Works by Kirik, Deniz

Results: 106

Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

Published in:

Scientific Reports, 2013, p. 1, doi. 10.1038/srep02157

By:

Cederfjäll, Erik;
Nilsson, Nathalie;
Sahin, Gurdal;
Chu, Yaping;
Nikitidou, Elisabeth;
Björklund, Tomas;
Kordower, Jeffrey H.;
Kirik, Deniz

Publication type:

Article

An animal model for interaction between epilepsy and Parkinson's disease.

Published in:

2018

By:

Karamahmutoğlu, Tuğba;
Akman, Özlem;
İdriz Oğlu, Medine Gülçebi;
Kırık, Deniz;
Onat, Filiz

Publication type:

Abstract

Gene Therapy for Dopamine Replacement in Parkinson's Disease.

Published in:

Science Translational Medicine, 2009, v. 1, n. 2, p. 1, doi. 10.1126/scitranslmed.3000350

By:

Björklund, Anders;
Björklund, Tomas;
Kirik, Deniz

Publication type:

Article

Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease.

Published in:

Movement Disorders, 2021, v. 36, n. 9, p. 2085, doi. 10.1002/mds.28615

By:

Huynh, Benjamin;
Fu, Yuhong;
Kirik, Deniz;
Shine, James M.;
Halliday, Glenda M.

Publication type:

Article

Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra.

Published in:

Movement Disorders, 2013, v. 28, n. 10, p. 1351, doi. 10.1002/mds.25493

By:

Reyes, Stefanie;
Cottam, Veronica;
Kirik, Deniz;
Double, Kay L.;
Halliday, Glenda M.

Publication type:

Article

Animal models of Parkinson's disease: Limits and relevance to neuroprotection studies.

Published in:

Movement Disorders, 2013, v. 28, n. 1, p. 61, doi. 10.1002/mds.25108

By:

Bezard, Erwan;
Yue, Zhenyu;
Kirik, Deniz;
Spillantini, Maria Grazia

Publication type:

Article

Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.

Published in:

Movement Disorders, 2010, v. 25, n. S1, p. S174, doi. 10.1002/mds.22792

By:

Carta, Manolo;
Carlsson, Thomas;
Muñoz, Ana;
Kirik, Deniz;
Björklund, Anders

Publication type:

Article

Functional Convergence of Dopaminergic and Cholinergic Input Is Critical for Hippocampus-Dependent Working Memory.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 31, p. 7797, doi. 10.1523/JNEUROSCI.1885-08.2008

By:

Wisman, Liselijn A. B.;
Sahin, Gurdal;
Maingay, Matthew;
Leanza, Giampiero;
Kirik, Deniz

Publication type:

Article

Serotonin Neuron Transplants Exacerbate L-DOPA-Induced Dyskinesias in a Rat Model of Parkinson's Disease.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 30, p. 8011, doi. 10.1523/JNEUROSCI.2079-07.2007

By:

Carlsson, Thomas;
Carta, Manolo;
Winkler, Christian;
Björklund, Anders;
Kirik, Deniz

Publication type:

Article

The Functional Impact of the Intrastriatal Dopamine Neuron Grafts in Parkinsonian Rats Is Reduced with Advancing Disease.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 22, p. 5849, doi. 10.1523/JNEUROSCI.0626-07.2007

By:

Breysse, Nathalie;
Carlsson, Thomas;
Winkler, Christian;
Björklund, Anders;
Kirik, Deniz

Publication type:

Article

Identification of Dopaminergic Neurons of Nigral and Ventral Tegmental Area Subtypes in Grafts of Fetal Ventral Mesencephalon Based on Cell Morphology, Protein Expression, and Efferent Projections.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 27, p. 6467, doi. 10.1523/JNEUROSCI.1676-05.2005

By:

Thompson, Lachlan;
Barraud, Perrine;
Andersson, Elin;
Kirik, Deniz;
Björklund, Anders

