Works by Kennedy, Brian K.

Results: 102

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast.

Published in:

PLoS Biology, 2004, v. 2, n. 9, p. 1381, doi. 10.1371/journal.pbio.0020296

By:

Kaeberlein, Matt;
Kirkland, Kathryn T.;
Fields, Stanley;
Kennedy, Brian K.

Publication type:

Article

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast.

Published in:

PLoS Biology, 2004, v. 2, n. 8, p. 1, doi. 10.1371/journal.pbio.0020296

By:

Kaeberlein, Matt;
Kirkland, Kathryn T;
Fields, Stanley;
Kennedy, Brian K

Publication type:

Article

LinAge2: providing actionable insights and benchmarking with epigenetic clocks.

Published in:

NPJ Aging, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41514-025-00221-4

By:

Fong, Sheng;
Denisov, Kirill A.;
Nefedova, Anastasiia A.;
Kennedy, Brian K.;
Gruber, Jan

Publication type:

Article

DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08021-y

By:

Tay, Jian Hua;
Chew, Yi Ern;
Wang, Weilan;
Lim, Zhi Meng;
Guan, Lihuan;
Dorajoo, Rajkumar;
Kennedy, Brian K.;
Brooke, Robert;
Gordevicius, Juozas;
Horvath, Steve;
Sandalova, Elena;
Maier, Andrea B.

Publication type:

Article

Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.

Published in:

2009

By:

Enns LC;
Morton JF;
Mangalindan RS;
McKnight GS;
Schwartz MW;
Kaeberlein MR;
Kennedy BK;
Rabinovitch PS;
Ladiges WC;
Enns, Linda C;
Morton, John F;
Mangalindan, Ruby Sue;
McKnight, G Stanley;
Schwartz, Michael W;
Kaeberlein, Matt R;
Kennedy, Brian K;
Rabinovitch, Peter S;
Ladiges, Warren C

Publication type:

journal article

Attenuation of Age-Related Metabolic Dysfunction in Mice With a Targeted Disruption of the Cβ Subunit of Protein Kinase A.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2009, v. 64A, n. 12, p. 1221, doi. 10.1093/gerona/glp133

By:

Enns, Linda C.;
Morton, John F.;
Mangalindan, Ruby Sue;
McKnight, G. Stanley;
Schwartz, Michael W.;
Kaeberlein, Matt R.;
Kennedy, Brian K.;
Rabinovitch, Peter S.;
Ladiges, Warren C.

Publication type:

Article

A Method for High-Throughput Quantitative Analysis of Yeast Chronological Life Span.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2008, v. 63, n. 2, p. 113, doi. 10.1093/gerona/63.2.113

By:

Murakami, Christopher J.;
Burtner, Christopher R.;
Kennedy, Brian K.;
Kaeberlein, Matt

Publication type:

Article

A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.87811

By:

Pabis, Kamil;
Barardo, Diogo;
Sirbu, Olga;
Selvarajoo, Kumar;
Gruber, Jan;
Kennedy, Brian K.

Publication type:

Article

Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity.

Published in:

Frontiers in Aging Neuroscience, 2024, p. 01, doi. 10.3389/fnagi.2024.1428244

By:

Navakkode, Sheeja;
Kennedy, Brian K.

Publication type:

Article

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival.

Published in:

Science Translational Medicine, 2012, v. 4, n. 144, p. 1, doi. 10.1126/scitranslmed.3003802

By:

Ramos, Fresnida J.;
Chen, Steven C.;
Garelick, Michael G.;
Dao-Fu Dai;
Chen-Yu Liao;
Schreiber, Katherine H.;
MacKay, Vivian L.;
An, Elroy H.;
Strong, Randy;
Ladiges, Warren C.;
Rabinovitch, Peter S.;
Kaeberlein, Matt;
Kennedy, Brian K.

Publication type:

Article

A new connection between VHL and cancer threads through progerin.

Published in:

Cell Cycle, 2013, v. 12, n. 17, p. 2721, doi. 10.4161/cc.26158

By:

Kennedy, Brian K.

Publication type:

Article

Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo.

Published in:

Cell Cycle, 2013, v. 12, n. 15, p. 2493, doi. 10.4161/cc.25512

By:

Garelick, Michael G.;
Mackay, Vivian L.;
Yanagida, Aya;
Academia, Emmeline C.;
Schreiber, Katherine H.;
Ladiges, Warren C.;
Kennedy, Brian K.

