Works matching AU Komander, David

Results: 43

Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes.

Published in:

ChemBioChem, 2016, v. 17, n. 9, p. 816, doi. 10.1002/cbic.201600017

By:

Geurink, Paul P.;
van Tol, Bianca D. M.;
van Dalen, Duco;
Brundel, Paul J. G.;
Mevissen, Tycho E. T.;
Pruneda, Jonathan N.;
Elliott, Paul R.;
van Tilburg, Gabriëlle B. A.;
Komander, David;
Ovaa, Huib

Publication type:

Article

The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro.

Published in:

Life Science Alliance, 2025, v. 8, n. 6, p. 1, doi. 10.26508/lsa.202503243

By:

Wang, Xiangyi S.;
Jiou, Jenny;
Cerra, Anthony;
Cobbold, Simon A.;
Jochem, Marco;
Ka Hin Toby Mak;
Corcilius, Leo;
Silke, John;
Payne, Richard J.;
Goddard-Borger, Ethan D.;
Komander, David;
Lechtenberg, Bernhard C.

Publication type:

Article

Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii.

Published in:

Life Science Alliance, 2023, v. 6, n. 6, p. 1, doi. 10.26508/lsa.202201710

By:

Wilde, Mary-Louise;
Ruparel, Ushma;
Klemm, Theresa;
Lee, V. Vern;
Calleja, Dale J.;
Komander, David;
Tonkin, Christopher J.

Publication type:

Article

The nuts and bolts of AGC protein kinases.

Published in:

Nature Reviews Molecular Cell Biology, 2010, v. 11, n. 1, p. 9, doi. 10.1038/nrm2822

By:

Pearce, Laura R.;
Komander, David;
Alessi, Dario R.

Publication type:

Article

Breaking the chains: structure and function of the deubiquitinases.

Published in:

Nature Reviews Molecular Cell Biology, 2009, v. 10, n. 8, p. 550, doi. 10.1038/nrm2731

By:

Komander, David;
Clague, Michael J.;
Urbé, Sylvie

Publication type:

Article

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains.

Published in:

EMBO Reports, 2009, v. 10, n. 6, p. 662, doi. 10.1038/embor.2009.106

By:

Komander, David;
Reyes-Turcu, Francisca;
Licchesi, Julien D F;
Odenwaelder, Peter;
Wilkinson, Keith D;
Barford, David

Publication type:

Article

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains.

Published in:

EMBO Reports, 2009, v. 10, n. 5, p. 466, doi. 10.1038/embor.2009.55

By:

Komander, David;
Reyes-Turcu, Francisca;
Licchesi, Julien D F;
Odenwaelder, Peter;
Wilkinson, Keith D;
Barford, David

Publication type:

Article

Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37363-6

By:

van Tol, Bianca D. M.;
van Doodewaerd, Bjorn R.;
Lageveen-Kammeijer, Guinevere S. M.;
Jansen, Bas C.;
Talavera Ormeño, Cami M. P.;
Hekking, Paul J. M.;
Sapmaz, Aysegul;
Kim, Robbert Q.;
Moutsiopoulou, Angeliki;
Komander, David;
Wuhrer, Manfred;
van der Heden van Noort, Gerbrand J.;
Ovaa, Huib;
Geurink, Paul P.

Publication type:

Article

Reassessing kinetin's effect on PINK1 and mitophagy.

Published in:

Autophagy, 2024, v. 20, n. 11, p. 2596, doi. 10.1080/15548627.2024.2395144

By:

Gan, Zhong Yan;
Komander, David;
Callegari, Sylvie

Publication type:

Article

Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis.

Published in:

EMBO Journal, 2021, v. 40, n. 23, p. 1, doi. 10.15252/embj.2019103718

By:

Liu, Zikou;
Dagley, Laura F;
Shield‐Artin, Kristy;
Young, Samuel N;
Bankovacki, Aleksandra;
Wang, Xiangyi;
Tang, Michelle;
Howitt, Jason;
Stafford, Che A;
Nachbur, Ueli;
Fitzgibbon, Cheree;
Garnish, Sarah E;
Webb, Andrew I;
Komander, David;
Murphy, James M;
Hildebrand, Joanne M;
Silke, John

Publication type:

Article

Identification and characterization of diverse OTU deubiquitinases in bacteria.

