Works by Karlsson, Mats O.

Results: 192

In the Cradle of Pharmacometric Methodology: Introducing Population PKPD Modeling, Simultaneous Analysis, and the Effect‐Compartment Model—Commentary on Sheiner et al.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 6, p. 1516, doi. 10.1002/cpt.3663

By:

Karlsson, Mats O.

Publication type:

Article

Item Response Modeling and Artificial Neural Network for Differentiation of Parkinson's Patients and Subjects Without Evidence of Dopaminergic Deficit.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 5, p. 881, doi. 10.1002/psp4.70000

By:

Arrington, Leticia;
van Dijkman, Sven C.;
Plan, Elodie L.;
Karlsson, Mats O.

Publication type:

Article

Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 65, n. 5, p. 839, doi. 10.1007/s00280-009-1089-3

By:

Hansson, Emma K.;
Wallin, Johan E.;
Lindman, Henrik;
Sandström, Marie;
Karlsson, Mats O.;
Friberg, Lena E.

Publication type:

Article

Clinical application of a semimechanistic-physiologic population PK/PD model for neutropenia following pemetrexed therapy.

Published in:

Cancer Chemotherapy & Pharmacology, 2006, v. 57, n. 4, p. 427, doi. 10.1007/s00280-005-0035-2

By:

Latz, Jane E.;
Rusthoven, James J.;
Karlsson, Mats O.;
Ghosh, Atalanta;
Johnson, Robert D.

Publication type:

Article

A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy.

Published in:

Cancer Chemotherapy & Pharmacology, 2006, v. 57, n. 4, p. 412, doi. 10.1007/s00280-005-0077-5

By:

Latz, Jane E.;
Karlsson, Mats O.;
Rusthoven, James J.;
Ghosh, Atalanta;
Johnson, Robert D.

Publication type:

Article

Pharmacokinetic modeling of paclitaxel encapsulation in Cremophor EL micelles.

Published in:

Cancer Chemotherapy & Pharmacology, 2001, v. 47, n. 4, p. 309, doi. 10.1007/s002800000215

By:

van Zuylen, Lia;
Karlsson, Mats O.;
Verweij, Jaap;
Brouwer, Eric;
de Bruijn, Peter;
Nooter, Kees;
Stoter, Gerrit;
Sparreboom, Alex

Publication type:

Article

Determination of drug effect on tumour cells, host animal toxicity and drug pharmacokinetics in a hollow-fibre model in rats.

Published in:

2000

By:

Jonsson, Elin;
Friberg, Lena E.;
Karlsson, Mats O.;
Bashir Hassan, Saadia;
Freijs, Agneta;
Hansen, Klaus;
Larsson, Rolf;
Jonsson, E;
Friberg, L E;
Karlsson, M O;
Hassan, S B;
Freijs, A;
Hansen, K;
Larsson, R

Publication type:

journal article

Rescue therapy with high-dose oral phenobarbitone loading for refractory status epilepticus.

Published in:

Journal of Paediatrics & Child Health, 2010, v. 46, n. 1/2, p. 17, doi. 10.1111/j.1440-1754.2009.01611.x

By:

Wilmshurst, Jo M.;
van der Walt, Jan-Stefan;
Ackermann, Sally;
Karlsson, Mats O.;
Blockman, Marc

Publication type:

Article

A simultaneous analysis of the time-course of leukocytes and neutrophils following docetaxel administration using a semi-mechanistic myelosuppression model.

Published in:

Investigational New Drugs, 2012, v. 30, n. 2, p. 833, doi. 10.1007/s10637-010-9603-3

By:

Quartino, Angelica Linnea;
Friberg, Lena E.;
Karlsson, Mats O.

Publication type:

Article

Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam.

Published in:

Investigational New Drugs, 2005, v. 23, n. 3, p. 225, doi. 10.1007/s10637-005-6730-3

By:

Charlotte van Kesteren;
Anthe S. Zandvliet;
Mats O. Karlsson;
Ron A. A. Matht;
Cornelis J. A. Punt;
Jean-Pierre Armand;
Eric Raymond;
Alwin D. R. Huitema;
Christian Dittrich;
Herlinde Dumez;
Henri H. Roch;
Jean-Pierre Droz;
Miroslav Ravic;
S. Murray Yule;
Jantien Wanders;
Jos H. Beijnen;
Pierre Fumoleau;
Jan H. M. Schellens

Publication type:

Article

Properties of the full random‐effect modeling approach with missing covariate data.

