Works by Koeppen, Hartmut

Results: 59

EM Optimized Cryostat Sections (EMOCS) for Wide Scale Ultrastructural Imaging of Tissue Morphology Combined with Antigen Detection by Immunohistochemistry.

Published in:

Microscopy & Microanalysis, 2024, v. 30, p. 1, doi. 10.1093/mam/ozae044.404

By:

Reichelt, Mike;
Baca, Miriam;
Chalouni, Cecile;
Sagolla, Meredith;
Koeppen, Hartmut

Publication type:

Article

Development of a Cryo-Pre-Embedding Immunogold Labeling Protocol for the Ultrastructural Localization of PDL1 in Human Tonsils.

Published in:

2023

By:

Baca, Miriam;
Chalouni, Cecile;
Koeppen, Hartmut;
Rangell, Linda;
Sagolla, Meredith;
Reichelt, Mike

Publication type:

Abstract

A Phase II Randomized Trial (GO27827) of First-Line FOLFOX Plus Bevacizumab with orWithout the MET Inhibitor Onartuzumab in Patients with Metastatic Colorectal Cancer.

Published in:

Oncologist, 2017, v. 22, n. 3, p. 264, doi. 10.1634/theoncologist.2016-0223

By:

Bendell, Johanna C.;
Hochster, Howard;
Hart, Lowell L.;
Firdaus, Irfan;
Mace, Joseph R.;
McFarlane, Joshua J.;
Kozloff, Mark;
Catenacci, Daniel;
Hsu, Jessie J.;
Hack, Stephen P.;
Shames, David S.;
Phan, See‐Chun;
Koeppen, Hartmut;
Cohn, Allen L.

Publication type:

Article

Association of programmed death ligand‐1 (PD‐L1) expression with treatment outcomes in patients with BRAF mutation‐positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib.

Published in:

Pigment Cell & Melanoma Research, 2018, v. 31, n. 4, p. 516, doi. 10.1111/pcmr.12670

By:

Wongchenko, Matthew J.;
Ribas, Antoni;
Dréno, Brigitte;
Ascierto, Paolo A.;
McArthur, Grant A.;
Gallo, Jorge D.;
Rooney, Isabelle A.;
Hsu, Jessie;
Koeppen, Hartmut;
Yan, Yibing;
Larkin, James

Publication type:

Article

Identification and immunotherapeutic targeting of antigens induced by chemotherapy.

Published in:

Nature Biotechnology, 2006, v. 24, n. 2, p. 205, doi. 10.1038/nbt1185

By:

Rubinfeld, Bonnee;
Upadhyay, Archana;
Clark, Suzanna L.;
Fong, Sharon E.;
Smith, Victoria;
Koeppen, Hartmut;
Ross, Sarajane;
Polakis, Paul

Publication type:

Article

NON-HODGKIN'S LYMPHOMA PRESENTING NINE YEARS AFTER ILEAL-POUCH ILEOANAL ANASTOMOSIS FOR ULCERATIVE COLITIS.

Published in:

American Journal of Gastroenterology (Springer Nature), 1998, v. 93, n. 9, p. 1589, doi. 10.1111/j.1572-0241.1998.00489.x

By:

Winter, Annette M.;
Koeppen, Hartmut;
Hanauer, Stephen B.

Publication type:

Article

The ubiquitin ligase COP1 is a critical negative regulator of p53.

Published in:

Nature, 2004, v. 429, n. 6987, p. 86, doi. 10.1038/nature02514

By:

Dornan, David;
Wertz, Ingrid;
Shimizu, Harumi;
Arnott, David;
Frantz, Gretchen D.;
Downd, Patrick;
O'Rourke, Karen;
Koeppen, Hartmut;
Dixit, Vishva M.

Publication type:

Article

Profiling Cancer Gene Mutations in Clinical Formalin-Fixed, Paraffin-Embedded Colorectal Tumor Specimens Using Targeted Next-Generation Sequencing.

