Works by Kengo Uemura

Results: 34

Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03312-0

By:

Asada-Utsugi, Megumi;
Uemura, Kengo;
Ayaki, Takashi;
T. Uemura, Maiko;
Minamiyama, Sumio;
Hikiami, Ryota;
Morimura, Toshifumi;
Shodai, Akemi;
Ueki, Takatoshi;
Takahashi, Ryosuke;
Kinoshita, Ayae;
Urushitani, Makoto

Publication type:

Article

Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus.

Published in:

Fluids & Barriers of the CNS, 2014, v. 11, n. 1, p. 1, doi. 10.1186/2045-8118-11-9

By:

Namiko Nishida;
Nanae Nagata;
Hiroki Toda;
Naoto Jingami;
Kengo Uemura;
Akihiko Ozaki;
Mitsuhito Mase;
Yoshihiro Urade;
Sadayuki Matsumoto;
Koichi Iwasaki;
Masatsune Ishikawa

Publication type:

Article

The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.

Published in:

Molecular Brain, 2015, v. 8, p. 1, doi. 10.1186/s13041-015-0174-2

By:

Kiwamu Watanabe;
Kengo Uemura;
Megumi Asada;
Masato Maesako;
Haruhiko Akiyama;
Shun Shimohama;
Ryosuke Takahashi;
Ayae Kinoshita

Publication type:

Article

Presenilin 1 is involved in the maturation of β‐site amyloid precursor protein‐cleaving enzyme 1 (BACE1).

Published in:

Journal of Neuroscience Research, 2007, v. 85, n. 1, p. 153, doi. 10.1002/jnr.21104

By:

Akira Kuzuya;
Kengo Uemura;
Naoyuki Kitagawa;
Nobuhisa Aoyagi;
Takeshi Kihara;
Haruaki Ninomiya;
Shoichi Ishiura;
Ryosuke Takahashi;
Shun Shimohama

Publication type:

Article

Pericyte‐derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion.

Published in:

Brain Pathology, 2018, v. 28, n. 4, p. 521, doi. 10.1111/bpa.12523

By:

Uemura, Maiko T.;
Ihara, Masafumi;
Maki, Takakuni;
Nakagomi, Takayuki;
Kaji, Seiji;
Uemura, Kengo;
Matsuyama, Tomohiro;
Kalaria, Raj N.;
Kinoshita, Ayae;
Takahashi, Ryosuke

Publication type:

Article

Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease.

Published in:

Acta Neuropathologica, 2013, v. 125, n. 2, p. 187, doi. 10.1007/s00401-012-1065-6

By:

Wahlster, Lara;
Arimon, Muriel;
Nasser-Ghodsi, Navine;
Post, Kathryn;
Serrano-Pozo, Alberto;
Uemura, Kengo;
Berezovska, Oksana

Publication type:

Article

Lipocalin-type prostaglandin D synthase: a glymphopathy marker in idiopathic hydrocephalus.

Published in:

Frontiers in Aging Neuroscience, 2024, p. 01, doi. 10.3389/fnagi.2024.1364325

By:

Namiko Nishida;
Nanae Nagata;
Keigo Shimoji;
Naoto Jingami;
Kengo Uemura;
Akihiko Ozaki;
Makio Takahashi;
Yoshihiro Urade;
Sadayuki Matsumoto;
Koichi Iwasaki;
Ryosuke Okumura;
Masatsune Ishikawa;
Hiroki Toda

Publication type:

Article

Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0072796

By:

Maesako, Masato;
Uemura, Kengo;
Iwata, Ayana;
Kubota, Masakazu;
Watanabe, Kiwamu;
Uemura, Maiko;
Noda, Yasuha;
Asada-Utsugi, Megumi;
Kihara, Takeshi;
Takahashi, Ryosuke;
Shimohama, Shun;
Kinoshita, Ayae

Publication type:

Article

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio.

Published in:

PLoS ONE, 2009, v. 4, n. 11, p. e7893, doi. 10.1371/journal.pone.0007893

By:

Uemura, Kengo;
Lill, Christina M.;
Li, Xuejing;
Peters, Jessica A.;
Ivanov, Alexander;
Fan, Zhanyun;
DeStrooper, Bart;
Bacskai, Brian J.;
Hyman, Bradley T.;
Berezovska, Oksana

Publication type:

Article

PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates.