Published in:

Statistics in Medicine, 2024, v. 43, n. 5, p. 935, doi. 10.1002/sim.9979

By:

Nyberg, Joakim;
Jonsson, E. Niclas;
Karlsson, Mats O.;
Häggström, Jonas

Publication type:

Article

Quantitative Comparisons of Progressive Supranuclear Palsy Rating Scale Versions Using Item Response Theory.

Published in:

Movement Disorders, 2024, v. 39, n. 12, p. 2181, doi. 10.1002/mds.30001

By:

Gewily, Mohamed;
Plan, Elodie L.;
Yousefi, Elham;
König, Franz;
Posch, Martin;
Hopfner, Franziska;
Höglinger, Günter;
Karlsson, Mats O.

Publication type:

Article

Semimechanistic model describing gastric emptying and glucose absorption in healthy subjects and patients with type 2 diabetes.

Published in:

Journal of Clinical Pharmacology, 2016, v. 56, n. 3, p. 340, doi. 10.1002/jcph.602

By:

Alskär, Oskar;
Bagger, Jonatan I.;
Røge, Rikke M.;
Knop, Filip K.;
Karlsson, Mats O.;
Vilsbøll, Tina;
Kjellsson, Maria C.

Publication type:

Article

Population pharmacokinetics of edoxaban and its main metabolite in a dedicated renal impairment study.

Published in:

Journal of Clinical Pharmacology, 2015, v. 55, n. 11, p. 1268, doi. 10.1002/jcph.541

By:

Jönsson, Siv;
Simonsson, Ulrika S. H.;
Miller, Raymond;
Karlsson, Mats O.

Publication type:

Article

A Model-Based Approach to Predict Longitudinal HbA1c, Using Early Phase Glucose Data From Type 2 Diabetes Mellitus Patients After Anti-Diabetic Treatment.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 6, p. 589, doi. 10.1002/jcph.86

By:

Kjellsson, Maria C.;
Cosson, Valérie F.;
Mazer, Norman A.;
Frey, Nicolas;
Karlsson, Mats O.

Publication type:

Article

Identification of the Mechanism of Action of a Glucokinase Activator From Oral Glucose Tolerance Test Data in Type 2 Diabetic Patients Based on an Integrated Glucose-Insulin Model.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 12, p. 1861, doi. 10.1177/0091270011422231

By:

Jauslin, Petra M.;
Karlsson, Mats O.;
Frey, Nicolas

Publication type:

Article

Pharmacokinetic-Pharmacodynamic Assessment of the Interrelationships Between Tesaglitazar Exposure and Renal Function in Patients With Type 2 Diabetes Mellitus.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 9, p. 1317, doi. 10.1177/0091270011416937

By:

Hamrén, Bengt;
Öhman, K. Peter;
Svensson, Maria K.;
Karlsson, Mats O.

Publication type:

Article

Modeling Longitudinal Daily Seizure Frequency Data From Pregabalin Add-On Treatment.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 6, p. 880, doi. 10.1177/0091270011407193

By:

Ahn, Jae Eun;
Plan, Elodie L.;
Karlsson, Mats O.;
Miller, Raymond

Publication type:

Article

Application of the Optimal Design Approach to Improve a Pretransplant Drug Dose Finding Design for Ciclosporin.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 3, p. 347, doi. 10.1177/0091270010397731

By:

Hennig, Stefanie;
Nyberg, Joakim;
Fanta, Samuel;
Backman, Janne T.;
Hoppu, Kalle;
Hooker, Andrew C.;
Karlsson, Mats O.

Publication type:

Article

Ethically Attractive Dose-Finding Designs for Drugs With a Narrow Therapeutic Index.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 1, p. 29, doi. 10.1177/0091270010390041

By:

Lledó-García, Rocío;
Hennig, Stefanie;
Nyberg, Joakim;
Hooker, Andrew C.;
Karlsson, Mats O.

