Works by Kleschevnikov, Alexander M.

Results: 19

P1-036: Suppression of GABAB receptors increases LTP without inducing pro-epileptic activity in the dentate gyrus of Ts65Dn mice, a genetic model for Down syndrome

Published in:

2008

By:

Kleschevnikov, Alexander M.;
Belichenko, Pavel V.;
Mobley, William

Publication type:

Abstract

PKC activation rescues LTP from NMDA receptor blockade.

Published in:

Hippocampus, 2001, v. 11, n. 2, p. 168, doi. 10.1002/hipo.1034

By:

Kleschevnikov, Alexander M.;
Routtenberg, Aryeh

Publication type:

Article

Hippocampal Long-Term Potentiation Suppressed by Increased Inhibition in the Ts65Dn Mouse, a Genetic Model of Down Syndrome.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 37, p. 8153, doi. 10.1523/JNEUROSCI.1766-04.2004

By:

Kleschevnikov, Alexander M.;
Belichenko, Pavel V.;
Villar, Angela J.;
Epstein, Charles J.;
Malenka, Robert C.;
Mobley, William C.

Publication type:

Article

Long-term potentiation recruits a trisynaptic excitatory associative network within the mouse dentate gyrus.

Published in:

European Journal of Neuroscience, 2003, v. 17, n. 12, p. 2690, doi. 10.1046/j.1460-9568.2003.02709.x

By:

Kleschevnikov, Alexander M.;
Routtenberg, Aryeh

Publication type:

Article

An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.

Published in:

PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0152471

By:

Belichenko, Pavel V.;
Madani, Rime;
Rey-Bellet, Lorianne;
Pihlgren, Maria;
Becker, Ann;
Plassard, Adeline;
Vuillermot, Stephanie;
Giriens, Valßrie;
Nosheny, Rachel L.;
Kleschevnikov, Alexander M.;
Valletta, Janice S.;
Bengtsson, Sara K. S.;
Linke, Gordon R.;
Maloney, Michael T.;
Hickman, David T.;
Reis, Pedro;
Granet, Anne;
Mlaki, Dorin;
Lopez-Deber, Maria Pilar;
Do, Long

Publication type:

Article

Enhanced GIRK2 channel signaling in Down syndrome: A feasible role in the development of abnormal nascent neural circuits.

Published in:

Frontiers in Genetics, 2022, v. 13, p. 1, doi. 10.3389/fgene.2022.1006068

By:

Kleschevnikov, Alexander M.

Publication type:

Article

Acute neuroinflammation provokes intracellular acidification in mouse hippocampus.

Published in:

Journal of Neuroinflammation, 2016, v. 13, p. 1, doi. 10.1186/s12974-016-0747-8

By:

Tyrtyshnaia, Anna A.;
Lysenko, Larisa V.;
Madamba, Francisco;
Manzhulo, Igor V.;
Khotimchenko, Maxim Y.;
Kleschevnikov, Alexander M.

Publication type:

Article

Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice.

Published in:

2014

By:

Niesman, Ingrid R;
Schilling, Jan M;
Shapiro, Lee A;
Kellerhals, Sarah E;
Bonds, Jacqueline A;
Kleschevnikov, Alexander M;
Cui, Weihua;
Voong, April;
Krajewski, Stan;
Ali, Sameh S;
Roth, David M;
Patel, Hemal H;
Patel, Piyush M;
Head, Brian P

Publication type:

journal article

Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities.

Published in:

Developmental Neuroscience, 2011, v. 33, n. 5, p. 404, doi. 10.1159/000329422

By:

Liu, Chunhong;
Belichenko, Pavel V.;
Zhang, Li;
Fu, Dawei;
Kleschevnikov, Alexander M.;
Baldini, Antonio;
Antonarakis, Stylianos E.;
Mobley, William C.;
Yu, Y. Eugene

Publication type:

Article

Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of down syndrome.

Published in:

Journal of Comparative Neurology, 2011, v. 519, n. 7, p. 1338, doi. 10.1002/cne.22573

By:

Popov, Victor I.;
Kleschevnikov, Alexander M.;
Klimenko, Oleg A.;
Stewart, Michael G.;
Belichenko, Pavel V.