Published in:

Oncologist, 2014, v. 19, n. 4, p. 336, doi. 10.1634/theoncologist.2013-0180

By:

Zhang, Liangxuan;
Chen, Liangjing;
Sah, Sachin;
Latham, Gary J.;
Patel, Rajesh;
Song, Qinghua;
Koeppen, Hartmut;
Tam, Rachel;
Schleifman, Erica;
Mashhedi, Haider;
Chalasani, Sreedevi;
Fu, Ling;
Sumiyoshi, Teiko;
Raja, Rajiv;
Forrest, William;
Hampton, Garret M.;
Lackner, Mark R.;
Hegde, Priti;
Jia, Shidong

Publication type:

Article

Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29655-0

By:

Savill, Kristin M. Zimmerman;
Lee, Brian B.;
Oeh, Jason;
Lin, Jie;
Lin, Eva;
Chung, Wei-Jen;
Young, Amy;
Chen, Wennie;
Miś, Monika;
Mesh, Kathryn;
Eastham, Jeffrey;
Gnad, Florian;
Jiang, Zhaoshi;
Stawiski, Eric W.;
Haley, Benjamin;
Daemen, Anneleen;
Wang, Xiaojing;
Koeppen, Hartmut;
Modrusan, Zora;
Martin, Scott E.

Publication type:

Article

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27597-7

By:

Le Thomas, Adrien;
Ferri, Elena;
Marsters, Scot;
Harnoss, Jonathan M.;
Lawrence, David A.;
Zuazo-Gaztelu, Iratxe;
Modrusan, Zora;
Chan, Sara;
Solon, Margaret;
Chalouni, Cécile;
Li, Weihan;
Koeppen, Hartmut;
Rudolph, Joachim;
Wang, Weiru;
Wu, Thomas D.;
Walter, Peter;
Ashkenazi, Avi

Publication type:

Article

High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate.

Published in:

British Journal of Haematology, 2008, v. 140, n. 1, p. 46, doi. 10.1111/j.1365-2141.2007.06883.x

By:

Ingle, Gladys S.;
Chan, Pamela;
Elliott, J. Michael;
Chang, Wesley S.;
Koeppen, Hartmut;
Stephan, Jean-Philippe;
Scales, Suzie J.

Publication type:

Article

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34562-5

By:

Cantley, Jennifer;
Ye, Xiaofen;
Rousseau, Emma;
Januario, Tom;
Hamman, Brian D.;
Rose, Christopher M.;
Cheung, Tommy K.;
Hinkle, Trent;
Soto, Leofal;
Quinn, Connor;
Harbin, Alicia;
Bortolon, Elizabeth;
Chen, Xin;
Haskell, Roy;
Lin, Eva;
Yu, Shang-Fan;
Del Rosario, Geoff;
Chan, Emily;
Dunlap, Debra;
Koeppen, Hartmut

Publication type:

Article

Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Published in:

2018

By:

Merchant, Mark;
Moffat, John;
Schaefer, Gabriele;
Chan, Jocelyn;
Wang, Xi;
Orr, Christine;
Cheng, Jason;
Hunsaker, Thomas;
Shao, Lily;
Wang, Stephanie J.;
Wagle, Marie-Claire;
Lin, Eva;
Haverty, Peter M.;
Shahidi-Latham, Sheerin;
Ngu, Hai;
Solon, Margaret;
Eastham-Anderson, Jeffrey;
Koeppen, Hartmut;
Huang, Shih-Min A.;
Schwarz, Jacob

Publication type:

Correction Notice

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Published in:

PLoS ONE, 2017, v. 12, n. 10, p. 1, doi. 10.1371/journal.pone.0185862

By:

Merchant, Mark;
Moffat, John;
Schaefer, Gabriele;
Chan, Jocelyn;
Wang, Xi;
Orr, Christine;
Cheng, Jason;
Hunsaker, Thomas;
Shao, Lily;
Wang, Stephanie J.;
Wagle, Marie-Claire;
Lin, Eva;
Haverty, Peter M.;
Shahidi-Latham, Sheerin;
Ngu, Hai;
Solon, Margaret;
Eastham-Anderson, Jeffrey;
Koeppen, Hartmut;
Huang, Shih-Min A.;
Schwarz, Jacob

Publication type:

Article

Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples.

