Works by Kaufman, Randal J.

Results: 98

Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins.

Published in:

PLoS Biology, 2006, v. 4, n. 11, p. 2024, doi. 10.1371/journal.pbio.0040374

By:

Rutkowski, D. Thomas;
Arnold, Stacey M.;
Miller, Corey N.;
Wu, Jun;
Li, Jack;
Gunnison, Kathryn M.;
Mori, Kazutoshi;
Sadighi Akha, Amir A.;
Raden, David;
Kaufman, Randal J.

Publication type:

Article

Molecular characterization and expression of the gene encoding human erythroid-potentiating activity.

Published in:

Nature, 1985, v. 315, n. 6022, p. 768, doi. 10.1038/315768a0

By:

Gasson, Judith C.;
Golde, David W.;
Kaufman, Susan E.;
Westbrook, Carol A.;
Hewick, Rodney M.;
Kaufman, Randal J.;
Wong, Gordon G.;
Temple, Patricia A.;
Leary, Ann C.;
Brown, Eugene L.;
Orr, Elizabeth C.;
Clark, Steven C.

Publication type:

Article

Isolation and characterization of genomic and cDNA clones of human erythropoietin.

Published in:

Nature, 1985, v. 313, n. 6005, p. 806, doi. 10.1038/313806a0

By:

Jacobs, Kenneth;
Shoemaker, Charles;
Rudersdorf, Richard;
Neill, Suzanne D.;
Kaufman, Randal J.;
Mufson, Allan;
Seehra, Jasbir;
Jones, Simon S.;
Hewick, Rodney;
Fritsch, Edward F.;
Kawakita, Makoto;
Shimizu, Tomoe;
Miyake, Takaji

Publication type:

Article

Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 5, p. 611, doi. 10.3390/jcm8050611

By:

Shah O'Brien, Priyanka;
Xi, Yue;
Miller, Justin R.;
Brownell, Amy L.;
Zeng, Qinghua;
Yoo, George H.;
Garshott, Danielle M.;
O'Brien, Matthew B.;
Galinato, Anthony E.;
Cai, Peter;
Narula, Neha;
Callaghan, Michael U.;
Kaufman, Randal J.;
Fribley, Andrew M.

Publication type:

Article

Biosynthesis, structure, and folding of the insulin precursor protein.

Published in:

Diabetes, Obesity & Metabolism, 2018, v. 20, p. 28, doi. 10.1111/dom.13378

By:

Liu, Ming;
Weiss, Michael A.;
Arunagiri, Anoop;
Yong, Jing;
Rege, Nischay;
Sun, Jinhong;
Haataja, Leena;
Kaufman, Randal J.;
Arvan, Peter

Publication type:

Article

A chamber of hope for hemophilia.

Published in:

Nature Biotechnology, 2000, v. 18, n. 3, p. 264, doi. 10.1038/73690

By:

Pipe, Steven W.;
Kaufman, Randal J.

Publication type:

Article

Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 21, p. 5891, doi. 10.1523/JNEUROSCI.3709-15.2016

By:

Liu Yang;
Shaohua Li;
Linqing Miao;
Haoliang Huang;
Feisi Liang;
Xiuyin Teng;
Lin Xu;
Qizhao Wang;
Weidong Xiao;
Ridder III, William H.;
Ferguson, Toby A.;
Dong Feng Chen;
Kaufman, Randal J.;
Yang Hu

Publication type:

Article

Potential role of PKR in double-stranded RNA-induced macrophage activation.

Published in:

EMBO Journal, 2000, v. 19, n. 14, p. 3630, doi. 10.1093/emboj/19.14.3630

By:

Maggi Jr., Leonard B.;
Heitmeier, Monique R.;
Scheuner, Donalyn;
Kaufman, Randal J.;
Buller, R. Mark L.;
Corbett, John A.

Publication type:

Article

From endoplasmic-reticulum stress to the inflammatory response.

Published in:

Nature, 2008, v. 454, n. 7203, p. 455, doi. 10.1038/nature07203

By:

Zhang, Kezhong;
Kaufman, Randal J.

Publication type:

Article

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

Published in:

Nature, 2004, v. 428, n. 6980, p. 341, doi. 10.1038/nature02405

By:

Li-Chung Hsu, C.;
Jin Mo Park;
Kezhong Zhang;
Jun-Li Luo, C.;
Maeda, Shin;
Kaufman, Randal J.;
Eckmann, Lars;
Guiney, Donald G.;
Karin, Michael

Publication type:

Article

eIF2α confers cellular tolerance to S. aureus α-toxin.