Publication type:

Article

Continuous Low-Level Glial Cell Line-Derived Neurotrophic Factor Delivery Using Recombinant Adeno-Associated Viral Vectors Provides Neuroprotection and Induces Behavioral Recovery in a Primate Model of Parkinson's Disease.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 4, p. 769, doi. 10.1523/JNEUROSCI.4421-04.2005

By:

Eslamboli, Andisheh;
Georgievska, Biljana;
Ridley, Rosalind M.;
Baker, Harry F.;
Muzyczka, Nicholas;
Burger, Corinna;
Mandel, Ronald J.;
Annett, Lucy;
Kirik, Deniz

Publication type:

Article

Overexpression of Glial Cell Line-Derived Neurotrophic Factor Using a Lentiviral Vector Induces Time- and Dose-Dependent Downregulation of Tyrosine Hydroxylase in the Intact Nigrostriatal Dopamine System.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 29, p. 6437, doi. 10.1523/JNEUROSCI.1122-04.2004

By:

Georgievska, Biljana;
Kirik, Deniz;
Björklund, Anders

Publication type:

Article

Huntington’s Disease – New Perspectives Based on Neuroendocrine Changes in Rodent Models.

Published in:

Neurodegenerative Diseases, 2009, v. 6, n. 4, p. 154, doi. 10.1159/000225377

By:

Petersén, Åsa;
Hult, Sofia;
Kirik, Deniz

Publication type:

Article

Twisting mice move the dystonia field forward.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 7, p. 2848, doi. 10.1172/JCI76624

By:

Petersén, Åsa;
Kirik, Deniz

Publication type:

Article

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.

Published in:

Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0125-0

By:

Landeck, Natalie;
Hall, Hélène;
Ardah, Mustafa T.;
Majbour, Nour K.;
El-Agnaf, Omar M. A.;
Halliday, Glenda;
Kirik, Deniz

Publication type:

Article

Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates.

Published in:

Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0451-7

By:

Mandel, Ronald J.;
Marmion, David J.;
Kirik, Deniz;
Yaping Chu;
Heindel, Clifford;
McCown, Thomas;
Gray, Steven J.;
Kordower, Jeffrey H.

Publication type:

Article

Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke.

Published in:

European Journal of Neuroscience, 2003, v. 17, n. 12, p. 2667, doi. 10.1046/j.1460-9568.2003.02713.x

By:

Gustafsson, Elin;
Andsberg, Gunnar;
Darsalia, Vladimer;
Mohapel, Paul;
Mandel, Ronald J.;
Kirik, Deniz;
Lindvall, Olle;
Kokaia, Zaal

Publication type:

Article

Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system.

Published in:

European Journal of Neuroscience, 2003, v. 17, n. 2, p. 260, doi. 10.1046/j.1460-9568.2003.02456.x

By:

Rosenblad, Carl;
Georgievska, Biljana;
Kirik, Deniz

Publication type:

Article

Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease.

Published in:

European Journal of Neuroscience, 2001, v. 13, n. 8, p. 1589, doi. 10.1046/j.0953-816X.2001.01534.x

By:

Kirik, Deniz;
Georgievska, Biljana;
Rosenblad, Carl;
Björklund, Anders

Publication type:

Article

Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor.

Published in:

European Journal of Neuroscience, 2000, v. 12, n. 11, p. 3871, doi. 10.1046/j.1460-9568.2000.00274.x

By:

Kirik, Deniz;
Rosenblad, Carl;
Björklund, Anders

Publication type:

Article

Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson’s disease after administration into the striatum or the lateral ventricle.

Published in:

European Journal of Neuroscience, 1999, v. 11, n. 5, p. 1554, doi. 10.1046/j.1460-9568.1999.00566.x

By:

Rosenblad, Carl;
Kirik, Deniz;
Devaux, Brigitte;
Moffat, Barbara;
Phillips, Heidi S.;
Björklund, Anders

Publication type:

Article

Basal activity of PINK1 and PRKN in cell models and rodent brain.

