Works by Kepp, Kasper P.

Results: 38

Accuracy of theoretical catalysis from a model of iron-catalyzed ammonia synthesis.

Published in:

Communications Chemistry, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42004-018-0063-6

By:

Kepp, Kasper P.

Publication type:

Article

Comment on "Associations of semaglutide with first‐time diagnosis of Alzheimer's disease in patients with type 2 diabetes: Target trial emulation using nationwide real‐world data in the US".

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2025, v. 21, n. 5, p. 1, doi. 10.1002/alz.70035

By:

Salehi‐Abargouei, Amin;
Muka, Taulant;
Collet, Tinh‐Hai;
Kepp, Kasper P.;
Chatelan, Angeline

Publication type:

Article

Response to "Variability of cognitive changes after donanemab treatment".

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2025, v. 21, n. 2, p. 1, doi. 10.1002/alz.14520

By:

Daly, Timothy;
Kepp, Kasper P.;
Imbimbo, Bruno P.

Publication type:

Article

Are lecanemab and donanemab disease‐modifying therapies?

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 9, p. 6659, doi. 10.1002/alz.14114

By:

Daly, Timothy;
Kepp, Kasper P.;
Imbimbo, Bruno P.

Publication type:

Article

The Dependence of Amyloid-β Dynamics on Protein Force Fields and Water Models.

Published in:

ChemPhysChem, 2015, v. 16, n. 15, p. 3278, doi. 10.1002/cphc.201500415

By:

Somavarapu, Arun Kumar;
Kepp, Kasper P.

Publication type:

Article

O2 Binding to Heme is Strongly Facilitated by Near-Degeneracy of Electronic States.

Published in:

ChemPhysChem, 2013, v. 14, n. 15, p. 3551, doi. 10.1002/cphc.201300658

By:

Kepp, Kasper P.

Publication type:

Article

The Influence of Selection for Protein Stability on dN/dS Estimations.

Published in:

Genome Biology & Evolution, 2014, v. 6, n. 10, p. 2956, doi. 10.1093/gbe/evu223

By:

Dasmeh, Pouria;
Serohijos, Adrian W.R.;
Kepp, Kasper P.;
Shakhnovich, Eugene I.

Publication type:

Article

Stability and expression of SARS-CoV-2 spike-protein mutations.

Published in:

Molecular & Cellular Biochemistry, 2023, v. 478, n. 6, p. 1269, doi. 10.1007/s11010-022-04588-w

By:

Bæk, Kristoffer T.;
Mehra, Rukmankesh;
Kepp, Kasper P.

Publication type:

Article

Estimates of excess mortality for the five Nordic countries during the COVID-19 pandemic 2020-2021.

Published in:

2022

By:

Kepp, Kasper P;
Björk, Jonas;
Kontis, Vasilis;
Parks, Robbie M;
Bæk, Kristoffer T;
Emilsson, Louise;
Lallukka, Tea

Publication type:

journal article

Communicating scientific evidence: drugs for Alzheimer's disease as a case study.

Published in:

Current Medical Research & Opinion, 2025, v. 41, n. 2, p. 347, doi. 10.1080/03007995.2025.2458530

By:

Kepp, Kasper P.;
Høilund-Carlsen, Poul F.;
Cristea, Ioana A.;
Cumming, Robert G.;
Daly, Timothy;
Emilsson, Louise;
Flacco, Maria E.;
Hemkens, Lars G.;
Janiaud, Perrine;
Johnsen, Kasper B.;
Lallukka, Tea;
Muka, Taulant;
Naudet, Florian;
Revheim, Mona-Elisabeth R.;
Squitti, Rosanna;
Thambisetty, Madhav

Publication type:

Article

Dioxygen Binding to all 3d, 4d, and 5d Transition Metals from Coupled‐Cluster Theory.

Published in:

ChemPhysChem, 2020, v. 21, n. 19, p. 2173, doi. 10.1002/cphc.202000529

By:

Moltved, Klaus A.;
Kepp, Kasper P.

Publication type:

Article

Cover Feature: Chemical Causes of Metal Nobleness (ChemPhysChem 5/2020).