Published in:

Frontiers in Immunology, 2015, p. 1, doi. 10.3389/fimmu.2015.00383

By:

von Hoven, Gisela;
Neukirch, Claudia;
Meyenburg, Martina;
Füser, Sabine;
Petrivna, Maria Bidna;
Rivas, Amable J.;
Ryazanov, Alexey;
Kaufman, Randal J.;
Aroian, Raffi V.;
Husmann, Matthias

Publication type:

Article

IRE1- and HAC1 -independent transcriptional regulation in the unfolded protein response of yeast.

Published in:

Molecular Microbiology, 2003, v. 49, n. 3, p. 591, doi. 10.1046/j.1365-2958.2003.03585.x

By:

Schröder, Martin;
Clark, Robert;
Kaufman, Randal J.

Publication type:

Article

Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response.

Published in:

Bioscience Reports, 2017, v. 37, n. 2, p. 1, doi. 10.1042/BSR20160574

By:

Poothong, Juthakorn;
Tirasophon, Witoon;
Kaufman, Randal J.

Publication type:

Article

Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis-Acting Elements ERSE, UPRE and ERSE-II.

Published in:

Journal of Biochemistry, 2004, v. 136, n. 3, p. 343, doi. 10.1093/jb/mvh122

By:

Yamamoto, Keisuke;
Yoshida, Hiderou;
Kokame, Koichi;
Kaufman, Randal J.;
Mori, Kazutoshi

Publication type:

Article

IRE1α nucleotide sequence cleavage specificity in the unfolded protein response.

Published in:

2018

By:

Poothong, Juthakorn;
Sopha, Pattarawut;
Kaufman, Randal J.;
Tirasophon, Witoon

Publication type:

Correction Notice

IRE1α nucleotide sequence cleavage specificity in the unfolded protein response.

Published in:

FEBS Letters, 2017, v. 591, n. 2, p. 406, doi. 10.1002/1873-3468.12546

By:

Poothong, Juthakorn;
Sopha, Pattarawut;
Kaufman, Randal J.;
Tirasophon, Witoon

Publication type:

Article

Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.

Published in:

Nature Genetics, 2003, v. 34, n. 2, p. 220, doi. 10.1038/ng1153

By:

Zhang, Bin;
Cunningham, Michael A;
Nichols, William C;
Bernat, John A;
Seligsohn, Uri;
Pipe, Steven W;
McVey, John H;
Schulte-Overberg, Ursula;
de Bosch, Norma B;
Ruiz-Saez, Arlette;
White, Gilbert C.;
Tuddenham, EGD;
Kaufman, Randal J.;
Ginsburg, David

Publication type:

Article

Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2.

Published in:

PLoS Genetics, 2014, v. 10, n. 5, p. 1, doi. 10.1371/journal.pgen.1004348

By:

Scortegagna, Marzia;
Kim, Hyungsoo;
Li, Jian-Liang;
Yao, Hang;
Brill, Laurence M.;
Han, Jaeseok;
Lau, Eric;
Bowtell, David;
Haddad, Gabriel;
Kaufman, Randal J.;
Ronai, Ze'ev A.

Publication type:

Article

Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans.

Published in:

PLoS Genetics, 2005, v. 1, n. 3, p. 355, doi. 10.1371/journal.pgen.0010037

By:

Xiaohua Shen;
Ellis, Ronald E.;
Sakaki, Kenjiro;
Kaufman, Randal J.;
Kim, Stuart

Publication type:

Article

Normal and defective pathways in biogenesis and maintenance of the insulin storage pool.

Published in:

2021

By:

Ming Liu;
Yumeng Huang;
Xiaoxi Xu;
Xin Li;
Alam, Maroof;
Arunagiri, Anoop;
Haataja, Leena;
Li Ding;
Shusen Wang;
Itkin-Ansari, Pamela;
Kaufman, Randal J.;
Tsai, Billy;
Ling Qi;
Arvan, Peter;
Liu, Ming;
Huang, Yumeng;
Xu, Xiaoxi;
Li, Xin;
Ding, Li;
Wang, Shusen

Publication type:

journal article

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.

Published in:

2008

By:

Song, Benbo;
Scheuner, Donalyn;
Ron, David;
Pennathur, Subramaniam;
Kaufman, Randal J.

