OpenURL Connection Search

Select item for more details and to access through your institution.

Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial.
Published in:
2018
By:
- Javitt, Daniel C.;
- Carter, Cameron S.;
- Krystal, John H.;
- Kantrowitz, Joshua T.;
- Girgis, Ragy R.;
- Kegeles, Lawrence S.;
- Ragland, John D.;
- Maddock, Richard J.;
- Lesh, Tyler A.;
- Tanase, Costin;
- Corlett, Philip R.;
- Rothman, Douglas L.;
- Mason, Graeme;
- Qiu, Maolin;
- Robinson, James;
- Potter, William Z.;
- Carlson, Marlene;
- Wall, Melanie M.;
- Choo, Tse-Hwei;
- Grinband, Jack
Publication type:
journal article
Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder.
Published in:
Translational Psychiatry, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41398-021-01541-1
By:
- Kantrowitz, Joshua T.;
- Dong, Zhengchao;
- Milak, Matthew S.;
- Rashid, Rain;
- Kegeles, Lawrence S.;
- Javitt, Daniel C.;
- Lieberman, Jeffrey A.;
- John Mann, J.
Publication type:
Article
99mTc HMPAO SPECT prediction of conversion from mild cognitive impairment to Alzheimer's disease
Published in:
2009
By:
- Devanand, D.P.;
- Van Heertum, Ronald L.;
- Kegeles, Lawrence S.;
- Liu, Xinhua;
- Jin, Zong H.;
- Mikhno, Arthur;
- Pelton, Gregory H.;
- Pradhaban, Gnanavalli;
- Pratap, Mali;
- Scarmeas, Nikolaos;
- Rusinek, Henry;
- Mann, J. John;
- Parsey, Ramin V.
Publication type:
Abstract
99mTc HMPAO SPECT prediction of conversion from mild cognitive impairment to Alzheimer's disease
Published in:
2009
By:
- Devanand, D.P.;
- Van Heertum, Ronald L.;
- Kegeles, Lawrence S.;
- Liu, Xinhua;
- Jin, Zong H.;
- Mikhno, Arthur;
- Pelton, Gregory H.;
- Pradhaban, Gnanavalli;
- Pratap, Mali;
- Scarmeas, Nikolaos;
- Rusinek, Henry;
- Mann, J. John;
- Parsey, Ramin V.
Publication type:
Abstract
Glutamate, Dopamine, and Schizophrenia.
Published in:
Annals of the New York Academy of Sciences, 2003, v. 1003, n. 1, p. 138, doi. 10.1196/annals.1300.063
By:
- LARUELLE, MARC;
- KEGELES, LAWRENCE S.;
- ABI-DARGHAM, ANISSA
Publication type:
Article
Brain γ-aminobutyric acid (GABA) detection in vivo with the J-editing 1H MRS technique: a comprehensive methodological evaluation of sensitivity enhancement, macromolecule contamination and test-retest reliability.
Published in:
NMR in Biomedicine, 2016, v. 29, n. 7, p. 932, doi. 10.1002/nbm.3539
By:
- Shungu, Dikoma C.;
- Mao, Xiangling;
- Gonzales, Robyn;
- Soones, Tacara N.;
- Dyke, Jonathan P.;
- Veen, Jan Willem;
- Kegeles, Lawrence S.
Publication type:
Article
Striatal and extrastriatal dopamine release measured with PET and [18F] fallypride.
Published in:
Synapse, 2010, v. 64, n. 5, p. 350, doi. 10.1002/syn.20734
By:
- Slifstein, Mark;
- Kegeles, Lawrence S.;
- Xu, Xiaoyan;
- Thompson, Judy L.;
- Urban, Nina;
- Castrillon, John;
- Hackett, Elizabeth;
- Bae, S.-A.;
- Laruelle, Marc;
- Abi-Dargham, Anissa
Publication type:
Article
In vivo vulnerability to competition by endogenous dopamine: Comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
Published in:
Synapse, 2004, v. 52, n. 3, p. 188, doi. 10.1002/syn.20013
By:
- Narendran, Rajesh;
- Hwang, Dah-Ren;
- Slifstein, Mark;
- Talbot, Peter S.;
- Erritzoe, David;
- Huang, Yiyun;
