Works by Knöchel, Jane

Results: 14

Sample‐based robust model reduction for non‐linear systems biology models.

Published in:

PAMM: Proceedings in Applied Mathematics & Mechanics, 2023, v. 23, n. 4, p. 1, doi. 10.1002/pamm.202200269

By:

Falkenhagen, Undine;
Himpe, Christian;
Knöchel, Jane;
Kloft, Charlotte;
Huisinga, Wilhelm

Publication type:

Article

Recent applications of pharmacometrics and systems pharmacology approaches to improve and optimize drug therapy for pregnant and lactating women.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 11, p. 1815, doi. 10.1002/psp4.13269

By:

Jayachandran, Priya;
Knöchel, Jane;
Cicali, Brian;
Rowland Yeo, Karen

Publication type:

Article

Enhancing inclusivity in clinical trials: Model‐informed drug development for pregnant individuals in the era of personalized medicine.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 11, p. 1824, doi. 10.1002/psp4.13218

By:

Dallmann, André;
Bonate, Peter L.;
Burnham, Janelle;
George, Blessy;
Yao, Lynne;
Knöchel, Jane

Publication type:

Article

A Markov model of fibrosis development in nonalcoholic fatty liver disease predicts fibrosis progression in clinical cohorts.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 12, p. 2038, doi. 10.1002/psp4.13052

By:

Knöchel, Jane;
Bergenholm, Linnéa;
Ibrahim, Eman;
Kechagias, Stergios;
Hansson, Sara;
Liljeblad, Mathias;
Nasr, Patrik;
Carlsson, Björn;
Ekstedt, Mattias;
Ueckert, Sebastian

Publication type:

Article

Deriving mechanism‐based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 4, p. 432, doi. 10.1002/psp4.12903

By:

Falkenhagen, Undine;
Knöchel, Jane;
Kloft, Charlotte;
Huisinga, Wilhelm

Publication type:

Article

A case‐study of model‐informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 12, p. 1569, doi. 10.1002/psp4.12866

By:

Knöchel, Jane;
Nilsson, Catarina;
Carlsson, Björn;
Wernevik, Linda;
Hofherr, Alexis;
Gennemark, Peter;
Jansson‐Löfmark, Rasmus;
Isaksson, Rikard;
Rydén‐Bergsten, Tina;
Hamrén, Bengt;
Rekić, Dinko

Publication type:

Article

Pharmacokinetics, Pharmacodynamics, and Tolerability of AZD5718, an Oral 5-Lipoxygenase-Activating Protein (FLAP) Inhibitor, in Healthy Japanese Male Subjects.

Published in:

Clinical Drug Investigation, 2021, v. 41, n. 10, p. 895, doi. 10.1007/s40261-021-01078-7

By:

Knöchel, Jane;
Nelander, Karin;
Heijer, Maria;
Lindstedt, Eva-Lotte;
Forsberg, Gun-Britt;
Whatling, Carl;
Shimada, Hitoshi;
Han, David S.;
Gabrielsen, Anders;
Garkaviy, Pavlo;
Ericsson, Hans

Publication type:

Article

An oral antisense oligonucleotide for PCSK9 inhibition.

Published in:

Science Translational Medicine, 2021, v. 13, n. 593, p. 1, doi. 10.1126/scitranslmed.abe9117

By:

Gennemark, Peter;
Walter, Katrin;
Clemmensen, Niclas;
Rekić, Dinko;
Nilsson, Catarina A.M.;
Knöchel, Jane;
Hölttä, Mikko;
Wernevik, Linda;
Rosengren, Birgitta;
Kakol-Palm, Dorota;
Wang, Yanfeng;
Yu, Rosie Z.;
Geary, Richard S.;
Riney, Stan J.;
Monia, Brett P.;
Isaksson, Rikard;
Jansson-Löfmark, Rasmus;
Rocha, Cristina S. J.;
Lindén, Daniel;
Hurt-Camejo, Eva

Publication type:

Article

Understanding and reducing complex systems pharmacology models based on a novel input–response index.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 1, p. 139, doi. 10.1007/s10928-017-9561-x

By:

Knöchel, Jane;
Kloft, Charlotte;
Huisinga, Wilhelm

Publication type:

Article

Index analysis: An approach to understand signal transduction with application to the EGFR signalling pathway.

Published in:

PLoS Computational Biology, 2024, v. 20, n. 2, p. 1, doi. 10.1371/journal.pcbi.1011777

By:

Knöchel, Jane;
Kloft, Charlotte;
Huisinga, Wilhelm

Publication type:

Article

Disposition of orally administered atuliflapon, a novel 5‐lipoxygenase‐activating protein inhibitor in healthy participants.

Published in:

Pharmacology Research & Perspectives, 2024, v. 12, n. 5, p. 1, doi. 10.1002/prp2.70029

By:

Li, Xue‐Qing;
Lindmark, Bo;
Amilon, Carl;
Samuelsson, Kristin;
Weidolf, Lars;
Nelander, Karin;
Knöchel, Jane;
Heijer, Maria;
Bragg, Ryan A.;
Gränfors, Malin;
Lindstedt, Eva‐Lotte;
Sidhu, Sharan;
Garkaviy, Pavlo;
Ericsson, Hans

Publication type:

Article

A drug–drug interaction study and physiologically based pharmacokinetic modelling to assess the effect of an oral 5‐lipoxygenase activating protein inhibitor on the pharmacokinetics of oral midazolam.

Published in:

British Journal of Clinical Pharmacology, 2024, v. 90, n. 9, p. 2180, doi. 10.1111/bcp.16131

By:

Knöchel, Jane;
Panduga, Vijender;
Nelander, Karin;
Heijer, Maria;
Lindstedt, Eva‐Lotte;
Ali, Hodan;
Aurell, Malin;
Ödesjö, Helena;
Forte, Pablo;
Connolly, Kat;
Ericsson, Hans;
MacPhee, Iain

Publication type:

Article

Population pharmacokinetics of a novel PCSK9 antisense oligonucleotide.

Published in:

British Journal of Clinical Pharmacology, 2024, v. 90, n. 6, p. 1503, doi. 10.1111/bcp.16046

By:

Clewe, Oskar;
Rekić, Dinko;
Quartino, Angelica L.;
Carlsson, Björn;
Higashimori, Mitsuo;
Wernevik, Linda;
Hofherr, Alexis;
Rydén‐Bergsten, Tina;
Nilsson, Catarina;
Knöchel, Jane

Publication type:

Article

AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 11, p. 4839, doi. 10.1111/bcp.15425

By:

Rekić, Dinko;
Azarov, Ivan;
Knöchel, Jane;
Sokolov, Victor;
Nilsson, Catarina;
Wernevik, Linda;
Han, David;
Rydén‐Bergsten, Tina;
Ebrahimi, Ahmad;
Dota, Corina;
Carlsson, Björn

Publication type:

Article