Publication type:

journal article

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

Published in:

2005

By:

Zhang, Kezhong;
Wong, Hetty N;
Song, Benbo;
Miller, Corey N;
Scheuner, Donalyn;
Kaufman, Randal J

Publication type:

journal article

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis.

Published in:

Journal of Clinical Investigation, 2005, v. 115, n. 2, p. 268, doi. 10.1172/JCI200521848

By:

Kezhong Zhang;
Wong, Hetty N.;
Benbo Song;
Miller, Corey N.;
Scheuner, Donalyn;
Kaufman, Randal J.

Publication type:

Article

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase.

Published in:

Nature, 1978, v. 275, n. 5681, p. 617, doi. 10.1038/275617a0

By:

Chang, Annie C. Y.;
Nunberg, Jack H.;
Kaufman, Randal J.;
Erlich, Henry A.;
Schimke, Robert T.;
Cohen, Stanley N.

Publication type:

Article

The unfolded protein response in nutrient sensing and differentiation.

Published in:

Nature Reviews Molecular Cell Biology, 2002, v. 3, n. 6, p. 411, doi. 10.1038/nrm829

By:

Kaufman, Randal J.;
Scheuner, Donalyn;
Schröder, Martin;
Shen, Xiaohua;
Lee, Kyungho;
Liu, Chuan Yin;
Arnold, Stacey M.

Publication type:

Article

Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy.

Published in:

Journal of Neuroscience, 2021, v. 41, n. 20, p. 4536, doi. 10.1523/JNEUROSCI.2384-20.2021

By:

Sidoli, Mariapaola;
Reed, Chelsey B.;
Scapin, Cristina;
Paez, Pablo;
Cavener, Douglas R.;
Kaufman, Randal J.;
D'Antonio, Maurizio;
Feltri, M. Laura;
Wrabetz, Lawrence

Publication type:

Article

Phosphorylation of eIF2_ Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR.

Published in:

Journal of Neuroscience, 2020, v. 40, n. 42, p. 8174, doi. 10.1523/JNEUROSCI.0957-20.2020

By:

Scapin, Cristina;
Ferri, Cinzia;
Pettinato, Emanuela;
Bianchi, Francesca;
Carro, Ubaldo Del;
Feltri, M. Laura;
Kaufman, Randal J.;
Wrabetz, Lawrence;
D'Antonio, Maurizio

Publication type:

Article

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.

Published in:

Nature Genetics, 2015, v. 47, n. 7, p. 757, doi. 10.1038/ng.3319

By:

Kohl, Susanne;
Zobor, Ditta;
Weisschuh, Nicole;
Staller, Jennifer;
Menendez, Irene Gonzalez;
Beck, Susanne C;
Garrido, Marina Garcia;
Sothilingam, Vithiyanjali;
Seeliger, Mathias W;
Wissinger, Bernd;
Hollander, Anneke I den;
Lopez, Irma;
Ren, Huanan;
Koenekoop, Robert K;
Moore, Anthony T;
Webster, Andrew R;
Michaelides, Michel;
Zrenner, Eberhart;
Kaufman, Randal J;
Tsang, Stephen H

Publication type:

Article

The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 4, p. 1373, doi. 10.3390/ijms21041373

By:

Stauffer, Winston T.;
Blackwood, Erik A.;
Azizi, Khalid;
Kaufman, Randal J.;
Glembotski, Christopher C.

Publication type:

Article

Concomitant Nrf2- and ATF4-Activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 7, p. 1706, doi. 10.3390/ijms20071706

By:

Mimura, Junsei;
Yamazaki, Hiromi;
Kasai, Shuya;
Itoh, Ken;
Inose-Maruyama, Atsushi;
Harada, Nobuhiko;
Taniuchi, Shusuke;
Oyadomari, Seiichi;
Kosaka, Kunio;
Yoshida, Hidemi;
Kaufman, Randal J.

Publication type:

Article

Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation.

Published in:

EMBO Reports, 2007, v. 8, n. 5, p. 483, doi. 10.1038/sj.embor.7400933

By:

Nagasawa, Koji;
Higashi, Toshio;
Hosokawa, Nobuko;
Kaufman, Randal J;
Nagata, Kazuhiro

Publication type:

Article

The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin.

Published in:

Journal of Cell Biology, 2010, v. 189, n. 5, p. 829, doi. 10.1083/jcb.200912105

By:

Pearse, Bradley R.;
Tamura, Taku;
Sunryd, Johan C.;
Grabowski, Gregory A.;
Kaufman, Randal J.;
Hebert, Daniel N.