Published in:

Breast Cancer Research & Treatment, 2014, v. 148, n. 2, p. 315, doi. 10.1007/s10549-014-3163-8

By:

Wilson, Timothy;
Xiao, Yuanyuan;
Spoerke, Jill;
Fridlyand, Jane;
Koeppen, Hartmut;
Fuentes, Eloisa;
Huw, Ling;
Abbas, Ilma;
Gower, Arjan;
Schleifman, Erica;
Desai, Rupal;
Fu, Ling;
Sumiyoshi, Teiko;
O'Shaughnessy, Joyce;
Hampton, Garret;
Lackner, Mark

Publication type:

Article

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 23, p. 3990, doi. 10.1128/MCB.00630-15

By:

Radu, Maria;
Lyle, Karen;
Hoeflich, Klaus P.;
Villamar-Cruz, Olga;
Koeppen, Hartmut;
Chernoff, Jonathan

Publication type:

Article

Chromosome 18 breakpoint in t(11;18)(q21;q21) translocation associated with MALT lymphoma is proximal to BCL2 and distal to DCC.

Published in:

Genes, Chromosomes & Cancer, 1999, v. 24, n. 2, p. 156, doi. 10.1002/(SICI)1098-2264(199902)24:2<156::AID-GCC9>3.0.CO;2-X

By:

Stoffel, Archontoula;
Rao, Pulivarthi H.;
Louie, Diane C.;
Krauter, Kenneth;
Liebowitz, David N.;
Koeppen, Hartmut;
Le Beau, Michelle M.;
Chaganti, R.S.K.

Publication type:

Article

Characterization of PD-L1 expression in Chinese non-small cell lung cancer patients with PTEN expression as a means for tissue quality screening.

Published in:

Cancer Immunology, Immunotherapy, 2018, v. 67, n. 3, p. 471, doi. 10.1007/s00262-017-2098-4

By:

Zhang, Xu-chao;
Cao, Xu;
Sun, Chun;
Xie, Zhi;
Guo, Jian-jun;
Yang, Jin-ji;
Yang, Xue-ning;
Dai, Hang-jun;
Li, Su-chun;
Xu, Xin-ran;
Zuo, Yun-xia;
Chen, Meng;
Koeppen, Hartmut;
He, Jing;
Kiermaier, Astrid;
Shames, David;
Cheng, Gang;
Wu, Yi-long

Publication type:

Article

Predicting benefit from anti-angiogenic agents in malignancy.

Published in:

Nature Reviews Cancer, 2006, v. 6, n. 8, p. 626, doi. 10.1038/nrc1946

By:

Jubb, Adrian M.;
Oates, Adam J.;
Holden, Scott;
Koeppen, Hartmut

Publication type:

Article

SUV420H2 is an epigenetic regulator of epithelial/ mesenchymal states in pancreatic cancer.

Published in:

Journal of Cell Biology, 2018, v. 217, n. 2, p. 763, doi. 10.1083/jcb.201705031

By:

Viotti, Manuel;
Wilson, Catherine;
Mccleland, Mark;
Koeppen, Hartmut;
Haley, Benjamin;
Jhunjhunwala, Suchit;
Klijn, Christiaan;
Modrusan, Zora;
Arnott, David;
Classon, Marie;
Stephan, Jean-Philippe;
Mellman, Ira

Publication type:

Article

Comparison of SP142 and 22C3 Immunohistochemistry PD-L1 Assays for Clinical Efficacy of Atezolizumab in Non–Small Cell Lung Cancer: Results From the Randomized OAK Trial.

Published in:

Clinical Lung Cancer, 2022, v. 23, n. 1, p. 21, doi. 10.1016/j.cllc.2021.05.007

By:

Gadgeel, Shirish;
Hirsch, Fred R.;
Kerr, Keith;
Barlesi, Fabrice;
Park, Keunchil;
Rittmeyer, Achim;
Zou, Wei;
Bhatia, Namrata;
Koeppen, Hartmut;
Paul, Sarah M.;
Shames, David;
Yi, Jing;
Matheny, Christina;
Ballinger, Marcus;
McCleland, Mark;
Gandara, David R.

Publication type:

Article

Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia.

Published in:

International Immunology, 2006, v. 18, n. 9, p. 1363, doi. 10.1093/intimm/dxl069

By:

Andrew G. Polson;
Bing Zheng;
Kristi Elkins;
Wesley Chang;
Changchun Du;
Patrick Dowd;
Lulu Yen;
Christine Tan;
Jo-Anne Hongo;
Hartmut Koeppen;
Allen Ebens

Publication type:

Article

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice.