Published in:

Human Molecular Genetics, 2013, v. 22, n. 12, p. 2423, doi. 10.1093/hmg/ddt095

By:

Matsui, Hideaki;
Gavinio, Roberto;
Asano, Takeshi;
Uemura, Norihito;
Ito, Hidefumi;
Taniguchi, Yoshihito;
Kobayashi, Yoshito;
Maki, Takakuni;
Shen, Jie;
Takeda, Shunichi;
Uemura, Kengo;
Yamakado, Hodaka;
Takahashi, Ryosuke

Publication type:

Article

Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane.

Published in:

Journal of Neuroscience Research, 2003, v. 74, n. 2, p. 184, doi. 10.1002/jnr.10753

By:

Kengo Uemura;
Naoyuki Kitagawa;
Ryuichi Kohno;
Akira Kuzuya;
Takashi Kageyama;
Kazuhisa Chonabayashi;
Hiroshi Shibasaki;
Shun Shimohama

Publication type:

Article

Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling.

Published in:

Journal of Neuroscience Research, 2003, v. 73, n. 2, p. 166, doi. 10.1002/jnr.10641

By:

Kengo Uemura;
Naoyuki Kitagawa;
Ryuichi Kohno;
Akira Kuzuya;
Takashi Kageyama;
Hiroshi Shibasaki;
Shun Shimohama

Publication type:

Article

Distinct Dendritic Spine and Nuclear Phases of Calcineurin Activation after Exposure to Amyloid- Revealed by a Novel Fluorescence Resonance Energy Transfer Assay.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 15, p. 5298, doi. 10.1523/JNEUROSCI.0227-12.2012

By:

Wu, Hai-Yan;
Hudry, Eloise;
Hashimoto, Tadafumi;
Uemura, Kengo;
Fan, Zhan-Yun;
Berezovska, Oksana;
Grosskreutz, Cynthia L.;
Bacskai, Brian J.;
Hyman, Bradley T.

Publication type:

Article

Two‐point dynamic observation of Alzheimer's disease cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus: Developing topics.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047148

By:

Jingami, Naoto;
Uemura, Kengo;
Asada, Megumi;
Kuzuya, Akira;
Takahashi, Ryosuke;
Kinoshita, Ayae

Publication type:

Article

Analysis of N-cadherin interacting proteins in Alzheimer's diesase

Published in:

2010

By:

Ando, Koichi;
Maesako, Masato;
Asada, Megumi;
Kubota, Masakazu;
Aoyagi, Nobuhisa;
Kuzuya, Akira;
Uemura, Kengo;
Kawamata, Jun;
Takahashi, Ryosuke;
Kinoshita, Ayae

Publication type:

Abstract

P4-262: N-cadherin–based adhesion enhances Abeta release and decreases Abeta42/40 ratio

Published in:

2008

By:

Uemura, Kengo;
Ando, Koichi;
Aoyagi, Nobuhisa;
Shimohama, Shun;
Takahashi, Ryosuke;
Kinoshita, Ayae

Publication type:

Abstract

P4-013: N-cadherin cleavage by ADAM10 after NMDA receptor stimulation is inhibited amyloid-beta peptides

Published in:

2006

By:

Uemura, Kengo;
Kuzuya, Akira;
Aoyagi, Nobuhisa;
Shimohama, Shun;
Kinoshita, Ayae

Publication type:

Abstract

P3-385: Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1(BACE1)

Published in:

2006

By:

Kuzuya, Akira;
Uemura, Kengo;
Kinoshita, Ayae;
Shimohama, Shun

Publication type:

Abstract

P3-091: Neuroproteomics in Alzheimer’s disease: Expression profiling of the brain proteomes and their relation to proteomes of body fluids

Published in:

2006

By:

Tsuji, Teruyuki;
Kawamata, Jun;
Uemura, Kengo;
Okawa, Katsuya;
Hirayoshi, Ippou;
Shimohama, Shun

Publication type:

Abstract

P4-013: N-cadherin cleavage by ADAM10 after NMDA receptor stimulation is inhibited amyloid-beta peptides

Published in:

2006

By:

Uemura, Kengo;
Kuzuya, Akira;
Aoyagi, Nobuhisa;
Shimohama, Shun;
Kinoshita, Ayae

Publication type:

Abstract

P3-385: Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1(BACE1)

Published in:

2006

By:

Kuzuya, Akira;
Uemura, Kengo;
Kinoshita, Ayae;
Shimohama, Shun

Publication type:

Abstract

P3-091: Neuroproteomics in Alzheimer’s disease: Expression profiling of the brain proteomes and their relation to proteomes of body fluids

Published in:

2006

By:

Tsuji, Teruyuki;
Kawamata, Jun;
Uemura, Kengo;
Okawa, Katsuya;
Hirayoshi, Ippou;
Shimohama, Shun

Publication type:

Abstract

Magnetic resonance imaging of primary spinal intramedullary lymphoma.

