Works by Knowles, Joshua W.

Results: 53
    1

    Finding missed cases of familial hypercholesterolemia in health systems using machine learning.

    Published in:
    NPJ Digital Medicine, 2019, v. 2, p. N.PAG, doi. 10.1038/s41746-019-0101-5
    By:
    • Banda, Juan M.;
    • Sarraju, Ashish;
    • Abbasi, Fahim;
    • Parizo, Justin;
    • Pariani, Mitchel;
    • Ison, Hannah;
    • Briskin, Elinor;
    • Wand, Hannah;
    • Dubois, Sebastien;
    • Jung, Kenneth;
    • Myers, Seth A.;
    • Rader, Daniel J.;
    • Leader, Joseph B.;
    • Murray, Michael F.;
    • Myers, Kelly D.;
    • Wilemon, Katherine;
    • Shah, Nigam H.;
    • Knowles, Joshua W.
    Publication type:
    Article
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    X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49764-2
    By:
    • Zhang, Peixiang;
    • Munier, Joseph J.;
    • Wiese, Carrie B.;
    • Vergnes, Laurent;
    • Link, Jenny C.;
    • Abbasi, Fahim;
    • Ronquillo, Emilio;
    • Scheker, Katherine;
    • Muñoz, Antonio;
    • Kuang, Yu-Lin;
    • Theusch, Elizabeth;
    • Lu, Meng;
    • Sanchez, Gabriela;
    • Oni-Orisan, Akinyemi;
    • Iribarren, Carlos;
    • McPhaul, Michael J.;
    • Nomura, Daniel K.;
    • Knowles, Joshua W.;
    • Krauss, Ronald M.;
    • Medina, Marisa W.
    Publication type:
    Article
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    Hymecromone Promotes Longevity and Insulin Sensitivity in Mice.

    Published in:
    Cells (2073-4409), 2024, v. 13, n. 20, p. 1727, doi. 10.3390/cells13201727
    By:
    • Nagy, Nadine;
    • Czepiel, Kathryn S.;
    • Kaber, Gernot;
    • Stefanovski, Darko;
    • Hargil, Aviv;
    • Pennetzdorfer, Nina;
    • Targ, Robert;
    • Reghupaty, Saranya C.;
    • Wight, Thomas N.;
    • Vernon, Robert B.;
    • Hull-Meichle, Rebecca L.;
    • Marshall, Payton;
    • Medina, Carlos O.;
    • Martinez, Hunter;
    • Kalinowski, Anissa;
    • Paladini, Rudolph D.;
    • Garantziotis, Stavros;
    • Knowles, Joshua W.;
    • Bollyky, Paul L.
    Publication type:
    Article
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    Genome‐wide scan for circulating vascular adhesion protein‐1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis.

    Published in:
    Journal of Diabetes Investigation, 2018, v. 9, n. 5, p. 1067, doi. 10.1111/jdi.12805
    By:
    • Chang, Yi‐cheng;
    • Hee, Siow‐wey;
    • Lee, Wei‐jei;
    • Li, Hung‐yuan;
    • Chang, Tien‐jyun;
    • Lin, Ming‐wei;
    • Hung, Yi‐jen;
    • Lee, I‐te;
    • Hung, Kuan‐yi;
    • Assimes, Themistocles;
    • Knowles, Joshua W.;
    • Nong, Jiun‐yi;
    • Lee, Po‐chu;
    • Chiu, Yen‐feng;
    • Chuang, Lee‐ming
    Publication type:
    Article
    8

    Genome-wide meta-analyses identify multiple loci associated with smoking behavior.

    Published in:
    Nature Genetics, 2010, v. 42, n. 5, p. 441, doi. 10.1038/ng.571
    By:
    • Furberg, Helena;
    • YunJung Kim;
    • Dackor, Jennifer;
    • Boerwinkle, Eric;
    • Franceschini, Nora;
    • Ardissino, Diego;
    • Bernardinelli, Luisa;
    • Mannucci, Pier M.;
    • Mauri, Francesco;
    • Merlini, Piera A.;
    • Absher, Devin;
    • Assimes, Themistocles L.;
    • Fortmann, Stephen P.;
    • Iribarren, Carlos;
    • Knowles, Joshua W.;
    • Quertermous, Thomas;
    • Ferrucci, Luigi;
    • Tanaka, Toshiko;
    • Bis, Joshua C.;
    • Furberg, Curt D.
    Publication type:
    Article
    9

    Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence.