Publication type:

Article

Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux.

Published in:

Journal of Cell Biology, 2007, v. 176, n. 5, p. 605, doi. 10.1083/jcb.200607007

By:

Jie Shang;
Ningguo Gao;
Kaufman, Randal J.;
Ron, David;
Harding, Heather P.;
Lehrman, Mark A.

Publication type:

Article

Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.

Published in:

Journal of Cell Biology, 2006, v. 172, n. 3, p. 383, doi. 10.1083/jcb.200507057

By:

Oda, Yukako;
Okada, Tetsuya;
Yoshida, Hiderou;
Kaufman, Randal J.;
Nagata, Kazuhiro;
Mori, Kazutoshi

Publication type:

Article

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.

Published in:

Journal of Cell Biology, 2005, v. 169, n. 6, p. 871, doi. 10.1083/jcb.200502088

By:

Kedersha, Nancy;
Stoecklin, Georg;
Ayodele, Marancitha;
Yacono, Patrick;
Lykke-Andersen, Jens;
Fitzler, Marvin J.;
Scheuner, Donalyn;
Kaufman, Randal J.;
Golan, David E.;
Anderson, Paul

Publication type:

Article

Cargo Selectivity of the ERGIC-53/MCFD2 Transport Receptor Complex.

Published in:

Traffic, 2006, v. 7, n. 11, p. 1473, doi. 10.1111/j.1600-0854.2006.00483.x

By:

Nyfeler, Beat;
Zhang, Bin;
Ginsburg, David;
Kaufman, Randal J.;
Hauri, Hans-Peter

Publication type:

Article

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.

Published in:

Science Translational Medicine, 2016, v. 8, n. 362, p. 1, doi. 10.1126/scitranslmed.aaf9440

By:

Oubaha, Malika;
Miloudi, Khalil;
Dejda, Agnieszka;
Guber, Vera;
Mawambo, Gaëlle;
Germain, Marie-Anne;
Bourdel, Guillaume;
Popovic, Natalija;
Rezende, Flavio A.;
Kaufman, Randal J.;
Mallette, Frédérick A.;
Sapieha, Przemyslaw

Publication type:

Article

Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 4, p. 1, doi. 10.1002/pro.4949

By:

Arunagiri, Anoop;
Alam, Maroof;
Haataja, Leena;
Draz, Hassan;
Alasad, Bashiyer;
Samy, Praveen;
Sadique, Nadeed;
Tong, Yue;
Cai, Ying;
Shakeri, Hadis;
Fantuzzi, Federica;
Ibrahim, Hazem;
Jang, Insook;
Sidarala, Vaibhav;
Soleimanpour, Scott A.;
Satin, Leslie S.;
Otonkoski, Timo;
Cnop, Miriam;
Itkin‐Ansari, Pamela;
Kaufman, Randal J.

Publication type:

Article

A common frameshift mutation in von Willebrand factor does not alter mRNA stability but interferes with normal propeptide processing.

Published in:

British Journal of Haematology, 1996, v. 95, n. 1, p. 184, doi. 10.1046/j.1365-2141.1996.7572377.x

By:

Mohlke, Karen L.;
Nichols, William C.;
Rehemtulla, Alnawaz;
Kaufman, Randal J.;
Fagerström, Heidi M.;
Ritvanen, K. L. Annukka;
Kekomäki, Riitta;
Ginsburg, David

Publication type:

Article

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.

Published in:

EMBO Journal, 2015, v. 34, n. 1, p. 4, doi. 10.15252/embj.201488896

By:

Genereux, Joseph C;
Qu, Song;
Zhou, Minghai;
Ryno, Lisa M;
Wang, Shiyu;
Shoulders, Matthew D;
Kaufman, Randal J;
Lasmézas, Corinne I;
Kelly, Jeffery W;
Wiseman, R Luke

Publication type:

Article

eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.

Published in:

Nutrition & Metabolism, 2017, v. 14, p. 1, doi. 10.1186/s12986-017-0202-6

By:

Woo-Gyun Choi;
Jaeseok Han;
Ji-Hyeon Kim;
Mi-Jeong Kim;
Jae-Woo Park;
Benbo Song;
Hee-Jeong Cha;
Hye-Seon Choi;
Hun-Taeg Chung;
In-Kyu Lee;
Tae-Sik Park;
Hatzoglou, Maria;
Hueng-Sik Choi;
Hyun Ju Yoo;
Kaufman, Randal J.;
Sung Hoon Back

Publication type:

Article

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α.

