Works by Keogh, Julia M.

Results: 30

Genetic architecture of human thinness compared to severe obesity.

Published in:

PLoS Genetics, 2019, v. 15, n. 1, p. 1, doi. 10.1371/journal.pgen.1007603

By:

Riveros-McKay, Fernando;
Mistry, Vanisha;
Bounds, Rebecca;
Hendricks, Audrey;
Keogh, Julia M.;
Thomas, Hannah;
Henning, Elana;
Corbin, Laura J.;
null, null;
O’Rahilly, Stephen;
Zeggini, Eleftheria;
Wheeler, Eleanor;
Barroso, Inês;
Farooqi, I. Sadaf

Publication type:

Article

Rare variants in single-minded 1 (SIM1) are associated with severe obesity.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 7, p. 3042, doi. 10.1172/JCI68016

By:

Ramachandrappa, Shwetha;
Raimondo, Anne;
Cali, Anna M. G.;
Keogh, Julia M.;
Henning, Elana;
Saeed, Sadia;
Thompson, Amanda;
Garg, Sumedha;
Bochukova, Elena G.;
Brage, Soren;
Trowse, Victoria;
Wheeler, Eleanor;
Sullivan, Adrienne E.;
Dattani, Mehul;
Clayton, Peter E.;
Datta, Vippan;
Bruning, John B.;
Wareham, Nick J.;
O’Rahilly, Stephen;
Peet, Daniel J.

Publication type:

Article

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 12, p. 4732, doi. 10.1172/JCI62696

By:

Doche, Michael E.;
Bochukova, Elena G.;
Hsiao-Wen Su;
Pearce, Laura R.;
Keogh, Julia M.;
Henning, Elana;
Cline, Joel M.;
Dale, Anne;
Cheetham, Tim;
Barroso, Inês;
Argetsinger, Lawrence S.;
O'Rahilly, Stephen;
Liangyou Rui;
Christin Carter-Su;
Farooqi, I. Sadaf

Publication type:

Article

The central melanocortin system directly controls peripheral lipid metabolism.

Published in:

2007

By:

Nogueiras, Ruben;
Wiedmer, Petra;
Perez-Tilve, Diego;
Veyrat-Durebex, Christelle;
Keogh, Julia M.;
Sutton, Gregory M.;
Pfluger, Paul T.;
Castaneda, Tamara R.;
Neschen, Susanne;
Hofmann, Susanna M.;
Howles, Philip N.;
Morgan, Donald A.;
Benoit, Stephen C.;
Szanto, Ildiko;
Schrott, Brigitte;
Schürmann, Annette;
Joost, Hans-Georg;
Hammond, Craig;
Hui, David Y.;
Woods, Stephen C.

Publication type:

journal article

High protein intake stimulates postprandial GLP1 and PYY release.

Published in:

Obesity (19307381), 2013, v. 21, n. 8, p. 1602, doi. 10.1002/oby.20154

By:

Klaauw, Agatha A.;
Keogh, Julia M.;
Henning, Elana;
Trowse, Victoria M.;
Dhillo, Waljit S.;
Ghatei, Mohammad A.;
Farooqi, I. Sadaf

Publication type:

Article

Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying.

Published in:

Clinical Endocrinology, 2022, v. 96, n. 2, p. 270, doi. 10.1111/cen.14615

By:

Seelig, Eleonora;
Henning, Elana;
Keogh, Julia M.;
Gillett, Daniel;
Shin, Evelyn;
Buscombe, John;
van der Klaauw, Agatha A.;
Farooqi, I. Sadaf

Publication type:

Article

Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis.

Published in:

Science Translational Medicine, 2025, v. 17, n. 781, p. 1, doi. 10.1126/scitranslmed.adr6459

By:

Xu, Baijie;
Lawler, Katherine;
Wyler, Steven C.;
Li, Li;
Swati;
Keogh, Julia M.;
Chen, Xiameng;
Wan, Rong;
Almeida, Amanda G.;
Kirsch, Susan;
Mountjoy, Kathleen G.;
Elmquist, Joel K.;
Farooqi, I. Sadaf;
Liu, Chen

Publication type:

Article

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.

