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Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS1 (832/3) cell glucose-stimulated insulin secretion.
Published in:
Pharmacology Research & Perspectives, 2021, v. 9, n. 2, p. 1, doi. 10.1002/prp2.736
By:
- Sandhu, Harpreet K.;
- Neuman, Joshua C.;
- Schaid, Michael D.;
- Davis, Sarah E.;
- Connors, Kelsey M.;
- Challa, Romith;
- Guthery, Erin;
- Fenske, Rachel J.;
- Patibandla, Chinmai;
- Breyer, Richard M.;
- Kimple, Michelle E.
Publication type:
Article
A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-11085-z
By:
- Tremmel, Daniel M.;
- Sackett, Sara Dutton;
- Feeney, Austin K.;
- Mitchell, Samantha A.;
- Schaid, Michael D.;
- Polyak, Erzsebet;
- Chlebeck, Peter J.;
- Gupta, Sakar;
- Kimple, Michelle E.;
- Fernandez, Luis A.;
- Odorico, Jon S.
Publication type:
Article
Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
Published in:
EMBO Journal, 2001, v. 20, n. 16, p. 4414, doi. 10.1093/emboj/20.16.4414
By:
- Kimple, Michelle E.;
- Siderovski, David P.;
- Sondek, John
Publication type:
Article
Plasma Prostaglandin E 2 Metabolite Levels Predict Type 2 Diabetes Status and One-Year Therapeutic Response Independent of Clinical Markers of Inflammation.
Published in:
Metabolites (2218-1989), 2022, v. 12, n. 12, p. 1234, doi. 10.3390/metabo12121234
By:
- Fenske, Rachel J.;
- Weeks, Alicia M.;
- Daniels, Michael;
- Nall, Randall;
- Pabich, Samantha;
- Brill, Allison L.;
- Peter, Darby C.;
- Punt, Margaret;
- Cox, Elizabeth D.;
- Davis, Dawn Belt;
- Kimple, Michelle E.
Publication type:
Article
Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass.
Published in:
Metabolites (2218-1989), 2022, v. 12, n. 4, p. N.PAG, doi. 10.3390/metabo12040342
By:
- Bosma, Karin J.;
- Kaiser, Cecilia E.;
- Kimple, Michelle E.;
- Gannon, Maureen
Publication type:
Article
Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E 2 Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes.
Published in:
Metabolites (2218-1989), 2021, v. 11, n. 1, p. 58, doi. 10.3390/metabo11010058
By:
- Schaid, Michael D.;
- Zhu, Yanlong;
- Richardson, Nicole E.;
- Patibandla, Chinmai;
- Ong, Irene M.;
- Fenske, Rachel J.;
- Neuman, Joshua C.;
- Guthery, Erin;
- Reuter, Austin;
- Sandhu, Harpreet K.;
- Fuller, Miles H.;
- Cox, Elizabeth D.;
- Davis, Dawn B.;
- Layden, Brian T.;
- Brasier, Allan R.;
- Lamming, Dudley W.;
- Ge, Ying;
- Kimple, Michelle E.
Publication type:
Article
Gαz-independent and -dependent Improvements With EPA Supplementation on the Early Type 1 Diabetes Phenotype of NOD Mice.
Published in:
Journal of the Endocrine Society, 2024, v. 8, n. 7, p. 1, doi. 10.1210/jendso/bvae100
By:
- Fenske, Rachel J;
- Wienkes, Haley N;
- Peter, Darby C;
- Schaid, Michael D;
- Hurley, Liam D;
- Pennati, Andrea;
- Galipeau, Jacques;
- Kimple, Michelle E
Publication type:
Article
The Importance of Exclusion of Obstructive Sleep Apnea During Screening for Adrenal Adenoma and Diagnosis of Pheochromocytoma.
Published in:
Journal of Investigative Medicine High Impact Case Reports, 2015, v. 3, n. 3, p. 1, doi. 10.1177/2324709615607062
By:
- Weeks, Alicia C.;
- Kimple, Michelle E.;
- Davis, Dawn Belt
Publication type:
Article
Spontaneous Tumor Lysis Syndrome: A Case Report and Critical Evaluation of Current Diagnostic Criteria and Optimal Treatment Regimens.