    Published in:
    PLoS Genetics, 2011, v. 7, n. 9, p. 1, doi. 10.1371/journal.pgen.1002280
    By:
    • Dewey, Frederick E.;
    • Chen, Rong;
    • Cordero, Sergio P.;
    • Ormond, Kelly E.;
    • Caleshu, Colleen;
    • Karczewski, Konrad J.;
    • Whirl-Carrillo, Michelle;
    • Wheeler, Matthew T.;
    • Dudley, Joel T.;
    • Byrnes, Jake K.;
    • Cornejo, Omar E.;
    • Knowles, Joshua W.;
    • Woon, Mark;
    • Sangkuhl, Katrin;
    • Li, Gong;
    • Thorn, Caroline F.;
    • Hebert, Joan M.;
    • Capriotti, Emidio;
    • David, Sean P.;
    • Pavlovic, Aleksandra
    Publication type:
    Article
    10

    Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.

    Published in:
    2016
    By:
    • Knowles, Joshua W;
    • Xie, Weijia;
    • Zhang, Zhongyang;
    • Chennamsetty, Indumathi;
    • Assimes, Themistocles L;
    • Paananen, Jussi;
    • Hansson, Ola;
    • Pankow, James;
    • Goodarzi, Mark O;
    • Carcamo-Orive, Ivan;
    • Morris, Andrew P;
    • Chen, Yii-Der I;
    • Mäkinen, Ville-Petteri;
    • Ganna, Andrea;
    • Mahajan, Anubha;
    • Guo, Xiuqing;
    • Abbasi, Fahim;
    • Greenawalt, Danielle M;
    • Lum, Pek;
    • Molony, Cliona
    Publication type:
    corrected article
    11

    Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.

    Published in:
    Journal of Clinical Investigation, 2015, v. 125, n. 4, p. 1739, doi. 10.1172/JCI74692
    By:
    • Knowles, Joshua W.;
    • Weijia Xie;
    • Zhongyang Zhang;
    • Chennemsetty, Indumathi;
    • Assimes, Themistocles L.;
    • Paananen, Jussi;
    • Hansson, Ola;
    • Pankow, James;
    • Goodarzi, Mark O.;
    • Carcamo-Orive, Ivan;
    • Morris, Andrew P.;
    • Chen, Yii-Der I.;
    • Mäkinen, Ville-Petteri;
    • Ganna, Andrea;
    • Mahajan, Anubha;
    • Xiuqing Guo;
    • Abbasi, Fahim;
    • Greenawalt, Danielle M.;
    • Pek Lum;
    • Molony, Cliona
    Publication type:
    Article
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    Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study.

    Published in:
    Human Molecular Genetics, 2008, v. 17, n. 15, p. 2320, doi. 10.1093/hmg/ddn132
    By:
    • Assimes, Themistocles L.;
    • Knowles, Joshua W.;
    • Basu, Analabha;
    • Iribarren, Carlos;
    • Southwick, Audrey;
    • Tang, Hua;
    • Absher, Devin;
    • Li, Jun;
    • Fair, Joan M.;
    • Rubin, Geoffrey D.;
    • Sidney, Stephen;
    • Fortmann, Stephen P.;
    • Go, Alan S.;
    • Hlatky, Mark A.;
    • Myers, Richard M.;
    • Risch, Neil;
    • Quertermous, Thomas
    Publication type:
    Article
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    Plasma proteomic signatures of a direct measure of insulin sensitivity in two population cohorts.

    Published in:
    Diabetologia, 2023, v. 66, n. 9, p. 1643, doi. 10.1007/s00125-023-05946-z
    By:
    • Zanetti, Daniela;
    • Stell, Laurel;
    • Gustafsson, Stefan;
    • Abbasi, Fahim;
    • Tsao, Philip S.;
    • Knowles, Joshua W.;
    • RISC Investigators;
    • Ferrannini, Ele;
    • Kozakova, Michaela;
    • Gastaldelli, Amalia;
    • Coppack, Simon;
    • Balkau, Beverley;
    • Dekker, Jacqueline;
    • Walker, Mark;
    • Mari, Andrea;
    • Tura, Andrea;
    • Laville, Martine;
    • Beck, Henning;
    • Nolan, John;
    • Bolli, Geremia
    Publication type:
    Article
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    Genetic Evidence for a Normal-Weight "Metabolically Obese" Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes.