Published in:

Nature Communications, 2017, v. 8, n. 2, p. 14572, doi. 10.1038/ncomms14572

By:

Lau, Janet;
Cheung, Jeanne;
Navarro, Armando;
Lianoglou, Steve;
Haley, Benjamin;
Totpal, Klara;
Sanders, Laura;
Koeppen, Hartmut;
Caplazi, Patrick;
McBride, Jacqueline;
Chiu, Henry;
Hong, Rebecca;
Grogan, Jane;
Javinal, Vincent;
Yauch, Robert;
Irving, Bryan;
Belvin, Marcia;
Mellman, Ira;
Kim, Jeong M.;
Schmidt, Maike

Publication type:

Article

High cell-surface density of HER2 deforms cell membranes.

Published in:

Nature Communications, 2016, v. 7, n. 9, p. 12742, doi. 10.1038/ncomms12742

By:

Chung, Inhee;
Reichelt, Mike;
Shao, Lily;
Akita, Robert W.;
Koeppen, Hartmut;
Rangell, Linda;
Schaefer, Gabriele;
Mellman, Ira;
Sliwkowski, Mark X.

Publication type:

Article

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma.

Published in:

Nature Communications, 2016, v. 7, n. 8, p. 12624, doi. 10.1038/ncomms12624

By:

Wallin, Jeffrey J.;
Bendell, Johanna C.;
Funke, Roel;
Sznol, Mario;
Korski, Konstanty;
Jones, Suzanne;
Hernandez, Genevive;
Mier, James;
He, Xian;
Hodi, F. Stephen;
Denker, Mitchell;
Leveque, Vincent;
Cañamero, Marta;
Babitski, Galina;
Koeppen, Hartmut;
Ziai, James;
Sharma, Neeraj;
Gaire, Fabien;
Chen, Daniel S.;
Waterkamp, Daniel

Publication type:

Article

A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study).

Published in:

2016

By:

Makker, Vicky;
Recio, Fernando O.;
Ma, Ling;
Matulonis, Ursula A.;
Lauchle, Jennifer O.;
Parmar, Hema;
Gilbert, Houston N.;
Ware, Joseph A.;
Zhu, Rui;
Lu, Shan;
Huw, Ling-Yuh;
Wang, Yulei;
Koeppen, Hartmut;
Spoerke, Jill M.;
Lackner, Mark R.;
Aghajanian, Carol A.

Publication type:

journal article

Impact of MET expression on outcome in BRAF<sup>V600E/K</sup> advanced melanoma.

Published in:

Histopathology, 2013, v. 63, n. 3, p. 351, doi. 10.1111/his.12169

By:

Jubb, Adrian M;
Ribas, Antoni;
Sosman, Jeffrey A;
McArthur, Grant A;
Yan, Yibing;
Rost, Sandra;
Zhao, Sherry;
Koeppen, Hartmut

Publication type:

Article

Neuropilin-2 expression in cancer.

Published in:

Histopathology, 2012, v. 61, n. 3, p. 340, doi. 10.1111/j.1365-2559.2012.04224.x

By:

Jubb, Adrian M;
Sa, Susan M;
Ratti, Navneet;
Strickland, Laura A;
Schmidt, Maike;
Callahan, Christopher A;
Koeppen, Hartmut

Publication type:

Article

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19408-2

By:

Desbois, Mélanie;
Udyavar, Akshata R.;
Ryner, Lisa;
Kozlowski, Cleopatra;
Guan, Yinghui;
Dürrbaum, Milena;
Lu, Shan;
Fortin, Jean-Philippe;
Koeppen, Hartmut;
Ziai, James;
Chang, Ching-Wei;
Keerthivasan, Shilpa;
Plante, Marie;
Bourgon, Richard;
Bais, Carlos;
Hegde, Priti;
Daemen, Anneleen;
Turley, Shannon;
Wang, Yulei

Publication type:

Article

MET Gene Copy Number Alterations and Expression of MET and Hepatocyte Growth Factor Are Potential Biomarkers in Angiosarcomas and Undifferentiated Pleomorphic Sarcomas.

