Works by Kell, Douglas B.

Results: 159

Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: Application to gibberellic acid production.

Published in:

Biotechnology & Bioengineering, 2002, v. 78, n. 5, p. 527, doi. 10.1002/bit.10226

By:

McGovern, Aoife C.;
Broadhurst, David;
Taylor, Janet;
Kaderbhai, Naheed;
Winson, Michael K.;
Small, David A.;
Rowland, Jem J.;
Kell, Douglas B.;
Goodacre, Royston

Publication type:

Article

The biology of ergothioneine, an antioxidant nutraceutical.

Published in:

Nutrition Research Reviews, 2020, v. 33, n. 2, p. 190, doi. 10.1017/S0954422419000301

By:

Borodina, Irina;
Kenny, Louise C.;
McCarthy, Cathal M.;
Paramasivan, Kalaivani;
Pretorius, Etheresia;
Roberts, Timothy J.;
van der Hoek, Steven A.;
Kell, Douglas B.

Publication type:

Article

TEG ® , Microclot and Platelet Mapping for Guiding Early Management of Severe COVID-19 Coagulopathy.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 22, p. 5381, doi. 10.3390/jcm10225381

By:

Laubscher, Gert Jacobus;
Lourens, Petrus Johannes;
Venter, Chantelle;
Kell, Douglas B;
Pretorius, Etheresia

Publication type:

Article

Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.

Published in:

Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00155

By:

Grixti, Justine M.;
O'hagan, Steve;
Day, Philip J.;
Kell, Douglas B.

Publication type:

Article

Event-based text mining for biology and functional genomics.

Published in:

Briefings in Functional Genomics, 2015, v. 14, n. 3, p. 213, doi. 10.1093/bfgp/elu015

By:

Ananiadou, Sophia;
Thompson, Paul;
Nawaz, Raheel;
McNaught, John;
Kell, Douglas B.

Publication type:

Article

Herpesvirus Infection of Endothelial Cells as a Systemic Pathological Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Published in:

Viruses (1999-4915), 2024, v. 16, n. 4, p. 572, doi. 10.3390/v16040572

By:

Nunes, Jean M.;
Kell, Douglas B.;
Pretorius, Etheresia

Publication type:

Article

High-throughput classification of yeast mutants for functional genomics using metabolic footprinting.

Published in:

Nature Biotechnology, 2003, v. 21, n. 6, p. 692, doi. 10.1038/nbt823

By:

Allen, Jess;
Davey, Hazel M;
Broadhurst, David;
Heald, Jim K;
Rowland, Jem J;
Oliver, Stephen G;
Kell, Douglas B

Publication type:

Article

A systematic approach to modeling, capturing, and disseminating proteomics experimental data.

Published in:

Nature Biotechnology, 2003, v. 21, n. 3, p. 247, doi. 10.1038/nbt0303-247

By:

Taylor, Chris F.;
Paton, Norman W.;
Garwood, Kevin L.;
Kirby, Paul D.;
Stead, David A.;
Yin, Zhikang;
Deutsch, Eric W.;
Selway, Laura;
Walker, Janet;
Riba-Garcia, Isabel;
Mohammed, Shabaz;
Deery, Michael J.;
Howard, Julie A.;
Dunkley, Tom;
Aebersold, Ruedi;
Kell, Douglas B.;
Lilley, Kathryn S.;
Roepstorff, Peter;
Yates, John R.

Publication type:

Article

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations.

Published in:

Nature Biotechnology, 2001, v. 19, n. 1, p. 45, doi. 10.1038/83496

By:

Raamsdonk, Léonie M.;
Teusink, Bas;
Broadhurst, David;
Zhang, Nianshu;
Hayes, Andrew;
Walsh, Michael C.;
Berden, Jan A.;
Brindle, Kevin M.;
Kell, Douglas B.;
Rowland, Jem J.;
Westerhoff, Hans V.;
van Dam, Karel;
Oliver, Stephen G.

Publication type:

Article

Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system.

