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Transcriptomic analysis of choroidal neovascularization reveals dysregulation of immune and fibrosis pathways that are attenuated by a novel anti-fibrotic treatment.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-04845-4
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- Article
Cannabinoid Receptor 2 Expression in Human Proximal Tubule Cells is Regulated by Albumin Independent of ERK1/2 Signaling.
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- Cellular Physiology & Biochemistry (Karger AG), 2013, v. 32, n. 5, p. 1309, doi. 10.1159/000354529
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- Article
Spironolactone mitigates, but does not reverse, the progression of renal fibrosis in a transgenic hypertensive rat.
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- Physiological Reports, 2020, v. 8, n. 10, p. 1, doi. 10.14814/phy2.14448
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- Article
Contribution of micro RNA to pathological fibrosis in cardio-renal syndrome: impact of uremic toxins.
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- Physiological Reports, 2015, v. 3, n. 4, p. n/a, doi. 10.14814/phy2.12371
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- Article
Aliskiren: a novel renoprotective agent or simply an alternative to ACE inhibitors?
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- Kidney International, 2009, v. 76, n. 1, p. 23, doi. 10.1038/ki.2009.105
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- Article
Cardiac Repair With a Novel Population of Mesenchymal Stem Cells Resident in the Human Heart.
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- Stem Cells, 2015, v. 33, n. 10, p. 3100, doi. 10.1002/stem.2101
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- Article
Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway.
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- Scientific Reports, 2016, p. 29196, doi. 10.1038/srep29196
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- Article
Cardiac fibrosis in the ageing heart: Contributors and mechanisms.
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- Clinical & Experimental Pharmacology & Physiology, 2017, v. 44, p. 55, doi. 10.1111/1440-1681.12753
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- Article
Renal cellular hypoxia in adenine-induced chronic kidney disease.
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- Clinical & Experimental Pharmacology & Physiology, 2016, v. 43, n. 10, p. 896, doi. 10.1111/1440-1681.12621
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- Article
Elevated cannabinoid receptor 1 and G protein-coupled receptor 55 expression in proximal tubule cells and whole kidney exposed to diabetic conditions.
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- Clinical & Experimental Pharmacology & Physiology, 2015, v. 42, n. 3, p. 256, doi. 10.1111/1440-1681.12355
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- Article
Cardiorenal syndrome: Pathophysiology, preclinical models, management and potential role of uraemic toxins.
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- Clinical & Experimental Pharmacology & Physiology, 2012, v. 39, n. 8, p. 692, doi. 10.1111/j.1440-1681.2011.05632.x
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- Article
FT23, an orally active antifibrotic compound, attenuates structural and functional abnormalities in an experimental model of diabetic cardiomyopathy.
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- Clinical & Experimental Pharmacology & Physiology, 2012, v. 39, n. 8, p. 650, doi. 10.1111/j.1440-1681.2012.05726.x
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- Article
Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart.
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- Clinical & Experimental Pharmacology & Physiology, 2011, v. 38, n. 9, p. 623, doi. 10.1111/j.1440-1681.2011.05572.x
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- Article
FT011, a Novel Cardiorenal Protective Drug, Reduces Inflammation, Gliosis and Vascular Injury in Rats with Diabetic Retinopathy.
- Published in:
- PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0134392
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- Article
Functional Interaction between Angiotensin II Receptor Type 1 and Chemokine (C-C Motif) Receptor 2 with Implications for Chronic Kidney Disease.
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- PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0119803
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- Article
SDF-1/CXCR4 Signaling Preserves Microvascular Integrity and Renal Function in Chronic Kidney Disease.
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- PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0092227
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- Article
The Uremic Toxin Adsorbent AST-120 Abrogates Cardiorenal Injury Following Myocardial Infarction.
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- PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0083687
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- Article
Obesity Is Associated with Lower Coronary Microvascular Density.
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- PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0081798
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- Article
Atrial Arrhythmia in Ageing Spontaneously Hypertensive Rats: Unraveling the Substrate in Hypertension and Ageing.
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- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0072416
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- Article
Diastolic Dysfunction of Aging Is Independent of Myocardial Structure but Associated with Plasma Advanced Glycation End-Product Levels.
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- PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0049813
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- Article
A Purpose-Synthesised Anti-Fibrotic Agent Attenuates Experimental Kidney Diseases in the Rat.
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- PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0047160
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- Article
Chronic Kidney Disease-Induced Cardiac Fibrosis Is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uremic Toxin, Indoxyl Sulfate.
- Published in:
- PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0041281
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- Article
39,49-Dihydroxyflavonol Antioxidant Attenuates Diastolic Dysfunction and Cardiac Remodeling in Streptozotocin- Induced Diabetic m(Ren2)27 Rats.
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- PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0022777
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- Article
Culture-Modified Bone Marrow Cells Attenuate Cardiac and Renal Injury in a Chronic Kidney Disease Rat Model via a Novel Antifibrotic Mechanism.
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- PLoS ONE, 2010, v. 5, n. 3, p. 1, doi. 10.1371/journal.pone.0009543
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- Article
Atrial Remodeling in an Ovine Model of Anthracycline-Induced Nonischemic Cardiomyopathy: Remodeling of the Same Sort.