Publication type:

Article

Chronological and replicative lifespan in yeast: Do they meet in the middle?

Published in:

Cell Cycle, 2012, v. 11, n. 19, p. 3531, doi. 10.4161/cc.22041

By:

Polymenis, Michael;
Kennedy, Brian K.

Publication type:

Article

Niche science: The aging stem cell.

Published in:

Cell Cycle, 2012, v. 11, n. 16, p. 2959, doi. 10.4161/cc.21558

By:

Jasper, Heinrich;
Kennedy, Brian K.

Publication type:

Article

PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae.

Published in:

Age (0161-9152), 2015, v. 37, n. 3, p. 1, doi. 10.1007/s11357-015-9788-7

By:

Cui, Hong-Jing;
Liu, Xin-Guang;
McCormick, Mark;
Wasko, Brian M.;
Zhao, Wei;
He, Xin;
Yuan, Yuan;
Fang, Bing-Xiong;
Sun, Xue-Rong;
Kennedy, Brian K.;
Suh, Yousin;
Zhou, Zhong-Jun;
Kaeberlein, Matt;
Feng, Wen-Li

Publication type:

Article

Localization of Sir2p: the nucleolus as a compartment for silent information regulators.

Published in:

EMBO Journal, 1997, v. 16, n. 11, p. 3243, doi. 10.1093/emboj/16.11.3243

By:

Gotta, Monica;
Strahl-Bolsinger, Sabine;
Renauld, Hubert;
Laroche, Thierry;
Kennedy, Brian K.;
Grunstein, Michael;
Gasser, Susan M.

Publication type:

Article

Aging inverts the effects of p75<sup>NTR</sup>-modulated mTOR manipulation on hippocampal neuron synaptic plasticity in male mice.

Published in:

FASEB Journal, 2023, v. 37, n. 8, p. e23067, doi. 10.1096/fj.202201640RRR

By:

Zijun Wang;
Kennedy, Brian K.;
Lik-Wei Wong;
Sajikumar, Sreedharan

Publication type:

Article

LipidClock: A Lipid-Based Predictor of Biological Age.

Published in:

Frontiers in Aging, 2022, p. 1, doi. 10.3389/fragi.2022.828239

By:

Unfried, Maximilian;
Li Fang Ng;
Cazenave-Gassiot, Amaury;
Batchu, Krishna Chaithanya;
Kennedy, Brian K.;
Wenk, Markus R.;
Tolwinski, Nicholas;
Gruber, Jan

Publication type:

Article

Late-life dietary folate restriction reduces biosynthesis without compromising healthspan in mice.

Published in:

Life Science Alliance, 2024, v. 7, n. 10, p. 1, doi. 10.26508/lsa.202402868

By:

Blank, Heidi M.;
Hammer, Staci E.;
Boatright, Laurel;
Roberts, Courtney;
Heyden, Katarina E.;
Nagarajan, Aravindh;
Mitsuhiro Tsuchiya;
Brun, Marcel;
Johnson, Charles D.;
Stover, Patrick J.;
Sitcheran, Raquel;
Kennedy, Brian K.;
Adams, L. Garry;
Kaeberlein, Matt;
Field, Martha S.;
Threadgill, David W.;
Andrews-Polymenis, Helene L.;
Polymenis, Michael

Publication type:

Article

Aging mechanisms and interventions that impact senior health: Introduction to a special issue on Geroscience.

Published in:

Aging Medicine, 2019, v. 2, n. 3, p. 126, doi. 10.1002/agm2.12086

By:

Leng, Sean X.;
Liu, Baohua;
Kennedy, Brian K.

Publication type:

Article

Inhibition of ATR Reverses a Mitochondrial Respiratory Insufficiency.

Published in:

Cells (2073-4409), 2022, v. 11, n. 11, p. 1731, doi. 10.3390/cells11111731

By:

Borror, Megan B.;
Girotti, Milena;
Kar, Adwitiya;
Cain, Meghan K.;
Gao, Xiaoli;
MacKay, Vivian L.;
Herron, Brent;
Bhaskaran, Shylesh;
Becerra, Sandra;
Novy, Nathan;
Ventura, Natascia;
Johnson, Thomas E.;
Kennedy, Brian K.;
Rea, Shane L.