Published in:

Cardiovascular Diabetology, 2022, v. 21, n. 1, p. 1, doi. 10.1186/s12933-022-01623-4

By:

Kruger, Arneaux;
Vlok, Mare;
Turner, Simone;
Venter, Chantelle;
Laubscher, Gert Jacobus;
Kell, Douglas B.;
Pretorius, Etheresia

Publication type:

Article

Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC).

Published in:

Cardiovascular Diabetology, 2022, v. 21, n. 1, p. 1, doi. 10.1186/s12933-022-01579-5

By:

Pretorius, Etheresia;
Venter, Chantelle;
Laubscher, Gert Jacobus;
Kotze, Maritha J;
Oladejo, Sunday O.;
Watson, Liam R.;
Rajaratnam, Kanshu;
Watson, Bruce W.;
Kell, Douglas B.

Publication type:

Article

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin.

Published in:

Cardiovascular Diabetology, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12933-021-01359-7

By:

Pretorius, Etheresia;
Vlok, Mare;
Venter, Chantelle;
Bezuidenhout, Johannes A.;
Laubscher, Gert Jacobus;
Steenkamp, Janami;
Kell, Douglas B.

Publication type:

Article

Metabolic footprinting and systems biology: the medium is the message.

Published in:

Nature Reviews Microbiology, 2005, v. 3, n. 7, p. 557, doi. 10.1038/nrmicro1177

By:

Kell, Douglas B.;
Brown, Marie;
Davey, Hazel M.;
Dunn, Warwick B.;
Spasic, Irena;
Oliver, Stephen G.

Publication type:

Article

Histometrics: Improvement of the dynamic range of fluorescently stained proteins resolved in electrophoretic gels using hyperspectral imaging.

Published in:

Proteomics, 2001, v. 1, n. 11, p. 1351, doi. 10.1002/1615-9861(200111)1:11<1351::AID-PROT1351>3.0.CO;2-0

By:

Woodward, Andrew M.;
Kaderbhai, Naheed;
Kaderbhai, Mustak;
Shaw, Adrian;
Rowland, Jem;
Kell, Douglas B.

Publication type:

Article

Functional genomic hypothesis generation and experimentation by a robot scientist.

Published in:

Nature, 2004, v. 427, n. 6971, p. 247, doi. 10.1038/nature02236

By:

King, Ross D.;
Whelan, Kenneth E.;
Jones, Ffion M.;
Reiser, Philip G. K.;
Bryant, Christopher H.;
Muggleton, Stephen H.;
Kell, Douglas B.;
Oliver, Stephen G.

Publication type:

Article

Fibrinaloid Microclots and Atrial Fibrillation.

Published in:

Biomedicines, 2024, v. 12, n. 4, p. 891, doi. 10.3390/biomedicines12040891

By:

Kell, Douglas B.;
Lip, Gregory Y. H.;
Pretorius, Etheresia

Publication type:

Article

Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation.

Published in:

Molecular Microbiology, 2006, v. 59, n. 1, p. 84, doi. 10.1111/j.1365-2958.2005.04930.x

By:

Mukamolova, Galina V.;
Murzin, Alexey G.;
Salina, Elena G.;
Demina, Galina R.;
Kell, Douglas B.;
Kaprelyants, Arseny S.;
Young, Michael

Publication type:

Article

The rpf gene ofMicrococcus luteus encodes an essential secreted growth factor.

Published in:

Molecular Microbiology, 2002, v. 46, n. 3, p. 611, doi. 10.1046/j.1365-2958.2002.03183.x

By:

Mukamolova, Galina V.;
Turapov, Obolbek A.;
Kazarian, Konstantin;
Telkov, Miroslav;
Kaprelyants, Arseny S.;
Kell, Douglas B.;
Young, Michael

Publication type:

Article

A family of autocrine growth factors in Mycobacterium tuberculosis.