    Published in:
    Diabetes, 2014, v. 63, n. 12, p. 4369, doi. 10.2337/db14-0318
    By:
    • Yaghootkar, Hanieh;
    • Scott, Robert A.;
    • White, Charles C.;
    • Weihua Zhang;
    • Speliotes, Elizabeth;
    • Munroe, Patricia B.;
    • Ehret, Georg B.;
    • Bis, Joshua C.;
    • Fox, Caroline S.;
    • Walker, Mark;
    • Borecki, Ingrid B.;
    • Knowles, Joshua W.;
    • Yerges-Armstrong, Laura;
    • Ohlsson, Claes;
    • Perry, John R. B.;
    • Chambers, John C.;
    • Kooner, Jaspal S.;
    • Franceschini, Nora;
    • Langenberg, Claudia;
    • Hivert, Marie-France
    Publication type:
    Article
    33

    Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity.

    Published in:
    Diabetes, 2014, v. 63, n. 6, p. 2158, doi. 10.2337/db13-0949
    By:
    • Dimas, Antigone S.;
    • Lagou, Vasiliki;
    • Barker, Adam;
    • Knowles, Joshua W.;
    • Mägi, Reedik;
    • Hivert, Marie-France;
    • Benazzo, Andrea;
    • Rybin, Denis;
    • Jackson, Anne U.;
    • Stringham, Heather M.;
    • Ci Song;
    • Fischer-Rosinsky, Antje;
    • Boesgaard, Trine Welløv;
    • Grarup, Niels;
    • Abbasi, Fahim A.;
    • Assimes, Themistocles L.;
    • Ke Hao;
    • Xia Yang;
    • Lecoeur, Cécile;
    • Barroso, Inês
    Publication type:
    Article
    34

    Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes.

    Published in:
    Diabetes, 2013, v. 62, n. 6, p. 2141, doi. 10.2337/db12-0876
    By:
    • Weijia Xie;
    • Wood, Andrew R.;
    • Lyssenko, Valeriya;
    • Weedon, Michael N.;
    • Knowles, Joshua W.;
    • Alkayyali, Sami;
    • Assimes, Themistocles L.;
    • Quertermous, Thomas;
    • Abbasi, Fahim;
    • Paananen, Jussi;
    • Häring, Hans;
    • Hansen, Torben;
    • Pedersen, Oluf;
    • Smith, Ulf;
    • Laakso, Markku;
    • Dekker, Jacqueline M.;
    • Nolan, John J.;
    • Groop, Leif;
    • Ferrannini, Ele;
    • Adam, Klaus-Peter
    Publication type:
    Article
    35

    A Bivariate Genome-Wide Approach to Metabolic Syndrome.

    Published in:
    Diabetes, 2011, v. 60, n. 4, p. 1329, doi. 10.2337/db10-1011
    By:
    • Kraja, Aldi T.;
    • Vaidya, Dhananjay;
    • Pankow, James S.;
    • Goodarzi, Mark O.;
    • Assimes, Themistocles L.;
    • Kullo, Iftikhar J.;
    • Sovio, Ulla;
    • Mathias, Rasika A.;
    • Sun, Yan V.;
    • Franceschini, Nora;
    • Absher, Devin;
    • Guo Li;
    • Qunyuan Zhang;
    • Feitosa, Mary F.;
    • Glazer, Nicole L.;
    • Haritunians, Talin;
    • Hartikainen, Anna-Liisa;
    • Knowles, Joshua W.;
    • North, Kari E.;
    • Iribarren, Carlos
    Publication type:
    Article
    36

    Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans.