Published in:

PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0120079

By:

Schmitz, Katja;
Koeppen, Hartmut;
Binot, Elke;
Fassunke, Jana;
Künstlinger, Helen;
Ihle, Michaela A.;
Heydt, Carina;
Wardelmann, Eva;
Büttner, Reinhard;
Merkelbach-Bruse, Sabine;
Rüschoff, Josef;
Schildhaus, Hans-Ulrich

Publication type:

Article

Targeted Biomarker Profiling of Matched Primary and Metastatic Estrogen Receptor Positive Breast Cancers.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0088401

By:

Schleifman, Erica B.;
Desai, Rupal;
Spoerke, Jill M.;
Xiao, Yuanyuan;
Wong, Cheryl;
Abbas, Ilma;
O’Brien, Carol;
Patel, Rajesh;
Sumiyoshi, Teiko;
Fu, Ling;
Tam, Rachel N.;
Koeppen, Hartmut;
Wilson, Timothy R.;
Raja, Rajiv;
Hampton, Garret M.;
Lackner, Mark R.

Publication type:

Article

TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018608

By:

Kui Lin;
Taylor Jr., James R.;
Wu, Thomas D.;
Gutierrez, Johnny;
Elliott, J. Michael;
Vernes, Jean-Michel;
Koeppen, Hartmut;
Phillips, Heidi S.;
de Sauvage, Frederic J.;
Y. Gloria Meng

Publication type:

Article

Genetically Engineered Vaccines Comparison of Active versus Passive Immunotherapy against Solid Tumorsa.

Published in:

Annals of the New York Academy of Sciences, 1993, v. 690, n. 1, p. 244, doi. 10.1111/j.1749-6632.1993.tb44013.x

By:

KOEPPEN, HARTMUT;
SINGH, SUNANDA;
SCHREIBER, HANS

Publication type:

Article

Quantification of tumor tissue populations by multispectral analysis.

Published in:

Magnetic Resonance in Medicine, 2004, v. 51, n. 3, p. 542, doi. 10.1002/mrm.10731

By:

Carano, Richard A.D.;
Ross, Adrienne L.;
Ross, Jed;
Williams, Simon P.;
Koeppen, Hartmut;
Schwall, Ralph H.;
Van Bruggen, Nicholas

Publication type:

Article

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

Published in:

Nature, 2012, v. 487, n. 7408, p. 505, doi. 10.1038/nature11249

By:

Wilson, Timothy R.;
Fridlyand, Jane;
Yan, Yibing;
Penuel, Elicia;
Burton, Luciana;
Chan, Emily;
Peng, Jing;
Lin, Eva;
Wang, Yulei;
Sosman, Jeff;
Ribas, Antoni;
Li, Jiang;
Moffat, John;
Sutherlin, Daniel P.;
Koeppen, Hartmut;
Merchant, Mark;
Neve, Richard;
Settleman, Jeff

Publication type:

Article

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Published in:

Nature, 2010, v. 464, n. 7287, p. 431, doi. 10.1038/nature08833

By:

Hatzivassiliou, Georgia;
Song, Kyung;
Yen, Ivana;
Brandhuber, Barbara J.;
Anderson, Daniel J.;
Alvarado, Ryan;
Ludlam, Mary J. C.;
Stokoe, David;
Gloor, Susan L.;
Vigers, Guy;
Morales, Tony;
Aliagas, Ignacio;
Liu, Bonnie;
Sideris, Steve;
Hoeflich, Klaus P.;
Jaiswal, Bijay S.;
Seshagiri, Somasekar;
Koeppen, Hartmut;
Belvin, Marcia;
Friedman, Lori S.

Publication type:

Article

P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma.

Published in:

JNCI: Journal of the National Cancer Institute, 2013, v. 105, n. 9, p. 606, doi. 10.1093/jnci/djt054

By:

Ong, Christy C.;
Jubb, Adrian M.;
Jakubiak, Diana;
Zhou, Wei;
Rudolph, Joachim;
Haverty, Peter M.;
Kowanetz, Marcin;
Yan, Yibing;
Tremayne, Jarrod;
Lisle, Richard;
Harris, Adrian L.;
Friedman, Lori S.;
Belvin, Marcia;
Middleton, Mark R.;
Blackwood, Elizabeth M.;
Koeppen, Hartmut;
Hoeflich, Klaus P.