Published in:

EMBO Journal, 2020, v. 39, n. 15, p. 1, doi. 10.15252/embj.2020105127

By:

Schubert, Alexander F;
Nguyen, Justine V;
Franklin, Tyler G;
Geurink, Paul P;
Roberts, Cameron G;
Sanderson, Daniel J;
Miller, Lauren N;
Ovaa, Huib;
Hofmann, Kay;
Pruneda, Jonathan N;
Komander, David

Publication type:

Article

An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1.

Published in:

EMBO Journal, 2017, v. 36, n. 24, p. 3555, doi. 10.15252/embj.201797876

By:

Gladkova, Christina;
Schubert, Alexander F;
Wagstaff, Jane L;
Pruneda, Jonathan N;
Freund, Stefan MV;
Komander, David

Publication type:

Article

Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy.

Published in:

EMBO Journal, 2016, v. 35, n. 16, p. 1779, doi. 10.15252/embj.201694491

By:

Thurston, Teresa LM;
Boyle, Keith B;
Allen, Mark;
Ravenhill, Benjamin J;
Karpiyevich, Maryia;
Bloor, Stuart;
Kaul, Annie;
Noad, Jessica;
Foeglein, Agnes;
Matthews, Sophie A;
Komander, David;
Bycroft, Mark;
Randow, Felix

Publication type:

Article

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.

Published in:

EMBO Journal, 2015, v. 34, n. 3, p. 307, doi. 10.15252/embj.201489847

By:

Wauer, Tobias;
Swatek, Kirby N;
Wagstaff, Jane L;
Gladkova, Christina;
Pruneda, Jonathan N;
Michel, Martin A;
Gersch, Malte;
Johnson, Christopher M;
Freund, Stefan MV;
Komander, David

Publication type:

Article

OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death.

Published in:

EMBO Molecular Medicine, 2019, v. 11, n. 3, p. N.PAG, doi. 10.15252/emmm.201809324

By:

Damgaard, Rune Busk;
Elliott, Paul R;
Swatek, Kirby N;
Maher, Eamonn R;
Stepensky, Polina;
Elpeleg, Orly;
Komander, David;
Berkun, Yackov

Publication type:

Article

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance.

Published in:

Molecular & Cellular Biology, 2008, v. 28, n. 10, p. 15, doi. 10.1128/MCB.02032-07

By:

Bayascas, Jose R.;
Wullschleger, Stephan;
Sakamoto, Kei;
García-Martínez, Juan M.;
Clacher, Carol;
Komander, David;
Van Aalten, Daan M. F.;
Boini, Krishna M.;
Lang, Florian;
Lipina, Christopher;
Logie, Lisa;
Sutherland, Calum;
Chudek, John A.;
Van Diepen, Janna A.;
Voshol, Peter J.;
Lucocq, John M.;
Alessi, Dario R.

Publication type:

Article

The tumour suppressor CYLD regulates the p53 DNA damage response.

Published in:

Nature Communications, 2016, v. 7, n. 8, p. 12508, doi. 10.1038/ncomms12508

By:

Fernández-Majada, Vanesa;
Welz, Patrick-Simon;
Ermolaeva, Maria A.;
Schell, Michael;
Adam, Alexander;
Dietlein, Felix;
Komander, David;
Büttner, Reinhard;
Thomas, Roman K.;
Schumacher, Björn;
Pasparakis, Manolis

Publication type:

Article

Regulation of A20 and other OTU deubiquitinases by reversible oxidation.

Published in:

Nature Communications, 2013, v. 4, n. 3, p. 1569, doi. 10.1038/ncomms2567

By:

Kulathu, Yogesh;
Garcia, Francisco J.;
Mevissen, Tycho E. T.;
Busch, Martin;
Arnaudo, Nadia;
Carroll, Kate S.;
Barford, David;
Komander, David

Publication type:

Article

An essential role for the ATG8 ortholog LC3C in antibacterial autophagy.