- Cooper, Thomas B.;
- Martinez, Diana;
- Kegeles, Lawrence S.;
- Abi-Dargham, Anissa;
- Laruelle, Marc
Publication type:
Article
NMDA antagonist effects on striatal dopamine release: Positron emission tomography studies in humans.
Published in:
Synapse, 2002, v. 43, n. 1, p. 19, doi. 10.1002/syn.10010
By:
- Kegeles, Lawrence S.;
- Martinez, Diana;
- Kochan, Lisa D.;
- Hwang, Dah-Ren;
- Huang, Yiyun;
- Mawlawi, Osama;
- Suckow, R. F.;
- Van Heertum, Ronald L.;
- Laruelle, Marc
Publication type:
Article
Stability of [123I]IBZM SPECT measurement of amphetamine-induced striatal dopamine release in humans.
Published in:
Synapse, 1999, v. 31, n. 4, p. 302, doi. 10.1002/(SICI)1098-2396(19990315)31:4<302::AID-SYN9>3.0.CO;2-A
By:
- Kegeles, Lawrence S.;
- Zea-Ponce, Yolanda;
- Abi-Dargham, Anissa;
- Rodenhiser, Janine;
- Wang, Theodore;
- Weiss, Richard;
- Van Heertum, Ronald L.;
- Mann, J. John;
- Laruelle, Marc
Publication type:
Article
[11C]NNC 112 selectivity for dopamine D1 and serotonin 5-HT2A receptors: a PET study in healthy human subjects.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2007, v. 27, n. 10, p. 1733, doi. 10.1038/sj.jcbfm.9600468
By:
- Slifstein, Mark;
- Kegeles, Lawrence S.;
- Gonzales, Robyn;
- Frankle, William G.;
- Xiaoyan Xu;
- Laruelle, Marc;
- Abi-Dargham, Anissa
Publication type:
Article
Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2002, v. 22, n. 11, p. 1377, doi. 10.1097/00004647-200211000-00011
By:
- Huang, Yiyun;
- Hwang, Dah-Ren;
- Narendran, Raj;
- Sudo, Yasuhiko;
- Chatterjee, Rano;
- Bae, Sung-A;
- Mawlawi, Osama;
- Kegeles, Lawrence S;
- Wilson, Alan A;
- Kung, Hank F;
- Laruelle, Marc
Publication type:
Article
Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept.
Published in:
Neuropsychopharmacology, 2013, v. 38, n. 12, p. 2475, doi. 10.1038/npp.2013.150
By:
- Rodriguez, Carolyn I;
- Kegeles, Lawrence S;
- Levinson, Amanda;
- Feng, Tianshu;
- Marcus, Sue M;
- Vermes, Donna;
- Flood, Pamela;
- Simpson, Helen B
Publication type:
Article
Effects of Davunetide on N-acetylaspartate and Choline in Dorsolateral Prefrontal Cortex in Patients with Schizophrenia.
Published in:
Neuropsychopharmacology, 2013, v. 38, n. 7, p. 1245, doi. 10.1038/npp.2013.23
By:
- Jarskog, L Fredrik;
- Dong, Zhengchao;
- Kangarlu, Alayar;
- Colibazzi, Tiziano;
- Girgis, Ragy R;
- Kegeles, Lawrence S;
- Barch, Deanna M;
- Buchanan, Robert W;
- Csernansky, John G;
- Goff, Donald C;
- Harms, Michael P;
- Javitt, Daniel C;
- Keefe, Richard SE;
- McEvoy, Joseph P;
- McMahon, Robert P;
- Marder, Stephen R;
- Peterson, Bradley S;
- Lieberman, Jeffrey A
Publication type:
Article
Investigation of Cortical Glutamate-Glutamine and γ-Aminobutyric Acid in Obsessive-Compulsive Disorder by Proton Magnetic Resonance Spectroscopy.
Published in:
Neuropsychopharmacology, 2012, v. 37, n. 12, p. 2684, doi. 10.1038/npp.2012.132
By:
- Simpson, Helen B;
- Shungu, Dikoma C;
- Bender, James;
- Mao, Xiangling;
- Xu, Xiaoyan;
- Slifstein, Mark;
- Kegeles, Lawrence S
Publication type:
Article
Sustained Recreational Use of Ecstasy Is Associated with Altered Pre and Postsynaptic Markers of Serotonin Transmission in Neocortical Areas: A PET Study with [11C]DASB and [11C]MDL 100907.
