Works by Kimball, Scot R.

Results: 56

4E‐BP1/2 Deletion Enhances mRNA Cap‐binding Complex Assembly and Protein Synthesis in Immobilized Skeletal Muscle But is Not Sufficient to Prevent Muscle Atrophy.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3610

By:

Kincheloe, Gregory N.;
Roberson, Paul A.;
Toro, Allyson L.;
Dennis, Michael D.;
Kimball, Scot R.

Publication type:

Article

Glucose Availability Regulates Sestrin3 Binding to Hexokinase2 to Affect Glucose‐induced mTORC1 Activation.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R5903

By:

Roberson, Paul A.;
Welles, Jaclyn E.;
Xu, Dandan;
Kincheloe, Gregory N.;
Jefferson, Leonard S.;
Kimball, Scot R.

Publication type:

Article

The 2020 FASEB Virtual Science Research Conference on Nutrient Sensing and Metabolic Signaling, August 10‐11, 2020.

Published in:

FASEB Journal, 2020, v. 34, n. 12, p. 15627, doi. 10.1096/fj.202002259

By:

Kimball, Scot R.;
Davis, Teresa A.

Publication type:

Article

An integrative approach to assessing effects of a short-term Western diet on gene expression in rat liver.

Published in:

Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.1032293

By:

Welles, Jaclyn E.;
Lacko, Holly;
Kawasawa, Yuka Imamura;
Dennis, Michael D.;
Jefferson, Leonard S.;
Kimball, Scot R.

Publication type:

Article

Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients.

Published in:

European Journal of Human Genetics, 2004, v. 12, n. 7, p. 561, doi. 10.1038/sj.ejhg.5201189

By:

Fogli, Anne;
Schiffmann, Raphael;
Hugendubler, Lynne;
Combes, Patricia;
Bertini, Enrico;
Rodriguez, Diana;
Kimball, Scot R.;
Boespflug-Tanguy, Odile

Publication type:

Article

Lower muscle protein synthesis in humans with obesity concurrent with lower expression of muscle IGF1 splice variants.

Published in:

Obesity (19307381), 2023, v. 31, n. 11, p. 2689, doi. 10.1002/oby.23896

By:

Freitas, Eduardo D. S.;
Kras, Katon A.;
Roust, Lori R.;
De Filippis, Elena A.;
Kimball, Scot R.;
Buras, Matthew;
Katsanos, Christos S.

Publication type:

Article

AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2022, v. 13, n. 1, p. 495, doi. 10.1002/jcsm.12846

By:

Jaiswal, Natasha;
Gavin, Matthew;
Loro, Emanuele;
Sostre‐Colón, Jaimarie;
Roberson, Paul A.;
Uehara, Kahealani;
Rivera‐Fuentes, Nicole;
Neinast, Michael;
Arany, Zoltan;
Kimball, Scot R.;
Khurana, Tejvir S.;
Titchenell, Paul M.

Publication type:

Article

Exercise Attenuates Ribosomal Protein Six Phosphorylation in Fatty Liver Disease.

Published in:

2020

By:

Stine, Jonathan G;
Xu, Dandan;
Schmitz, Kathryn;
Sciamanna, Christopher;
Kimball, Scot R

Publication type:

journal article

Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 7, p. 3481, doi. 10.3390/ijms23073481

By:

Dinavahi, Saketh S.;
Chen, Yu-Chi;
Gowda, Raghavendra;
Dhanyamraju, Pavan Kumar;
Punnath, Kishore;
Desai, Dhimant;
Berg, Arthur;
Kimball, Scot R.;
Amin, Shantu;
Yang, Jin-Ming;
Robertson, Gavin P.

Publication type:

Article

Studies on Pyrazinoylguanidine.

Published in:

Pharmacology, 1996, v. 53, n. 4, p. 211, doi. 10.1159/000139432

By:

A-Rahim, Yousif I.;
Rannels, Sharon L.;
Kimball, Scot R.;
Beyer Jr., Karl H.;
Vesell, Elliot S.

Publication type:

Article

Translational control by RGS2.