Publication type:

Article

Modeling of 24-Hour Glucose and Insulin Profiles of Patients With Type 2 Diabetes.

Published in:

Journal of Clinical Pharmacology, 2011, v. 51, n. 2, p. 153, doi. 10.1177/0091270010362536

By:

Jauslin, Petra M.;
Frey, Nicolas;
Karlsson, Mats O.

Publication type:

Article

A Model for Glucose, Insulin, and Beta-Cell Dynamics in Subjects With Insulin Resistance and Patients With Type 2 Diabetes.

Published in:

Journal of Clinical Pharmacology, 2010, v. 50, n. 8, p. 861, doi. 10.1177/0091270009349711

By:

Ribbing, Jakob;
Hamrén, Bengt;
Svensson, Maria K.;
Karlsson, Mats O.

Publication type:

Article

Long-Term Changes in Cyclosporine Pharmacokinetics After Renal Transplantation in Children: Evidence for Saturable Presystemic Metabolism and Effect of NR1I2 Polymorphism.

Published in:

Journal of Clinical Pharmacology, 2010, v. 50, n. 5, p. 581, doi. 10.1177/0091270009348223

By:

Fanta, Samuel;
Jönsson, Siv;
Karlsson, Mats O.;
Niemi, Mikko;
Holmberg, Christer;
Hoppu, Kalle;
Backman, Janne T.

Publication type:

Article

An Integrated Glucose-Insulin Model to Describe Oral Glucose Tolerance Test Data in Healthy Volunteers.

Published in:

Journal of Clinical Pharmacology, 2010, v. 50, n. 3, p. 246, doi. 10.1177/0091270009341185

By:

Silber, Hanna E.;
Frey, Nicolas;
Karlsson, Mats O.

Publication type:

Article

Estimation of Cefuroxime Dosage Using Pharmacodynamic Targets, MIC Distributions, and Minimization of a Risk Function.

Published in:

Journal of Clinical Pharmacology, 2008, v. 48, n. 11, p. 1270, doi. 10.1177/0091270008320923

By:

Viberg, Anders;
Cars, Otto;
Karlsson, Mats O.;
Jönsson, Siv

Publication type:

Article

An Integrated Model for Glucose and Insulin Regulation in Healthy Volunteers and Type 2 Diabetic Patients Following Intravenous Glucose Provocations.

Published in:

Journal of Clinical Pharmacology, 2007, v. 47, n. 9, p. 1159, doi. 10.1177/0091270007304457

By:

Silber, Hanna E.;
Jauslin, Petra M.;
Frey, Nicolas;
Gieschke, Ronald;
Simonsson, Ulrika S. H.;
Karlsson, Mats O.

Publication type:

Article

Pharmacokinetics of Desmopressin Administrated as an Oral Lyophilisate Dosage Form in Children With Primary Nocturnal Enuresis and Healthy Adults.

Published in:

Journal of Clinical Pharmacology, 2006, v. 46, n. 10, p. 1204, doi. 10.1177/0091270006291838

By:

Østerberg, Ole;
Savic, Radojka M.;
Karlsson, Mats O.;
Simonsson, Ulrika S. H.;
Nørgaard, Jens Peter;
Walle, Johan Vande;
Agersø, Henrik

Publication type:

Article

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6.

Published in:

PLoS ONE, 2019, v. 14, n. 2, p. 1, doi. 10.1371/journal.pone.0211981

By:

Thorsted, Anders;
Bouchene, Salim;
Tano, Eva;
Castegren, Markus;
Lipcsey, Miklós;
Sjölin, Jan;
Karlsson, Mats O.;
Friberg, Lena E.;
Nielsen, Elisabet I.

Publication type:

Article

Optimization of blood pressure measurement practices for pharmacodynamic analyses of tyrosine-kinase inhibitors.

Published in:

CTS: Clinical & Translational Science, 2023, v. 16, n. 1, p. 73, doi. 10.1111/cts.13423

By:

Centanni, Maddalena;
Thijs, Abel;
Desar, Ingrid;
Karlsson, Mats O.;
Friberg, Lena E.