Published in:

Autophagy, 2024, v. 20, n. 5, p. 1147, doi. 10.1080/15548627.2023.2286414

By:

Watzlawik, Jens O.;
Fiesel, Fabienne C.;
Fiorino, Gabriella;
Bustillos, Bernardo A.;
Baninameh, Zahra;
Markham, Briana N.;
Hou, Xu;
Hayes, Caleb S.;
Bredenberg, Jenny M.;
Kurchaba, Nicholas W.;
Fričová, Dominika;
Siuda, Joanna;
Wszolek, Zbigniew K.;
Noda, Sachiko;
Sato, Shigeto;
Hattori, Nobutaka;
Prasad, Asheeta A.;
Kirik, Deniz;
Fox, Howard S.;
Stauch, Kelly L.

Publication type:

Article

Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results.

Published in:

Brain: A Journal of Neurology, 2005, v. 128, n. 7, p. 1478, doi. 10.1093/brain/awh570

By:

Deniz Kirik;
Anders Björklund

Publication type:

Article

Reversal of dyskinesias in an animal model of Parkinson's disease by continuous l-DOPA delivery using rAAV vectors.

Published in:

Brain: A Journal of Neurology, 2005, v. 128, n. 3, p. 559, doi. 10.1093/brain/awh374

By:

Carlsson, Thomas;
Winkler, Christian;
Burger, Corinna;
Muzyczka, Nicholas;
Mandel, Ronald J.;
Cenci, Angela;
Björklund, Anders;
Kirik, Deniz

Publication type:

Article

Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 9, p. 3364, doi. 10.1523/JNEUROSCI.2734-13.2014

By:

Ledri, Marco;
Madsen, Marita Grønning;
Nikitidou, Litsa;
Kirik, Deniz;
Kokaia, Merab

Publication type:

Article

Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy.

Published in:

Journal of Neuroscience, 2009, v. 29, n. 5, p. 1544, doi. 10.1523/JNEUROSCI.4491-08.2009

By:

Leriche, Ludovic;
Björklund, Tomas;
Breysse, Nathalie;
Besret, Laurent;
Grégoire, Marie-Claude;
Carlsson, Thomas;
Dollé, Frédéric;
Mandel, Ronald J.;
Déglon, Nicole;
Hantraye, Philippe;
Kirik, Deniz

Publication type:

Article

Imaging in cell-based therapy for neurodegenerative diseases.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2005, v. 32, p. S417, doi. 10.1007/s00259-005-1909-6

By:

Kirik, Deniz;
Breysse, Nathalie;
Björklund, Tomas;
Besret, Laurent;
Hantraye, Philippe

Publication type:

Article

Dopamine and cortical neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction.

Published in:

NPJ Parkinson's Disease, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41531-025-01048-2

By:

Chedid, Jessica;
Li, Yan;
Labrador-Garrido, Adahir;
Abu-Bonsrah, Dad;
Pavan, Chiara;
Fraser, Tyra;
Ovchinnikov, Dmitry;
Zhong, Melanie;
Davis, Ryan;
Strbenac, Dario;
Johnston, Jennifer A.;
Thompson, Lachlan H.;
Kirik, Deniz;
Parish, Clare L.;
Halliday, Glenda M.;
Sue, Carolyn M.;
Wali, Gautam;
Dzamko, Nicolas

Publication type:

Article

Novel tools to quantify total, phospho-Ser129 and aggregated alpha-synuclein in the mouse brain.

Published in:

NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-024-00830-y

By:

Trist, Benjamin Guy;
Wright, Courtney Jade;
Rangel, Alejandra;
Cottle, Louise;
Prasad, Asheeta;
Jensen, Nanna Møller;
Gram, Hjalte;
Dzamko, Nicolas;
Jensen, Poul Henning;
Kirik, Deniz

Publication type:

Article

TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice.