Published in:

Nature Genetics, 2013, v. 45, n. 5, p. 513, doi. 10.1038/ng.2607

By:

Wheeler, Eleanor;
Huang, Ni;
Bochukova, Elena G;
Keogh, Julia M;
Lindsay, Sarah;
Garg, Sumedha;
Henning, Elana;
Blackburn, Hannah;
Loos, Ruth J F;
Wareham, Nick J;
O'Rahilly, Stephen;
Hurles, Matthew E;
Barroso, Inês;
Farooqi, I Sadaf

Publication type:

Article

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.

Published in:

Human Molecular Genetics, 2002, v. 11, n. 17, p. 1997, doi. 10.1093/hmg/11.17.1997

By:

Challis, Benjamin G.;
Pritchard, Lynn E.;
Creemers, John W.M.;
Delplanque, Jerome;
Keogh, Julia M.;
Luan, Jian'an;
Wareham, Nicholas J.;
Yeo, Giles S.H.;
Bhattacharyya, Sumit;
Froguel, Phillipe;
White, Anne;
Farooqi, I. Sadaf;
O'Rahilly, Stephen

Publication type:

Article

A Metabolomic Signature of Acute Caloric Restriction.

Published in:

2017

By:

Collet, Tinh-Hai;
Sonoyama, Takuhiro;
Henning, Elana;
Keogh, Julia M;
Ingram, Brian;
Kelway, Sarah;
Guo, Lining;
Farooqi, I Sadaf

Publication type:

journal article

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene.

Published in:

2015

By:

Wabitsch, Martin;
Funcke, Jan-Bernd;
von Schnurbein, Julia;
Denzer, Friederike;
Lahr, Georgia;
Mazen, Inas;
El-Gammal, Mona;
Denzer, Christian;
Moss, Anja;
Debatin, Klaus-Michael;
Gierschik, Peter;
Mistry, Vanisha;
Keogh, Julia M;
Farooqi, I Sadaf;
Moepps, Barbara;
Fischer-Posovszky, Pamela

Publication type:

journal article

Obesity-associated melanocortin-4 receptor mutations are associated with changes in the brain response to food cues.

Published in:

2014

By:

van der Klaauw, Agatha A;
von dem Hagen, Elisabeth A H;
Keogh, Julia M;
Henning, Elana;
O'Rahilly, Stephen;
Lawrence, Andrew D;
Calder, Andrew J;
Farooqi, I Sadaf

Publication type:

journal article

Postprandial total ghrelin suppression is modulated by melanocortin signaling in humans.

Published in:

2013

By:

van der Klaauw AA;
Keogh JM;
Henning E;
Blackwood A;
Haqq AM;
Purnell JQ;
Farooqi IS;
van der Klaauw, Agatha A;
Keogh, Julia M;
Henning, Elana;
Blackwood, Anthea;
Haqq, Andrea M;
Purnell, Jonathan Q;
Farooqi, I Sadaf

Publication type:

journal article

Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion.

Published in:

2011

By:

Martinelli, Carlos E;
Keogh, Julia M;
Greenfield, Jerry R;
Henning, Elana;
van der Klaauw, Agatha A;
Blackwood, Anthea;
O'Rahilly, Stephen;
Roelfsema, Ferdinand;
Camacho-Hübner, Cecilia;
Pijl, Hanno;
Farooqi, I Sadaf

Publication type:

journal article

Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila.

Published in:

PLoS Biology, 2021, v. 19, n. 11, p. 1, doi. 10.1371/journal.pbio.3001255

By:

Agrawal, Neha;
Lawler, Katherine;
Davidson, Catherine M.;
Keogh, Julia M.;
Legg, Robert;
Barroso, Inês;
Farooqi, I. Sadaf;
Brand, Andrea H.