Published in:
Neuropsychopharmacology, 2012, v. 37, n. 6, p. 1465, doi. 10.1038/npp.2011.332
By:
- Urban, Nina BL;
- Girgis, Ragy R;
- Talbot, Peter S;
- Kegeles, Lawrence S;
- Xu, X;
- Frankle, W Gordon;
- Hart, Carl L;
- Slifstein, Mark;
- Abi-Dargham, Anissa;
- Laruelle, Marc
Publication type:
Article
Dose–Occupancy Study of Striatal and Extrastriatal Dopamine D2 Receptors by Aripiprazole in Schizophrenia with PET and [18F]Fallypride.
Published in:
Neuropsychopharmacology, 2008, v. 33, n. 13, p. 3111, doi. 10.1038/npp.2008.33
By:
- Kegeles, Lawrence S.;
- Slifstein, Mark;
- Frankle, W. Gordon;
- Xiaoyan Xu;
- Hackett, Elizabeth;
- Sung-A Bae;
- Gonzales, Robyn;
- Jong-Hoon Kim;
- Alvarez, Beatriz;
- Gil, Roberto;
- Laruelle, Marc;
- Abi-Dargham, Anissa
Publication type:
Article
Modulation of Amphetamine-Induced Dopamine Release by Group II Metabotropic Glutamate Receptor Agonist LY354740 in Non-Human Primates Studied with Positron Emission Tomography.
Published in:
Neuropsychopharmacology, 2006, v. 31, n. 5, p. 967, doi. 10.1038/sj.npp.1300902
By:
- van Berckel, Bart N. M.;
- Kegeles, Lawrence S.;
- Waterhouse, Rikki;
- Ningning Guo;
- Dah-Ren Hwang;
- Yiyun Huang;
- Narendran, Rajesh;
- Van Heertum, Ronald;
- Laruelle, Marc
Publication type:
Article
Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635.
Published in:
Psychopharmacology, 2006, v. 189, n. 2, p. 155, doi. 10.1007/s00213-006-0543-8
By:
- Frankle, W. Gordon;
- Lombardo, Ilise;
- Kegeles, Lawrence S.;
- Slifstein, Mark;
- Martin, John H.;
- Huang, Yiyun;
- Hwang, Dah-Ren;
- Reich, Elisa;
- Cangiano, Claudine;
- Gil, Roberto;
- Laruelle, Marc;
- Abi-Dargham, Anissa
Publication type:
Article
Estimating the effect of endogenous dopamine on baseline [11C]-(+)-PHNO binding in the human brain.
Published in:
Synapse, 2016, v. 70, n. 11, p. 453, doi. 10.1002/syn.21920
By:
- Caravaggio, Fernando;
- Kegeles, Lawrence S.;
- Wilson, Alan A.;
- Remington, Gary;
- Borlido, Carol;
- Mamo, David C.;
- Graff‐Guerrero, Ariel
Publication type:
Article
Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial.
Published in:
JAMA Network Open, 2020, v. 3, n. 8, p. e2013211, doi. 10.1001/jamanetworkopen.2020.13211
By:
- Milak, Matthew S.;
- Rashid, Rain;
- Dong, Zhengchao;
- Kegeles, Lawrence S.;
- Grunebaum, Michael F.;
- Ogden, R. Todd;
- Lin, Xuejing;
- Mulhern, Stephanie T.;
- Suckow, Raymond F.;
- Cooper, Thomas B.;
- Keilp, John G.;
- Mao, Xiangling;
- Shungu, Dikoma C.;
- Mann, J. John
Publication type:
Article
Amphetamine-induced striatal dopamine release in schizotypal personality disorder.
Published in:
Psychopharmacology, 2020, v. 237, n. 9, p. 2649, doi. 10.1007/s00213-020-05561-5
By:
- Thompson, Judy L.;
- Rosell, Daniel R.;
- Slifstein, Mark;
- Xu, Xiaoyan;
- Rothstein, Ethan G.;
- Modiano, Yosefa A.;
- Kegeles, Lawrence S.;
- Koenigsberg, Harold W.;
- New, Antonia S.;
- Hazlett, Erin A.;
- McClure, Margaret M.;
- Perez-Rodriguez, M. Mercedes;
- Siever, Larry J.;
- Abi-Dargham, Anissa
Publication type:
Article
Biodistribution and radiation dosimetry of the glycine transporter-1 ligand 11C-GSK931145 determined from primate and human whole-body PET.