Published in:

Molecular Microbiology, 2002, v. 46, n. 3, p. 623, doi. 10.1046/j.1365-2958.2002.03184.x

By:

Mukamolova, Galina V.;
Turapov, Obolbek A.;
Young, Danielle I.;
Kaprelyants, Arseny S.;
Kell, Douglas B.;
Young, Michael

Publication type:

Article

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape.

Published in:

Nucleic Acids Research, 2009, v. 37, n. 1, p. e6, doi. 10.1093/nar/gkn899

By:

Knight, Christopher G.;
Platt, Mark;
Rowe, William;
Wedge, David C.;
Khan, Farid;
Day, Philip J. R.;
McShea, Andy;
Knowles, Joshua;
Kell, Douglas B.

Publication type:

Article

A Direct Relationship Between 'Blood Stasis' and Fibrinaloid Microclots in Chronic, Inflammatory, and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 712, doi. 10.3390/ph18050712

By:

Kell, Douglas B.;
Pretorius, Etheresia;
Zhao, Huihui

Publication type:

Article

Evidence for the Role of the Mitochondrial ABC Transporter MDL1 in the Uptake of Clozapine and Related Molecules into the Yeast Saccharomyces cerevisiae.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 7, p. 938, doi. 10.3390/ph17070938

By:

Theron, Chrispian W.;
Salcedo-Sora, J. Enrique;
Grixti, Justine M.;
Møller-Hansen, Iben;
Borodina, Irina;
Kell, Douglas B.

Publication type:

Article

The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 8, p. 931, doi. 10.3390/ph15080931

By:

Nunes, Jean M.;
Kruger, Arneaux;
Proal, Amy;
Kell, Douglas B.;
Pretorius, Etheresia

Publication type:

Article

Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia.

Published in:

PLoS ONE, 2020, v. 15, n. 3, p. 1, doi. 10.1371/journal.pone.0230977

By:

Morillon, Aude-Claire;
Williamson, Rachel D.;
Baker, Philip N.;
Kell, Douglas B.;
Kenny, Louise C.;
English, Jane A.;
McCarthy, Fergus P.;
McCarthy, Cathal

Publication type:

Article

Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia.

Published in:

Bioscience Reports, 2023, v. 43, n. 7, p. 1, doi. 10.1042/BSR20230160

By:

Kenny, Louise C.;
Brown, Leslie W.;
Ortea, Paloma;
Tuytten, Robin;
Kell, Douglas B.

Publication type:

Article

SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19.

Published in:

Bioscience Reports, 2021, v. 41, n. 8, p. 1, doi. 10.1042/BSR20210611

By:

Grobbelaar, Lize M.;
Venter, Chantelle;
Vlok, Mare;
Ngoepe, Malebogo;
Laubscher, Gert Jacobus;
Lourens, Petrus Johannes;
Steenkamp, Janami;
Kell, Douglas B.;
Pretorius, Etheresia

Publication type:

Article

Engineering ergothioneine production in Yarrowia lipolytica.

Published in:

FEBS Letters, 2022, v. 596, n. 10, p. 1356, doi. 10.1002/1873-3468.14239

By:

van der Hoek, Steven A.;
Rusnak, Matej;
Jacobsen, Irene Hjorth;
Martınez, Jose L.;
Kell, Douglas B.;
Borodina, Irina

Publication type:

Article

Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures.

Published in:

Nature Genetics, 2008, v. 40, n. 1, p. 113, doi. 10.1038/ng.2007.49

By:

Delneri, Daniela;
Hoyle, David C.;
Gkargkas, Konstantinos;
Cross, Emma J. M.;
Rash, Bharat;
Zeef, Leo;
Hui-Sun Leong;
Davey, Hazel M.;
Hayes, Andrew;
Kell, Douglas B.;
Griffith, Gareth W.;
Oliver, Stephen G.

Publication type:

Article

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.

Published in:

FEBS Journal, 2013, v. 280, n. 23, p. 5957, doi. 10.1111/febs.12268

By:

Kell, Douglas B.

Publication type:

Article

Enzyme kinetics informatics: from instrument to browser.