Published in:

2002

By:

Nakamizo, Tomoki;
Inoue, Haruhisa;
Udaka, Fukashi;
Oda, Masaya;
Kawai, Makoto;
Uemura, Kengo;
Takahashi, Makio;
Nishinaka, Kazuto;
Sawada, Hideyuki;
Kameyama, Masakuni;
Koyama, Tsunemaro

Publication type:

journal article

Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation.

Published in:

Molecular Neurodegeneration, 2011, v. 6, n. 1, p. 15, doi. 10.1186/1750-1326-6-15

By:

Uemura, Kengo;
Farner, Katherine C.;
Nasser-Ghodsi, Navine;
Jones, Phill;
Berezovska, Oksana

Publication type:

Article

Optineurin suppression causes neuronal cell death via NF-κB pathway.

Published in:

Journal of Neurochemistry, 2013, v. 126, n. 6, p. 699, doi. 10.1111/jnc.12326

By:

Akizuki, Mayumi;
Yamashita, Hirofumi;
Uemura, Kengo;
Maruyama, Hirofumi;
Kawakami, Hideshi;
Ito, Hidefumi;
Takahashi, Ryosuke

Publication type:

Article

Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling.

Published in:

Journal of Neurochemistry, 2012, v. 121, n. 6, p. 964, doi. 10.1111/j.1471-4159.2012.07741.x

By:

Maesako, Masato;
Uemura, Kengo;
Kuzuya, Akira;
Sasaki, Kazuki;
Asada, Megumi;
Watanabe, Kiwamu;
Ando, Koichi;
Kubota, Masakazu;
Akiyama, Haruhiko;
Takahashi, Ryosuke;
Kihara, Takeshi;
Shimohama, Shun;
Kinoshita, Ayae

Publication type:

Article

N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.

Published in:

Journal of Neurochemistry, 2011, v. 119, n. 2, p. 354, doi. 10.1111/j.1471-4159.2011.07364.x

By:

Asada-Utsugi, Megumi;
Uemura, Kengo;
Noda, Yasuha;
Kuzuya, Akira;
Maesako, Masato;
Ando, Koichi;
Kubota, Masakazu;
Watanabe, Kiwamu;
Takahashi, Makio;
Kihara, Takeshi;
Shimohama, Shun;
Takahashi, Ryosuke;
Berezovska, Oksana;
Kinoshita, Ayae

Publication type:

Article

N-cadherin-based adhesion enhances Aβ release and decreases Aβ42/40 ratio.

Published in:

Journal of Neurochemistry, 2009, v. 108, n. 2, p. 350, doi. 10.1111/j.1471-4159.2008.05760.x

By:

Uemura, Kengo;
Lill, Christina M.;
Banks, Mary;
Asada, Megumi;
Aoyagi, Nobuhisa;
Ando, Koichi;
Kubota, Masakazu;
Kihara, Takeshi;
Nishimoto, Takaaki;
Sugimoto, Hachiro;
Takahashi, Ryosuke;
Hyman, Bradley T.;
Shimohama, Shun;
Berezovska, Oksana;
Kinoshita, Ayae

Publication type:

Article

Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case report and literature review.

Published in:

Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.), 2012, v. 18, n. 3, p. 390, doi. 10.1007/s10156-011-0315-1

By:

Tanioka, Kosuke;
Nagao, Miki;
Yamamoto, Masaki;
Matsumura, Yasufumi;
Tabu, Hayato;
Matsushima, Aki;
Uemura, Kengo;
Matsumoto, Riki;
Ito, Yutaka;
Takakura, Shunji;
Takahashi, Ryosuke;
Ichiyama, Satoshi

Publication type:

Article

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.

Published in:

PLoS ONE, 2015, v. 10, n. 9, p. 1, doi. 10.1371/journal.pone.0131199

By:

Maesako, Masato;
Uemura, Maiko;
Tashiro, Yoshitaka;
Sasaki, Kazuki;
Watanabe, Kiwamu;
Noda, Yasuha;
Ueda, Karin;
Asada-Utsugi, Megumi;
Kubota, Masakazu;
Okawa, Katsuya;
Ihara, Masafumi;
Shimohama, Shun;
Uemura, Kengo;
Kinoshita, Ayae

Publication type:

Article

Proteome analysis of brain proteins in Alzheimer's disease: subproteomics following sequentially extracted protein preparation.

