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A Multi‐action Pt<sup>IV</sup> Conjugate with Oleate and Cinnamate Ligands Targets Human Epithelial Growth Factor Receptor HER2 in Aggressive Breast Cancer Cells.
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- Angewandte Chemie, 2020, v. 132, n. 47, p. 21343, doi. 10.1002/ange.202009491
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- Article
Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo.
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- Angewandte Chemie, 2020, v. 132, n. 34, p. 14785, doi. 10.1002/ange.202006814
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- Article
Platinum (IV) Derivatives with Cinnamate Axial Ligands as Potent Agents Against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells.
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- Angewandte Chemie, 2020, v. 132, n. 8, p. 3355, doi. 10.1002/ange.201913996
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- Article
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir<sup>III</sup> Complex Conjugated to a Far‐Red Emitting Coumarin.
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- Angewandte Chemie, 2019, v. 131, n. 19, p. 6377, doi. 10.1002/ange.201901268
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- Article
A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases.
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- Angewandte Chemie International Edition, 2015, v. 54, n. 48, p. 14478, doi. 10.1002/anie.201506533
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- Article
Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair.
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- EMBO Journal, 2001, v. 20, n. 13, p. 3554, doi. 10.1093/emboj/20.13.3554
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- Article
Walking of antitumor bifunctional trinuclear PtII complex on double-helical DNA.
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- Nucleic Acids Research, 2011, v. 39, n. 2, p. 720, doi. 10.1093/nar/gkq803
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Mechanism of the formation of DNA–protein cross-links by antitumor cisplatin.
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- Nucleic Acids Research, 2007, v. 35, n. 6, p. 1812
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- Article
Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells.
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- Bioinorganic Chemistry & Applications, 2022, p. 1, doi. 10.1155/2022/3095749
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- Article
Novel cis-Pt(II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action.
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- Bioinorganic Chemistry & Applications, 2022, p. 1, doi. 10.1155/2022/1717200
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- Article
Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes.
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- FEBS Journal, 2006, v. 273, n. 15, p. 3467, doi. 10.1111/j.1742-4658.2006.05356.x
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- Article
Recognition of DNA modified by trans-[PtCl<sub>2</sub>NH<sub>3</sub>(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex.
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- FEBS Journal, 2006, v. 273, n. 2, p. 301, doi. 10.1111/j.1742-4658.2005.05061.x
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- Article
A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases.
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- Angewandte Chemie, 2015, v. 127, n. 48, p. 14686, doi. 10.1002/ange.201506533
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- Article
Potentiating Effect of UVA Irradiation on Anticancer Activity of Carboplatin Derivatives Involving 7-Azaindoles.
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- PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0123595
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Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells.
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- Molecules, 2023, v. 28, n. 13, p. 5173, doi. 10.3390/molecules28135173
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An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-49774-x
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- Article
Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of Antitumor trans-[PtCl2(NH3)(thiazole)].
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- Nucleic Acids Research, 2005, v. 33, n. 18, p. 5819, doi. 10.1093/nar/gki884
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- Article
Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin.
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- Nucleic Acids Research, 2004, v. 32, n. 18, p. 5546, doi. 10.1093/nar/gkh896
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- Article
DNA–protein cross‐linking by trans‐[PtCl2(E‐iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes.
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- Nucleic Acids Research, 2003, v. 31, n. 22, p. 6450, doi. 10.1093/nar/gkg863
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- Article
DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent.
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- Nucleic Acids Research, 2002, v. 30, n. 13, p. 2894, doi. 10.1093/nar/gkf405
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- Article
Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer.
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- FEBS Journal, 2014, v. 281, n. 5, p. 1393, doi. 10.1111/febs.12711
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- Article
An Anticancer Pt<sup>IV</sup> Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects.
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- Chemistry - A European Journal, 2019, v. 25, n. 20, p. 5235, doi. 10.1002/chem.201805626
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- Article
Exploring the Effect of Polypyridyl Ligands on the Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents.