Published in:

FEBS Journal, 2010, v. 277, n. 18, p. 3769, doi. 10.1111/j.1742-4658.2010.07778.x

By:

Swainston, Neil;
Golebiewski, Martin;
Messiha, Hanan L.;
Malys, Naglis;
Kania, Renate;
Kengne, Sylvestre;
Krebs, Olga;
Mir, Saqib;
Sauer-Danzwith, Heidrun;
Smallbone, Kieran;
Weidemann, Andreas;
Wittig, Ulrike;
Kell, Douglas B.;
Mendes, Pedro;
Müller, Wolfgang;
Paton, Norman W.;
Rojas, Isabel

Publication type:

Article

Something from nothing − bridging the gap between constraint-based and kinetic modelling.

Published in:

FEBS Journal, 2007, v. 274, n. 21, p. 5576, doi. 10.1111/j.1742-4658.2007.06076.x

By:

Smallbone, Kieran;
Simeonidis, Evangelos;
Broomhead, David S.;
Kell, Douglas B.

Publication type:

Article

Metabolomics, modelling and machine learning in systems biology – towards an understanding of the languages of cells.

Published in:

FEBS Journal, 2006, v. 273, n. 5, p. 873, doi. 10.1111/j.1742-4658.2006.05136.x

By:

Kell, Douglas B.

Publication type:

Article

Automated manipulation of systems biology models using libSBML within Taverna workflows.

Published in:

Bioinformatics, 2008, v. 24, n. 2, p. 287

By:

Peter Li;
Tom Oinn;
Stian Soiland;
Douglas B. Kell

Publication type:

Article

Computational cluster validation in post-genomic data analysis.

Published in:

Bioinformatics, 2005, v. 21, n. 15, p. 3201, doi. 10.1093/bioinformatics/bti517

By:

Julia Handl;
Joshua Knowles;
Douglas B. Kell

Publication type:

Article

MEG (Model Extender for Gepasi): a program for the modelling of complex, heterogeneous, cellular systems.

Published in:

Bioinformatics, 2001, v. 17, n. 3, p. 288, doi. 10.1093/bioinformatics/17.3.288

By:

Mendes, Pedro;
Kell, Douglas B.

Publication type:

Article

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.

Published in:

Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0520-5

By:

Zhang, Shaowei;
Sakuma, Michiyo;
Deora, Girdhar S.;
Levy, Colin W.;
Klausing, Alex;
Breda, Carlo;
Read, Kevin D.;
Edlin, Chris D.;
Ross, Benjamin P.;
Wright Muelas, Marina;
Day, Philip J.;
O'Hagan, Stephen;
Kell, Douglas B.;
Schwarcz, Robert;
Leys, David;
Heyes, Derren J.;
Giorgini, Flaviano;
Scrutton, Nigel S.

Publication type:

Article

Analysis of a Library of Escherichia coli Transporter Knockout Strains to Identify Transport Pathways of Antibiotics.

Published in:

Antibiotics (2079-6382), 2022, v. 11, n. 8, p. 1, doi. 10.3390/antibiotics11081129

By:

Munro, Lachlan Jake;
Kell, Douglas B.

Publication type:

Article

A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery.

Published in:

Antibiotics (2079-6382), 2020, v. 9, n. 8, p. 508, doi. 10.3390/antibiotics9080508

By:

Salcedo-Sora, Jesus Enrique;
Kell, Douglas B.

Publication type:

Article

Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS): Focus on Long COVID.

Published in:

Journal of Personalized Medicine, 2024, v. 14, n. 2, p. 170, doi. 10.3390/jpm14020170

By:

Kell, Douglas B.;
Khan, Muhammed Asad;
Kane, Binita;
Lip, Gregory Y. H.;
Pretorius, Etheresia

Publication type:

Article

Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability.

