Works by Khosla, Chaitan

Results: 71

In Living Color: Bacterial Pigments as an Untapped Resource in the Classroom and Beyond.

Published in:

PLoS Biology, 2010, v. 8, n. 10, p. 1, doi. 10.1371/journal.pbio.1000510

By:

Charkoudian, Louise K.;
Fitzgerald, Jay T.;
Khosla, Chaitan;
Champlin, Andrea

Publication type:

Article

Transglutaminase 2 Undergoes a Large Conformational Change upon Activation.

Published in:

PLoS Biology, 2007, v. 5, n. 12, p. e327, doi. 10.1371/journal.pbio.0050327

By:

Pinkas, Daniel M.;
Strop, Pavel;
Brunger, Axel T.;
Khosla, Chaitan

Publication type:

Article

Bioassay-Guided Evolution of Glycosylated Macrolide Antibiotics in Escherichia coli.

Published in:

PLoS Biology, 2007, v. 5, n. 2, p. 243, doi. 10.1371/journal.pbio.0050045

By:

Ho Young Lee;
Khosla, Chaitan

Publication type:

Article

Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases.

Published in:

PLoS Biology, 2004, v. 2, n. 2, p. 1, doi. 10.1371/journal.pbio.0020031

By:

Tang, Yi;
Lee, Taek Soon;
Khosla, Chaitan

Publication type:

Article

Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases.

Published in:

PLoS Biology, 2004, v. 2, n. 2, p. 0227, doi. 10.1371/journal.pbio.0020031

By:

Yi Tang;
Taek Soon Lee;
Chaitan Khosla

Publication type:

Article

Chain Elongation, Macrolactonization, and Hydrolysis of Natural and Reduced Hexaketide Substrates by the Picromycin/Methymycin Polyketide Synthase.

Published in:

Angewandte Chemie, 2005, v. 117, n. 46, p. 7729, doi. 10.1002/ange.200502246

By:

Jiaquan Wu;
Weiguo He;
Chaitan Khosla;
David E. Cane

Publication type:

Article

Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas.

Published in:

Journal of Neuro-Oncology, 2011, v. 103, n. 2, p. 207, doi. 10.1007/s11060-010-0379-2

By:

Yuan, Liya;
Holmes, Tracy;
Watts, R.;
Khosla, Chaitan;
Broekelmann, Tom;
Mecham, Robert;
Zheng, Hong;
Izaguirre, Enrique;
Rich, Keith

Publication type:

Article

Tissue transgluaminase 2 expression in meningiomas.

Published in:

Journal of Neuro-Oncology, 2008, v. 90, n. 2, p. 125, doi. 10.1007/s11060-008-9642-1

By:

Liya Yuan;
Amir Behdad;
Matthew Siegel;
Chaitan Khosla;
Ryuji Higashikubo

Publication type:

Article

Cholestyramine as a promising, strong anion exchange resin for direct capture of genetic biomarkers from raw pancreatic fluids.

Published in:

Biotechnology & Bioengineering, 2017, v. 114, n. 4, p. 934, doi. 10.1002/bit.26207

By:

Hilmer, Andrew J.;
Jeffrey, R. Brooke;
Park, Walter G.;
Khosla, Chaitan

Publication type:

Article

A scaleable manufacturing process for pro-EP-B2, a cysteine protease from barley indicated for celiac sprue.

Published in:

Biotechnology & Bioengineering, 2007, v. 98, n. 1, p. 177, doi. 10.1002/bit.21423

By:

Vora, Harmit;
McIntire, James;
Kumar, Pawan;
Deshpande, Milind;
Khosla, Chaitan

Publication type:

Article

Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: Implications for Celiac Sprue therapy.

Published in:

Biotechnology & Bioengineering, 2005, v. 92, n. 6, p. 674, doi. 10.1002/bit.20643

By:

Gass, Jonathan;
Ehren, Jennifer;
Strohmeier, Gregg;
Isaacs, Indu;
Khosla, Chaitan

Publication type:

Article

Engineering of molecular and cellular biocatalysts: Selected contributions by James E. Bailey.

Published in:

Biotechnology & Bioengineering, 2002, v. 79, n. 5, p. 490, doi. 10.1002/bit.10404

By:

Dordick, Jonathan S.;
Khosla, Chaitan

Publication type:

Article

Generation of food-grade recombinant Lactobacillus casei delivering Myxococcus xanthus prolyl endopeptidase.

Published in:

Applied Microbiology & Biotechnology, 2014, v. 98, n. 15, p. 6689, doi. 10.1007/s00253-014-5730-7

By:

Alvarez-Sieiro, Patricia;
Martin, Maria;
Redruello, Begoña;
Rio, Beatriz;
Ladero, Victor;
Palanski, Brad;
Khosla, Chaitan;
Fernandez, Maria;
Alvarez, Miguel

Publication type:

Article

From Active Sites to Machines: A Challenge for Enzyme Chemists.

