Found: 3

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  • The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.

    Published in:
    Cell Death & Disease, 2022, v. 13, n. 4, p. 1, doi. 10.1038/s41419-022-04740-w
    By:
    • Jacobsen, Annette V.;
    • Pierotti, Catia L.;
    • Lowes, Kym N.;
    • Au, Amanda E.;
    • Zhang, Ying;
    • Etemadi, Nima;
    • Fitzgibbon, Cheree;
    • Kersten, Wilhelmus J. A.;
    • Samson, André L.;
    • van Delft, Mark F.;
    • Huang, David C. S.;
    • Sabroux, Hélène Jousset;
    • Lessene, Guillaume;
    • Silke, John;
    • Murphy, James M.
    Publication type:
    Article

  • Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

    Published in:
    Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04714-7
    By:
    • Petrie, Emma J.;
    • Sandow, Jarrod J.;
    • Jacobsen, Annette V.;
    • Smith, Brian J.;
    • Griffin, Michael D. W.;
    • Lucet, Isabelle S.;
    • Weiwen Dai;
    • Young, Samuel N.;
    • Tanzer, Maria C.;
    • Wardak, Ahmad;
    • Lung-Yu Liang;
    • Cowan, Angus D.;
    • Hildebrand, Joanne M.;
    • Kersten, Wilhelmus J. A.;
    • Lessene, Guillaume;
    • Silke, John;
    • Czabotar, Peter E.;
    • Webb, Andrew I.;
    • Murphy, James M.
    Publication type:
    Article

  • Structure-guided design of a selective BCL-X<sub>L</sub> inhibitor.

    Published in:
    Nature Chemical Biology, 2013, v. 9, n. 6, p. 390, doi. 10.1038/nchembio.1246
    By:
    • Lessene, Guillaume;
    • Czabotar, Peter E;
    • Sleebs, Brad E;
    • Zobel, Kerry;
    • Lowes, Kym N;
    • Adams, Jerry M;
    • Baell, Jonathan B;
    • Colman, Peter M;
    • Deshayes, Kurt;
    • Fairbrother, Wayne J;
    • Flygare, John A;
    • Gibbons, Paul;
    • Kersten, Wilhelmus J A;
    • Kulasegaram, Sanji;
    • Moss, Rebecca M;
    • Parisot, John P;
    • Smith, Brian J;
    • Street, Ian P;
    • Yang, Hong;
    • Huang, David C S
    Publication type:
    Article