    Published in:
    Diabetes, 2010, v. 59, n. 5, p. 1266, doi. 10.2337/DB09-1568
    By:
    • Ingelsson, Erik;
    • Langenberg, Claudia;
    • Hivert, Marie-France;
    • Prokopenko, Inga;
    • Lyssenko, Valeriya;
    • Dupuis, Josée;
    • Mägi, Reedik;
    • Sharp, Stephen;
    • Jackson, Anne U.;
    • Assimes, Themistocles L.;
    • Shrader, Peter;
    • Knowles, Joshua W.;
    • Zethelius, Björn;
    • Abbasi, Fahim A.;
    • Bergman, Richard N.;
    • Bergmann, Antje;
    • Berne, Christian;
    • Boehnke, Michael;
    • Bonnycastle, Lori L.;
    • Bornstein, Stefan R.
    Publication type:
    Article
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    Development and utility of a clinical research informatics application for participant recruitment and workflow management for a return of results pilot trial in familial hypercholesterolemia in the Million Veteran Program.

    Published in:
    JAMIA Open, 2024, v. 7, n. 1, p. 1, doi. 10.1093/jamiaopen/ooae020
    By:
    • Brunette, Charles A;
    • Yi, Thomas;
    • Danowski, Morgan E;
    • Cardellino, Mark;
    • Harrison, Alicia;
    • Assimes, Themistocles L;
    • Knowles, Joshua W;
    • Christensen, Kurt D;
    • Sturm, Amy C;
    • Sun, Yan V;
    • Hui, Qin;
    • Pyarajan, Saiju;
    • Shi, Yunling;
    • Whitbourne, Stacey B;
    • Gaziano, J Michael;
    • Muralidhar, Sumitra;
    • Vassy, Jason L
    Publication type:
    Article
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    Properties of structural variants and short tandem repeats associated with gene expression and complex traits.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16482-4
    By:
    • Jakubosky, David;
    • D'Antonio, Matteo;
    • Bonder, Marc Jan;
    • Smail, Craig;
    • Donovan, Margaret K. R.;
    • Young Greenwald, William W.;
    • Matsui, Hiroko;
    • i2QTL Consortium;
    • Bonder, Marc J.;
    • Cai, Na;
    • Carcamo-Orive, Ivan;
    • Frazer, Kelly A.;
    • Young Greenwald, William W.;
    • Knowles, Joshua W.;
    • McCarthy, Davis J.;
    • Mirauta, Bogdan A.;
    • Montgomery, Stephen B.;
    • Quertermous, Thomas;
    • Seaton, Daniel D.;
    • Smith, Erin N.
    Publication type:
    Article
    42

    Discovery and quality analysis of a comprehensive set of structural variants and short tandem repeats.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16481-5
    By:
    • Jakubosky, David;
    • Smith, Erin N.;
    • D'Antonio, Matteo;
    • Jan Bonder, Marc;
    • Young Greenwald, William W.;
    • D'Antonio-Chronowska, Agnieszka;
    • Matsui, Hiroko;
    • i2QTL Consortium;
    • Bonder, Marc J.;
    • Cai, Na;
    • Carcamo-Orive, Ivan;
    • Frazer, Kelly A.;
    • Knowles, Joshua W.;
    • McCarthy, Davis J.;
    • Mirauta, Bogdan A.;
    • Montgomery, Stephen B.;
    • Quertermous, Thomas;
    • Seaton, Daniel D.;
    • Smail, Craig;
    • Stegle, Oliver
    Publication type:
    Article
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    One-year real-world experience with mavacamten and its physiologic effects on obstructive hypertrophic cardiomyopathy.

    Published in:
    Frontiers in Cardiovascular Medicine, 2024, p. 1, doi. 10.3389/fcvm.2024.1429230
    By:
    • Seung Kim, Daniel;
    • Chu, Emily L.;
    • Keamy-Minor, Emily E.;
    • Paranjpe, Ishan Dhananjay;
    • Tang, Wilson L.;
    • O'Sullivan, Jack W.;
    • Desai, Yaanik B.;
    • Liu, Michael B.;
    • Munsey, Elise;
    • Hecker, Kimberly;
    • Cuenco, Isabella;
    • Kao, Beth;
    • Bacolor, Ellen;
    • Bonnett, Colleen;
    • Linder, Andrea;
    • Lacar, Kathleen;
    • Robles, Nancy;
    • Lamendola, Cindy;
    • Smith, Allysonne;
    • Knowles, Joshua W.
    Publication type:
    Article
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