Works by Kettenberger, Hubert

Results: 18

Procollagen-lysine 2-oxoglutarate 5-dioxygenases are responsible for 5R-hydroxylysine modification of therapeutic T-cell bispecific monoclonal antibodies produced by Chinese hamster ovary cells.

Published in:

Frontiers in Bioengineering & Biotechnology, 2024, p. 1, doi. 10.3389/fbioe.2024.1414408

By:

Bauer, Niels;
Boettger, Marco;
Papadaki, Styliani;
Leitner, Tanja;
Klostermann, Stefan;
Kettenberger, Hubert;
Georges, Guy;
Larraillet, Vincent;
Gluhacevic von Kruechten, Dino;
Hillringhaus, Lars;
Vogt, Annette;
Ausländer, Simon;
Popp, Oliver

Publication type:

Article

Structure of an RNA polymerase II–RNA inhibitor complex elucidates transcription regulation by noncoding RNAs.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 1, p. 44, doi. 10.1038/nsmb1032

By:

Kettenberger, Hubert;
Eisenführ, Alexander;
Brueckner, Florian;
Theis, Mirko;
Famulok, Michael;
Cramer, Patrick

Publication type:

Article

Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies.

Published in:

AAPS Open, 2022, v. 8, n. 1, p. 1, doi. 10.1186/s41120-021-00048-9

By:

Stüber, Jakob C.;
Rechberger, Karin F.;
Miladinović, Saša M.;
Pöschinger, Thomas;
Zimmermann, Tamara;
Villenave, Remi;
Eigenmann, Miro J.;
Kraft, Thomas E.;
Shah, Dhaval K.;
Kettenberger, Hubert;
Richter, Wolfgang F.

Publication type:

Article

Assessing developability early in the discovery process for novel biologics.

Published in:

mAbs (1942-0862), 2023, v. 15, n. 1, p. 1, doi. 10.1080/19420862.2023.2171248

By:

Fernández-Quintero, Monica L.;
Ljungars, Anne;
Waibl, Franz;
Greiff, Victor;
Andersen, Jan Terje;
Gjølberg, Torleif T.;
Jenkins, Timothy P.;
Voldborg, Bjørn Gunnar;
Grav, Lise Marie;
Kumar, Sandeep;
Georges, Guy;
Kettenberger, Hubert;
Liedl, Klaus R.;
Tessier, Peter M.;
McCafferty, John;
Laustsen, Andreas H.

Publication type:

Article

Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies.

Published in:

2021

By:

Liu, Shufang;
Verma, Ashwni;
Kettenberger, Hubert;
Richter, Wolfgang F.;
Shah, Dhaval K.

Publication type:

Report

Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis.

Published in:

2020

By:

Kraft, Thomas E.;
Richter, Wolfgang F.;
Emrich, Thomas;
Knaupp, Alexander;
Schuster, Michaela;
Wolfert, Andreas;
Kettenberger, Hubert

Publication type:

Report

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity.

Published in:

2019

By:

Sustmann, Claudio;
Dickopf, Steffen;
Regula, Jörg T.;
Kettenberger, Hubert;
Mølhøj, Michael;
Gassner, Christian;
Weininger, Diana;
Fenn, Sebastian;
Manigold, Tobias;
Kling, Lothar;
Künkele, Klaus-Peter;
Schwaiger, Manfred;
Bossenmaier, Birgit;
Griese, Julia J.;
Hopfner, Karl-Peter;
Graff-Meyer, Alexandra;
Stahlberg, Henning;
Ringler, Philippe;
Lauer, Matthias E.;
Brinkmann, Ulrich

Publication type:

Report

XGFR*, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic cancer.

Published in:

mAbs (1942-0862), 2016, v. 8, n. 4, p. 811, doi. 10.1080/19420862.2016.1160989

By:

Schanzer, Juergen M.;
Wartha, Katharina;
Moessner, Ekkehard;
Hosse, Ralf J.;
Moser, Samuel;
Croasdale, Rebecca;
Trochanowska, Halina;
Shao, Cuiying;
Wang, Peng;
Shi, Lei;
Weinzierl, Tina;
Rieder, Natascha;
Bacac, Marina;
Ries, Carola H.;
Kettenberger, Hubert;
Schlothauer, Tilman;
Friess, Thomas;
Umana, Pablo;
Klein, Christian

Publication type:

Article

Anti-tumoral, anti-angiogenic and anti-metastatic efficacy of a tetravalent bispecific antibody (TAvi6) targeting VEGF-A and angiopoietin-2.