Published in:

Autophagy, 2013, v. 9, n. 5, p. 784, doi. 10.4161/auto.23698

By:

Von Muhlinen, Natalia;
Akutsu, Masato;
Ravenhill, Benjamin J.;
Foeglein, Ágnes;
Bloor, Stuart;
Rutherford, Trevor J.;
Freund, Stefan M. V.;
Komander, David;
Randow, Felix

Publication type:

Article

Structure of the human Parkin ligase domain in an autoinhibited state.

Published in:

EMBO Journal, 2013, v. 32, n. 15, p. 2099, doi. 10.1038/emboj.2013.125

By:

Wauer, Tobias;
Komander, David

Publication type:

Article

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure.

Published in:

EMBO Journal, 2008, v. 27, n. 23, p. 3175, doi. 10.1038/emboj.2008.226

By:

Komander, David;
Garg, Ritu;
Wan, Paul T. C.;
Ridley, Anne J.;
Barford, David

Publication type:

Article

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

Published in:

EMBO Journal, 2004, v. 23, n. 20, p. 3918, doi. 10.1038/sj.emboj.7600379

By:

Komander, David;
Fairservice, Alison;
Deak, Maria;
Kular, Gursant S;
Prescott, Alan R;
Peter Downes, C;
Safrany, Stephen T;
Alessi, Dario R;
M F van Aalten, Daan

Publication type:

Article

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.

Published in:

EMBO Journal, 2002, v. 21, n. 16, p. 4219, doi. 10.1093/emboj/cdf437

By:

Biondi, Ricardo M.;
Komander, David;
Thomas, Christine C.;
Lizcano, Jose M.;
Deak, Maria;
Alessi, Dario R.;
Aalten, Daan M.F.Van

Publication type:

Article

The JAMM in the proteasome.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 4, p. 346, doi. 10.1038/nsmb.2800

By:

Wauer, Tobias;
Komander, David

Publication type:

Article

Assembly, analysis and architecture of atypical ubiquitin chains.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 5, p. 555, doi. 10.1038/nsmb.2547

By:

Hospenthal, Manuela K;
Freund, Stefan M V;
Komander, David

Publication type:

Article

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 1, p. 62, doi. 10.1038/nsmb.2169

By:

Licchesi, Julien D F;
Mieszczanek, Juliusz;
Mevissen, Tycho E T;
Rutherford, Trevor J;
Akutsu, Masato;
Virdee, Satpal;
Oualid, Farid El;
Chin, Jason W;
Ovaa, Huib;
Bienz, Mariann;
Komander, David

Publication type:

Article

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 8, p. 939, doi. 10.1038/nsmb.1873

By:

Bremm, Anja;
Freund, Stefan M. V.;
Komander, David

Publication type:

Article

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 12, p. 1328, doi. 10.1038/nsmb.1731

By:

Kulathu, Yogesh;
Akutsu, Masato;
Bremm, Anja;
Hofmann, Kay;
Komander, David

Publication type:

Article

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

Published in:

Biochemical Journal, 2016, v. 473, n. 20, p. 3563, doi. 10.1042/BCJ20160387

By:

Teixeira, Felipe Roberti;
Randle, Suzanne J.;
Patel, Shachi P.;
Mevissen, Tycho E. T.;
Zenkeviciute, Grasilda;
Tie Koide;
Komander, David;
Laman, Heike

Publication type:

Article

Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest)

Published in:

Nature Protocols, 2015, v. 10, n. 2, p. 349, doi. 10.1038/nprot.2015.018

By:

Hospenthal, Manuela K;
Mevissen, Tycho E T;
Komander, David

Publication type:

Article

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Published in:

Nature, 2012, v. 492, n. 7428, p. 266, doi. 10.1038/nature11722

By:

Ye, Yu;
Blaser, Georg;
Horrocks, Mathew H.;
Ruedas-Rama, Maria J.;
Ibrahim, Shehu;
Zhukov, Alexander A.;
Orte, Angel;
Klenerman, David;
Jackson, Sophie E.;
Komander, David

Publication type:

Article

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase.

Published in:

Nature Chemical Biology, 2010, v. 6, n. 10, p. 750, doi. 10.1038/nchembio.426

By:

Virdee, Satpal;
Ye, Yu;
Nguyen, Duy P.;
Komander, David;
Chin, Jason W.