Publication type:

Article

MicroRNAs Associated with Chronic Mucus Hypersecretion in COPD Are Involved in Fibroblast–Epithelium Crosstalk.

Published in:

Cells (2073-4409), 2022, v. 11, n. 3, p. 526, doi. 10.3390/cells11030526

By:

Tasena, Hataitip;
Timens, Wim;
van den Berge, Maarten;
van Broekhuizen, Joy;
Kennedy, Brian K.;
Hylkema, Machteld N.;
Brandsma, Corry-Anke;
Heijink, Irene H.

Publication type:

Article

Proteasomes, Sir2, and Hxk2 Form an Interconnected Aging Network That Impinges on the AMPK/Snf1-Regulated Transcriptional Repressor Mig1.

Published in:

PLoS Genetics, 2015, v. 11, n. 1, p. 1, doi. 10.1371/journal.pgen.1004968

By:

Yao, Yanhua;
Tsuchiyama, Scott;
Yang, Ciyu;
Bulteau, Anne Laure;
He, Chong;
Robison, Brett;
Tsuchiya, Mitsuhiro;
Miller, Delana;
Briones, Valeria;
Tar, Krisztina;
Potrero, Anahi;
Friguet, Bertrand;
Kennedy, Brian K.;
Schmidt, Marion

Publication type:

Article

Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import.

Published in:

PLoS Genetics, 2014, v. 10, n. 12, p. 1, doi. 10.1371/journal.pgen.1004860

By:

He, Chong;
Tsuchiyama, Scott K.;
Nguyen, Quynh T.;
Plyusnina, Ekaterina N.;
Terrill, Samuel R.;
Sahibzada, Sarah;
Patel, Bhumil;
Faulkner, Alena R.;
Shaposhnikov, Mikhail V.;
Tian, Ruilin;
Tsuchiya, Mitsuhiro;
Kaeberlein, Matt;
Moskalev, Alexey A.;
Kennedy, Brian K.;
Polymenis, Michael

Publication type:

Article

Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response.

Published in:

PLoS Genetics, 2014, v. 10, n. 1, p. 1, doi. 10.1371/journal.pgen.1004019

By:

Labunskyy, Vyacheslav M.;
Gerashchenko, Maxim V.;
Delaney, Joe R.;
Kaya, Alaattin;
Kennedy, Brian K.;
Kaeberlein, Matt;
Gladyshev, Vadim N.

Publication type:

Article

The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1.

Published in:

PLoS Genetics, 2013, v. 9, n. 8, p. 1, doi. 10.1371/journal.pgen.1003708

By:

O'Leary, Monique N.;
Schreiber, Katherine H.;
Zhang, Yong;
Duc, Anne-Cécile E.;
Rao, Shuyun;
Hale, J. Scott;
Academia, Emmeline C.;
Shah, Shreya R.;
Morton, John F.;
Holstein, Carly A.;
Martin, Dan B.;
Kaeberlein, Matt;
Ladiges, Warren C.;
Fink, Pamela J.;
MacKay, Vivian L.;
Wiest, David L.;
Kennedy, Brian K.

Publication type:

Article

A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan.

Published in:

PLoS Genetics, 2013, v. 9, n. 3, p. 1, doi. 10.1371/journal.pgen.1003329

By:

Kwan, Elizabeth X.;
Foss, Eric J.;
Tsuchiyama, Scott;
Alvino, Gina M.;
Kruglyak, Leonid;
Kaeberlein, Matt;
Raghuraman, M. K.;
Brewer, Bonita J.;
Kennedy, Brian K.;
Bedalov, Antonio

Publication type:

Article

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae.

Published in:

PLoS Genetics, 2011, v. 7, n. 9, p. 1, doi. 10.1371/journal.pgen.1002253

By:

Kruegel, Undine;
Robison, Brett;
Dange, Thomas;
Kahlert, Günther;
Delaney, Joe R.;
Kotireddy, Soumya;
Tsuchiya, Mitsuhiro;
Tsuchiyama, Scott;
Murakami, Christopher J.;
Schleit, Jennifer;
Sutphin, George;
Carr, Daniel;
Tar, Krisztina;
Dittmar, Gunnar;
Kaeberlein, Matt;
Kennedy, Brian K.;
Schmidt, Marion

Publication type:

Article

Recent Developments in Yeast Aging.