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- Chemistry - A European Journal, 2018, v. 24, n. 18, p. 4607, doi. 10.1002/chem.201705362
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- Article
Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action.
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- Chemistry - A European Journal, 2017, v. 23, n. 61, p. 15294, doi. 10.1002/chem.201703581
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- Article
Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose-Coated Magnetic Nanoparticles.
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- Chemistry - A European Journal, 2016, v. 22, n. 28, p. 9750, doi. 10.1002/chem.201600949
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- Article
Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death.
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- Angewandte Chemie, 2023, v. 135, n. 42, p. 1, doi. 10.1002/ange.202310774
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- Article
Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug?
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- Metallomics, 2022, v. 14, n. 7, p. 1, doi. 10.1093/mtomcs/mfac048
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- Article
A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex.
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- Metallomics, 2014, v. 6, n. 8, p. 1491, doi. 10.1039/c4mt00112e
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- Article
Mechanism of cellular accumulation of an iridium(iii) pentamethylcyclopentadienyl anticancer complex containing a C,N-chelating ligand.
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- Metallomics, 2014, v. 6, n. 3, p. 682, doi. 10.1039/c3mt00341h
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- Article
Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death.
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- Angewandte Chemie International Edition, 2023, v. 62, n. 42, p. 1, doi. 10.1002/anie.202310774
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- Article
A Multi‐action Pt<sup>IV</sup> Conjugate with Oleate and Cinnamate Ligands Targets Human Epithelial Growth Factor Receptor HER2 in Aggressive Breast Cancer Cells.
- Published in:
- Angewandte Chemie International Edition, 2020, v. 59, n. 47, p. 21157, doi. 10.1002/anie.202009491
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- Publication type:
- Article
Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo.
- Published in:
- Angewandte Chemie International Edition, 2020, v. 59, n. 34, p. 14677, doi. 10.1002/anie.202006814
- By:
- Publication type:
- Article
Platinum (IV) Derivatives with Cinnamate Axial Ligands as Potent Agents Against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells.
- Published in:
- Angewandte Chemie International Edition, 2020, v. 59, n. 8, p. 3329, doi. 10.1002/anie.201913996
- By:
- Publication type:
- Article
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir<sup>III</sup> Complex Conjugated to a Far‐Red Emitting Coumarin.
- Published in:
- Angewandte Chemie International Edition, 2019, v. 58, n. 19, p. 6311, doi. 10.1002/anie.201901268
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- Publication type:
- Article
Energetics, Conformation, and Recognition of DNA Duplexes Modified by Monodentate Ru<sup>II</sup> Complexes Containing Terphenyl Arenes.
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- Chemistry - A European Journal, 2010, v. 16, n. 19, p. 5744, doi. 10.1002/chem.200903078
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- Article
Factors Affecting DNA-DNA Interstrand Cross-Links in the Antiparallel 3′-3′ Sense: A Comparison with the 5′-5′ Directional Isomer.
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- Chemistry - A European Journal, 2009, v. 15, n. 37, p. 9365, doi. 10.1002/chem.200900958
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- Article
Unique Properties of DNA Interstrand Cross-Links of Antitumor Oxaliplatin and the Effect of Chirality of the Carrier Ligand.
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- Chemistry - A European Journal, 2008, v. 14, n. 4, p. 1330, doi. 10.1002/chem.200701352
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- Publication type:
- Article
Structure and Unique Interactions with DNA of a Cationic Trans-Platinum Complex with the Nonplanar Bicyclic Piperidinopiperidine LigandD.G. acknowledges the partial support of the Israel Science Foundation and of the Alex Grass Center For Drug Design and Synthesis. This work was partially supported by Spanish CICYT (grant SAF2004-03111). The research of J.K. and V.B. was supported by the Grant Agency of the Academy of Sciences of the Czech Republic (Grants 5004101, B5004301) Support and sponsorship by European COSTD20/0003/00 action is gratefully acknowledged. Y.B. thanks the Belfer Foundation and the Barenholz Fund.
