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Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected.
- Published in:
- EMBO Molecular Medicine, 2020, v. 12, n. 12, p. 1, doi. 10.15252/emmm.202012921
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- Article
CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 9, p. 5819, doi. 10.1002/alz.13862
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- Article
Time‐encoded ASL reveals lower cerebral blood flow in the early AD continuum.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 8, p. 5183, doi. 10.1002/alz.14059
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- Article
KLOTHO KL‐VS heterozygosity is associated with diminished age‐related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 8, p. 5347, doi. 10.1002/alz.13912
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- Article
Post‐GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 7, p. 5044, doi. 10.1002/alz.13848
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- Article
Astrocyte biomarkers GFAP and YKL‐40 mediate early Alzheimer's disease progression.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 1, p. 483, doi. 10.1002/alz.13450
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- Article
Associations of physical activity with cerebrospinal fluid biomarkers of neurodegeneration, neuroinflammation, and Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.083058
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- Article
CSF markers YKL40, sTREM2, and a‐synuclein enhance the Alzheimer's disease A/T/N criteria to detect early changes in cognition.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082891
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- Article
Associations between NIH‐Toolbox Flanker test and the Picture Sequence Memory Test and multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082714
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The associations between glial biomarkers and cognitive changes in individuals at risk of Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082594
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- Article
Longitudinal change in CSF β‐amyloid<sub>1−42</sub> predicts PTSD symptomatology after the COVID‐19 lockdown in cognitively unimpaired older adults.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074613
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- Article
Reproductive span as a modifier of the association between AD biomarkers and cognitive decline in cognitively unimpaired women.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 22, p. 1, doi. 10.1002/alz.078662
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- Article
Sex‐dependent effects on the association between air pollution and longitudinal changes in CSF and plasma biomarkers of Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 22, p. 1, doi. 10.1002/alz.078184
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Association between blood pressure and Alzheimer's disease biomarkers in cognitively unimpaired adults.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 22, p. 1, doi. 10.1002/alz.076777
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- Article
Domain‐specific subtle cognitive decline associations with cerebrospinal fluid and plasma β‐amyloid and p‐tau Alzheimer's disease biomarkers in cognitively unimpaired individuals.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073008
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- Article
A comparison of word‐list and story recall tests for prediction of biomarker‐determined Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.070748
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- Article
Longitudinal trajectories of myelin loss in the context of Alzhiemer's disease biomarkers, glial activation, and APOE4.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080495
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- Article
Exploring biomarker profiles of the cognitively unimpaired individuals in early tau PET Braak stage.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077921
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- Article
Analysis of blood and cerebrospinal fluid flows in preclinical AD. Preliminary results from ALFA+ cohort.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079680
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Brain‐age prediction and its associations with glial and synaptic CSF markers.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078194
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CSF sTREM2 and YKL‐40 modify the balance between soluble and fibrillary β‐amyloid in non‐demented individuals.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078807
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Pathophysiological mechanisms of grey matter morphometry changes in preclinical Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074804
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- Article
CSF Aβ42/40 is associated with neurodegeneration independently of CSF p‐tau in the earliest AD continuum.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074606
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Two novel cerebrospinal fluid markers for vascular injury are associated with CSF markers of AD, neurodegeneration, and gliosis.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079948
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- Article
Cognitively Unimpaired Multiparous Women Have Higher CSF p‐tau181 Levels Which Have More Deleterious Effects on Neurodegeneration and Executive Function.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078157
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Gut microbiome moderates the association between metabolic syndrome and the cerebrospinal fluid concentration of YKL‐40 in a cognitively unimpaired cohort.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077952
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- Article
Association of waist‐to‐hip ratio with Alzheimer's disease and neuroinflammation biomarkers in cognitively unimpaired adults.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076415
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Metabolic changes in preclinical AD as detected by magnetic resonance spectroscopy.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078346
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Effect of neuroinflammation markers on the relation between A, T and N: sex‐specific resilience or vulnerability?
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078155
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Sleep changes during the COVID‐19 lockdown contribute to cerebrospinal fluid phosphorylated tau and neurofilament light increases independent of β‐amyloid.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077876
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Self‐reported COVID‐19 and biomarkers of Alzheimer's disease: interim analyses from an Alzheimer's disease risk‐enriched cohort.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077721
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- Article
The cerebrospinal fluid A‐T+ Alzheimer disease biomarker profile: prevalence and clinical relevance.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076814
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- Article
Effect of age, sex, cognitive status and Apolipoprotein E genotype on plasma biomarkers of amyloid pathology.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076587
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- Article
Klotho protein concentrations as a function of sex, APOE, family history or Alzheimer's disease biomarker status in an at‐risk cohort.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075750
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Preclinical Alzheimer's disease is associated with distinct gut microbial metagenomic profiles.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073847
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- Article
Different astrocyte phenotypes mediate the pathological cascade early in the Alzheimer's disease continuum.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074674
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- Article
Relationships between KLOTHO and APOE4‐associated β‐amyloid and tau alterations across AD continuum.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075730
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- Publication type:
- Article
Longitudinal trajectories of myelin loss in the context of Alzhiemer's disease biomarkers, glial activation, and APOE4.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.082011
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- Publication type:
- Article
CSF sTREM2 and YKL‐40 modify the balance between soluble and fibrillary β‐amyloid in non‐demented individuals.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081843
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- Article
Brain‐age prediction and its associations with glial and synaptic CSF markers.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081795
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- Article
Exploring biomarker profiles of the cognitively unimpaired individuals in early tau PET Braak stage.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081775
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- Publication type:
- Article
Pathophysiological mechanisms of grey matter morphometry changes in preclinical Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081662
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- Publication type:
- Article
CSF Aβ42/40 is associated with neurodegeneration independently of CSF p‐tau in the earliest AD continuum.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081652
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- Article
Relationships between KLOTHO and APOE4‐associated β‐amyloid and tau alterations across AD continuum.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075730
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- Article
Large‐scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 12, p. 5447, doi. 10.1002/alz.13130
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- Article
Neuropathology‐based APOE genetic risk score better quantifies Alzheimer's risk.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 8, p. 3406, doi. 10.1002/alz.12990
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Optimal combinations of CSF biomarkers for predicting cognitive decline and clinical conversion in cognitively unimpaired participants and mild cognitive impairment patients: A multi‐cohort study.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 7, p. 2943, doi. 10.1002/alz.12907
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- Article
Cerebrospinal fluid soluble TREM2 is associated with accelerated AD‐related longitudinal neurodegeneration in preclinical Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.068312
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Improving statistical modeling with a neuropathology‐based APOE genetic risk score.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.060701
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An accurate fully automated panel of plasma biomarkers for Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 4, p. 1204, doi. 10.1002/alz.12751
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- Article