Works by Kaulich, Manuel

Results: 28

BaCoN (Balanced Correlation Network) improves prediction of gene buffering.

Published in:

Molecular Systems Biology, 2025, v. 21, n. 7, p. 807, doi. 10.1038/s44320-025-00103-7

By:

Rohde, Thomas;
Demirtas, Talip Yasir;
Süsser, Sebastian;
Shaw, Angela Helen;
Kaulich, Manuel;
Billmann, Maximilian

Publication type:

Article

ReCo: automated NGS read-counting of single and combinatorial CRISPR gRNAs.

Published in:

Bioinformatics, 2023, v. 39, n. 8, p. 1, doi. 10.1093/bioinformatics/btad448

By:

Wegner, Martin;
Kaulich, Manuel

Publication type:

Article

Functional Genomics Approaches to Elucidate Vulnerabilities of Intrinsic and Acquired Chemotherapy Resistance.

Published in:

Cells (2073-4409), 2021, v. 10, n. 2, p. 260, doi. 10.3390/cells10020260

By:

Cetin, Ronay;
Quandt, Eva;
Kaulich, Manuel;
Michaelis, Martin

Publication type:

Article

Computational prediction of CRISPR-impaired non-coding regulatory regions.

Published in:

Biological Chemistry, 2021, v. 402, n. 8, p. 973, doi. 10.1515/hsz-2020-0392

By:

Baumgarten, Nina;
Schmidt, Florian;
Wegner, Martin;
Hebel, Marie;
Kaulich, Manuel;
Schulz, Marcel H.

Publication type:

Article

S105: CLONAL DIFFERENTIATION TRAJECTORIES OF ADULT ACUTE LYMPHOBLASTIC LEUKEMIA AT SINGLE CELL LEVEL.

Published in:

HemaSphere, 2023, v. 7, p. 1, doi. 10.1097/01.HS9.0000967332.12393.2c

By:

Geßner, Alec;
Jolly, Adrien;
Sijmonsma, Tjeerd;
Yu, Weijia;
Abou‐El‐Ardat, Khalil;
Kaulich, Manuel;
Guenther, Stefan;
Lang, Fabian;
Buettner, Florian;
Rieger, Michael

Publication type:

Article

P447: DECIPHERING THE MITOPHAGY RECEPTOR NETWORK IDENTIFIES A CRUCIAL ROLE FOR OPTINEURIN IN ACUTE MYELOID LEUKEMIA.

Published in:

2023

By:

Meyer, Laura;
Koschade, Sebastian;
Vischedyk, Jonas;
Thölken, Marlyn;
Gubas, Andrea;
Wegner, Martin;
Basoglu, Marion;
Knapp, Stefan;
Kaulich, Manuel;
Eimer, Stefan;
Shaid, Shabnam;
Brandts, Christian

Publication type:

Abstract

Optimized metrics for orthogonal combinatorial CRISPR screens.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-34597-8

By:

Cetin, Ronay;
Wegner, Martin;
Luwisch, Leah;
Saud, Sarada;
Achmedov, Tatjana;
Süsser, Sebastian;
Vera-Guapi, Antonella;
Müller, Konstantin;
Matthess, Yves;
Quandt, Eva;
Schaubeck, Simone;
Beisel, Chase L.;
Kaulich, Manuel

Publication type:

Article

Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32564-x

By:

Michaelis, Jonas Benjamin;
Brunstein, Melinda Elaine;
Bozkurt, Süleyman;
Alves, Ludovico;
Wegner, Martin;
Kaulich, Manuel;
Pohl, Christian;
Münch, Christian

Publication type:

Article

Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia.

Published in:

Autophagy, 2023, v. 19, n. 11, p. 2982, doi. 10.1080/15548627.2023.2230839

By:

Meyer, Laura M.;
Koschade, Sebastian E.;
Vischedyk, Jonas B.;
Thoelken, Marlyn;
Gubas, Andrea;
Wegner, Martin;
Basoglu, Marion;
Knapp, Stefan;
Kaulich, Manuel;
Eimer, Stefan;
Shaid, Shabnam;
Brandts, Christian H.

Publication type:

Article

FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels.

Published in:

EMBO Journal, 2023, v. 42, n. 13, p. 1, doi. 10.15252/embj.2022112799

By:

Elcocks, Hannah;
Brazel, Ailbhe J;
McCarron, Katy R;
Kaulich, Manuel;
Husnjak, Koraljka;
Mortiboys, Heather;
Clague, Michael J;
Urbé, Sylvie

Publication type:

Article

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.