Publication type:

Article

Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60457-2

By:

Lehrich, Brandon M.;
Delgado, Evan R.;
Yasaka, Tyler M.;
Liu, Silvia;
Cao, Catherine;
Liu, Yuqing;
Taheri, Mohammad N.;
Guan, Xiangnan;
Koeppen, Hartmut;
Singh, Sucha;
Meadows, Vik;
Liu, Jia-Jun;
Singh-Varma, Anya;
Krutsenko, Yekaterina;
Poddar, Minakshi;
Hitchens, T. Kevin;
Foley, Lesley M.;
Liang, Binyong;
Rialdi, Alex;
Rai, Ravi P.

Publication type:

Article

Clusterin expression correlates with stage and presence of large cells in mycosis fungoides.

Published in:

American Journal of Clinical Pathology, 2009, v. 131, n. 4, p. 511, doi. 10.1309/AJCPH43ZDVLSOSNB

By:

Pranil Chandra;
Jose A Plaza;
Zhuang Zuo;
A Hafeez Diwan;
Hartmut Koeppen;
Madeleine Duvic;
L Jeffrey Medeiros;
Victor G Prieto

Publication type:

Article

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.

Published in:

Nature, 2014, v. 515, n. 7528, p. 563, doi. 10.1038/nature14011

By:

Herbst, Roy S.;
Gettinger, Scott N.;
Horn, Leora;
Lawrence, Donald P.;
Hodi, F. Stephen;
Soria, Jean-Charles;
Kowanetz, Marcin;
Fine, Gregg D.;
Rost, Sandra;
Leabman, Maya;
Xiao, Yuanyuan;
Mokatrin, Ahmad;
Koeppen, Hartmut;
Hegde, Priti S.;
Mellman, Ira;
Chen, Daniel S.;
Hamid, Omid;
Gordon, Michael S.;
Sosman, Jeffery A.;
McDermott, David F.

Publication type:

Article

Smad3‐mediated recruitment of the methyltransferase SETDB1/ESET controls <italic>Snail1</italic> expression and epithelial–mesenchymal transition.

Published in:

EMBO Reports, 2018, v. 19, n. 1, p. 135, doi. 10.15252/embr.201744250

By:

Du, Dan;
Katsuno, Yoko;
Meyer, Dominique;
Budi, Erine H.;
Chen, Si‐Han;
Koeppen, Hartmut;
Wang, Hongjun;
Akhurst, Rosemary J.;
Derynck, Rik

Publication type:

Article

Characterization of Tumor-immune Microenvironment by High-throughput Image Analysis of CD8 Immunohistochemistry Combined With Modified Masson's Trichrome.

Published in:

Journal of Histochemistry & Cytochemistry, 2021, v. 69, n. 9, p. 611, doi. 10.1369/00221554211034935

By:

Havnar, Charles;
Lau, Shari;
Hung, Jeffrey;
Eastham-Anderson, Jeff;
Espiritu, Carmina;
Rangell, Linda;
Koeppen, Hartmut;
Ziai, James;
Foreman, Oded

Publication type:

Article

Tumors with reduced expression of a cytotoxic T lymphocyte recognized antigen lack immunogenicity but retain sensitivity to lysis by cytotoxic T lymphocytes.

Published in:

European Journal of Immunology, 1993, v. 23, n. 11, p. 2770, doi. 10.1002/eji.1830231108

By:

Koeppen, Hartmut;
Acena, Maria;
Drolet, Aimee;
Rowley, Donald A.;
Schreiber, Hans

Publication type:

Article

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor.

Published in:

mAbs (1942-0862), 2016, v. 8, n. 3, p. 593, doi. 10.1080/19420862.2015.1136043

By:

Deng, Rong;
Bumbaca, Daniela;
Pastuskovas, Cinthia V.;
Boswell, C. Andrew;
West, David;
Cowan, Kyra J.;
Chiu, Henry;
McBride, Jacqueline;
Johnson, Clarissa;
Xin, Yan;
Koeppen, Hartmut;
Leabman, Maya;
Iyer, Suhasini

Publication type:

Article

Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.