Published in:

ChemPhysChem, 2020, v. 21, n. 5, p. 357, doi. 10.1002/cphc.202000091

By:

Kepp, Kasper P.

Publication type:

Article

Chemical Causes of Metal Nobleness.

Published in:

ChemPhysChem, 2020, v. 21, n. 5, p. 360, doi. 10.1002/cphc.202000013

By:

Kepp, Kasper P.

Publication type:

Article

Performance of Density Functional Theory for Transition Metal Oxygen Bonds.

Published in:

ChemPhysChem, 2019, v. 20, n. 23, p. 3210, doi. 10.1002/cphc.201900862

By:

Moltved, Klaus A.;
Kepp, Kasper P.

Publication type:

Article

Common mechanism of thermostability in small α‐ and β‐proteins studied by molecular dynamics.

Published in:

Proteins, 2020, v. 88, n. 9, p. 1233, doi. 10.1002/prot.25897

By:

Jana, Kalyanashis;
Mehra, Rukmankesh;
Dehury, Budheswar;
Blundell, Tom L.;
Kepp, Kasper P.

Publication type:

Article

Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's disease.

Published in:

Journal of Neurochemistry, 2016, v. 137, n. 1, p. 101, doi. 10.1111/jnc.13535

By:

Somavarapu, Arun Kumar;
Kepp, Kasper P.

Publication type:

Article

The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu2+-Aβ Complex.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 55, p. 13591, doi. 10.1002/chem.201703440

By:

Somavarapu, Arun K.;
Shen, Fei;
Teilum, Kaare;
Zhang, Jingdong;
Mossin, Susanne;
Thulstrup, Peter W.;
Bjerrum, Morten J.;
Tiwari, Manish K.;
Szunyogh, Daniel;
Søtofte, Peter M.;
Kepp, Kasper P.;
Hemmingsen, Lars

Publication type:

Article

Membrane dynamics of γ‐secretase with the anterior pharynx‐defective 1B subunit.

Published in:

Journal of Cellular Biochemistry, 2021, v. 122, n. 1, p. 69, doi. 10.1002/jcb.29832

By:

Dehury, Budheswar;
Kepp, Kasper P.

Publication type:

Article

A structural-chemical explanation of fungal laccase activity.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-35633-8

By:

Mehra, Rukmankesh;
Muschiol, Jan;
Meyer, Anne S.;
Kepp, Kasper P.

Publication type:

Article

Positively Selected Sites in Cetacean Myoglobins Contribute to Protein Stability.

Published in:

PLoS Computational Biology, 2013, v. 9, n. 3, p. 1, doi. 10.1371/journal.pcbi.1002929

By:

Dasmeh, Pouria;
Serohijos, Adrian W. R.;
Kepp, Kasper P.;
Shakhnovich, Eugene I.

Publication type:

Article

Cause-specific excess mortality in Denmark, Finland, Norway, and Sweden during the COVID-19 pandemic 2020–2022: a study using nationwide population data.

Published in:

European Journal of Epidemiology, 2024, v. 39, n. 9, p. 1037, doi. 10.1007/s10654-024-01154-0

By:

Nilsson, Anton;
Emilsson, Louise;
Kepp, Kasper P.;
Knudsen, Ann Kristin Skrindo;
Forthun, Ingeborg;
Madsen, Christian;
Björk, Jonas;
Lallukka, Tea

Publication type:

Article

Data set and fitting dependencies when estimating protein mutant stability: Toward simple, balanced, and interpretable models.

Published in:

Journal of Computational Chemistry, 2022, v. 43, n. 8, p. 504, doi. 10.1002/jcc.26810

By:

Bæk, Kristoffer T.;
Kepp, Kasper P.

Publication type:

Article

The amyloid cascade hypothesis: an updated critical review.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 10, p. 3969, doi. 10.1093/brain/awad159

By:

Kepp, Kasper P;
Robakis, Nikolaos K;
Høilund-Carlsen, Poul F;
Sensi, Stefano L;
Vissel, Bryce

Publication type:

Article

Survival of the cheapest: how proteome cost minimization drives evolution.