Published in:

mAbs (1942-0862), 2016, v. 8, n. 3, p. 562, doi. 10.1080/19420862.2016.1147640

By:

Scheuer, Werner;
Thomas, Markus;
Hanke, Petra;
Sam, Johannes;
Osl, Franz;
Weininger, Diana;
Baehner, Monika;
Seeber, Stefan;
Kettenberger, Hubert;
Schanzer, Jürgen;
Brinkmann, Ulrich;
Weidner, K. Michael;
Regula, Jörg;
Klein, Christian

Publication type:

Article

Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies.

Published in:

mAbs (1942-0862), 2012, v. 4, n. 6, p. 653, doi. 10.4161/mabs.21379

By:

Klein, Christian;
Sustmann, Claudio;
Thomas, Markus;
Stubenrauch, Kay;
Croasdale, Rebecca;
Schanzer, Jürgen;
Brinkmann, Ulrich;
Kettenberger, Hubert;
Regula, Jörg T.;
Schaefer, Wolfgang

Publication type:

Article

Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1406643

By:

Siegel, Michel;
Bolender, Anna-Lena;
Ducret, Axel;
Fraidling, Johannes;
Hartman, Katharina;
Looney, Cary M.;
Rohr, Olivier;
Hickling, Timothy P.;
Kettenberger, Hubert;
Lechmann, Martin;
Marban-Doran, Céline;
Kraft, Thomas E.

Publication type:

Article

TriFabs--Trivalent IgG-Shaped Bispecific Antibody Derivatives: Design, Generation, Characterization and Application for Targeted Payload Delivery.

Published in:

International Journal of Molecular Sciences, 2015, v. 16, n. 11, p. 27497, doi. 10.3390/ijms161126037

By:

Mayer, Klaus;
Baumann, Anna-Lena;
Grote, Michael;
Seeber, Stefan;
Kettenberger, Hubert;
Breuer, Sebastian;
Killian, Tobias;
Schäfer, Wolfgang;
Brinkmann, Ulrich

Publication type:

Article

DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-20949-3

By:

Beckmann, Roland;
Jensen, Kristian;
Fenn, Sebastian;
Speck, Janina;
Krause, Katrin;
Meier, Anastasia;
Röth, Melanie;
Fauser, Sascha;
Kimbung, Raymond;
Logan, Derek T.;
Steegmaier, Martin;
Kettenberger, Hubert

Publication type:

Article

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100736

By:

Sydow, Jasmin F.;
Lipsmeier, Florian;
Larraillet, Vincent;
Hilger, Maximiliane;
Mautz, Bjoern;
Mølhøj, Michael;
Kuentzer, Jan;
Klostermann, Stefan;
Schoch, Juergen;
Voelger, Hans R.;
Regula, Joerg T.;
Cramer, Patrick;
Papadimitriou, Apollon;
Kettenberger, Hubert

Publication type:

Article

Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061953

By:

Fenn, Sebastian;
Schiller, Christian B.;
Griese, Julia J.;
Duerr, Harald;
Imhof-Jung, Sabine;
Gassner, Christian;
Moelleken, Joerg;
Regula, Joerg Thomas;
Schaefer, Wolfgang;
Thomas, Markus;
Klein, Christian;
Hopfner, Karl-Peter;
Kettenberger, Hubert

Publication type:

Article

Molecular polygamy: The promiscuity of l-phenylalanyl-tRNA-synthetase triggers misincorporation of meta- and ortho-tyrosine in monoclonal antibodies expressed by Chinese hamster ovary cells.

Published in:

Biotechnology & Bioengineering, 2015, v. 112, n. 6, p. 1187, doi. 10.1002/bit.25528

By:

Popp, Oliver;
Larraillet, Vincent;
Kettenberger, Hubert;
Gorr, Ingo H.;
Hilger, Maximiliane;
Lipsmeier, Florian;
Zeck, Anne;
Beaucamp, Nicola

Publication type:

Article

Radiolabeled IgG antibodies: Impact of various labels on neonatal Fc receptor binding.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2019, v. 62, n. 11, p. 751, doi. 10.1002/jlcr.3793

By:

Edelmann, Martin R.;
Kettenberger, Hubert;
Knaupp, Alexander;
Schlothauer, Tilman;
Otteneder, Michael B.

Publication type:

Article

Germline-Dependent Antibody Paratope States and Pairing Specific V<sub>H</sub>-V<sub>L</sub> Interface Dynamics.

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.675655

By:

Fernández-Quintero, Monica L.;
Kroell, Katharina B.;
Bacher, Lisa M.;
Loeffler, Johannes R.;
Quoika, Patrick K.;
Georges, Guy;
Bujotzek, Alexander;
Kettenberger, Hubert;
Liedl, Klaus R.

Publication type:

Article