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- Journal of Cardiovascular Electrophysiology, 2011, v. 22, n. 2, p. 175, doi. 10.1111/j.1540-8167.2010.01851.x
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- Article
Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?
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- European Heart Journal, 2010, v. 31, n. 14, p. 1771, doi. 10.1093/eurheartj/ehp574
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- Article
Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-β
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- Cardiovascular Research, 2005, v. 65, n. 3, p. 694, doi. 10.1016/j.cardiores.2004.10.041
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- Article
Aliskiren, a novel renin inhibitor versus angiotensin-converting enzyme-inhibitor in advanced experimental diabetic nephropathy.
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- Journal of the Renin-Angiotensin-Aldosterone System, 2008, v. 9, n. 1S, p. S7, doi. 10.1177/14703203080090010114
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- Article
Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.
- Published in:
- Cardiovascular Diabetology, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12933-015-0256-6
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- Article
Chronic Rho‑kinase inhibition improves left ventricular contractile dysfunction in early type‑1 diabetes by increasing myosin cross‑bridge extension.
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- Cardiovascular Diabetology, 2015, v. 14, n. 1, p. 92, doi. 10.1186/s12933-015-0256-6
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- Article
High glucose induces smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy.
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- Cardiovascular Diabetology, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1475-2840-13-89
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- Article
Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation.
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- Cardiovascular Diabetology, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1475-2840-12-111
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- Article
Cost-Effectiveness of Renal Denervation Therapy for Treatment-Resistant Hypertension: A Best Case Scenario.
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- American Journal of Hypertension, 2018, v. 31, n. 10, p. 1156, doi. 10.1093/ajh/hpy108
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- Article
Cells expressing the stem cell factor receptor, c-kit, contribute to neoangiogenesis in diabetes.
- Published in:
- Diabetes & Vascular Disease Research, 2005, v. 2, n. 2, p. 76, doi. 10.3132/dvdr.2005.013
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- Article
Chronic kidney disease with comorbid cardiac dysfunction exacerbates cardiac and renal damage.
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- Journal of Cellular & Molecular Medicine, 2018, v. 22, n. 1, p. 628, doi. 10.1111/jcmm.13349
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- Article
Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia.
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- Journal of Cellular & Molecular Medicine, 2011, v. 15, n. 10, p. 2117, doi. 10.1111/j.1582-4934.2010.01241.x
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- Article
The role of dihydrosphingolipids in disease.
- Published in:
- Cellular & Molecular Life Sciences, 2019, v. 76, n. 6, p. 1107, doi. 10.1007/s00018-018-2984-8
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- Article
Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy.
- Published in:
- FASEB Journal, 2015, v. 29, n. 2, p. 540, doi. 10.1096/fj.14-254789
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- Article
Effect of Ruboxistaurin on Urinary Transforming Growth Factor-β in Patients With Diabetic Nephropathy and Type 2 Diabetes.
- Published in:
- Diabetes Care, 2007, v. 30, n. 4, p. 995, doi. 10.2337/dc06-2079
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- Article
Transforming Growth Factor-β in Human Diabetic Nephropathy.
- Published in:
- Diabetes Care, 2006, v. 29, n. 12, p. 2670, doi. 10.2337/dc06-0911
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- Publication type:
- Article
FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy.
- Published in:
- European Journal of Heart Failure, 2012, v. 14, n. 5, p. 549, doi. 10.1093/eurjhf/hfs011
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- Publication type:
- Article
Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings.
- Published in:
- Toxins, 2022, v. 14, n. 2, p. N.PAG, doi. 10.3390/toxins14020100
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- Article
Increased Diabetes Complications in a Mouse Model of Oxidative Stress Due to 'Mismatched' Mitochondrial DNA.
- Published in:
- Antioxidants, 2024, v. 13, n. 2, p. 187, doi. 10.3390/antiox13020187
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- Article
Cardiorenal syndrome: Multi-organ dysfunction involving the heart, kidney and vasculature.
- Published in:
- 2020
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- Publication type:
- journal article
The Challenges of Stem Cell Therapy in Myocardial Infarction and Heart Failure and the Potential Strategies to Improve the Outcomes.
- Published in:
- Nano Life, 2018, v. 08, n. 04, p. N.PAG, doi. 10.1142/S1793984418410088
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- Publication type:
- Article
The Interaction between the Renin-Angiotensin System and Vascular Endothelial Growth Factor in the Pathogenesis of Retinal Neovascularization in Diabetes.
- Published in:
- Journal of Vascular Research, 2001, v. 38, n. 6, p. 527, doi. 10.1159/000051088
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- Article
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension.
- Published in:
- 2003
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- Publication type:
- journal article
Protein Kinase C Β Inhibition Attenuates the Progression of Experimental Diabetic Nephropathy in the Presence of Continued Hypertension.
- Published in:
- Diabetes, 2003, v. 52, n. 2, p. 512, doi. 10.2337/diabetes.52.2.512
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- Article
ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.
- Published in:
- 2002
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- Publication type:
- journal article
Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes.
- Published in:
- 1999
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- Publication type:
- journal article