Published in:

Journal of Cell Biology, 2009, v. 186, n. 5, p. 755, doi. 10.1083/jcb.200811058

By:

Nguyen, Chau H.;
Ming, Hong;
Zhao, Peishen;
Hugendubler, Lynne;
Gros, Robert;
Kimball, Scot R.;
Chidiac, Peter

Publication type:

Article

Translational Control of Protein Synthesis: Implications for Understanding Changes in Skeletal Muscle Mass.

Published in:

International Journal of Sport Nutrition & Exercise Metabolism, 2001, v. 11, n. 4, p. S143, doi. 10.1123/ijsnem.11.s1.s143

By:

Jefferson, Leonard S.;
Kimball, Scot R.

Publication type:

Article

Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle.

Published in:

Journal of Physiology, 2006, v. 573, n. 2, p. 497, doi. 10.1113/jphysiol.2005.103481

By:

Williamson, David L.;
Kubica, Neil;
Kimball, Scot R.;
Jefferson, Leonard S.

Publication type:

Article

Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle.

Published in:

Journal of Physiology, 2003, v. 553, n. 1, p. 213, doi. 10.1113/jphysiol.2003.047019

By:

Bolster, Douglas R.;
Kubica, Neil;
Crozier, Stephen J.;
Williamson, David L.;
Farrell, Peter A.;
Kimball, Scot R.;
Jefferson, Leonard S.

Publication type:

Article

Palmitate- and C6 ceramide-induced Tnnt3 pre-mRNA alternative splicing occurs in a PP2A dependent manner.

Published in:

Nutrition & Metabolism, 2018, v. 15, n. 1, p. 1, doi. 10.1186/s12986-018-0326-3

By:

Black, Adam J.;
Schilder, Rudolf J.;
Kimball, Scot R.

Publication type:

Article

Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.

Published in:

Journal of Cellular Biochemistry, 2000, v. 79, n. 3, p. 427, doi. 10.1002/1097-4644(20001201)79:3<427::AID-JCB80>3.0.CO;2-0

By:

Pham, Phuong-Truc T.;
Heydrick, Stan J.;
Fox, Heather L.;
Kimball, Scot R.;
Jefferson,, Leonard S.;
Lynch, Christopher J.

Publication type:

Article

Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes.

Published in:

Journal of Cellular Biochemistry, 2000, v. 77, n. 2, p. 234, doi. 10.1002/(SICI)1097-4644(20000501)77:2<234::AID-JCB7>3.0.CO;2-I

By:

Lynch, Christopher J.;
Fox, Heather L.;
Vary, Thomas C.;
Jefferson, Leonard S.;
Kimball, Scot R.

Publication type:

Article

Acute Alcohol-Induced Decrease in Muscle Protein Synthesis in Female Mice Is REDD-1 and mTOR-Independent.

Published in:

Alcohol & Alcoholism, 2016, v. 51, n. 3, p. 242, doi. 10.1093/alcalc/agv105

By:

Steiner, Jennifer L.;
Kimball, Scot R.;
Lang, Charles H.

Publication type:

Article

Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling.

Published in:

Proceedings of the Nutrition Society, 2004, v. 63, n. 2, p. 351, doi. 10.1079/PNS2004355

By:

Bolster, Douglas R.;
Jefferson, Leonard S.;
Kimball, Scot R.

Publication type:

Article

Exercise Attenuates Ribosomal Protein Six Phosphorylation in Fatty Liver Disease.

Published in:

Digestive Diseases & Sciences, 2020, v. 65, n. 11, p. 3238, doi. 10.1007/s10620-020-06226-1

By:

Stine, Jonathan G.;
Xu, Dandan;
Schmitz, Kathryn;
Sciamanna, Christopher;
Kimball, Scot R.

Publication type:

Article

IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis.

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 16, p. 2761, doi. 10.1128/MCB.00215-15

By:

Jae-Seon So;
Sungyun Cho;
Sang-Hyun Min;
Kimball, Scot R.;
Ann-Hwee Lee

Publication type:

Article

Exercise Is Medicine for Nonalcoholic Fatty Liver Disease: Exploration of Putative Mechanisms.