Publication type:

Article

Synaptic and cognitive abnormalities in mouse models of down syndrome: Exploring genotype-phenotype relationships.

Published in:

Journal of Comparative Neurology, 2007, v. 504, n. 4, p. 329, doi. 10.1002/cne.21433

By:

Belichenko, Pavel V.;
Kleschevnikov, Alexander M.;
Salehi, Ahmad;
Epstein, Charles J.;
Mobley, William C.

Publication type:

Article

Genetic dissection of the Down syndrome critical region.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 22, p. 6540, doi. 10.1093/hmg/ddv364

By:

Xiaoling Jiang;
Chunhong Liu;
Tao Yu;
Li Zhang;
Kai Meng;
Zhuo Xing;
Belichenko, Pavel V.;
Kleschevnikov, Alexander M.;
Pao, Annie;
Peresie, Jennifer;
Wie, Sarah;
Mobley, William C.;
Yu, Y. Eugene

Publication type:

Article

Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.

Published in:

Human Molecular Genetics, 2014, v. 23, n. 3, p. 578, doi. 10.1093/hmg/ddt446

By:

Zhang, Li;
Meng, Kai;
Jiang, Xiaoling;
Liu, Chunhong;
Pao, Annie;
Belichenko, Pavel V.;
Kleschevnikov, Alexander M.;
Josselyn, Sheena;
Liang, Ping;
Ye, Ping;
Mobley, William C.;
Yu, Y. Eugene

Publication type:

Article

Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity.

Published in:

Cerebral Cortex, 2018, v. 28, n. 9, p. 3255, doi. 10.1093/cercor/bhx196

By:

Egawa, Junji;
Zemljic-Harpf, Alice;
Mandyam, Chitra D;
Niesman, Ingrid R;
Lysenko, Larisa V;
Kleschevnikov, Alexander M;
Roth, David M;
Patel, Hemal H;
Patel, Piyush M;
Head, Brian P

Publication type:

Article

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.

Published in:

PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0134861

By:

Belichenko, Pavel V.;
Kleschevnikov, Alexander M.;
Becker, Ann;
Wagner, Grant E.;
Lysenko, Larisa V.;
Yu, Y. Eugene;
Mobley, William C.

Publication type:

Article

Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrome.

Published in:

PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0114521

By:

Lysenko, Larisa V.;
Kim, Jeesun;
Henry, Cassandra;
Tyrtyshnaia, Anna;
Kohnz, Rebecca A.;
Madamba, Francisco;
Simon, Gabriel M.;
Kleschevnikova, Natalia E.;
Nomura, Daniel K.;
Ezekowitz, R . Alan B.;
Kleschevnikov, Alexander M.

Publication type:

Article

Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABA<sup>B</sup> Receptor Antagonists.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 27, p. 9217, doi. 10.1523/JNEUROSCI.1673-12.2012

By:

Kleschevnikov, Alexander M.;
Belichenko, Pavel V.;
Faizi, Mehrdad;
Jacobs, Lucia F.;
Htun, Khin;
Shamloo, Mehrdad;
Mobley, William C.

Publication type:

Article

The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome.

Published in:

Journal of Neuroscience, 2009, v. 29, n. 18, p. 5938, doi. 10.1523/JNEUROSCI.1547-09.2009

By:

Belichenko, Nadia P.;
Belichenko, Pavel V.;
Kleschevnikov, Alexander M.;
Salehi, Ahmad;
Reeves, Roger H.;
Mobley, William C.

Publication type:

Article

Targeting increased levels of APP in Down syndrome: Posiphen‐mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 2, p. 271, doi. 10.1002/alz.12185

By:

Chen, Xu‐Qiao;
Salehi, Ahmad;
Pearn, Matthew L.;
Overk, Cassia;
Nguyen, Phuong D.;
Kleschevnikov, Alexander M.;
Maccecchini, Maria;
Mobley, William C.

Publication type:

Article