Published in:

Environmental Microbiology, 2012, v. 14, n. 5, p. 1249, doi. 10.1111/j.1462-2920.2012.02705.x

By:

Davey, Hazel M.;
Cross, Emma J. M.;
Davey, Christopher, L.;
Gkargkas, Konstantinos;
Delneri, Daniela;
Hoyle, David C.;
Oliver, Stephen G.;
Kell, Douglas B.;
Griffith, Gareth W.

Publication type:

Article

Chemometric criteria for the characterisation of Italian Protected Denomination of Origin (DOP) olive oils from their metabolic profiles.

Published in:

European Journal of Lipid Science & Technology, 2001, v. 103, n. 3, p. 141, doi. 10.1002/1438-9312(200103)103:3<141::AID-EJLT141>3.0.CO;2-X

By:

Bianchi, Giorgio;
Giansante, Lucia;
Shaw, Adrian;
Kell, Douglas B.

Publication type:

Article

Identification of transporters involved in aromatic compounds tolerance through screening of transporter deletion libraries.

Published in:

Microbial Biotechnology, 2024, v. 17, n. 4, p. 1, doi. 10.1111/1751-7915.14460

By:

Sáez‐Sáez, Javier;
Munro, Lachlan Jake;
Møller‐Hansen, Iben;
Kell, Douglas B.;
Borodina, Irina

Publication type:

Article

Metabolic footprinting as a tool for discriminating between brewing yeasts.

Published in:

Yeast, 2007, v. 24, n. 8, p. 667, doi. 10.1002/yea.1499

By:

Pope, Georgina A.;
MacKenzie, Donald A.;
Defernez, Marianne;
Aroso, Miguel A. M. M.;
Fuller, Linda J.;
Mellon, Fred A.;
Dunn, Warwick B.;
Brown, Marie;
Goodacre, Royston;
Kell, Douglas B.;
Marvin, Marcus E.;
Louis, Edward J;
Roberts, Ian N.

Publication type:

Article

Proteomic Evidence for Amyloidogenic Cross-Seeding in Fibrinaloid Microclots.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 19, p. 10809, doi. 10.3390/ijms251910809

By:

Kell, Douglas B.;
Pretorius, Etheresia

Publication type:

Article

The Biology and Biochemistry of Kynurenic Acid, a Potential Nutraceutical with Multiple Biological Effects.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 16, p. 9082, doi. 10.3390/ijms25169082

By:

Alves, Luana de Fátima;
Moore, J. Bernadette;
Kell, Douglas B.

Publication type:

Article

Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 8234, doi. 10.3390/ijms21218234

By:

Venter, Chantelle;
Bezuidenhout, Johannes Andries;
Laubscher, Gert Jacobus;
Lourens, Petrus Johannes;
Steenkamp, Janami;
Kell, Douglas B.;
Pretorius, Etheresia

Publication type:

Article

Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 14, p. 5168, doi. 10.3390/ijms21145168

By:

Grobler, Corlia;
Maphumulo, Siphosethu C.;
Grobbelaar, L. Mireille;
Bredenkamp, Jhade C.;
Laubscher, Gert J.;
Lourens, Petrus J.;
Steenkamp, Janami;
Kell, Douglas B.;
Pretorius, Etheresia

Publication type:

Article

The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation.

Published in:

Chronic Stress, 2022, v. 6, p. 1, doi. 10.1177/24705470221076390

By:

Page, Martin J.;
Kell, Douglas B.;
Pretorius, Etheresia

Publication type:

Article

The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation.

Published in:

Chronic Stress, 2022, p. 1, doi. 10.1177/24705470221076390

By:

Page, Martin J.;
Kell, Douglas B.;
Pretorius, Etheresia

Publication type:

Article

Mechanisms for the interaction between nonstationary electric fields and biological systems II. Nonlinear dielectric theory and free-energy transduction.

Published in:

Ferroelectrics, 1988, v. 86, n. 1, p. 79, doi. 10.1080/00150198808227005

By:

Westerhoff, Hans V.;
Astumian, R. Dean;
Kell, Douglas B.

Publication type:

Article