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- Angewandte Chemie, 2005, v. 117, n. 19, p. 2945, doi. 10.1002/ange.200462389
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- Article
Toxicity in tumor cells, DNA binding mode, and resistance to decomposition by sulfur nucleophiles of new dinuclear bifunctional trans-Pt<sup>II</sup> complexes containing long alkane linkers.
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- Pure & Applied Chemistry, 2013, v. 85, n. 2, p. 343, doi. 10.1351/PAC-CON-12-07-08
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- Publication type:
- Article
Structure and Unique Interactions with DNA of a Cationic Trans-Platinum Complex with the Nonplanar Bicyclic Piperidinopiperidine LigandD.G. acknowledges the partial support of the Israel Science Foundation and of the Alex Grass Center For Drug Design and Synthesis. This work was partially supported by Spanish CICYT (grant SAF2004-03111). The research of J.K. and V.B. was supported by the Grant Agency of the Academy of Sciences of the Czech Republic (Grants 5004101, B5004301) Support and sponsorship by European COSTD20/0003/00 action is gratefully acknowledged. Y.B. thanks the Belfer Foundation and the Barenholz Fund.
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- Angewandte Chemie International Edition, 2005, v. 44, n. 19, p. 2885, doi. 10.1002/anie.200462389
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- Article
DNA‐Intercalative Platinum Anticancer Complexes Photoactivated by Visible Light.
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- Chemistry - A European Journal, 2021, v. 27, n. 41, p. 10711, doi. 10.1002/chem.202101168
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- Article
A Cyclometalated Ir<sup>III</sup> Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells.
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- Chemistry - A European Journal, 2021, v. 27, n. 33, p. 8547, doi. 10.1002/chem.202100568
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- Article
Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic.
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- Chemistry - A European Journal, 2016, v. 22, n. 8, p. 2728, doi. 10.1002/chem.201504671
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- Article
Diazido Mixed-Amine Platinum(IV) Anticancer Complexes Activatable by Visible-Light Form Novel DNA Adducts.
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- Chemistry - A European Journal, 2013, v. 19, n. 29, p. 9578, doi. 10.1002/chem.201300374
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- Article
Thermodynamic and Mechanistic Insights into Translesion DNA Synthesis Catalyzed by Y-Family DNA Polymerase Across a Bulky Double-Base Lesion of an Antitumor Platinum Drug.
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- Chemistry - A European Journal, 2012, v. 18, n. 48, p. 15439, doi. 10.1002/chem.201202117
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- Article
Biochemical Studies of the Thermal Effects on DNA Modifications by the Antitumor Cisplatin and Their Repair.
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- ChemBioChem, 2007, v. 8, n. 16, p. 2008, doi. 10.1002/cbic.200700288
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- Article
Synthesis, antiproliferative activity in cancer cells and DNA interaction studies of [Pt(cis-1,3-diaminocycloalkane)Cl<sub>2</sub>] analogs.
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- Journal of Biological Inorganic Chemistry (JBIC), 2020, v. 25, n. 6, p. 913, doi. 10.1007/s00775-020-01809-9
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- Article
Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand.
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- Journal of Biological Inorganic Chemistry (JBIC), 2020, v. 25, n. 2, p. 339, doi. 10.1007/s00775-020-01765-4
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- Article
A new 4-(pyridinyl)-4H-benzo[g]chromene-5,10-dione ruthenium(II) complex inducing senescence in 518A2 melanoma cells.
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- Journal of Biological Inorganic Chemistry (JBIC), 2019, v. 24, n. 5, p. 647, doi. 10.1007/s00775-019-01677-y
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- Article
Insight into the toxic effects of cis-dichloridoplatinum(II) complexes containing 7-azaindole halogeno derivatives in tumor cells.
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- Journal of Biological Inorganic Chemistry (JBIC), 2013, v. 18, n. 5, p. 579, doi. 10.1007/s00775-013-1003-7
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- Article