Works by Klimczak, Leszek J

Results: 15

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.

Published in:

Nature Genetics, 2015, v. 47, n. 9, p. 1067, doi. 10.1038/ng.3378

By:

Sterling, Joan F;
Malc, Ewa P;
Fargo, David C;
Mieczkowski, Piotr A;
Kwiatkowski, David J;
Saini, Natalie;
Kim, Jaegil;
Roberts, Steven A;
Getz, Gad;
Chan, Kin;
Gordenin, Dmitry A;
Klimczak, Leszek J

Publication type:

Article

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.

Published in:

Nature Genetics, 2013, v. 45, n. 9, p. 970, doi. 10.1038/ng.2702

By:

Roberts, Steven A;
Lawrence, Michael S;
Klimczak, Leszek J;
Grimm, Sara A;
Fargo, David;
Stojanov, Petar;
Kiezun, Adam;
Kryukov, Gregory V;
Carter, Scott L;
Saksena, Gordon;
Harris, Shawn;
Shah, Ruchir R;
Resnick, Michael A;
Getz, Gad;
Gordenin, Dmitry A

Publication type:

Article

Detection of genome-wide polymorphisms in the AT-rich Plasmodium falciparum genome using a high-density microarray.

Published in:

BMC Genomics, 2008, v. 9, p. 1, doi. 10.1186/1471-2164-9-398

By:

Hongying Jiang;
Ming Yi;
Jianbing Mu;
Zhang, Louie;
Ivens, Al;
Klimczak, Leszek J.;
Huyen, Yentram;
Stephens, Robert M.;
Xinzhuan Su

Publication type:

Article

Correction: Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.

Published in:

2020

By:

Sakofsky, Cynthia J.;
Saini, Natalie;
Klimczak, Leszek J.;
Chan, Kin;
Malc, Ewa P.;
Mieczkowski, Piotr A.;
Burkholder, Adam B.;
Fargo, David;
Gordenin, Dmitry A.

Publication type:

Correction Notice

Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.

Published in:

PLoS Biology, 2019, v. 17, n. 9, p. 1, doi. 10.1371/journal.pbio.3000464

By:

Sakofsky, Cynthia J.;
Saini, Natalie;
Klimczak, Leszek J.;
Chan, Kin;
Malc, Ewa P.;
Mieczkowski, Piotr A.;
Burkholder, Adam B.;
Fargo, David;
Gordenin, Dmitry A.

Publication type:

Article

Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature.

Published in:

PLoS Biology, 2019, v. 17, n. 5, p. 1, doi. 10.1371/journal.pbio.3000263

By:

Degtyareva, Natalya P.;
Saini, Natalie;
Sterling, Joan F.;
Placentra, Victoria C.;
Klimczak, Leszek J.;
Gordenin, Dmitry A.;
Doetsch, Paul W.

Publication type:

Article

UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin.

Published in:

PLoS Genetics, 2021, v. 17, n. 1, p. 1, doi. 10.1371/journal.pgen.1009302

By:

Saini, Natalie;
Giacobone, Camille K.;
Klimczak, Leszek J.;
Papas, Brian N.;
Burkholder, Adam B.;
Li, Jian-Liang;
Fargo, David C.;
Bai, Re;
Gerrish, Kevin;
Innes, Cynthia L.;
Schurman, Shepherd H.;
Gordenin, Dmitry A.

Publication type:

Article

Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies.

Published in:

PLoS Pathogens, 2019, v. 15, n. 10, p. 1, doi. 10.1371/journal.ppat.1008080

By:

Perelygina, Ludmila;
Chen, Min-hsin;
Suppiah, Suganthi;
Adebayo, Adebola;
Abernathy, Emily;
Dorsey, Morna;
Bercovitch, Lionel;
Paris, Kenneth;
White, Kevin P.;
Krol, Alfons;
Dhossche, Julie;
Torshin, Ivan Y.;
Saini, Natalie;
Klimczak, Leszek J.;
Gordenin, Dmitry A.;
Zharkikh, Andrey;
Plotkin, Stanley;
Sullivan, Kathleen E.;
Icenogle, Joseph

Publication type:

Article

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.

Published in:

PLoS Genetics, 2016, v. 12, n. 10, p. 1, doi. 10.1371/journal.pgen.1006385

By:

Saini, Natalie;
Roberts, Steven A.;
Klimczak, Leszek J.;
Chan, Kin;
Grimm, Sara A.;
Dai, Shuangshuang;
Fargo, David C.;
Boyer, Jayne C.;
Kaufmann, William K.;
Taylor, Jack A.;
Lee, Eunjung;
Cortes-Ciriano, Isidro;
Park, Peter J.;
Schurman, Shepherd H.;
Malc, Ewa P.;
Mieczkowski, Piotr A.;
Gordenin, Dmitry A.

Publication type:

Article

APOBEC affects tumor evolution and age at onset of lung cancer in smokers.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59923-8

By:

Zhang, Tongwu;
Sang, Jian;
Hoang, Phuc H.;
Zhao, Wei;
Rosenbaum, Jennifer;
Johnson, Kofi Ennu;
Klimczak, Leszek J.;
McElderry, John;
Klein, Alyssa;
Wirth, Christopher;
Bergstrom, Erik N.;
Díaz-Gay, Marcos;
Vangara, Raviteja;
Colon-Matos, Frank;
Hutchinson, Amy;
Lawrence, Scott M.;
Cole, Nathan;
Zhu, Bin;
Przytycka, Teresa M.;
Shi, Jianxin

Publication type:

Article

Glycidamide-induced hypermutation in yeast single-stranded DNA reveals a ubiquitous clock-like mutational motif in humans.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 17, p. 9075, doi. 10.1093/nar/gkad611

By:

Hudson, Kathleen M;
Klimczak, Leszek J;
Sterling, Joan F;
Burkholder, Adam B;
Kazanov, Marat D;
Saini, Natalie;
Mieczkowski, Piotr A;
Gordenin, Dmitry A

Publication type:

Article

Changes in metabolic landscapes shape divergent but distinct mutational signatures and cytotoxic consequences of redox stress.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 10, p. 5056, doi. 10.1093/nar/gkad305

By:

Degtyareva, Natalya P;
Placentra, Victoria C;
Gabel, Scott A;
Klimczak, Leszek J;
Gordenin, Dmitry A;
Wagner, Brett A;
Buettner, Garry R;
Mueller, Geoffrey A;
Smirnova, Tatyana I;
Doetsch, Paul W

Publication type:

Article

Mutation signatures specific to DNA alkylating agents in yeast and cancers.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 7, p. 3692, doi. 10.1093/nar/gkaa150

By:

Saini, Natalie;
Sterling, Joan F;
Sakofsky, Cynthia J;
Giacobone, Camille K;
Klimczak, Leszek J;
Burkholder, Adam B;
Malc, Ewa P;
Mieczkowski, Piotr A;
Gordenin, Dmitry A

Publication type:

Article

Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast.

Published in:

G3: Genes | Genomes | Genetics, 2024, v. 14, n. 10, p. 1, doi. 10.1093/g3journal/jkae196

By:

Dennen, Matthew S;
Kockler, Zachary W;
Roberts, Steven A;
Burkholder, Adam B;
Klimczak, Leszek J;
Gordenin, Dmitry A

Publication type:

Article

Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic.

Published in:

PLoS ONE, 2020, v. 15, n. 10, p. 1, doi. 10.1371/journal.pone.0237689

By:

Klimczak, Leszek J.;
Randall, Thomas A.;
Saini, Natalie;
Li, Jian-Liang;
Gordenin, Dmitry A.

Publication type:

Article