Publication type:

Article

Pharmacokinetics of ximelagatran and relationship to clinical response in acute deep vein thrombosis.

Published in:

Clinical Pharmacology & Therapeutics, 2005, v. 77, n. 4, p. 279, doi. 10.1016/j.clpt.2004.11.001

By:

Cullberg, Marie;
Eriksson, Ulf G.;
Wåhlander, Karin;
Eriksson, Henry;
Schulman, Sam;
Karlsson, Mats O.

Publication type:

Article

A rational approach for selection of optimal covariate-based dosing strategies*.

Published in:

Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 1, p. 7, doi. 10.1067/mcp.2003.2

By:

Jönsson, Siv;
Karlsson, Mats O.

Publication type:

Article

Clinical pharmacokinetics of irinotecan and its metabolites in relation with diarrhea*.

Published in:

Clinical Pharmacology & Therapeutics, 2002, v. 72, n. 3, p. 265, doi. 10.1067/mcp.2002.126741

By:

Xie, Rujia;
Mathijssen, Ron H. J.;
Sparreboom, Alex;
Verweij, Jaap;
Karlsson, Mats O.

Publication type:

Article

A pharmacodynamic Markov mixed-effect model for the effect of temazepam on sleep.

Published in:

Clinical Pharmacology & Therapeutics, 2000, v. 68, n. 2, p. 175, doi. 10.1067/mcp.2000.108669

By:

Karlsson, Mats O.;
Schoemaker, Rik C.;
Kemp, Bob;
Cohen, Adam F.;
van Gerven, Joop M.A.;
Tuk, Bert;
Peck, Carl C.;
Danhof, Meindert

Publication type:

Article

Population pharmacokinetic-pharmacodynamic modeling of moxonidine using 24-hour ambulatory blood pressure measurements.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 64, n. 6, p. 622, doi. 10.1016/S0009-9236(98)90053-4

By:

Hempel, Georg;
Karlsson, Mats O.;
de Alwis, Dinesh P.;
Toublanc, Nathalie;
McNay, John;
Schaefer, Hans G.

Publication type:

Article

A model for the turnover of dihydrotestosterone in the presence of the irreversible 5α-reductase inhibitors GI198745 and finasteride.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 64, n. 6, p. 636, doi. 10.1016/S0009-9236(98)90054-6

By:

Gisleskog, Per Olsson;
Hermann, David;
Hammarlund-Udenaes, Margareta;
Karlsson, Mats O.

Publication type:

Article

Population pharmacodynamic modeling of levodopa in patients with Parkinson's disease receiving entacapone.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 64, n. 1, p. 106, doi. 10.1016/S0009-9236(98)90028-5

By:

Trocóniz, Iñaki F.;
Naukkarinen, Tarja H.;
Ruottinen, Hanna M.;
Rinne, Urpo K.;
Gordin, Ariel;
Karlsson, Mats O.

Publication type:

Article

A general model for time-dissociated pharmacokinetic-pharmacodynamic relationships exemplified by paclitaxel myelosuppression*.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 63, n. 1, p. 11, doi. 10.1016/S0009-9236(98)90117-5

By:

Karlsson, Mats O.;
Molnar, Valeria;
Bergh, Jonas;
Freijs, Agneta;
Larsson, Rolf

Publication type:

Article

A population model for the follicular growth in women treated with follicle stimulating hormone.

Published in:

Clinical Pharmacology & Therapeutics, 1997, v. 62, n. 6, p. 665, doi. 10.1016/S0009-9236(97)90086-2

By:

Karlsson, Mats O.;
Wade, Janet R.;
Loumaye, Ernest;
Munafo, Alain

Publication type:

Article

A population model for the leukopenic effect of etoposide*.

Published in:

Clinical Pharmacology & Therapeutics, 1995, v. 57, n. 3, p. 325, doi. 10.1016/0009-9236(95)90158-2

By:

Karlsson, Mats O.;
Port, Rüdiger E.;
Ratain, Mark J.;
Sheiner, Lewis B.

Publication type:

Article

Population pharmacokinetic and pharmacodynamic properties of artesunate in patients with artemisinin sensitive and resistant infections in Southern Myanmar.