Published in:

Acta Neuropathologica Communications, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40478-025-02018-8

By:

Bergh, Sofia;
Casadei, Nicolas;
Gabery, Sanaz;
Simonsson, Oskar;
Duarte, João M. N.;
Kirik, Deniz;
Nguyen, Huu Phuc;
Petersén, Åsa

Publication type:

Article

Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease.

Published in:

Neuropathology & Applied Neurobiology, 2023, v. 49, n. 2, p. 1, doi. 10.1111/nan.12891

By:

Bergh, Sofia;
Gabery, Sanaz;
Tonetto, Simone;
Kirik, Deniz;
Petersén, Åsa;
Cheong, Rachel Y.

Publication type:

Article

Effects of mutant huntingtin in oxytocin neurons on non‐motor features of Huntington's disease.

Published in:

Neuropathology & Applied Neurobiology, 2023, v. 49, n. 1, p. 1, doi. 10.1111/nan.12891

By:

Bergh, Sofia;
Gabery, Sanaz;
Tonetto, Simone;
Kirik, Deniz;
Petersén, Åsa;
Cheong, Rachel Y.

Publication type:

Article

Effects of mutant huntingtin inactivation on Huntington disease‐related behaviours in the BACHD mouse model.

Published in:

Neuropathology & Applied Neurobiology, 2021, v. 47, n. 4, p. 564, doi. 10.1111/nan.12682

By:

Cheong, Rachel Y.;
Baldo, Barbara;
Sajjad, Muhammad U.;
Kirik, Deniz;
Petersén, Åsa

Publication type:

Article

Selective loss of oxytocin and vasopressin in the hypothalamus in early Huntington disease: a case study.

Published in:

Neuropathology & Applied Neurobiology, 2015, v. 41, n. 6, p. 843, doi. 10.1111/nan.12236

By:

Gabery, Sanaz;
Halliday, Glenda;
Kirik, Deniz;
Englund, Elisabet;
Petersén, Åsa

Publication type:

Article

GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area.

Published in:

Journal of Comparative Neurology, 2012, v. 520, n. 12, p. 2591, doi. 10.1002/cne.23051

By:

Reyes, Stefanie;
Fu, Yuhong;
Double, Kay;
Thompson, Lachlan;
Kirik, Deniz;
Paxinos, George;
Halliday, Glenda M.

Publication type:

Article

In vivo quantification of glial activation in minipigs overexpressing human α‐synuclein.

Published in:

Synapse, 2018, v. 72, n. 12, p. N.PAG, doi. 10.1002/syn.22060

By:

Lillethorup, Thea Pinholt;
Glud, Andreas Nørgaard;
Landeck, Natalie;
Alstrup, Aage Kristian Olsen;
Jakobsen, Steen;
Vang, Kim;
Doudet, Doris J.;
Brooks, David J.;
Kirik, Deniz;
Hinz, Rainer;
Sørensen, Jens Christian;
Landau, Anne M.

Publication type:

Article

Neuronal replacement from endogenous precursors in the adult brain after stroke.

Published in:

Nature Medicine, 2002, v. 8, n. 9, p. 963, doi. 10.1038/nm747

By:

Arvidsson, Andreas;
Collin, Tove;
Kirik, Deniz;
Kokaia, Zaal;
Lindvall, Olle

Publication type:

Article

How is alpha‐synuclein cleared from the cell?

Published in:

Journal of Neurochemistry, 2019, v. 150, n. 5, p. 577, doi. 10.1111/jnc.14704

By:

Stefanis, Leonidas;
Emmanouilidou, Evangelia;
Pantazopoulou, Marina;
Kirik, Deniz;
Vekrellis, Kostas;
Tofaris, George K.

Publication type:

Article

How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?

