Works matching AU Kartha, Reena V.

Results: 25

Neurochemical abnormalities in patients with type 1 Gaucher disease on standard of care therapy.

Published in:

Journal of Inherited Metabolic Disease, 2020, v. 43, n. 3, p. 564, doi. 10.1002/jimd.12182

By:

Kartha, Reena V.;
Joers, James;
Terluk, Marcia R.;
Travis, Abigail;
Rudser, Kyle;
Tuite, Paul J.;
Weinreb, Neal J.;
Jarnes, Jeanine R.;
Cloyd, James C.;
Öz, Gülin

Publication type:

Article

N -Acetylcysteine Reverses the Mitochondrial Dysfunction Induced by Very Long-Chain Fatty Acids in Murine Oligodendrocyte Model of Adrenoleukodystrophy.

Published in:

Biomedicines, 2021, v. 9, n. 12, p. 1826, doi. 10.3390/biomedicines9121826

By:

Zhou, Jie;
Terluk, Marcia R.;
Orchard, Paul J.;
Cloyd, James C.;
Kartha, Reena V.

Publication type:

Article

N-acetylcysteine Provides Cytoprotection in Murine Oligodendrocytes through Heme Oxygenase-1 Activity.

Published in:

Biomedicines, 2020, v. 8, n. 8, p. 240, doi. 10.3390/biomedicines8080240

By:

Zhou, Jie;
Terluk, Marcia R.;
Basso, Lisa;
Mishra, Usha R.;
Orchard, Paul J.;
Cloyd, James C.;
Schröder, Henning;
Kartha, Reena V.

Publication type:

Article

Effects of yoga on oxidative stress, motor function, and non-motor symptoms in Parkinson's disease: a pilot randomized controlled trial.

Published in:

Pilot & Feasibility Studies, 2018, v. 4, n. 1, p. N.PAG, doi. 10.1186/s40814-018-0355-8

By:

Cheung, Corjena;
Bhimani, Rozina;
Wyman, Jean F.;
Konczak, Jürgen;
Zhang, Lei;
Mishra, Usha;
Terluk, Marcia;
Kartha, Reena V.;
Tuite, Paul

Publication type:

Article

The MiRNA Journey from Theory to Practice as a CNS Biomarker.

Published in:

Frontiers in Genetics, 2016, p. 1, doi. 10.3389/fgene.2016.00011

By:

Stoicea, Nicoleta;
Du, Amy;
Lakis, D. Christie;
Tipton, Courtney;
Arias-Morales, Carlos E.;
Bergese, Sergio D.;
Thayanithy, Venugopal;
Kartha, Reena V.

Publication type:

Article

Model-informed repurposing of eliglustat for treatment and prophylaxis of Shiga toxin-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) in children.

Published in:

Pediatric Nephrology, 2025, v. 40, n. 6, p. 2009, doi. 10.1007/s00467-025-06688-3

By:

Wolthuis, David F. G. J.;
Freriksen, Jolien J. M.;
ter Avest, Mendy;
Kartha, Reena V.;
de Wildt, Saskia N.;
Wijnsma, Kioa;
van de Kar, Nicole C. A. J.;
ter Heine, Rob

Publication type:

Article

Population Pharmacokinetic Analysis of N‐Acetylcysteine in Pediatric Patients With Inherited Metabolic Disorders Undergoing Hematopoietic Stem Cell Transplant.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1638, doi. 10.1002/jcph.1943

By:

Sahasrabudhe, Siddhee A.;
Kartha, Reena V.;
Ng, Michelle;
Basso, Lisa M.;
Mishra, Usha;
Cloyd, James C.;
Orchard, Paul J.;
Brundage, Richard C.;
Coles, Lisa D.

Publication type:

Article

Repeated‐Dose Oral N‐Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 2, p. 158, doi. 10.1002/jcph.1008

By:

Coles, Lisa D.;
Tuite, Paul J.;
Öz, Gülin;
Mishra, Usha R.;
Kartha, Reena V.;
Sullivan, Kathleen M.;
Cloyd, James C.;
Terpstra, Melissa

Publication type:

Article

Building cross-border collaborations to increase diversity and accelerate rare disease drug development -- meeting report from the inaugural IndoUSrare Annual Conference 2021.

Published in:

Therapeutic Advances in Rare Disease, 2022, v. 3, p. 1, doi. 10.1177/26330040221133124

By:

Khera, Harvinder Kour;
Venugopal, Nisha;
Karur, Ramya T.;
Mishra, Rakesh;
Kartha, Reena V.;
Rajasimha, Harsha K.

Publication type:

Article

N-acetylcysteine Pharmacology and Applications in Rare Diseases—Repurposing an Old Antioxidant.

Published in:

Antioxidants, 2023, v. 12, n. 7, p. 1316, doi. 10.3390/antiox12071316

By:

Sahasrabudhe, Siddhee A.;
Terluk, Marcia R.;
Kartha, Reena V.

Publication type:

Article

Mechanisms of Antioxidant Induction with High-Dose N-Acetylcysteine in Childhood Cerebral Adrenoleukodystrophy.

Published in:

2015

By:

Kartha, Reena;
Zhou, Jie;
Basso, Lisa;
Schröder, Henning;
Orchard, Paul;
Cloyd, James;
Kartha, Reena V;
Schröder, Henning;
Orchard, Paul J

Publication type:

journal article

Orphan drug development: the increasing role of clinical pharmacology.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2019, v. 46, n. 5, p. 395, doi. 10.1007/s10928-019-09646-3

By:

Ahmed, Mariam A.;
Okour, Malek;
Brundage, Richard;
Kartha, Reena V.