Published in:

PLoS Genetics, 2007, v. 3, n. 5, p. e84, doi. 10.1371/journal.pgen.0030084

By:

Kaeberlein, Matt;
Burtner, Christopher R.;
Kennedy, Brian K.

Publication type:

Article

Author's Reply.

Published in:

2006

By:

Kaeberlein, Matt;
Hu, Di;
Kerr, Emily O.;
Tsuchiya, Mitsuhiro;
Westman, Eric A.;
Dang, Nick;
Fields, Stanley;
Kennedy, Brian K.

Publication type:

Letter

Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast.

Published in:

PLoS Genetics, 2005, v. 1, n. 5, p. 614, doi. 10.1371/journal.pgen.0010069

By:

Kaeberlein, Matt;
Hu, Di;
Kerr, Emily O.;
Tsuchiya, Mitsuhiro;
Westman, Eric A.;
Dang, Nick;
Fields, Stanley;
Kennedy, Brian K.;
Kim, Stuart

Publication type:

Article

Mixing old and young: enhancing rejuvenation and accelerating aging.

Published in:

2019

By:

Lau, Ashley;
Kennedy, Brian K.;
Kirkland, James L.;
Tullius, Stefan G.

Publication type:

journal article

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity.

Published in:

Journal of Clinical Investigation, 2015, v. 125, n. 8, p. 2952, doi. 10.1172/JCI77361

By:

Tsai, Shihyin;
Sitzmann, Joanna M.;
Dastidar, Somasish G.;
Rodriguez, Ariana A.;
Vu, Stephanie L.;
McDonald, Circe E.;
Academia, Emmeline C.;
O'Leary, Monique N.;
Ashe, Travis D.;
La Spada, Albert R.;
Kennedy, Brian K.

Publication type:

Article

Werner and Hutchinson–Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

Published in:

Nature Reviews Molecular Cell Biology, 2007, v. 8, n. 5, p. 394, doi. 10.1038/nrm2161

By:

Kudlow, Brian A.;
Kennedy, Brian K.;
Monnat, Raymond J.

Publication type:

Article

TRANSCRIPTION: MAMMALIAN TRANSCRIPTION FACTORS IN YEAST: STRANGERS IN A FAMILIAR LAND.

Published in:

Nature Reviews Molecular Cell Biology, 2002, v. 3, n. 1, p. 41, doi. 10.1038/nrm704

By:

Kennedy, Brian K.

Publication type:

Article

Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs.

Published in:

JBMR Plus, 2021, v. 5, n. 3, p. 1, doi. 10.1002/jbm4.10466

By:

Evans, Daniel S;
O'Leary, Monique N;
Murphy, Ryan;
Schmidt, Minna;
Koenig, Kristin;
Presley, Michael;
Garrett, Brittany;
Kim, Ha‐Neui;
Han, Li;
Academia, Emmeline C;
Laye, Matt J;
Edgar, Daniel;
Zambataro, Christopher A;
Barhydt, Tracey;
Dewey, Colleen M;
Mayfield, Jarrott;
Wilson, Joy;
Alavez, Silvestre;
Lucanic, Mark;
Kennedy, Brian K

Publication type:

Article

Front Cover: Aging: Mechanisms, Measures, and Interventions.

Published in:

Proteomics, 2020, v. 20, n. 5/6, p. 1, doi. 10.1002/pmic.202070031

By:

Chung, Maxey C. M.;
Kennedy, Brian K.

Publication type:

Article

Aging: Mechanisms, Measures, and Interventions.

Published in:

Proteomics, 2020, v. 20, n. 5/6, p. 1, doi. 10.1002/pmic.201800336

By:

Chung, Maxey C. M.;
Kennedy, Brian K.

Publication type:

Article

Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches.

Published in:

Proteomics, 2020, v. 20, n. 5/6, p. 1, doi. 10.1002/pmic.201900408

By:

Kudryashova, Ksenia S.;
Burka, Ksenia;
Kulaga, Anton Y.;
Vorobyeva, Nataliya S.;
Kennedy, Brian K.

Publication type:

Article

Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability.

Published in:

Nucleus (1949-1034), 2013, v. 4, n. 5, p. 410, doi. 10.4161/nucl.26873

By:

Das, Arindam;
Grotsky, David A;
Neumann, Martin A;
Kreienkamp, Ray;
Gonzalez-Suarez, Ignacio;
Redwood, Abena B;
Kennedy, Brian K;
Stewart, Colin L;
Gonzalo, Susana

Publication type:

Article

Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.