Published in:

Nature Neuroscience, 2014, v. 17, n. 8, p. 1073, doi. 10.1038/nn.3754

By:

Di Prisco, Gonzalo Viana;
Huang, Wei;
Buffington, Shelly A;
Hsu, Chih-Chun;
Bonnen, Penelope E;
Placzek, Andon N;
Sidrauski, Carmela;
Krnjević, Krešimir;
Kaufman, Randal J;
Walter, Peter;
Costa-Mattioli, Mauro

Publication type:

Article

Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism.

Published in:

EMBO Molecular Medicine, 2010, v. 2, n. 6, p. 189, doi. 10.1002/emmm.201000076

By:

Kaufman, Randal J.;
Cao, Siyan

Publication type:

Article

Human HRD1 Promoter Carries a Functional Unfolded Protein Response Element to Which XBP1 but not ATF6 Directly Binds.

Published in:

Journal of Biochemistry, 2008, v. 144, n. 4, p. 477, doi. 10.1093/jb/mvn091

By:

Yamamoto, Keisuke;
Suzuki, Natsumi;
Wada, Tadashi;
Okada, Tetsuya;
Yoshida, Hiderou;
Kaufman, Randal J.;
Mori, Kazutoshi

Publication type:

Article

Domain compatibility in Ire1 kinase is critical for the unfolded protein response

Published in:

FEBS Letters, 2010, v. 584, n. 14, p. 3203, doi. 10.1016/j.febslet.2010.06.003

By:

Poothong, Juthakorn;
Sopha, Pattarawut;
Kaufman, Randal J.;
Tirasophon, Witoon

Publication type:

Article

HIF1α-dependent hypoxia response in myeloid cells requires IRE1α.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02793-y

By:

Mawambo, Gaëlle;
Oubaha, Malika;
Ichiyama, Yusuke;
Blot, Guillaume;
Crespo-Garcia, Sergio;
Dejda, Agnieszka;
Binet, François;
Diaz-Marin, Roberto;
Sawchyn, Christina;
Sergeev, Mikhail;
Juneau, Rachel;
Kaufman, Randal J.;
Affar, El Bachir;
Mallette, Frédérick A.;
Wilson, Ariel M.;
Sapieha, Przemyslaw

Publication type:

Article

A Novel Feedback Loop Regulates the Response to Endoplasmic Reticulum Stress via the Cooperation of Cytoplasmic Splicing and mRNA Translation.

Published in:

Molecular & Cellular Biology, 2012, v. 32, n. 5, p. 992, doi. 10.1128/MCB.06665-11

By:

Majumder, Mithu;
Huang, Charlie;
Snider, Martin D.;
Komar, Anton A.;
Tanaka, Junichi;
Kaufman, Randal J.;
Krokowski, Dawid;
Hatzoglou, Maria

Publication type:

Article

Phosphorylation of Eukaryotic Translation Initiation Factor 2α Coordinates rRNA Transcription and Translation Inhibition during Endoplasmic Reticulum Stress.

Published in:

Molecular & Cellular Biology, 2009, v. 29, n. 15, p. 4295, doi. 10.1128/MCB.00260-09

By:

DuRose, Jenny B.;
Scheuner, Donalyn;
Kaufman, Randal J.;
Rothblum, Lawrence I.;
Niwa, Maho

Publication type:

Article

Correction of Murine Hemophilia A and Immunological Differences of Factor VIII Variants Delivered by Helper-dependent Adenoviral Vectors.

Published in:

Molecular Therapy, 2007, v. 15, n. 12, p. 2080, doi. 10.1038/sj.mt.6300308

By:

Cerullo, Vincenzo;
Seiler, Michael P.;
Mane, Viraj;
Cela, Racel;
Clarke, Christian;
Kaufman, Randal J.;
Pipe, Steven W.;
Lee, Brendan

Publication type:

Article

Naked DNA Transfer of Factor VIII Induced Transgene-Specific, Species-Independent Immune Response in Hemophilia A Mice

Published in:

Molecular Therapy, 2004, v. 10, n. 1, p. 117, doi. 10.1016/j.ymthe.2004.04.009

By:

Ye, Peiqing;
Thompson, Arthur R.;
Sarkar, Rita;
Shen, Zhenping;
Lillicrap, David P.;
Kaufman, Randal J.;
Ochs, Hans D.;
Rawlings, David J.;
Miao, Carol H.

Publication type:

Article