Published in:

Malaria Journal, 2018, v. 17, p. 1, doi. 10.1186/s12936-018-2278-5

By:

Lohy Das, Jesmin Permala;
Kyaw, Myat P.;
Nyunt, Myat H.;
Chit, Khin;
Aye, Kyin H.;
Aye, Moe M.;
Karlsson, Mats O.;
Bergstrand, Martin;
Tarning, Joel

Publication type:

Article

Comparison of the power and type 1 error of total score models for drug effect detection in clinical trials.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s10928-024-09949-0

By:

Haem, Elham;
Karlsson, Mats O.;
Ueckert, Sebastian

Publication type:

Article

Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2024, v. 51, n. 1, p. 65, doi. 10.1007/s10928-023-09890-8

By:

Brekkan, Ari;
Lledo-Garcia, Rocío;
Lacroix, Brigitte;
Jönsson, Siv;
Karlsson, Mats O.;
Plan, Elodie L.

Publication type:

Article

Correction to: Training the next generation of pharmacometric modelers: a multisector perspective.

Published in:

2024

By:

Bonate, Peter L.;
Barrett, Jeffrey S.;
Ait-Oudhia, Sihem;
Brundage, Richard;
Corrigan, Brian;
Duffull, Stephen;
Gastonguay, Marc;
Karlsson, Mats O.;
Kijima, Shinichi;
Krause, Andreas;
Lovern, Mark;
Riggs, Matthew M.;
Neely, Michael;
Ouellet, Daniele;
Plan, Elodie L.;
Rao, Gauri G.;
Standing, Joseph;
Wilkins, Justin;
Zhu, Hao

Publication type:

Correction Notice

Training the next generation of pharmacometric modelers: a multisector perspective.

Published in:

2024

By:

Bonate, Peter L.;
Barrett, Jeffrey S.;
Ait-Oudhia, Sihem;
Brundage, Richard;
Corrigan, Brian;
Duffull, Stephen;
Gastonguay, Marc;
Karlsson, Mats O.;
Kijima, Shinichi;
Krause, Andreas;
Lovern, Mark;
Riggs, Matthew M.;
Neely, Michael;
Ouellet, Daniele;
Plan, Elodie L.;
Rao, Gauri G.;
Standing, Joseph;
Wilkins, Justin;
Zhu, Hao

Publication type:

Letter

Generation and application of avatars in pharmacometric modelling.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2023, v. 50, n. 5, p. 411, doi. 10.1007/s10928-023-09873-9

By:

Chasseloup, Estelle;
Hooker, Andrew C.;
Karlsson, Mats O.

Publication type:

Article

Joint longitudinal model-based meta-analysis of FEV1 and exacerbation rate in randomized COPD trials.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2023, v. 50, n. 4, p. 297, doi. 10.1007/s10928-023-09853-z

By:

Llanos-Paez, Carolina;
Ambery, Claire;
Yang, Shuying;
Beerahee, Misba;
Plan, Elodie L.;
Karlsson, Mats O.

Publication type:

Article

Improved numerical stability for the bounded integer model.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2021, v. 48, n. 2, p. 241, doi. 10.1007/s10928-020-09727-8

By:

Ueckert, Sebastian;
Karlsson, Mats O.

Publication type:

Article

A general model for cell death and biomarker release from injured tissues.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2021, v. 48, n. 1, p. 69, doi. 10.1007/s10928-020-09720-1

By:

Li, Jingyun;
Karlsson, Mats O.;
Sanhajariya, Suchaya;
Isbister, Geoffrey K.;
Duffull, Stephen B.

Publication type:

Article

Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both?

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 5, p. 485, doi. 10.1007/s10928-020-09700-5

By:

Chasseloup, Estelle;
Yngman, Gunnar;
Karlsson, Mats O.

Publication type:

Article

Performance of longitudinal item response theory models in shortened or partial assessments.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 5, p. 461, doi. 10.1007/s10928-020-09697-x

By:

Arrington, Leticia;
Ueckert, Sebastian;
Ahamadi, Malidi;
Macha, Sreeraj;
Karlsson, Mats O.

Publication type:

Article