Published in:

Israel Journal of Chemistry, 2019, v. 59, n. 1/2, p. 37, doi. 10.1002/ijch.201800098

By:

Khosla, Chaitan

Publication type:

Article

Discovery and Mechanism of Type III Secretion System Inhibitors.

Published in:

Israel Journal of Chemistry, 2013, v. 53, n. 8, p. 577, doi. 10.1002/ijch.201300025

By:

May, Aaron Elijah;
Khosla, Chaitan

Publication type:

Article

Intracellular TG2 Activity Increases Microtubule Stability but is not Sufficient to Prompt Neurite Growth.

Published in:

2017

By:

Guo, Shunling;
Palanski, Brad;
Kloeck, Cornelius;
Khosla, Chaitan;
Cui, Bianxiao

Publication type:

Letter

CYP3A4-Catalyzed Simvastatin Metabolism as a Non-Invasive Marker of Small Intestinal Health in Celiac Disease.

Published in:

American Journal of Gastroenterology (Springer Nature), 2013, v. 108, n. 8, p. 1344, doi. 10.1038/ajg.2013.151

By:

Morón, Belén;
Verma, Anil K;
Das, Prasenjit;
Taavela, Juha;
Dafik, Laila;
DiRaimondo, Thomas R;
Albertelli, Megan A;
Kraemer, Thomas;
Mäki, Markku;
Khosla, Chaitan;
Rogler, Gerhard;
Makharia, Govind K

Publication type:

Article

ABCA1 rare variants interact with APOE isoforms to confer Alzheimer's Disease risk.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.092053

By:

Peña‐Tauber, Andrés;
Arriaza, Ricardo Hernandez;
Guen, Yann Le;
Khosla, Chaitan;
Greicius, Michael D

Publication type:

Article

Biochemistry: Fit for an enzyme.

Published in:

Nature, 2008, v. 454, n. 7206, p. 832, doi. 10.1038/454832a

By:

Kapur, Shiven;
Khosla, Chaitan

Publication type:

Article

An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28353-1

By:

Palanski, Brad A.;
Weng, Nielson;
Zhang, Lichao;
Hilmer, Andrew J.;
Fall, Lalla A.;
Swaminathan, Kavya;
Jabri, Bana;
Sousa, Carolina;
Fernandez-Becker, Nielsen Q.;
Khosla, Chaitan;
Elias, Joshua E.

Publication type:

Article

Evaluation of Acebilustat, a Selective Inhibitor of Leukotriene B4 Biosynthesis, for Treatment of Outpatients With Mild-Moderate Coronavirus Disease 2019: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial.

Published in:

Clinical Infectious Diseases, 2023, v. 77, n. 2, p. 186, doi. 10.1093/cid/ciad187

By:

Levitt, Joseph E;
Hedlin, Haley;
Duong, Sophie;
Lu, Di;
Lee, Justin;
Bunning, Bryan;
Elkarra, Nadia;
Pinsky, Benjamin A;
Heffernan, Eileen;
Springman, Eric;
Moss, Richard B;
Bonilla, Hector F;
Parsonnet, Julie;
Zamanian, Roham T;
Langguth, Jamison J;
Bollyky, Jenna;
Khosla, Chaitan;
Nicolls, Mark R;
Desai, Manisha;
Rogers, Angela J

Publication type:

Article

Biochemistry-engineering interface in biochemical engineering.

Published in:

AIChE Journal, 2002, v. 48, n. 7, p. 1366, doi. 10.1002/aic.690480702

By:

Khosla, Chaitan

Publication type:

Article

A tribute to Professor Jay Bailey: A pioneer in biochemical engineering.

Published in:

AIChE Journal, 2018, v. 64, n. 12, p. 4179, doi. 10.1002/aic.16441

By:

Khosla, Chaitan;
Clark, Douglas S.;
Chen, Wilfred

Publication type:

Article

Modular Biocatalysts.

Published in:

AIChE Journal, 2009, v. 55, n. 8, p. 1926, doi. 10.1002/aic.11981

By:

Khosla, Chaitan

Publication type:

Article

Latiglutenase Improves Symptoms in Seropositive Celiac Disease Patients While on a Gluten-Free Diet.

Published in:

2017

By:

Syage, Jack;
Murray, Joseph;
Green, Peter;
Khosla, Chaitan;
Syage, Jack A;
Murray, Joseph A;
Green, Peter H R

Publication type:

journal article

Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 7, p. 859, doi. 10.1038/ja.2017.38

By:

Vandova, Gergana A;
O'Brien, Robert V;
Lowry, Brian;
Robbins, Thomas F;
Fischer, Curt R;
Davis, Ronald W;
Khosla, Chaitan;
Harvey, Colin JB;
Hillenmeyer, Maureen E

Publication type:

Article

Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases.