Published in:

Journal of Cell Biology, 2016, v. 214, n. 2, p. 155, doi. 10.1083/jcb.201604081

By:

Meitinger, Franz;
Anzola, John V.;
Kaulich, Manuel;
Richardson, Amelia;
Stender, Joshua D.;
Benner, Christopher;
Glass, Christopher K.;
Dowdy, Steven F.;
Desai, Arshad;
Shiau, Andrew K.;
Oegema, Karen

Publication type:

Article

DGK and DZHK position paper on genome editing: basic science applications and future perspective.

Published in:

Basic Research in Cardiology, 2021, v. 116, n. 1, p. 1, doi. 10.1007/s00395-020-00839-3

By:

Brandes, Ralf P.;
Dueck, Anne;
Engelhardt, Stefan;
Kaulich, Manuel;
Kupatt, Christian;
De Angelis, Maria Teresa;
Leisegang, Matthias S.;
le Noble, Ferdinand;
Moretti, Alessandra;
Müller, Oliver J.;
Skryabin, Boris V.;
Thum, Thomas;
Wurst, Wolfgang

Publication type:

Article

Integrative analysis of epigenetics data identifies gene-specific regulatory elements.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 18, p. 10397, doi. 10.1093/nar/gkab798

By:

Schmidt, Florian;
Marx, Alexander;
Baumgarten, Nina;
Hebel, Marie;
Wegner, Martin;
Kaulich, Manuel;
Leisegang, Matthias S;
Brandes, Ralf P;
Göke, Jonathan;
Vreeken, Jilles;
Schulz, Marcel H

Publication type:

Article

Minimized combinatorial CRISPR screens identify genetic interactions in autophagy.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 10, p. 5684, doi. 10.1093/nar/gkab309

By:

Diehl, Valentina;
Wegner, Martin;
Grumati, Paolo;
Husnjak, Koraljka;
Schaubeck, Simone;
Gubas, Andrea;
Shah, Varun Jayeshkumar;
Polat, Ibrahim H;
Langschied, Felix;
Prieto-Garcia, Cristian;
Müller, Konstantin;
Kalousi, Alkmini;
Ebersberger, Ingo;
Brandts, Christian H;
Dikic, Ivan;
Kaulich, Manuel

Publication type:

Article

A novel TPR-BEN domain interaction mediates PICH-BEND3 association.

Published in:

Nucleic Acids Research, 2017, v. 45, n. 19, p. 11413, doi. 10.1093/nar/gkx792

By:

Pitchai, Ganesha P.;
Kaulich, Manuel;
Bizard, Anna H.;
Mesa, Pablo;
Qi Yao;
Sarlos, Kata;
Streicher, Werner W.;
Nigg, Erich A.;
Montoya, Guillermo;
Hickson, Ian D.

Publication type:

Article

Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi.

Published in:

Nucleic Acids Research, 2015, v. 43, n. 7, p. e45, doi. 10.1093/nar/gku1403

By:

Kaulich, Manuel;
Lee, Yeon J.;
Lönn, Peter;
Springer, Aaron D.;
Meade, Bryan R.;
Dowdy, Steven F.

Publication type:

Article

Metabolic Rewiring Is Essential for AML Cell Survival to Overcome Autophagy Inhibition by Loss of ATG3.

Published in:

Cancers, 2021, v. 13, n. 23, p. 6142, doi. 10.3390/cancers13236142

By:

Baker, Fatima;
Polat, Ibrahim H.;
Abou-El-Ardat, Khalil;
Alshamleh, Islam;
Thoelken, Marlyn;
Hymon, Daniel;
Gubas, Andrea;
Koschade, Sebastian E.;
Vischedyk, Jonas B.;
Kaulich, Manuel;
Schwalbe, Harald;
Shaid, Shabnam;
Brandts, Christian H.

Publication type:

Article

Delayed Mesoderm and Erythroid Differentiation of Murine Embryonic Stem Cells in the Absence of the Transcriptional Regulator FUBP1.

Published in:

Stem Cells International, 2017, p. 1, doi. 10.1155/2017/5762301

By:

Wesely, Josephine;
Steiner, Marlene;
Schnütgen, Frank;
Kaulich, Manuel;
Rieger, Michael A.;
Zörnig, Martin

Publication type:

Article

Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint.

Published in:

EMBO Journal, 2011, v. 30, n. 16, p. 3322, doi. 10.1038/emboj.2011.239

By:

Fava, Luca L;
Kaulich, Manuel;
Nigg, Erich A;
Santamaria, Anna

Publication type:

Article

Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation.