Published in:

2004

By:

Shiozaki, Aiko;
Tsuji, Teruyuki;
Kohno, Ryuichi;
Kawamata, Jun;
Uemura, Kengo;
Teraoka, Hiroshi;
Shimohama, Shun

Publication type:

journal article

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer's disease.

Published in:

Molecular Brain, 2018, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13041-018-0401-8

By:

Noda, Yasuha;
Kuzuya, Akira;
Tanigawa, Kyousuke;
Araki, Mitsugu;
Kawai, Ryoko;
Ma, Biao;
Sasakura, Yoko;
Maesako, Masato;
Tashiro, Yoshitaka;
Miyamoto, Masakazu;
Uemura, Kengo;
Okuno, Yasushi;
Kinoshita, Ayae

Publication type:

Article

Phenylpiperidine-type ?-secretase modulators target the transmembrane domain 1 of presenilin 1.

Published in:

EMBO Journal, 2011, v. 30, n. 23, p. 4815, doi. 10.1038/emboj.2011.372

By:

Ohki, Yu;
Higo, Takuya;
Uemura, Kengo;
Shimada, Naoaki;
Osawa, Satoko;
Berezovska, Oksana;
Yokoshima, Satoshi;
Fukuyama, Tohru;
Tomita, Taisuke;
Iwatsubo, Takeshi

Publication type:

Article

The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.

Published in:

PLoS Genetics, 2015, v. 11, n. 9, p. 1, doi. 10.1371/journal.pgen.1005503

By:

Imai, Yuzuru;
Kobayashi, Yoshito;
Inoshita, Tsuyoshi;
Meng, Hongrui;
Arano, Taku;
Uemura, Kengo;
Asano, Takeshi;
Yoshimi, Kenji;
Zhang, Chang-Liang;
Matsumoto, Gen;
Ohtsuka, Toshiyuki;
Kageyama, Ryoichiro;
Kiyonari, Hiroshi;
Shioi, Go;
Nukina, Nobuyuki;
Hattori, Nobutaka;
Takahashi, Ryosuke

Publication type:

Article

Works by Kengo Uemura

Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro.

Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus.

The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.

Presenilin 1 is involved in the maturation of β‐site amyloid precursor protein‐cleaving enzyme 1 (BACE1).

Pericyte‐derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion.

Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease.

Lipocalin-type prostaglandin D synthase: a glymphopathy marker in idiopathic hydrocephalus.

Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice.

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β<sub>42/40</sub> Ratio.

PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates.

Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane.

Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling.

Distinct Dendritic Spine and Nuclear Phases of Calcineurin Activation after Exposure to Amyloid- Revealed by a Novel Fluorescence Resonance Energy Transfer Assay.

Two‐point dynamic observation of Alzheimer's disease cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus: Developing topics.

Analysis of N-cadherin interacting proteins in Alzheimer's diesase

P4-262: N-cadherin–based adhesion enhances Abeta release and decreases Abeta<sub>42/40</sub> ratio

P4-013: N-cadherin cleavage by ADAM10 after NMDA receptor stimulation is inhibited amyloid-beta peptides

P3-385: Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1(BACE1)

P3-091: Neuroproteomics in Alzheimer’s disease: Expression profiling of the brain proteomes and their relation to proteomes of body fluids

P4-013: N-cadherin cleavage by ADAM10 after NMDA receptor stimulation is inhibited amyloid-beta peptides

P3-385: Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1(BACE1)

P3-091: Neuroproteomics in Alzheimer’s disease: Expression profiling of the brain proteomes and their relation to proteomes of body fluids

Magnetic resonance imaging of primary spinal intramedullary lymphoma.

Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation.

Optineurin suppression causes neuronal cell death via NF-κB pathway.

Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling.

N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.

N-cadherin-based adhesion enhances Aβ release and decreases Aβ<sub>42/40</sub> ratio.

Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case report and literature review.

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.

Proteome analysis of brain proteins in Alzheimer's disease: subproteomics following sequentially extracted protein preparation.

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer's disease.

Phenylpiperidine-type ?-secretase modulators target the transmembrane domain 1 of presenilin 1.

The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.