Publication type:

Article

Dissecting distinct proteolytic activities of FMDV L<sup>pro</sup> implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression.

Published in:

PLoS Pathogens, 2020, v. 16, n. 7, p. 1, doi. 10.1371/journal.ppat.1008702

By:

Visser, Linda J.;
Aloise, Chiara;
Swatek, Kirby N.;
Medina, Gisselle N.;
Olek, Karin Maria;
Rabouw, Huib H.;
de Groot, Raoul J.;
Langereis, Martijn Alexander;
de los Santos, Teresa;
Komander, David;
Skern, Tim;
van Kuppeveld, Frank J. M.

Publication type:

Article

Erratum: Mechanism of phospho-ubiquitin-induced PARKIN activation.

Published in:

2015

By:

Wauer, Tobias;
Simicek, Michal;
Schubert, Alexander;
Komander, David

Publication type:

Correction Notice

Mechanism of phospho-ubiquitin-induced PARKIN activation.

Published in:

Nature, 2015, v. 524, n. 7565, p. 370, doi. 10.1038/nature14879

By:

Wauer, Tobias;
Simicek, Michal;
Schubert, Alexander;
Komander, David

Publication type:

Article

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4.

Published in:

EMBO Reports, 2024, v. 25, n. 8, p. 3324, doi. 10.1038/s44319-024-00181-y

By:

Nguyen-Dien, Giang Thanh;
Townsend, Brendan;
Kulkarni, Prajakta Gosavi;
Kozul, Keri-Lyn;
Ooi, Soo Siang;
Eldershaw, Denaye N;
Weeratunga, Saroja;
Liu, Meihan;
Jones, Mathew JK;
Millard, S Sean;
Ng, Dominic CH;
Pagano, Michele;
Bonfim-Melo, Alexis;
Schneider, Tobias;
Komander, David;
Lazarou, Michael;
Collins, Brett M;
Pagan, Julia K

Publication type:

Article

Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteins.

Published in:

EMBO Reports, 2018, v. 19, n. 10, p. 1, doi. 10.15252/embr.201745680

By:

Morrow, Marie E.;
Morgan, Michael T.;
Clerici, Marcello;
Growkova, Katerina;
Yan, Ming;
Komander, David;
Sixma, Titia K.;
Simicek, Michal;
Wolberger, Cynthia

Publication type:

Article

Cezanne ( OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.

Published in:

EMBO Reports, 2014, v. 15, n. 12, p. 1268, doi. 10.15252/embr.201438850

By:

Bremm, Anja;
Moniz, Sonia;
Mader, Julia;
Rocha, Sonia;
Komander, David

Publication type:

Article

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.

Published in:

EMBO Reports, 2011, v. 12, n. 4, p. 350, doi. 10.1038/embor.2011.17

By:

Ye, Yu;
Akutsu, Masato;
Reyes-Turcu, Francisca;
Enchev, Radoslav I;
Wilkinson, Keith D;
Komander, David

Publication type:

Article

A further case of Dop-ing in bacterial pupylation.

Published in:

EMBO Reports, 2010, v. 11, n. 10, p. 722, doi. 10.1038/embor.2010.149

By:

Bremm, Anja;
Komander, David

Publication type:

Article

Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.

Published in:

Nature Reviews Molecular Cell Biology, 2012, v. 13, n. 8, p. 508, doi. 10.1038/nrm3394

By:

Kulathu, Yogesh;
Komander, David

Publication type:

Article

Regulation of the endosomal SNX27-retromer by OTULIN.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12309-z

By:

Stangl, Aurelia;
Elliott, Paul R.;
Pinto-Fernandez, Adan;
Bonham, Sarah;
Harrison, Luke;
Schaub, Annalisa;
Kutzner, Kerstin;
Keusekotten, Kirstin;
Pfluger, Paul T.;
El Oualid, Farid;
Kessler, Benedikt M.;
Komander, David;
Krappmann, Daniel

Publication type:

Article

Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN.

Published in:

FEBS Journal, 2016, v. 283, n. 1, p. 39, doi. 10.1111/febs.13547

By:

Elliott, Paul R.;
Komander, David

Publication type:

Article