Published in:

Quarterly Reviews of Biophysics, 2020, v. 53, p. 1, doi. 10.1017/S0033583520000037

By:

Kepp, Kasper P.

Publication type:

Article

Molecular dynamics of C99-bound γ-secretase reveal two binding modes with distinct compactness, stability, and active-site retention: implications for Aβ production.

Published in:

Biochemical Journal, 2019, v. 476, n. 7, p. 1173, doi. 10.1042/BCJ20190023

By:

Dehury, Budheswar;
Ning Tang;
Kepp, Kasper P.

Publication type:

Article

FDG-PET versus Amyloid-PET Imaging for Diagnosis and Response Evaluation in Alzheimer's Disease: Benefits and Pitfalls.

Published in:

Diagnostics (2075-4418), 2023, v. 13, n. 13, p. 2254, doi. 10.3390/diagnostics13132254

By:

Høilund-Carlsen, Poul F.;
Revheim, Mona-Elisabeth;
Costa, Tommaso;
Kepp, Kasper P.;
Castellani, Rudolph J.;
Perry, George;
Alavi, Abass;
Barrio, Jorge R.

Publication type:

Article

Structural heterogeneity and precision of implications drawn from cryo-electron microscopy structures: SARS-CoV-2 spike-protein mutations as a test case.

Published in:

European Biophysics Journal, 2022, v. 51, n. 7/8, p. 555, doi. 10.1007/s00249-022-01619-8

By:

Mehra, Rukmankesh;
Kepp, Kasper P.

Publication type:

Article

Excess mortality in Denmark, Finland, Norway and Sweden during the COVID-19 pandemic 2020–2022.

Published in:

European Journal of Public Health, 2024, v. 34, n. 4, p. 737, doi. 10.1093/eurpub/ckae091

By:

Forthun, Ingeborg;
Madsen, Christian;
Emilsson, Louise;
Nilsson, Anton;
Kepp, Kasper P;
Björk, Jonas;
Vollset, Stein Emil;
Lallukka, Tea;
Knudsen, Ann Kristin Skrindo

Publication type:

Article

Genotype-Property Patient-Phenotype Relations Suggest that Proteome Exhaustion Can Cause Amyotrophic Lateral Sclerosis.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0118649

By:

Kepp, Kasper P.

Publication type:

Article

Characterization of an Alkali- and Halide-Resistant Laccase Expressed in E. coli: CotA from Bacillus clausii.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0099402

By:

Brander, Søren;
Mikkelsen, Jørn D.;
Kepp, Kasper P.

Publication type:

Article

A Model of Proteostatic Energy Cost and Its Use in Analysis of Proteome Trends and Sequence Evolution.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0090504

By:

Kepp, Kasper P.;
Dasmeh, Pouria

Publication type:

Article

Rational Design of a New Trypanosoma rangeli Trans-Sialidase for Efficient Sialylation of Glycans.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0083902

By:

Jers, Carsten;
Michalak, Malwina;
Larsen, Dorte M.;
Kepp, Kasper P.;
Li, Haiying;
Guo, Yao;
Kirpekar, Finn;
Meyer, Anne S.;
Mikkelsen, Jørn D.

Publication type:

Article

Unfolding Simulations of Holomyoglobin from Four Mammals: Identification of Intermediates and β-Sheet Formation from Partially Unfolded States.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0080308

By:

Dasmeh, Pouria;
Kepp, Kasper P.

Publication type:

Article

Stability Mechanisms of a Thermophilic Laccase Probed by Molecular Dynamics.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061985

By:

Christensen, Niels J.;
Kepp, Kasper P.

Publication type:

Article

Insights into membrane-bound presenilin 2 from all-atom molecular dynamics simulations.

Published in:

Journal of Biomolecular Structure & Dynamics, 2020, v. 38, n. 11, p. 3196, doi. 10.1080/07391102.2019.1655481

By:

Dehury, Budheswar;
Tang, Ning;
Kepp, Kasper P.

Publication type:

Article

β-Amyloid pathogenesis: Chemical properties versus cellular levels.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, n. 2, p. 184, doi. 10.1016/j.jalz.2015.06.1895

By:

Tiwari, Manish K.;
Kepp, Kasper P.