Published in:
Journal of Investigative Medicine High Impact Case Reports, 2015, v. 3, n. 3, p. 1, doi. 10.1177/2324709615603199
By:
- Weeks, Alicia C.;
- Kimple, Michelle E.
Publication type:
Article
Bombesin Preserves Goblet Cell Resistin-Like Molecule β During Parenteral Nutrition but Not Other Goblet Cell Products.
Published in:
2016
By:
- Busch, Rebecca A.;
- Heneghan, Aaron F.;
- Pierre, Joseph F.;
- Neuman, Joshua C.;
- Reimer, Claire A.;
- Wang, Xinying;
- Kimple, Michelle E.;
- Kudsk, Kenneth A.
Publication type:
journal article
A gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q like-3 secreted protein as a regulator of β-cell function.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-46219-3
By:
- Koltes, James E.;
- Arora, Itika;
- Gupta, Rajesh;
- Nguyen, Dan C.;
- Schaid, Michael;
- Kim, Jeong-a;
- Kimple, Michelle E.;
- Bhatnagar, Sushant
Publication type:
Article
Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms.
Published in:
FASEB Journal, 2018, v. 32, n. 6, p. 3471, doi. 10.1096/fj.201701211R
By:
- Deyang Yu;
- Yang, Shany E.;
- Miller, Blake R.;
- Wisinski, Jaclyn A.;
- Sherman, Dawn S.;
- Brinkman, Jacqueline A.;
- Tomasiewicz, Jay L.;
- Cummings, Nicole E.;
- Kimple, Michelle E.;
- Cryns, Vincent L.;
- Lamming, Dudley W.
Publication type:
Article
Structual determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits.
Published in:
Nature, 2002, v. 416, n. 6883, p. 878, doi. 10.1038/416878a
By:
- Kimple, Randall J.;
- Kimple, Michelle E.;
- Betts, Laurie;
- Sondek, John;
- Siderovski, David P.
Publication type:
Article
Restoration of metabolic health by decreased consumption of branched‐chain amino acids.
Published in:
Journal of Physiology, 2018, v. 596, n. 4, p. 623, doi. 10.1113/JP275075
By:
- Cummings, Nicole E.;
- Williams, Elizabeth M.;
- Kasza, Ildiko;
- Konon, Elizabeth N.;
- Schaid, Michael D.;
- Schmidt, Brian A.;
- Poudel, Chetan;
- Sherman, Dawn S.;
- Yu, Deyang;
- Arriola Apelo, Sebastian I.;
- Cottrell, Sara E.;
- Geiger, Gabriella;
- Barnes, Macy E.;
- Wisinski, Jaclyn A.;
- Fenske, Rachel J.;
- Matkowskyj, Kristina A.;
- Kimple, Michelle E.;
- Alexander, Caroline M.;
- Merrins, Matthew J.;
- Lamming, Dudley W.
Publication type:
Article
Targeting dysfunctional beta-cell signaling for the potential treatment of type 1 diabetes mellitus.
Published in:
Experimental Biology & Medicine, 2018, v. 243, n. 6, p. 586, doi. 10.1177/1535370218761662
By:
- Fenske, Rachel J.;
- Kimple, Michelle E.
Publication type:
Article
Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-36289-0
By:
- De Leon, Elizabeth R.;
- Brinkman, Jacqueline A.;
- Fenske, Rachel J.;
- Gregg, Trillian;
- Schmidt, Brian A.;
- Sherman, Dawn S.;
- Cummings, Nicole E.;
- Peter, Darby C.;
- Kimple, Michelle E.;
- Lamming, Dudley W.;
- Merrins, Matthew J.
Publication type:
Article
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.