Published in:

Autophagy, 2021, v. 17, n. 12, p. 4119, doi. 10.1080/15548627.2021.1904489

By:

Bailus, Barbara J.;
Scheeler, Stephen M.;
Simons, Jesse;
Sanchez, Maria A.;
Tshilenge, Kizito-Tshitoko;
Creus-Muncunill, Jordi;
Naphade, Swati;
Lopez-Ramirez, Alejandro;
Zhang, Ningzhe;
Lakshika Madushani, Kuruwitage;
Moroz, Stanislav;
Loureiro, Ashley;
Schreiber, Katherine H.;
Hausch, Felix;
Kennedy, Brian K.;
Ehrlich, Michelle E.;
Ellerby, Lisa M.

Publication type:

Article

Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells.

Published in:

EMBO Journal, 2017, v. 36, n. 4, p. 487, doi. 10.15252/embj.201695050

By:

Blank, Heidi M;
Perez, Ricardo;
He, Chong;
Maitra, Nairita;
Metz, Richard;
Hill, Joshua;
Lin, Yuhong;
Johnson, Charles D;
Bankaitis, Vytas A;
Kennedy, Brian K;
Aramayo, Rodolfo;
Polymenis, Michael

Publication type:

Article

Lifespan extension in Caenorhabditis elegans by complete removal of food.

Published in:

Aging Cell, 2006, v. 5, n. 6, p. 487, doi. 10.1111/j.1474-9726.2006.00238.x

By:

Kaeberlein, Tammi L.;
Smith, Erica D.;
Tsuchiya, Mitsuhiro;
Welton, K. Linnea;
Thomas, James H.;
Fields, Stanley;
Kennedy, Brian K.;
Kaeberlein, Matt

Publication type:

Article

Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.

Published in:

Aging Cell, 2006, v. 5, n. 6, p. 505, doi. 10.1111/j.1474-9726.2006.00240.x

By:

Tsuchiya, Mitsuhiro;
Dang, Nick;
Kerr, Emily O.;
Di Hu;
Steffen, Kristan K.;
Oakes, Jonathan A.;
Kennedy, Brian K.;
Kaeberlein, Matt

Publication type:

Article

Vacuolar dynamics and replicative aging.

Published in:

Cell Cycle, 2012, v. 11, n. 15, p. 2778, doi. 10.4161/cc.21393

By:

Tsuchiyama, Scott;
Kennedy, Brian K.

Publication type:

Article

A new chronological survival assay in mammalian cell culture.

Published in:

Cell Cycle, 2012, v. 11, n. 2, p. 201, doi. 10.4161/cc.11.2.18959

By:

Kaeberlein, Matt;
Kennedy, Brian K.

Publication type:

Article

A genomic analysis of chronological longevity factors in budding yeast.

Published in:

Cell Cycle, 2011, v. 10, n. 9, p. 1385, doi. 10.4161/cc.10.9.15464

By:

Burtner, Christopher R.;
Murakami, Christopher J.;
Olsen, Brady;
Kennedy, Brian K.;
Kaeberlein, Matt

Publication type:

Article

Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast.

Published in:

Cell Cycle, 2011, v. 10, n. 1, p. 156, doi. 10.4161/cc.10.1.14457

By:

Delaney, Joe R.;
Murakami, Christopher J.;
Olsen, Brady;
Kennedy, Brian K.;
Kaeberlein, Matt

Publication type:

Article

A molecular mechanism of chronological aging in yeast.

Published in:

Cell Cycle, 2009, v. 8, n. 8, p. 1256, doi. 10.4161/cc.8.8.8287

By:

Burtner, Christopher R.;
Murakami, Christopher J.;
Kennedy, Brian K.;
Kaeberlein, Matt

Publication type:

Article

Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer's disease but not Lewy body dementias.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02789-8

By:

Chai, Yuek Ling;
Lee, Jasinda H.;
Chong, Joyce R.;
Ballard, Clive;
Francis, Paul T.;
Kennedy, Brian K.;
Arumugam, Thiruma V.;
Chen, Christopher P.;
Aarsland, Dag;
Lai, Mitchell K. P.

Publication type:

Article