Published in:

Nutrients, 2023, v. 15, n. 11, p. 2452, doi. 10.3390/nu15112452

By:

Heinle, James Westley;
DiJoseph, Kara;
Sabag, Angelo;
Oh, Sechang;
Kimball, Scot R.;
Keating, Shelley;
Stine, Jonathan G.

Publication type:

Article

Serum Fibroblast Growth Factor 21 Is Markedly Decreased following Exercise Training in Patients with Biopsy-Proven Nonalcoholic Steatohepatitis.

Published in:

Nutrients, 2023, v. 15, n. 6, p. 1481, doi. 10.3390/nu15061481

By:

Stine, Jonathan G.;
Welles, Jaclyn E.;
Keating, Shelley;
Hussaini, Zeba;
Soriano, Christopher;
Heinle, J. Wes;
Geyer, Nathaniel;
Chinchilli, Vernon M.;
Loomba, Rohit;
Kimball, Scot R.

Publication type:

Article

Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells.

Published in:

Autophagy, 2013, v. 9, n. 2, p. 208, doi. 10.4161/auto.22801

By:

Yan Cheng;
Xingcong Ren;
Yi Zhang;
Yu Shan;
Huber-Keener, Kathryn J.;
Li Zhang;
Kimball, Scot R.;
Harvey, Harold;
Jeferson, Leonard S.;
Jin-Ming Yang

Publication type:

Article

Factors Affecting Secretory Protein Production in Primary Cultures of Rat Hepatocytes.

Published in:

Proceedings of the Society for Experimental Biology & Medicine, 1993, v. 203, n. 1, p. 38, doi. 10.3181/00379727-203-43570

By:

Dahn, Michael S.;
Hsu, Ching Ju;
Lange, M. Patricia;
Kimball, Scot R.;
Jefferson, Leonard S.

Publication type:

Article

Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation.

Published in:

FASEB Journal, 2018, v. 32, n. 12, p. 6883, doi. 10.1096/fj.201800413RR

By:

Weiwei Dai;
Miller, William P.;
Toro, Allyson L.;
Black, Adam J.;
Dierschke, Sadie K.;
Feehan, Robert P.;
Kimball, Scot R.;
Dennis, Michael D.

Publication type:

Article

RhoA regulates the mechanistic target of rapamycin complex 1 (mTORC1).

Published in:

FASEB Journal, 2013, v. 27, p. 603.3, doi. 10.1096/fasebj.27.1_supplement.603.3

By:

Gordon, Bradley S.;
Kazi, Abid A.;
Coleman, Catherine S.;
Jefferson, Leonard S.;
Chau, Vincent;
Kimball, Scot R.

Publication type:

Article

Molecular Basis for Anabolic Resistance in Disuse Atrophy of Skeletal Muscle.

Published in:

FASEB Journal, 2013, v. 27, p. 1199.3, doi. 10.1096/fasebj.27.1_supplement.1199.3

By:

Kelleher, Andrew Ryan;
Kimball, Scot R;
Dennis, Michael D;
Schilder, Rudolf J;
Jefferson, Leonard S

Publication type:

Article

Hyperglycemia mediates a shift from cap‐dependent to capindependent mRNA translation through a 4E‐BP1 dependent mechanism.

Published in:

FASEB Journal, 2013, v. 27, p. 1080.5, doi. 10.1096/fasebj.27.1_supplement.1080.5

By:

Dennis, Michael D;
Kimball, Scot R;
Jefferson, Leonard S

Publication type:

Article

Repressed elF2B-epsilon expression delays tumor growth in transformed mouse embryonic fibroblasts (TMEF).

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A651, doi. 10.1096/fasebj.21.5.a651-b

By:

Gallagher, James Walter;
Kubica, Neil;
Kimball, Scot R.;
Jefferson, Leonard S.

Publication type:

Article

Dexamethasone represses signaling through mammalian target of rapamycin (mTOR) in muscle cells by enhancing expression of REDD1.

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A651, doi. 10.1096/fasebj.21.5.a651-a

By:

Kimball, Scot R.;
Hongmei Wang;
Kubica, Neil;
Ellisen, Leif W.;
Jefferson, Leonard S.