Published in:

Journal of Neurochemistry, 2016, v. 139, p. 131, doi. 10.1111/jnc.13627

By:

Volpicelli-Daley, Laura A.;
Kirik, Deniz;
Stoyka, Lindsay E.;
Standaert, David G.;
Harms, Ashley S.

Publication type:

Article

Assessment of brain metabolite correlates of adeno-associated virus-mediated over-expression of human alpha-synuclein in cortical neurons by in vivo <sup>1</sup>H- MR spectroscopy at 9.4 T.

Published in:

Journal of Neurochemistry, 2016, v. 137, n. 5, p. 806, doi. 10.1111/jnc.13547

By:

Cuellar‐Baena, Sandra;
Landeck, Natalie;
Sonnay, Sarah;
Buck, Kerstin;
Mlynarik, Vladimir;
in ‘t Zandt, René;
Kirik, Deniz

Publication type:

Article

Controlled Striatal DOPA Production From a Gene Delivery System in a Rodent Model of Parkinson's Disease.

Published in:

Molecular Therapy, 2015, v. 23, n. 5, p. 896, doi. 10.1038/mt.2015.8

By:

Cederfjäll, Erik;
Broom, Lauren;
Kirik, Deniz

Publication type:

Article

Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease.

Published in:

Molecular Therapy, 2012, v. 20, n. 7, p. 1315, doi. 10.1038/mt.2012.1

By:

Cederfjäll, Erik;
Sahin, Gurdal;
Kirik, Deniz;
Björklund, Tomas

Publication type:

Article

Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates.

Published in:

Molecular Therapy, 2010, v. 18, n. 3, p. 579, doi. 10.1038/mt.2009.216

By:

Dodiya, Hemraj B.;
Bjorklund, Tomas;
Stansell, III, James;
Mandel, Ronald J.;
Kirik, Deniz;
Kordower, Jeffrey H.

Publication type:

Article

Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons.

Published in:

Molecular Therapy, 2009, v. 17, n. 9, p. 1574, doi. 10.1038/mt.2009.142

By:

Ulusoy, Ayse;
Sahin, Gurdal;
Björklund, Tomas;
Aebischer, Patrick;
Kirik, Deniz

Publication type:

Article

Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy.

Published in:

Molecular Therapy, 2007, v. 15, n. 6, p. 1106, doi. 10.1038/sj.mt.6300148

By:

Kanter-Schlifke, Irene;
Georgievska, Biljana;
Kirik, Deniz;
Kokaia, Merab

Publication type:

Article

941. Delayed GDNF Exposure to Mature Dopaminergic Grafts Impairs Their Ability To Improve Motor Function in Parkinsonian Rats

Published in:

2005

By:

Georgievska, Biljana;
Winkler, Christian;
Carlsson, Thomas;
Lacar, Benjamin;
Kirik, Deniz

Publication type:

Abstract

Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-34084-5

By:

Lillethorup, Thea P.;
Glud, Andreas N.;
Alstrup, Aage K. O.;
Noer, Ove;
Nielsen, Erik H. T.;
Schacht, Anna C.;
Landeck, Natalie;
Kirik, Deniz;
Orlowski, Dariusz;
Sørensen, Jens Christian H.;
Doudet, Doris J.;
Landau, Anne M.

Publication type:

Article

State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons.

Published in:

Biology (2079-7737), 2024, v. 13, n. 9, p. 690, doi. 10.3390/biology13090690

By:

Basso, Valentina;
Döbrössy, Máté D.;
Thompson, Lachlan H.;
Kirik, Deniz;
Fuller, Heidi R.;
Gates, Monte A.

Publication type:

Article

Microtubule stabilization promoted axonal regeneration and functional recovery after spinal root avulsion.

Published in:

European Journal of Neuroscience, 2017, v. 46, n. 1, p. 1650, doi. 10.1111/ejn.13585

By:

Li, Heng;
Wu, Wutian;
Kirik, Deniz

Publication type:

Article