Publication type:

Article

A hierarchical Bayesian approach for combining pharmacokinetic/pharmacodynamic modeling and Phase IIa trial design in orphan drugs: Treating adrenoleukodystrophy with Lorenzo’s oil.

Published in:

Journal of Biopharmaceutical Statistics, 2016, v. 26, n. 6, p. 1025, doi. 10.1080/10543406.2016.1226326

By:

Basu, Cynthia;
Ahmed, Mariam A.;
Kartha, Reena V.;
Brundage, Richard C.;
Raymond, Gerald V.;
Cloyd, James C.;
Carlin, Bradley P.

Publication type:

Article

Translational and clinical pharmacology considerations in drug repurposing for X‐linked adrenoleukodystrophy—A rare peroxisomal disorder.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 6, p. 2552, doi. 10.1111/bcp.15090

By:

Tieu, Julianne H.;
Sahasrabudhe, Siddhee A.;
Orchard, Paul J.;
Cloyd, James C.;
Kartha, Reena V.

Publication type:

Article

A model-based approach to assess the exposure-response relationship of Lorenzo's oil in adrenoleukodystrophy.

Published in:

British Journal of Clinical Pharmacology, 2016, v. 81, n. 6, p. 1058, doi. 10.1111/bcp.12897

By:

Ahmed, Mariam A.;
Kartha, Reena V.;
Brundage, Richard C.;
Cloyd, James;
Basu, Cynthia;
Carlin, Bradley P.;
Jones, Richard O.;
Moser, Ann B.;
Fatemi, Ali;
Raymond, Gerald V.

Publication type:

Article

Getting the Dose Right in Drug Development for Rare Diseases: Barriers and Enablers.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 6, p. 1412, doi. 10.1002/cpt.3407

By:

Ahmed, Mariam A.;
Krishna, Rajesh;
Rayad, Noha;
Albusaysi, Salwa;
Mitra, Amitava;
Shang, Elizabeth;
Hon, Yuen Yi;
AbuAsal, Bilal;
Bakhaidar, Rana;
Roman, Youssef M.;
Bhattacharya, Indranil;
Cloyd, James;
Patel, Munjal;
Kartha, Reena V.;
Younis, Islam R.

Publication type:

Article

Physiologically‐Based Pharmacokinetic Model Development, Validation, and Application for Prediction of Eliglustat Drug–Drug Interactions.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 6, p. 1254, doi. 10.1002/cpt.2738

By:

Sahasrabudhe, Siddhee A.;
Cheng, Shen;
Al‐Kofahi, Mahmoud;
Jarnes, Jeanine R.;
Weinreb, Neal J.;
Kartha, Reena V.

Publication type:

Article

Biological Variation in Peripheral Inflammation and Oxidative Stress Biomarkers in Individuals with Gaucher Disease.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 16, p. 9189, doi. 10.3390/ijms23169189

By:

Sahasrabudhe, Siddhee A.;
Terluk, Marcia R.;
Rudser, Kyle D.;
Cloyd, James C.;
Kartha, Reena V.

Publication type:

Article

Molecular Interactions between Gasotransmitters in Patients with Obstructive Sleep Apnea.

Published in:

International Journal of Translational Medicine, 2022, v. 2, n. 3, p. 408, doi. 10.3390/ijtm2030032

By:

Pusalavidyasagar, Snigdha;
Hovde, Laurie B.;
Lee, Jessie;
Zhang, Lei;
Abbasi, Adnan;
Kartha, Reena V.

Publication type:

Article

Gaucher disease – more than just a rare lipid storage disease.

Published in:

Journal of Molecular Medicine, 2022, v. 100, n. 4, p. 499, doi. 10.1007/s00109-021-02174-z

By:

Roh, Jaehyeok;
Subramanian, Subbaya;
Weinreb, Neal J.;
Kartha, Reena V.

Publication type:

Article

Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0043720

By:

Thayanithy, Venugopal;
Park, ChangWon;
Sarver, Aaron L.;
Kartha, Reena V.;
Korpela, Derek M.;
Graef, Ashley J.;
Steer, Clifford J.;
Modiano, Jaime F.;
Subramanian, Subbaya;
Cinti, Caterina

Publication type:

Article

Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities.

Published in:

2021

By:

Cheff, Dorian M.;
Muotri, Alysson R.;
Stockwell, Brent R.;
Schmidt, Edward E.;
Ran, Qitao;
Kartha, Reena V.;
Johnson, Simon C.;
Mittal, Plavi;
Arnér, Elias S. J.;
Wigby, Kristen M.;
Hall, Matthew D.;
Ramesh, Sanath Kumar

Publication type:

journal article

MicroRNAs as Biomarkers in Cancer.

Published in:

Diagnostics (2075-4418), 2013, v. 3, n. 1, p. 84, doi. 10.3390/diagnostics3010084

By:

Sundarbose, Kamini;
Kartha, Reena V.;
Subramanian, Subbaya

Publication type:

Article

N-Acetyl-L-cysteine Protects Human Retinal Pigment Epithelial Cells from Oxidative Damage: Implications for Age-Related Macular Degeneration.

Published in:

Oxidative Medicine & Cellular Longevity, 2019, p. 1, doi. 10.1155/2019/5174957

By:

Terluk, Marcia R.;
Ebeling, Mara C.;
Fisher, Cody R.;
Kapphahn, Rebecca J.;
Yuan, Ching;
Kartha, Reena V.;
Montezuma, Sandra R.;
Ferrington, Deborah A.

Publication type:

Article

Intravital microscopy: An innovative approach to track real‐time muscle integrity and pathology in Pompe disease.

Published in:

Clinical & Translational Discovery, 2024, v. 4, n. 4, p. 1, doi. 10.1002/ctd2.322

By:

Pillai, Nishitha R.;
Kartha, Reena V.

Publication type:

Article