Published in:

Biochemical Journal, 2016, v. 473, n. 4, p. 509, doi. 10.1042/BJ20151013

By:

Irene S. Tobias;
Kim, Peter K.;
Simon, Nitya;
Jacinto, Estela;
Dowdy, Steven F.;
King, Charles C.;
Kaulich, Manuel;
Newton, Alexandra C.

Publication type:

Article

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15995-2

By:

Trembinski, D. Julia;
Bink, Diewertje I.;
Theodorou, Kosta;
Sommer, Janina;
Fischer, Ariane;
van Bergen, Anke;
Kuo, Chao-Chung;
Costa, Ivan G.;
Schürmann, Christoph;
Leisegang, Matthias S.;
Brandes, Ralf P.;
Alekseeva, Tijna;
Brill, Boris;
Wietelmann, Astrid;
Johnson, Christopher N.;
Spring-Connell, Alexander;
Kaulich, Manuel;
Werfel, Stanislas;
Engelhardt, Stefan;
Hirt, Marc N.

Publication type:

Article

The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05236-9

By:

Sporbeck, Katharina;
Haas, Maximilian L.;
Pastor-Maldonado, Carmen J.;
Schüssele, David S.;
Hunter, Catherine;
Takacs, Zsuzsanna;
Diogo de Oliveira, Ana L.;
Franz-Wachtel, Mirita;
Charsou, Chara;
Pfisterer, Simon G.;
Gubas, Andrea;
Haller, Patricia K.;
Knorr, Roland L.;
Kaulich, Manuel;
Macek, Boris;
Eskelinen, Eeva-Liisa;
Simonsen, Anne;
Proikas-Cezanne, Tassula

Publication type:

Article

A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-94200-w

By:

Kaulich, Manuel;
Link, Verena M.;
Lapek, John D.;
Lee, Yeon J.;
Glass, Christopher K.;
Gonzalez, David J.;
Dowdy, Steven F.

Publication type:

Article

Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics.

Published in:

Scientific Reports, 2016, p. 32301, doi. 10.1038/srep32301

By:

Lönn, Peter;
Kacsinta, Apollo D.;
Cui, Xian-Shu;
Hamil, Alexander S.;
Kaulich, Manuel;
Gogoi, Khirud;
Dowdy, Steven F.

Publication type:

Article

The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions.

Published in:

Cell Death & Disease, 2022, v. 13, n. 4, p. 1, doi. 10.1038/s41419-022-04829-2

By:

Eichler, Madeleine;
Distler, Ute;
Nasrullah, Usman;
Krishnan, Aswini;
Kaulich, Manuel;
Husnjak, Koraljka;
Eberhardt, Wolfgang;
Rajalingam, Krishnaraj;
Tenzer, Stefan;
Pfeilschifter, Josef;
Imre, Gergely

Publication type:

Article

ERK5 modulates IL-6 secretion and contributes to tumor-induced immune suppression.

Published in:

Cell Death & Disease, 2021, v. 12, n. 11, p. 1, doi. 10.1038/s41419-021-04257-8

By:

Riegel, Kristina;
Yurugi, Hajime;
Schlöder, Janine;
Jonuleit, Helmut;
Kaulich, Manuel;
Kirschner, Friederike;
Arnold-Schild, Danielle;
Tenzer, Stefan;
Schild, Hansjörg;
Rajalingam, Krishnaraj

Publication type:

Article

Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications.

Published in:

Nature Biotechnology, 2014, v. 32, n. 12, p. 1256, doi. 10.1038/nbt.3078

By:

Meade, Bryan R;
Gogoi, Khirud;
Hamil, Alexander S;
Palm-Apergi, Caroline;
Berg, Arjen van den;
Hagopian, Jonathan C;
Springer, Aaron D;
Eguchi, Akiko;
Kacsinta, Apollo D;
Dowdy, Connor F;
Lönn, Peter;
Kaulich, Manuel;
Yoshioka, Naohisa;
Gros, Edwige;
Cui, Xian-Shu;
Dowdy, Steven F;
Presente, Asaf

Publication type:

Article

UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells.

Published in:

Cellular & Molecular Life Sciences, 2018, v. 75, n. 18, p. 3393, doi. 10.1007/s00018-018-2799-7

By:

Wegner, Marthe-Susanna;
Schömel, Nina;
Gruber, Lisa;
Örtel, Stephanie Beatrice;
Kjellberg, Matti Aleksi;
Mattjus, Peter;
Kurz, Jennifer;
Trautmann, Sandra;
Peng, Bing;
Wegner, Martin;
Kaulich, Manuel;
Ahrends, Robert;
Geisslinger, Gerd;
Grösch, Sabine

Publication type:

Article