIg-based bispecific T-cell engagers targeting EGFR: Format matters.

Published in:

2023

By:

Kühl, Lennart;
Schäfer, Annelie K.;
Kraft, Sebastian;
Aschmoneit, Nadine;
Kontermann, Roland E.;
Seifert, Oliver

Publication type:

Report

The eIg technology to generate Ig-like bispecific antibodies.

Published in:

2022

By:

Kühl, Lennart;
Aschmoneit, Nadine;
Kontermann, Roland E.;
Seifert, Oliver

Publication type:

Report

Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics.

Published in:

mAbs (1942-0862), 2021, v. 13, n. 1, p. 1, doi. 10.1080/19420862.2021.1982447

By:

Kontermann, Roland E.;
Ungerechts, Guy;
Nettelbeck, Dirk M.

Publication type:

Article

A bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3.

Published in:

2021

By:

Rau, Alexander;
Kocher, Katharina;
Rommel, Mirjam;
Kühl, Lennart;
Albrecht, Maximilian;
Gotthard, Hannes;
Aschmoneit, Nadine;
Noll, Bettina;
Olayioye, Monilola A.;
Kontermann, Roland E.;
Seifert, Oliver

Publication type:

Report

CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins.

Published in:

2020

By:

Jost, Christian;
Darowski, Diana;
Challier, John;
Pulko, Vesna;
Hanisch, Lydia J;
Xu, Wei;
Mössner, Ekkehard;
Bujotzek, Alexander;
Klostermann, Stefan;
Umana, Pablo;
Kontermann, Roland E.;
Klein, Christian

Publication type:

Report

Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules.

Published in:

2019

By:

Seifert, Oliver;
Rau, Alexander;
Beha, Nadine;
Richter, Fabian;
Kontermann, Roland E.

Publication type:

Report

Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc.

Published in:

2019

By:

Richter, Fabian;
Seifert, Oliver;
Herrmann, Andreas;
Pfizenmaier, Klaus;
Kontermann, Roland E.

Publication type:

Report

Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity.

Published in:

mAbs (1942-0862), 2019, v. 11, n. 1, p. 166, doi. 10.1080/19420862.2018.1524664

By:

Richter, Fabian;
Zettlitz, Kirstin A.;
Seifert, Oliver;
Herrmann, Andreas;
Scheurich, Peter;
Pfizenmaier, Klaus;
Kontermann, Roland E.

Publication type:

Article

Design, selection and optimization of an anti-TRAIL-R2/anti-CD3 bispecific antibody able to educate T cells to recognize and destroy cancer cells.

Published in:

mAbs (1942-0862), 2018, v. 10, n. 7, p. 1084, doi. 10.1080/19420862.2018.1494105

By:

Satta, Alessandro;
Mezzanzanica, Delia;
Caroli, Francesco;
Frigerio, Barbara;
Di Nicola, Massimo;
Kontermann, Roland E.;
Iacovelli, Federico;
Desideri, Alessandro;
Anichini, Andrea;
Canevari, Silvana;
Gianni, Alessandro Massimo;
Figini, Mariangela

Publication type:

Article

Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV.

Published in:

mAbs (1942-0862), 2017, v. 9, n. 5, p. 831, doi. 10.1080/19420862.2017.1319023

By:

Schmitt, Lisa C.;
Rau, Alexander;
Seifert, Oliver;
Honer, Jonas;
Hutt, Meike;
Schmid, Simone;
Zantow, Jonas;
Hust, Michael;
Dübel, Stefan;
Olayioye, Monilola A.;
Kontermann, Roland E.

Publication type:

Article

The making of bispecific antibodies.

Published in:

mAbs (1942-0862), 2017, v. 9, n. 2, p. 182, doi. 10.1080/19420862.2016.1268307

By:

Brinkmann, Ulrich;
Kontermann, Roland E.

Publication type:

Article

An optimized antibody-single-chain TRAIL fusion protein for cancer therapy.

Published in:

mAbs (1942-0862), 2016, v. 8, n. 5, p. 879, doi. 10.1080/19420862.2016.1172163

By:

Siegemund, Martin;
Seifert, Oliver;
Zarani, Maria;
Džinić, Tamara;
De Leo, Valentino;
Göttsch, Doris;
Münkel, Sabine;
Hutt, Meike;
Pfizenmaier, Klaus;
Kontermann, Roland E.