Publication type:

Article

Divergent effects of central melanocortin signalling on fat and sucrose preference in humans.

Published in:

Nature Communications, 2016, v. 7, n. 10, p. 13055, doi. 10.1038/ncomms13055

By:

van der Klaauw, Agatha A.;
Keogh, Julia M.;
Henning, Elana;
Stephenson, Cheryl;
Kelway, Sarah;
Trowse, Victoria M.;
Subramanian, Naresh;
O'Rahilly, Stephen;
Fletcher, Paul C.;
Farooqi, I. Sadaf

Publication type:

Article

Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression.

Published in:

FASEB Journal, 2018, v. 32, n. 4, p. 1830, doi. 10.1096/fj.201700831R

By:

Lin Jiang;
Haoran Su;
Keogh, Julia M.;
Zheng Chen;
Henning, Elana;
Wilkinson, Paul;
Goodyer, Ian;
Farooqi, I. Sadaf;
Liangyou Rui

Publication type:

Article

Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene.

Published in:

Diabetes, 2006, v. 55, n. 12, p. 3366, doi. 10.2337/db06-0550

By:

Gray, Juliette;
Yeo, Giles S. H.;
Cox, James J.;
Morton, Jenny;
Adlam, Anna-Lynne R.;
Keogh, Julia M.;
Yanovski, Jack A.;
El Gharbawy, Areeg;
Han, Joan C.;
Tung, Y. C. Loraine;
Hodges, John R.;
Raymond, F. Lucy;
O'Rahiily, Stephen;
Farooqi, I. Sadaf

Publication type:

Article

Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans.

Published in:

Diabetes, 2006, v. 55, n. 9, p. 2549, doi. 10.2337/db06-0214

By:

Farooqi, I. Sadaf;
Drop, Stenvert;
Clements, Agnes;
Keogh, Julia M.;
Biernacka, Joanna;
Lowenbein, Sarah;
Challis, Benjamin G.;
O'Rahilly, Stephen

Publication type:

Article

Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.

Published in:

2004

By:

Hung, Chiao-Chien Connie;
Pirie, Fraser;
Luan, Jian'an;
Lank, Emma;
Motala, Ayesha;
Yeo, Giles S.H.;
Keogh, Julia M.;
Wareham, Nicholas J.;
O'Rahilly, Stephen;
Farooqi, I. Sadaf

Publication type:

journal article

Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations.

Published in:

2003

By:

Hung, Chiao-Chien Connie;
Farooqi, I. Sadaf;
Ong, Ken;
Luan, Jian'an;
Keogh, Julia M.;
Pembrey, Marcus;
Yeo, Giles S. H.;
Dunger, David;
Wareham, Nicholas J.;
O'Rahilly, Stephen

Publication type:

journal article

The CART Gene and Human Obesity.

Published in:

Diabetes, 2000, v. 49, n. 5, p. 872, doi. 10.2337/diabetes.49.5.872

By:

Challis, Benjamin G.;
Yeo, Giles S.H.;
Farooqi, I. Sadaf;
Luan, Jian'an;
Aminian, Shiva;
Halsall, David J.;
Keogh, Julia M.;
Wareham, Nicholas J.;
O'Rahilly, Stephen

Publication type:

Article

Partial leptin deficiency and human adiposity.

Published in:

Nature, 2001, v. 414, n. 6859, p. 34, doi. 10.1038/35102112

By:

Farooqi, I. Sadaf;
Keogh, Julia M.;
Kamath, Sri;
Jones, Sarah;
Gibson, William T.;
Trussell, Rebecca;
Jebb, Susan A.;
Lip, Gregory Y.H.;
O'Rahilly, Stephen

Publication type:

Article

Neural networks associated with body composition in frontotemporal dementia.

