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Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.
- Published in:
- Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 4, p. 1, doi. 10.1002/pro.4949
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- Article
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α.
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- Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02793-y
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- Article
ER stress and inflammation crosstalk in obesity.
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- Medicinal Research Reviews, 2023, v. 43, n. 1, p. 5, doi. 10.1002/med.21921
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- Article
Elevation of membralin can improve the cognitive decline in 5xFAD mice.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.068185
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- Article
Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets.
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- Journal of Clinical Endocrinology & Metabolism, 2022, v. 107, n. 11, p. 3100, doi. 10.1210/clinem/dgac493
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- Article
Astroglial ER protein Membralin is an essential neuroinflammation regulator.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058566
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- Article
ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-95895-7
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- Article
Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice.
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- Science Translational Medicine, 2021, v. 13, n. 604, p. 1, doi. 10.1126/scitranslmed.aba9796
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- Article
292-OR: Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets.
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- Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-292-OR
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- Article
Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy.
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- Journal of Neuroscience, 2021, v. 41, n. 20, p. 4536, doi. 10.1523/JNEUROSCI.2384-20.2021
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- Article
Normal and defective pathways in biogenesis and maintenance of the insulin storage pool.
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- 2021
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- Publication type:
- journal article
Phosphorylation of eIF2_ Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR.
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- Journal of Neuroscience, 2020, v. 40, n. 42, p. 8174, doi. 10.1523/JNEUROSCI.0957-20.2020
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- Article
Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding.
- Published in:
- 2020
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- journal article
47-OR: A Reference Map of the Human Proinsulin Biosynthetic Interaction Network.
- Published in:
- Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-47-OR
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- Article
Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth.
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- Diabetes, 2020, v. 69, n. 5, p. 954, doi. 10.2337/db19-1106
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- Article
The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 4, p. 1373, doi. 10.3390/ijms21041373
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- Article
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
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- 2019
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- journal article
Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma.
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- Journal of Clinical Medicine, 2019, v. 8, n. 5, p. 611, doi. 10.3390/jcm8050611
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- Article
Concomitant Nrf2- and ATF4-Activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.
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- International Journal of Molecular Sciences, 2019, v. 20, n. 7, p. 1706, doi. 10.3390/ijms20071706
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- Article
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
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- Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-08908-5
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- Article
Biosynthesis, structure, and folding of the insulin precursor protein.
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- Diabetes, Obesity & Metabolism, 2018, v. 20, p. 28, doi. 10.1111/dom.13378
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- Article
IRE1α nucleotide sequence cleavage specificity in the unfolded protein response.
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- 2018
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- Correction Notice
High-content screen for modifiers of Niemann-Pick type C disease in patient cells.
- Published in:
- Human Molecular Genetics, 2018, v. 27, n. 12, p. 2101, doi. 10.1093/hmg/ddy117
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- Article
IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs.
- Published in:
- Science Signaling, 2018, v. 11, n. 530, p. 1, doi. 10.1126/scisignal.aao4617
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- Publication type:
- Article
eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.
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- Nutrition & Metabolism, 2017, v. 14, p. 1, doi. 10.1186/s12986-017-0202-6
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- Publication type:
- Article
Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response.
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- Bioscience Reports, 2017, v. 37, n. 2, p. 1, doi. 10.1042/BSR20160574
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- Article
in Neurons Is Required for Thermogenesis and Glycemia.
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- 2017
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- Publication type:
- journal article
IRE1α nucleotide sequence cleavage specificity in the unfolded protein response.
- Published in:
- FEBS Letters, 2017, v. 591, n. 2, p. 406, doi. 10.1002/1873-3468.12546
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- Publication type:
- Article
eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons.
- Published in:
- eLife, 2016, p. 1, doi. 10.7554/eLife.17517
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- Article
Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.
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- Science Translational Medicine, 2016, v. 8, n. 362, p. 1, doi. 10.1126/scitranslmed.aaf9440
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- Publication type:
- Article
Read-Split-Run: an improved bioinformatics pipeline for identification of genome-wide non-canonical spliced regions using RNA-Seq data.
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- BMC Genomics, 2016, v. 17, p. 107, doi. 10.1186/s12864-016-2896-7
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- Publication type:
- Article
Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.
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- Journal of Neuroscience, 2016, v. 36, n. 21, p. 5891, doi. 10.1523/JNEUROSCI.3709-15.2016
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- Publication type:
- Article
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.
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- PLoS Biology, 2015, v. 13, n. 10, p. 1, doi. 10.1371/journal.pbio.1002277
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- Article
Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis.
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- Diabetes, 2015, v. 64, n. 8, p. 2892, doi. 10.2337/db14-1357
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- Article
eIF2α confers cellular tolerance to S. aureus α-toxin.
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- Frontiers in Immunology, 2015, p. 1, doi. 10.3389/fimmu.2015.00383
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- Article
Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.
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- Nature Genetics, 2015, v. 47, n. 7, p. 757, doi. 10.1038/ng.3319
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- Article
Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress.
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- PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0130635
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- Article
Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.
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- EMBO Journal, 2015, v. 34, n. 1, p. 4, doi. 10.15252/embj.201488896
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- Article
The impact of the endoplasmic reticulum protein-folding environment on cancer development.
- Published in:
- Nature Reviews Cancer, 2014, v. 14, n. 9, p. 581, doi. 10.1038/nrc3800
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- Article
The impact of the endoplasmic reticulum protein-folding environment on cancer development.
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- 2014
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- Publication type:
- journal article
Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α.
- Published in:
- Nature Neuroscience, 2014, v. 17, n. 8, p. 1073, doi. 10.1038/nn.3754
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- Publication type:
- Article
Novel Bioinformatics Method for Identification of Genome-Wide Non-Canonical Spliced Regions Using RNA-Seq Data.
- Published in:
- PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0100864
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- Publication type:
- Article
Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease.
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- PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0101643
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- Publication type:
- Article
Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis.
- Published in:
- Science Signaling, 2014, v. 7, n. 329, p. 1, doi. 10.1126/scisignal.2004983
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- Article
Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2.
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- PLoS Genetics, 2014, v. 10, n. 5, p. 1, doi. 10.1371/journal.pgen.1004348
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- Publication type:
- Article
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis.
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- EMBO Journal, 2013, v. 32, n. 18, p. 2477, doi. 10.1038/emboj.2013.183
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- Article
Transcriptional cross talk between orphan nuclear receptor ERRγ and transmembrane transcription factor ATF6α coordinates endoplasmic reticulum stress response.
- Published in:
- Nucleic Acids Research, 2013, v. 41, n. 14, p. 6960, doi. 10.1093/nar/gkt429
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- Publication type:
- Article
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.
- Published in:
- Nature Cell Biology, 2013, v. 15, n. 5, p. 481, doi. 10.1038/ncb2738
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- Article
Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction.
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- Journal of Pathology, 2012, v. 228, n. 4, p. 554, doi. 10.1002/path.4068
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- Publication type:
- Article
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis.
- Published in:
- EMBO Journal, 2011, v. 30, n. 7, p. 1357, doi. 10.1038/emboj.2011.52
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- Article