Published in:
2011
By:
- Bullich, Santiago;
- Slifstein, Mark;
- Passchier, Jan;
- Murthy, N.;
- Kegeles, Lawrence;
- Kim, Jong-Hoon;
- Xu, Xiaoyan;
- Gunn, Roger;
- Herance, Raul;
- Gispert, Juan;
- Gutiérrez, Antonio;
- Farré, Magí;
- Laruelle, Marc;
- Catafau, Ana;
- Murthy, N Venkatesha;
- Kegeles, Lawrence S;
- Gunn, Roger N;
- Gispert, Juan Domingo;
- Gutiérrez, Antonio;
- Farré, Magí
Publication type:
journal article
Detecting schizophrenia with 3D structural brain MRI using deep learning.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-41359-z
By:
- Zhang, Junhao;
- Rao, Vishwanatha M.;
- Tian, Ye;
- Yang, Yanting;
- Acosta, Nicolas;
- Wan, Zihan;
- Lee, Pin-Yu;
- Zhang, Chloe;
- Kegeles, Lawrence S.;
- Small, Scott A.;
- Guo, Jia
Publication type:
Article
Detecting schizophrenia with 3D structural brain MRI using deep learning.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-41359-z
By:
- Zhang, Junhao;
- Rao, Vishwanatha M.;
- Tian, Ye;
- Yang, Yanting;
- Acosta, Nicolas;
- Wan, Zihan;
- Lee, Pin-Yu;
- Zhang, Chloe;
- Kegeles, Lawrence S.;
- Small, Scott A.;
- Guo, Jia
Publication type:
Article
A proof-of-concept, randomized controlled trial of DAR-0100A, a dopamine-1 receptor agonist, for cognitive enhancement in schizophrenia.
Published in:
2016
By:
- Girgis, Ragy R.;
- Van Snellenberg, Jared X.;
- Glass, Andrew;
- Kegeles, Lawrence S.;
- Thompson, Judy L.;
- Wall, Melanie;
- Cho, Raymond Y.;
- Carter, Cameron S.;
- Slifstein, Mark;
- Abi-Dargham, Anissa;
- Lieberman, Jeffrey A.
Publication type:
journal article
Increased prefrontal cortical D1 receptors in drug naïve patients with schizophrenia: a PET study with [11C]NNC112.
Published in:
Journal of Psychopharmacology, 2012, v. 26, n. 6, p. 794, doi. 10.1177/0269881111409265
By:
- Abi-Dargham, Anissa;
- Xu, Xiaoyan;
- Thompson, Judy L;
- Gil, Roberto;
- Kegeles, Lawrence S;
- Urban, Nina;
- Narendran, Raj;
- Hwang, Dah-Ren;
- Laruelle, Marc;
- Slifstein, Mark
Publication type:
Article
Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone.
Published in:
Journal of Psychopharmacology, 2011, v. 25, n. 6, p. 734, doi. 10.1177/0269881110388329
By:
- Frankle, W Gordon;
- Lombardo, Ilise;
- Kegeles, Lawrence S;
- Slifstein, Mark;
- Martin, John H;
- Huang, Yiyun;
- Hwang, Dah-Ren;
- Reich, Elisa;
- Cangiano, Claudine;
- Gil, Roberto;
- Abi-Dargham, Anissa;
- Laruelle, Marc
Publication type:
Article
Quantitative Analysis of (--)-N-11C-Propyl-Norapomorphine In Vivo Binding in Nonhuman Primates.
Published in:
Journal of Nuclear Medicine, 2004, v. 45, n. 2, p. 338
By:
- Dah-Ren Hwang;
- Narendran, Rajesh;
- Yiyun Huang;
- Slifstein, Mark;
- Talbot, Peter S.;
- Sudo, Yasuhiko;
- Van Berckel, Bart N.;
- Kegeles, Lawrence S.;
- Martinez, Diana;
- Laruelle, Marc
Publication type:
Article
In Vivo Quantification of Brain Serotonin Transporters in Humans Using [11C]McN 5652.
Published in:
Journal of Nuclear Medicine, 2000, v. 41, n. 9, p. 1465
By:
- Parsey, Ramin V.;
- Kegeles, Lawrence S.;
- Hwang, Dah-Ren;
- Simpson, Norman;
- Abi.-Dargham, Anissa;
- Mawlawi, Osama;
- Slifstein, Mark;
- Van Heertum, Ronald L.;
- Mann, J. John;
- Laruelle, Marc
Publication type:
Article