Publication type:

Article

mTORC1-Independent Reduction of Retinal Protein Synthesis in Type 1 Diabetes.

Published in:

Diabetes, 2014, v. 63, n. 9, p. 3077, doi. 10.2337/db14-0235

By:

Fort, Patrice E.;
Losiewicz, Mandy K.;
Pennathur, Subramaniam;
Jefferson, Leonard S.;
Kimball, Scot R.;
Abcouwer, Steven F.;
Gardner, Thomas W.

Publication type:

Article

Hyperglycemia Mediates a Shift From Cap-Dependent to Cap-Independent Translation Via a 4E-BP1--Dependent Mechanism.

Published in:

Diabetes, 2013, v. 62, n. 7, p. 2204, doi. 10.2337/db12-1453

By:

Dennis, Michael D.;
Shenberger, Jeffrey S.;
Stanley, Bruce A.;
Kimball, Scot R.;
Jefferson, Leonard S.

Publication type:

Article

Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture.

Published in:

2010

By:

Schrufer TL;
Antonetti DA;
Sonenberg N;
Kimball SR;
Gardner TW;
Jefferson LS;
Schrufer, Tabitha L;
Antonetti, David A;
Sonenberg, Nahum;
Kimball, Scot R;
Gardner, Thomas W;
Jefferson, Leonard S

Publication type:

journal article

Ablation of 4E-BP1/2 Prevents Hyperglycemia-Mediated Induction of VEGF Expression in the Rodent Retina and in Müller Cells in Culture.

Published in:

Diabetes, 2010, v. 59, n. 9, p. 2107, doi. 10.2337/db10-0148

By:

Schrufer, Tabitha L.;
Antonetti, David A.;
Sonenberg, Nahum;
Kimball, Scot R.;
Gardner, Thomas W.;
Jefferson, Leonard S.

Publication type:

Article

Rapid Impairment of Retinal Protein Synthesis: A Potential Mechanism for Cellular Dysfunction in Diabetic Retinopathy.

Published in:

Diabetes, 2007, v. 56, p. A216

By:

Fort, Patrice E.;
Singh, Ravi S.;
Losiewicz, Mandy K.;
Reiter, Chad E.;
Freeman, Willard M.;
Gilbert, Kirk A.;
Jefferson, Leonard S.;
Kimball, Scot R.;
Gardner, Thomas W.

Publication type:

Article

Diabetic Retinopathy.

Published in:

Diabetes, 2006, v. 55, n. 9, p. 2401, doi. 10.2337/db05-1635

By:

Antonetti, David A.;
Barber, Alistair J.;
Bronson, Sarah K.;
Freeman, Willard M.;
Gardner, Thomas W.;
Jefferson, Leonard S.;
Kester, Mark;
Kimball, Scot R.;
Krady, J. Kyle;
LaNoue, Kathryn F.;
Norbury, Christopher C.;
Quinn, Patrick G.;
Sandirasegarane, Lakshman;
Simpson, Ian A.

Publication type:

Article

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.

Published in:

Nature Cell Biology, 2012, v. 14, n. 2, p. 192, doi. 10.1038/ncb2408

By:

Woo, Connie W.;
Kutzler, Lydia;
Kimball, Scot R.;
Tabas, Ira

Publication type:

Article

Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras.

Published in:

Journal of Pineal Research, 2008, v. 44, n. 4, p. 379, doi. 10.1111/j.1600-079X.2007.00539.x

By:

Kimball, Scot R.;
Abbas, Ahmed;
Jefferson, Leonard S.

Publication type:

Article

Disruption of Genes Encoding eIF4E Binding Proteins-1 And -2 Does Not Alter Basal or Sepsis-Induced Changes in Skeletal Muscle Protein Synthesis in Male or Female Mice.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0099582

By:

Steiner, Jennifer L.;
Pruznak, Anne M.;
Deiter, Gina;
Navaratnarajah, Maithili;
Kutzler, Lydia;
Kimball, Scot R.;
Lang, Charles H.