Published in:

Journal of Antibiotics, 2016, v. 69, n. 7, p. 507, doi. 10.1038/ja.2016.41

By:

Ostrowski, Matthew P;
Cane, David E;
Khosla, Chaitan

Publication type:

Article

Computational identification and analysis of orphan assembly-line polyketide synthases.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 1, p. 89, doi. 10.1038/ja.2013.125

By:

O'Brien, Robert V;
Davis, Ronald W;
Khosla, Chaitan;
Hillenmeyer, Maureen E

Publication type:

Article

In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei.

Published in:

Journal of Antibiotics, 2011, v. 64, n. 12, p. 799, doi. 10.1038/ja.2011.94

By:

Fitzgerald, Jay T;
Henrich, Philipp P;
O'Brien, Connor;
Krause, Michael;
Ekland, Eric H;
Mattheis, Corinna;
Sá, Juliana M;
Fidock, David;
Khosla, Chaitan

Publication type:

Article

Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally designed analogs in a heterologous host.

Published in:

Journal of Antibiotics, 2011, v. 64, n. 12, p. 759, doi. 10.1038/ja.2011.86

By:

Fitzgerald, Jay T;
Ridley, Christian P;
Khosla, Chaitan

Publication type:

Article

Improved precursor-directed biosynthesis in E. coli via directed evolution.

Published in:

Journal of Antibiotics, 2011, v. 64, n. 1, p. 59, doi. 10.1038/ja.2010.129

By:

Lee, Ho Young;
Harvey, Colin J B;
Cane, David E;
Khosla, Chaitan

Publication type:

Article

Heterologous expression of a bacterial haemoglobin improves the growth properties of recombinant Escherichia coli.

Published in:

Nature, 1988, v. 331, n. 6157, p. 633, doi. 10.1038/331633a0

By:

Khosla, Chaitan;
Bailey, James E.

Publication type:

Article

Regulation of the activities of the mammalian transglutaminase family of enzymes.

Published in:

Protein Science: A Publication of the Protein Society, 2012, v. 21, n. 12, p. 1781, doi. 10.1002/pro.2162

By:

Klöck, Cornelius;
Khosla, Chaitan

Publication type:

Article

Probing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase.

Published in:

Protein Science: A Publication of the Protein Society, 2011, v. 20, n. 7, p. 1244, doi. 10.1002/pro.652

By:

Charkoudian, Louise K.;
Liu, Corey W.;
Capone, Stefania;
Kapur, Shiven;
Cane, David E.;
Togni, Antonio;
Seebach, Dieter;
Khosla, Chaitan

Publication type:

Article

Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase.

Published in:

Protein Science: A Publication of the Protein Society, 2007, v. 16, n. 10, p. 2093, doi. 10.1110/ps.073011407

By:

Alekseyev, Viktor Y.;
Liu, Corey W.;
Cane, David E.;
Puglisi, Joseph D.;
Khosla, Chaitan

Publication type:

Article

Evolutionally guided enzyme design.

Published in:

Biotechnology & Bioengineering, 1996, v. 52, n. 1, p. 122, doi. 10.1002/(SICI)1097-0290(19961005)52:1<122::AID-BIT12>3.0.CO;2-Q

By:

Khosla, Chaitan;
Caren, Robert;
Kao, Camilla M.;
McDaniel, Robert;
Wang, Szu-Wen

Publication type:

Article

Challenges in Harnessing Shared Within-Host Severe Acute Respiratory Syndrome Coronavirus 2 Variation for Transmission Inference.

Published in:

Open Forum Infectious Diseases, 2023, v. 10, n. 2, p. 1, doi. 10.1093/ofid/ofad001

By:

Walter, Katharine S;
Kim, Eugene;
Verma, Renu;
Altamirano, Jonathan;
Leary, Sean;
Carrington, Yuan J;
Jagannathan, Prasanna;
Singh, Upinder;
Holubar, Marisa;
Subramanian, Aruna;
Khosla, Chaitan;
Maldonado, Yvonne;
Andrews, Jason R

Publication type:

Article

SARS-CoV-2 Subgenomic RNA Kinetics in Longitudinal Clinical Samples.

Published in:

Open Forum Infectious Diseases, 2021, v. 8, n. 7, p. 1, doi. 10.1093/ofid/ofab310

By:

Verma, Renu;
Kim, Eugene;
Martínez-Colón, Giovanny Joel;
Jagannathan, Prasanna;
Rustagi, Arjun;
Parsonnet, Julie;
Bonilla, Hector;
Khosla, Chaitan;
Holubar, Marisa;
Subramanian, Aruna;
Singh, Upinder;
Maldonado, Yvonne;
Blish, Catherine A;
Andrews, Jason R

Publication type:

Article

Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation

Published in:

FEBS Letters, 2006, v. 580, n. 9, p. 2351, doi. 10.1016/j.febslet.2006.03.051

By:

Strnad, Pavel;
Siegel, Matthew;
Toivola, Diana M.;
Choi, Kihang;
Kosek, Jon C.;
Khosla, Chaitan;
Omary, M. Bishr

Publication type:

Article

Quo vadis, enzymology?