Published in:

Nature Biotechnology, 2022, v. 40, n. 5, p. 769, doi. 10.1038/s41587-021-01126-9

By:

Davies, Christopher W.;
Oh, Angela J.;
Mroue, Rana;
Steffek, Micah;
Bruning, John M.;
Xiao, Yang;
Feng, Siyu;
Jayakar, Sangeeta;
Chan, Emily;
Arumugam, Vidhyalakshmi;
Uribe, Sean Carlo;
Drummond, Jake;
Frommlet, Alexandra;
Lu, Cheng;
Franke, Yvonne;
Merchant, Mark;
Koeppen, Hartmut;
Quinn, John G.;
Malhotra, Sushant;
Do, Steve

Publication type:

Article

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models.

Published in:

Nature Biotechnology, 2010, v. 28, n. 6, p. 585, doi. 10.1038/nbt.1640

By:

Singh, Mallika;
Lima, Anthony;
Molina, Rafael;
Hamilton, Patricia;
Clermont, Anne C.;
Devasthali, Vidusha;
Thompson, Jennifer D.;
Cheng, Jason H.;
Reslan, Hani Bou;
Ho, Calvin C. K.;
Cao, Timothy C.;
Lee, Chingwei V.;
Nannini, Michelle A.;
Fuh, Germaine;
Carano, Richard A. D.;
Koeppen, Hartmut;
Yu, Ron X.;
Forrest, William F.;
Plowman, Gregory D.;
Johnson, Leisa

Publication type:

Article

Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation.

Published in:

2009

By:

Chen W;
Konoplev S;
Medeiros LJ;
Koeppen H;
Leventaki V;
Vadhan-Raj S;
Jones D;
Kantarjian HM;
Falini B;
Bueso-Ramos CE;
Chen, Weina;
Konoplev, Sergej;
Medeiros, L Jeffrey;
Koeppen, Hartmut;
Leventaki, Vasiliki;
Vadhan-Raj, Saroj;
Jones, Dan;
Kantarjian, Hagop M;
Falini, Brunangelo;
Bueso-Ramos, Carlos E

Publication type:

journal article

Cuplike Nuclei (Prominent Nuclear Invaginations) in Acute Myeloid Leukemia Are Highly Associated With FLT3 Internal Tandem Duplication and NPMT1 Mutation.

Published in:

Cancer (0008543X), 2009, v. 115, n. 23, p. 5481, doi. 10.1002/cncr.24610

By:

Weina Chen;
Konoplev, Sergei;
Medeiros, L. Jeffrey;
Koeppen, Hartmut;
Leventaki, Vasiliki;
Vadhan-Rai, Saroi;
Jones, Dan;
Kantarjian, Hagop M.;
Falini, Brunangelo;
Bueso-Ramos, Carlos E.

Publication type:

Article

Cytoplasmic Localization of Nucleophosmin in Bone Marrow Blasts of Acute Myeloid Leukemia Patients Is Not Completely Concordant With NPM1 Mutation and Is Not Predictive of Prognosis.

Published in:

Cancer (0008543X), 2009, v. 115, n. 20, p. 4737, doi. 10.1002/cncr.24543

By:

Konoplev, Sergei;
Xuelin Huang;
Drabkin, Harry A.;
Koeppen, Hartmut;
Jones, Dan;
Kantarjian, Hagop M.;
Garcia-Manero, Guillermo;
Weina Chen;
Medeiros, L. Jeffrey;
Bueso-Pamos, Carlos E.

Publication type:

Article

Automated tumor immunophenotyping predicts clinical benefit from anti‐PD‐L1 immunotherapy.

Published in:

Journal of Pathology, 2024, v. 263, n. 2, p. 190, doi. 10.1002/path.6274

By:

Li, Xiao;
Eastham, Jeffrey;
Giltnane, Jennifer M;
Zou, Wei;
Zijlstra, Andries;
Tabatsky, Evgeniy;
Banchereau, Romain;
Chang, Ching‐Wei;
Nabet, Barzin Y;
Patil, Namrata S;
Molinero, Luciana;
Chui, Steve;
Harryman, Maureen;
Lau, Shari;
Rangell, Linda;
Waumans, Yannick;
Kockx, Mark;
Orlova, Darya;
Koeppen, Hartmut

Publication type:

Article