Published in:

Annals of Clinical & Translational Neurology, 2019, v. 6, n. 9, p. 1707, doi. 10.1002/acn3.50869

By:

Ahmed, Rebekah M.;
Landin‐Romero, Ramon;
Liang, Cheng T.;
Keogh, Julia M.;
Henning, Elana;
Strikwerda‐Brown, Cherie;
Devenney, Emma M.;
Hodges, John R.;
Kiernan, Matthew C.;
Farooqi, I. Sadaf;
Piguet, Olivier

Publication type:

Article

Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-65531-x

By:

Sonoyama, Takuhiro;
Stadler, Lukas K. J.;
Zhu, Mingyan;
Keogh, Julia M.;
Henning, Elana;
Hisama, Fuki;
Kirwan, Peter;
Jura, Magdalena;
Blaszczyk, Beata K.;
DeWitt, David C.;
Brouwers, Bas;
Hyvönen, Marko;
Barroso, Inês;
Merkle, Florian T.;
Appleyard, Suzanne M.;
Wayman, Gary A.;
Farooqi, I. Sadaf

Publication type:

Article

Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance.

Published in:

2019

By:

Flores, Anabel;
Argetsinger, Lawrence S.;
Stadler, Lukas K. J.;
Malaga, Alvaro E.;
Vander, Paul B.;
DeSantis, Lauren C.;
Joe, Ray M.;
Cline, Joel M.;
Keogh, Julia M.;
Henning, Elana;
Barroso, Ines;
Mendes de Oliveira, Edson;
Chandrashekar, Gowri;
Clutter, Erik S.;
Yixin Hu;
Stuckey, Jeanne;
Farooqi, I. Sadaf;
Myers Jr., Martin G.;
Carter-Su, Christin;
Hu, Yixin

Publication type:

journal article

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism.

Published in:

Human Molecular Genetics, 2009, v. 18, n. 17, p. 3257, doi. 10.1093/hmg/ddp263

By:

de Smith, Adam J.;
Purmann, Carolin;
Walters, Robin G.;
Ellis, Richard J.;
Holder, Susan E.;
Van Haelst, Mieke M.;
Brady, Angela F.;
Fairbrother, Una L.;
Dattani, Mehul;
Keogh, Julia M.;
Henning, Elana;
Yeo, Giles S.H.;
O'Rahilly, Stephen;
Froguel, Philippe;
Farooqi, I. Sadaf;
Blakemore, Alexandra I.F.

Publication type:

Article

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-08737-6

By:

Yang, Yongjie;
van der Klaauw, Agatha A.;
Zhu, Liangru;
Cacciottolo, Tessa M.;
He, Yanlin;
Stadler, Lukas K. J.;
Wang, Chunmei;
Xu, Pingwen;
Saito, Kenji;
Hinton, Antentor;
Yan, Xiaofeng;
Keogh, Julia M.;
Henning, Elana;
Banton, Matthew C.;
Hendricks, Audrey E.;
Bochukova, Elena G.;
Mistry, Vanisha;
Lawler, Katherine L.;
Liao, Lan;
Xu, Jianming

Publication type:

Article

Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2022, v. 107, n. 6, p. e2532, doi. 10.1210/clinem/dgac067

By:

Cacciottolo, Tessa M.;
Henning, Elana;
Keogh, Julia M.;
Bel Lassen, Pierre;
Lawler, Katherine;
Bounds, Rebecca;
Ahmed, Rachel;
Perdikari, Aliki;
Mendes de Oliveira, Edson;
Smith, Miriam;
Godfrey, Edmund M.;
Johnson, Elspeth;
Hodson, Leanne;
Clément, Karine;
van der Klaauw, Agatha A.;
Farooqi, I. Sadaf

Publication type:

Article

Leptin-Mediated Changes in the Human Metabolome.

Published in:

2020

By:

Lawler, Katherine;
Huang-Doran, Isabel;
Sonoyama, Takuhiro;
Tinh-Hai Collet;
Keogh, Julia M.;
Henning, Elana;
O'Rahilly, Stephen;
Bottolo, Leonardo;
Farooqi, I. Sadaf;
Collet, Tinh-Hai

Publication type:

journal article