Published in:

Nature Chemical Biology, 2015, v. 11, n. 7, p. 438, doi. 10.1038/nchembio.1844

By:

Khosla, Chaitan

Publication type:

Article

Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3.

Published in:

Malaria Journal, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1475-2875-13-210

By:

Le, Binh V.;
Klöck, Cornelius;
Schatz, Alexandra;
Nguyen, Jennifer B.;
Kakani, Evdoxia G.;
Catteruccia, Flaminia;
Khosla, Chaitan;
Baxter, Richard H. G.

Publication type:

Article

Parallels between Pathogens and Gluten Peptides in Celiac Sprue.

Published in:

PLoS Pathogens, 2008, v. 4, n. 2, p. 0001, doi. 10.1371/journal.ppat.0040034

By:

Bethune, Michael T.;
Khosla, Chaitan

Publication type:

Article

Investigating Nonribosomal Peptide and Polyketide Biosynthesis by Direct Detection of Intermediates on >70 kDa Polypeptides by Using Fourier-Transform Mass Spectrometry.

Published in:

ChemBioChem, 2006, v. 7, n. 6, p. 904, doi. 10.1002/cbic.200500416

By:

Leslie M. Hicks;
Matthew T. Mazur;
Leah M. Miller;
Pieter C. Dorrestein;
Nathan A. Schnarr;
Chaitan Khosla;
Neil L. Kelleher

Publication type:

Article

Chain Elongation, Macrolactonization, and Hydrolysis of Natural and Reduced Hexaketide Substrates by the Picromycin/Methymycin Polyketide SynthaseThis research was supported by NIH Grants GM22172 (D.E.C) and CA66736 (C.K.).

Published in:

Angewandte Chemie International Edition, 2005, v. 44, n. 46, p. 7557, doi. 10.1002/anie.200502246

By:

Jiaquan Wu;
Weiguo He;
Chaitan Khosla;
David E. Cane

Publication type:

Article

Orthogonal Protein Interactions in Spore Pigment Producing and Antibiotic Producing Polyketide Synthases.

Published in:

Journal of Antibiotics, 2005, v. 58, n. 10, p. 663, doi. 10.1038/ja.2005.91

By:

Lee, Taek Soon;
Khosla, Chaitan;
Tang, Yi

Publication type:

Article

Nichtproteinogene Aminosäurebausteine für Peptidgerüste aus nichtribosomalen Peptiden und hybriden Polyketiden.

Published in:

Angewandte Chemie, 2013, v. 125, n. 28, p. 7238, doi. 10.1002/ange.201208344

By:

Walsh, Christopher T.;
O'Brien, Robert V.;
Khosla, Chaitan

Publication type:

Article

Resolving Multiple Protein-Peptide Binding Events: Implication for HLA-DQ2 Mediated Antigen Presentation in Celiac Disease.

Published in:

Chemistry - An Asian Journal, 2012, v. 7, n. 5, p. 992, doi. 10.1002/asia.201101041

By:

Wang, Jianhao;
Jin, Xi;
Liu, Jiahui;
Khosla, Chaitan;
Xia, Jiang

Publication type:

Article

Inhibition of Tubulogenesis and of Carcinogen-mediated Signaling in Brain Endothelial Cells Highlight the Antiangiogenic Properties of a Mumbaistatin Analog.

Published in:

Chemical Biology & Drug Design, 2010, v. 75, n. 5, p. 481, doi. 10.1111/j.1747-0285.2010.00961.x

By:

Tahanian, Elizabeth;
Lord-Dufour, Simon;
Das, Abhirup;
Khosla, Chaitan;
Roy, René;
Annabi, Borhane

Publication type:

Article

Enhancing the Atom Economy of Polyketide Biosynthetic Processes through Metabolic Engineering.

Published in:

Biotechnology Progress, 2001, v. 17, n. 4, p. 612, doi. 10.1021/bp010045j

By:

Lombó, Felipe;
Pfeifer, Blaine;
Leaf, Timothy;
Ou, Sally;
Kim, Y. S.;
Cane, David E.;
Licari, Peter;
Khosla, Chaitan

Publication type:

Article

An antibiotic factory caught in action.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 9, p. 888, doi. 10.1038/nsmb808

By:

Keatinge-Clay, Adrian T.;
Maltby, David A.;
Medzihradszky, Katalin F.;
Khosla, Chaitan;
Stroud, Robert M.

Publication type:

Article