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Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.
Published in:
Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 4, p. 237, doi. 10.1002/bdd.1889
By:
- Basavapathruni, Aravind;
- Olhava, Edward J.;
- Daigle, Scott R.;
- Therkelsen, Carly A.;
- Jin, Lei;
- Boriack‐Sjodin, P. Ann;
- Allain, Christina J.;
- Klaus, Christine R.;
- Raimondi, Alejandra;
- Scott, Margaret Porter;
- Dovletoglou, Angelos;
- Richon, Victoria M.;
- Pollock, Roy M.;
- Copeland, Robert A.;
- Moyer, Mikel P.;
- Chesworth, Richard;
- Pearson, Paul G.;
- Waters, Nigel J.
Publication type:
Article
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.
Published in:
PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0111840
By:
- Knutson, Sarah K.;
- Warholic, Natalie M.;
- Johnston, L. Danielle;
- Klaus, Christine R.;
- Wigle, Tim J.;
- Iwanowicz, Dorothy;
- Littlefield, Bruce A.;
- Porter-Scott, Margaret;
- Smith, Jesse J.;
- Moyer, Mikel P.;
- Copeland, Robert A.;
- Pollock, Roy M.;
- Kuntz, Kevin W.;
- Raimondi, Alejandra;
- Keilhack, Heike
Publication type:
Article
Initial testing (stage 1) of tazemetostat (EPZ-6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program.
Published in:
2017
By:
- Kurmasheva, Raushan T.;
- Sammons, Melissa;
- Favours, Edward;
- Wu, Jianwrong;
- Kurmashev, Dias;
- Cosmopoulos, Katherine;
- Keilhack, Heike;
- Klaus, Christine R.;
- Houghton, Peter J.;
- Smith, Malcolm A.
Publication type:
journal article
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
Published in:
Nature Chemical Biology, 2012, v. 8, n. 11, p. 890, doi. 10.1038/nchembio.1084
By:
- Knutson, Sarah K;
- Wigle, Tim J;
- Warholic, Natalie M;
- Sneeringer, Christopher J;
- Allain, Christina J;
- Klaus, Christine R;
- Sacks, Joelle D;
- Raimondi, Alejandra;
- Majer, Christina R;
- Song, Jeffrey;
- Scott, Margaret Porter;
- Jin, Lei;
- Smith, Jesse J;
- Olhava, Edward J;
- Chesworth, Richard;
- Moyer, Mikel P;
- Richon, Victoria M;
- Copeland, Robert A;
- Keilhack, Heike;
- Pollock, Roy M
Publication type:
Article

Found: 4

Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.

Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.

Initial testing (stage 1) of tazemetostat (EPZ-6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program.

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.