Published in:
Aging Cell, 2016, v. 15, n. 1, p. 28, doi. 10.1111/acel.12405
By:
- Arriola Apelo, Sebastian I.;
- Neuman, Joshua C.;
- Baar, Emma L.;
- Syed, Faizan A.;
- Cummings, Nicole E.;
- Brar, Harpreet K.;
- Pumper, Cassidy P.;
- Kimple, Michelle E.;
- Lamming, Dudley W.
Publication type:
Article
Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes.
Published in:
2017
By:
- Hernandez, Reinier;
- Graves, Stephen A.;
- Gregg, Trillian;
- VanDeusen, Halena R.;
- Fenske, Rachel J.;
- Wienkes, Haley N.;
- England, Christopher G.;
- Valdovinos, Hector F.;
- Jeffery, Justin J.;
- Barnhart, Todd E.;
- Severin, Gregory W.;
- Nickles, Robert J.;
- Kimple, Michelle E.;
- Merrins, Matthew J.;
- Weibo Cai;
- Cai, Weibo
Publication type:
journal article
Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E<sub>2</sub> Signaling and Enhances Diabetic β-Cell Function.
Published in:
2017
By:
- Neuman, Joshua C.;
- Schaid, Michael D.;
- Brill, Allison L.;
- Fenske, Rachel J.;
- Kibbe, Carly R.;
- Fontaine, Danielle A.;
- Sdao, Sophia M.;
- Brar, Harpreet K.;
- Connors, Kelsey M.;
- Wienkes, Haley N.;
- Eliceiri, Kevin W.;
- Merrins, Matthew J.;
- Davis, Dawn B.;
- Kimple, Michelle E.
Publication type:
journal article
Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.
Published in:
2016
By:
- Gregg, Trillian;
- Poudel, Chetan;
- Schmidt, Brian A.;
- Dhillon, Rashpal S.;
- Sdao, Sophia M.;
- Truchan, Nathan A.;
- Baar, Emma L.;
- Fernandez, Luis A.;
- Denu, John M.;
- Eliceiri, Kevin W.;
- Rogers, Jeremy D.;
- Kimple, Michelle E.;
- Lamming, Dudley W.;
- Merrin, Matthew J.;
- Merrins, Matthew J
Publication type:
journal article
Platelet Dysfunction in Type 1 Diabetes: Stressing the Thromboxanes.
Published in:
2016
By:
- Wisinski, Jaclyn A.;
- Kimple, Michelle E.
Publication type:
journal article
Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.
Published in:
2015
By:
- Oropeza, Daniel;
- Jouvet, Nathalie;
- Budry, Lionel;
- Campbell, Jonathan E.;
- Bouyakdan, Khalil;
- Lacombe, Julie;
- Perron, Gabrielle;
- Bergeron, Valerie;
- Neuman, Joshua C.;
- Brar, Harpreet K.;
- Fenske, Rachel J.;
- Meunier, Clemence;
- Sczelecki, Sarah;
- Kimple, Michelle E.;
- Drucker, Daniel J.;
- Screaton, Robert A.;
- Poitout, Vincent;
- Ferron, Mathieu;
- Alquier, Thierry;
- Estall, Jennifer L.
Publication type:
journal article
Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion.
Published in:
2013
By:
- Kimple, Michelle E;
- Keller, Mark P;
- Rabaglia, Mary R;
- Pasker, Renee L;
- Neuman, Joshua C;
- Truchan, Nathan A;
- Brar, Harpreet K;
- Attie, Alan D
Publication type:
journal article
Prostaglandin E<sub>2</sub> Receptor, EP3, Is Induced in Diabetic Islets and Negatively Regulates Glucose- and Hormone-Stimulated Insulin Secretion.
Published in:
Diabetes, 2013, v. 62, n. 6, p. 1904, doi. 10.2337/db12-0769
By:
- Kimple, Michelle E.;
- Keller, Mark P.;
- Rabaglia, Mary R.;
- Pasker, Renee L.;
- Neuman, Joshua C.;
- Truchan, Nathan A.;
- Brar, Harpreet K.;
- Attie, Alan D.
Publication type:
Article

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