Found: 30

Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial.

Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder.

99mTc HMPAO SPECT prediction of conversion from mild cognitive impairment to Alzheimer's disease

99mTc HMPAO SPECT prediction of conversion from mild cognitive impairment to Alzheimer's disease

Glutamate, Dopamine, and Schizophrenia.

Brain γ-aminobutyric acid (GABA) detection in vivo with the J-editing <sup>1</sup>H MRS technique: a comprehensive methodological evaluation of sensitivity enhancement, macromolecule contamination and test-retest reliability.

Striatal and extrastriatal dopamine release measured with PET and [<sup>18</sup>F] fallypride.

In vivo vulnerability to competition by endogenous dopamine: Comparison of the D<sub>2</sub> receptor agonist radiotracer (-)-N-[<sup>11</sup>C]propyl-norapomorphine ([<sup>11</sup>C]NPA) with the D<sub>2</sub> receptor antagonist radiotracer [<sup>11</sup>C]-raclopride

NMDA antagonist effects on striatal dopamine release: Positron emission tomography studies in humans.

Stability of [<sup>123</sup>I]IBZM SPECT measurement of amphetamine-induced striatal dopamine release in humans.

[<sup>11</sup>C]NNC 112 selectivity for dopamine D<sub>1</sub> and serotonin 5-HT<sub>2A</sub> receptors: a PET study in healthy human subjects.

Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [<sup>11</sup>C]McN 5652, [<sup>11</sup>C]ADAM, [<sup>11</sup>C]DASB, [<sup>11</sup>C]DAPA, and [<sup>11</sup>C]AFM.

Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept.

Effects of Davunetide on N-acetylaspartate and Choline in Dorsolateral Prefrontal Cortex in Patients with Schizophrenia.

Investigation of Cortical Glutamate-Glutamine and γ-Aminobutyric Acid in Obsessive-Compulsive Disorder by Proton Magnetic Resonance Spectroscopy.

Sustained Recreational Use of Ecstasy Is Associated with Altered Pre and Postsynaptic Markers of Serotonin Transmission in Neocortical Areas: A PET Study with [<sup>11</sup>C]DASB and [<sup>11</sup>C]MDL 100907.

Dose–Occupancy Study of Striatal and Extrastriatal Dopamine D<sub>2</sub> Receptors by Aripiprazole in Schizophrenia with PET and [<sup>18</sup>F]Fallypride.

Modulation of Amphetamine-Induced Dopamine Release by Group II Metabotropic Glutamate Receptor Agonist LY354740 in Non-Human Primates Studied with Positron Emission Tomography.

Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [<sup>11</sup>C]WAY 100635.

Estimating the effect of endogenous dopamine on baseline [<sup>11</sup>C]-(+)-PHNO binding in the human brain.

Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial.

Amphetamine-induced striatal dopamine release in schizotypal personality disorder.

Biodistribution and radiation dosimetry of the glycine transporter-1 ligand 11C-GSK931145 determined from primate and human whole-body PET.

Detecting schizophrenia with 3D structural brain MRI using deep learning.

Detecting schizophrenia with 3D structural brain MRI using deep learning.

A proof-of-concept, randomized controlled trial of DAR-0100A, a dopamine-1 receptor agonist, for cognitive enhancement in schizophrenia.

Increased prefrontal cortical D1 receptors in drug naïve patients with schizophrenia: a PET study with [11C]NNC112.

Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone.

Quantitative Analysis of (--)-N-<sup>11</sup>C-Propyl-Norapomorphine In Vivo Binding in Nonhuman Primates.

In Vivo Quantification of Brain Serotonin Transporters in Humans Using [<sup>11</sup>C]McN 5652.