Publication type:

Article

Pharmacokinetic properties of IgG and various Fc fusion proteins in mice.

Published in:

mAbs (1942-0862), 2016, v. 8, n. 1, p. 120, doi. 10.1080/19420862.2015.1113360

By:

Unverdorben, Felix;
Richter, Fabian;
Hutt, Meike;
Seifert, Oliver;
Malinge, Pauline;
Fischer, Nicolas;
Kontermann, Roland E.

Publication type:

Article

Generation of "LYmph Node Derived Antibody Libraries" (LYNDAL) for selecting fully human antibody fragments with therapeutic potential.

Published in:

mAbs (1942-0862), 2014, v. 6, n. 1, p. 1, doi. 10.4161/mabs.27236

By:

Diebolder, Philipp;
Keller, Armin;
Haase, Stephanie;
Schlegelmilch, Anne;
Kiefer, Jonathan D.;
Karimi, Tamana;
Weber, Tobias;
Moldenhauer, Gerhard;
Kehm, Roland;
Eis-Hübinger, Anna M.;
Jäger, Dirk;
Federspil, Philippe A.;
Herold-Mende, Christel;
Dyckhoff, Gerhard;
Kontermann, Roland E.;
Arndt, Michaela A. E.;
Krauss, Jürgen

Publication type:

Article

Dual targeting strategies with bispecific antibodies.

Published in:

mAbs (1942-0862), 2012, v. 4, n. 2, p. 182, doi. 10.4161/mabs.4.2.19000

By:

Kontermann, Roland E.

Publication type:

Article

Isolation from phage display libraries of lysine‐deficient human epidermal growth factor variants for directional conjugation as targeting ligands.

Published in:

Protein Engineering, 2003, v. 16, n. 12, p. 1107, doi. 10.1093/protein/gzg145

By:

Miriam Bach;
Peter Hölig;
Eva Schlosser;
Tina Völkel;
Andreas Graser;
Rolf Müller;
Roland E. Kontermann

Publication type:

Article

Optimized linker sequences for the expression of monomeric and dimeric bispecific single-chain diabodies.

Published in:

Protein Engineering, 2001, v. 14, n. 10, p. 815, doi. 10.1093/protein/14.10.815

By:

Völkel, Tina;
Korn, Tina;
Bach, Miriam;
Müller, Rolf;
Kontermann, Roland E.

Publication type:

Article

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury.

Published in:

CNS Neuroscience & Therapeutics, 2019, v. 25, n. 8, p. 884, doi. 10.1111/cns.13125

By:

Gerald, Marcus J.;
Bracchi‐Ricard, Valerie;
Ricard, Jerome;
Fischer, Roman;
Nandakumar, Bharadwaj;
Blumenthal, Gary H.;
Williams, Raushaun;
Kontermann, Roland E.;
Pfizenmaier, Klaus;
Moxon, Karen A.;
Bethea, John R.

Publication type:

Article

Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors.

Published in:

Nature Methods, 2010, v. 7, n. 11, p. 929, doi. 10.1038/nmeth.1514

By:

Anliker, Brigitte;
Abel, Tobias;
Kneissl, Sabrina;
Hlavaty, Juraj;
Caputi, Antonio;
Brynza, Julia;
Schneider, Irene C.;
Münch, Robert C.;
Petznek, Helga;
Kontermann, Roland E.;
Koehl, Ulrike;
Johnston, Ian C. D.;
Keinänen, Kari;
Müller, Ulrike C.;
Hohenadl, Christine;
Monyer, Hannah;
Cichutek, Klaus;
Buchholz, Christian J.

Publication type:

Article

Characterization of the Epitope Recognized by a Monoclonal Antibody Directed against the Largest Subunit of Drosophila RNA Polymerase II.

Published in:

Biological Chemistry, 1995, v. 376, n. 8, p. 473

By:

Kontermann, Roland E.;
Zhihong Liu;
Schulze, Rüdiger A.;
Sommer, Kai A.;
Queitsch, Iris;
Dübel, Stefan;
Kipriyanov, Sergey M.;
Breitling, Frank;
Bautz, Ekkehard K. R.

Publication type:

Article

Half-life extended biotherapeutics.

Published in:

Expert Opinion on Biological Therapy, 2016, v. 16, n. 7, p. 903, doi. 10.1517/14712598.2016.1165661

By:

Kontermann, Roland E.

Publication type:

Article