Publication type:

Article

Post-Translational Processing of Synaptophysin in the Rat Retina Is Disrupted by Diabetes.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044711

By:

D'Cruz, Travis S.;
Weibley, Brittany N.;
Kimball, Scot R.;
Barber, Alistair J.;
Linden, Rafael

Publication type:

Article

Multi-Modal Proteomic Analysis of Retinal Protein Expression Alterations in a Rat Model of Diabetic Retinopathy.

Published in:

PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0016271

By:

VanGuilder, Heather D.;
Bixler, Georgina V.;
Kutzler, Lydia;
Brucklacher, Robert M.;
Bronson, Sarah K.;
Kimball, Scot R.;
Freeman, Willard M.

Publication type:

Article

Effects of age and hindlimb immobilization and remobilization on fast troponin T precursor mRNA alternative splicing in rat gastrocnemius muscle.

Published in:

Applied Physiology, Nutrition & Metabolism, 2016, v. 41, n. 2, p. 142, doi. 10.1139/apnm-2015-0381

By:

Ravi, Suhana;
Schilder, Rudolf J.;
Berg, Arthur S.;
Kimball, Scot R.

Publication type:

Article

Influence of ageing and essential amino acids on quantitative patterns of troponin T alternative splicing in human skeletal muscle.

Published in:

Applied Physiology, Nutrition & Metabolism, 2015, v. 40, n. 8, p. 788, doi. 10.1139/apnm-2014-0568

By:

Coble, Joel;
Schilder, Rudolf J.;
Berg, Arthur;
Drummond, Micah J.;
Rasmussen, Blake B.;
Kimball, Scot R.

Publication type:

Article

Intermittent Bolus Feeding Enhances Organ Growth More Than Continuous Feeding in a Neonatal Piglet Model.

Published in:

Current Developments in Nutrition, 2020, v. 4, n. 12, p. 1, doi. 10.1093/cdn/nzaa170

By:

El-Kadi, Samer W;
Boutry-Regard, Claire;
Suryawan, Agus;
Nguyen, Hanh V;
Kimball, Scot R;
Fiorotto, Marta L;
Davis, Teresa A

Publication type:

Article

Preventing loss of sirt1 lowers mitochondrial oxidative stress and preserves C2C12 myotube diameter in an in vitro model of cancer cachexia.

Published in:

Physiological Reports, 2024, v. 12, n. 13, p. 1, doi. 10.14814/phy2.16103

By:

Hain, Brian A.;
Kimball, Scot R.;
Waning, David L.

Publication type:

Article

Tissue‐specific expression differences in Ras‐related GTP‐binding proteins in male rats.

Published in:

Physiological Reports, 2024, v. 12, n. 3, p. 1, doi. 10.14814/phy2.15928

By:

Kincheloe, Gregory N.;
Roberson, Paul A.;
Jefferson, Leonard S.;
Kimball, Scot R.

Publication type:

Article

Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast‐immobilized mouse hindlimb.

Published in:

Physiological Reports, 2018, v. 6, n. 20, p. N.PAG, doi. 10.14814/phy2.13891

By:

Shimkus, Kevin L.;
Jefferson, Leonard S.;
Gordon, Bradley S.;
Kimball, Scot R.

Publication type:

Article

REDD1 enhances protein phosphatase 2A–mediated dephosphorylation of Akt to repress mTORC1 signaling.

Published in:

Science Signaling, 2014, v. 7, n. 335, p. 1, doi. 10.1126/scisignal.2005103

By:

Dennis, Michael D.;
Coleman, Catherine S.;
Berg, Arthur;
Jefferson, Leonard S.;
Kimball, Scot R.

Publication type:

Article

Podocyte-Specific Expression of the Stress Response Protein REDD1 Is Necessary for Diabetes-Induced Podocytopenia.

Published in:

Diabetes, 2025, v. 74, n. 3, p. 398, doi. 10.2337/db24-0533

By:

Sunilkumar, Siddharth;
Yerlikaya, Esma I.;
Toro, Allyson L.;
Chen, Han;
Zhou, Yandong;
Gill, Donald L.;
Kimball, Scot R.;
Dennis, Michael D.

Publication type:

Article