Publication type:

Article

Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data.

Published in:

eNeuro, 2024, v. 11, n. 7, p. 1, doi. 10.1523/ENEURO.0319-23.2024

By:

Espay, Alberto J.;
Kepp, Kasper P.;
Herrup, Karl

Publication type:

Article

A base measure of precision for protein stability predictors: structural sensitivity.

Published in:

BMC Bioinformatics, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s12859-021-04030-w

By:

Caldararu, Octav;
Blundell, Tom L.;
Kepp, Kasper P.

Publication type:

Article

Works by Kepp, Kasper P.

Accuracy of theoretical catalysis from a model of iron-catalyzed ammonia synthesis.

Comment on "Associations of semaglutide with first‐time diagnosis of Alzheimer's disease in patients with type 2 diabetes: Target trial emulation using nationwide real‐world data in the US".

Response to "Variability of cognitive changes after donanemab treatment".

Are lecanemab and donanemab disease‐modifying therapies?

The Dependence of Amyloid-β Dynamics on Protein Force Fields and Water Models.

O<sub>2</sub> Binding to Heme is Strongly Facilitated by Near-Degeneracy of Electronic States.

The Influence of Selection for Protein Stability on dN/dS Estimations.

Stability and expression of SARS-CoV-2 spike-protein mutations.

Estimates of excess mortality for the five Nordic countries during the COVID-19 pandemic 2020-2021.

Communicating scientific evidence: drugs for Alzheimer's disease as a case study.

Dioxygen Binding to all 3d, 4d, and 5d Transition Metals from Coupled‐Cluster Theory.

Cover Feature: Chemical Causes of Metal Nobleness (ChemPhysChem 5/2020).

Chemical Causes of Metal Nobleness.

Performance of Density Functional Theory for Transition Metal Oxygen Bonds.

Common mechanism of thermostability in small α‐ and β‐proteins studied by molecular dynamics.

Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's disease.

The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu<sup>2+</sup>-Aβ Complex.

Membrane dynamics of γ‐secretase with the anterior pharynx‐defective 1B subunit.

A structural-chemical explanation of fungal laccase activity.

Positively Selected Sites in Cetacean Myoglobins Contribute to Protein Stability.

Cause-specific excess mortality in Denmark, Finland, Norway, and Sweden during the COVID-19 pandemic 2020–2022: a study using nationwide population data.

Data set and fitting dependencies when estimating protein mutant stability: Toward simple, balanced, and interpretable models.

The amyloid cascade hypothesis: an updated critical review.

Survival of the cheapest: how proteome cost minimization drives evolution.

Molecular dynamics of C99-bound γ-secretase reveal two binding modes with distinct compactness, stability, and active-site retention: implications for Aβ production.

FDG-PET versus Amyloid-PET Imaging for Diagnosis and Response Evaluation in Alzheimer's Disease: Benefits and Pitfalls.

Structural heterogeneity and precision of implications drawn from cryo-electron microscopy structures: SARS-CoV-2 spike-protein mutations as a test case.

Excess mortality in Denmark, Finland, Norway and Sweden during the COVID-19 pandemic 2020–2022.

Genotype-Property Patient-Phenotype Relations Suggest that Proteome Exhaustion Can Cause Amyotrophic Lateral Sclerosis.

Characterization of an Alkali- and Halide-Resistant Laccase Expressed in <i>E. coli</i>: CotA from <i>Bacillus clausii</i>.

A Model of Proteostatic Energy Cost and Its Use in Analysis of Proteome Trends and Sequence Evolution.

Rational Design of a New <i>Trypanosoma rangeli</i> Trans-Sialidase for Efficient Sialylation of Glycans.

Unfolding Simulations of Holomyoglobin from Four Mammals: Identification of Intermediates and β-Sheet Formation from Partially Unfolded States.

Stability Mechanisms of a Thermophilic Laccase Probed by Molecular Dynamics.

Insights into membrane-bound presenilin 2 from all-atom molecular dynamics simulations.

β-Amyloid pathogenesis: Chemical properties versus cellular levels.

Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data.

A base measure of precision for protein stability predictors: structural sensitivity.