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Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP.
- Published in:
- Translational Psychiatry, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41398-018-0319-z
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- Publication type:
- Article
CXCR4 involvement in neurodegenerative diseases.
- Published in:
- Translational Psychiatry, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41398-017-0049-7
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- Publication type:
- Article
Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models.
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- Cells (2073-4409), 2020, v. 9, n. 6, p. 1406, doi. 10.3390/cells9061406
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- Article
An examination of αB-crystallin as a modifier of SOD1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis.
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- Journal of Neurochemistry, 2010, v. 113, n. 5, p. 1092, doi. 10.1111/j.1471-4159.2010.06572.x
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- Publication type:
- Article
Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex.
- Published in:
- Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-31075-4
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- Publication type:
- Article
Coding variants in TREM2 increase risk for Alzheimer's disease.
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- Human Molecular Genetics, 2014, v. 23, n. 21, p. 5838, doi. 10.1093/hmg/ddu277
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- Publication type:
- Article
Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: αB-crystallin modulates aggregation.
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- Human Molecular Genetics, 2005, v. 14, n. 16, p. 2335, doi. 10.1093/hmg/ddi236
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- Publication type:
- Article
Astrocytic α2-Na<sup>+</sup>/K<sup>+</sup> ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model.
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- Science Translational Medicine, 2022, v. 14, n. 632, p. 1, doi. 10.1126/scitranslmed.abm4107
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- Article
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.
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- Science Translational Medicine, 2019, v. 11, n. 485, p. N.PAG, doi. 10.1126/scitranslmed.aat3005
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- Publication type:
- Article
Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease.
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- Molecular Neurodegeneration, 2023, p. 1, doi. 10.1186/s13024-023-00688-3
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- Publication type:
- Article
Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease.
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- Molecular Neurodegeneration, 2023, v. 18, n. 1, p. N.PAG, doi. 10.1186/s13024-023-00688-3
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- Article
Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease.
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- Brain: A Journal of Neurology, 2023, v. 146, n. 7, p. 2928, doi. 10.1093/brain/awac498
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- Article
Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease.
- Published in:
- 2021
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- Publication type:
- journal article
Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease.
- Published in:
- 2019
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- Publication type:
- journal article
White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease.
- Published in:
- 2018
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- Publication type:
- journal article
Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease.
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- Annals of Neurology, 2023, v. 93, n. 6, p. 1158, doi. 10.1002/ana.26620
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- Publication type:
- Article
Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease.
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- Acta Neuropathologica, 2021, v. 142, n. 4, p. 689, doi. 10.1007/s00401-021-02342-y
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- Article
Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition.
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- Acta Neuropathologica, 2018, v. 135, n. 1, p. 85, doi. 10.1007/s00401-017-1789-4
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- Publication type:
- Article
Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia.
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- Acta Neuropathologica, 2017, v. 133, n. 5, p. 825, doi. 10.1007/s00401-017-1693-y
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- Publication type:
- Article
CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline.
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- EMBO Molecular Medicine, 2018, v. 10, n. 12, p. N.PAG, doi. 10.15252/emmm.201809712
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- Article
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
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- PLoS Genetics, 2014, v. 10, n. 10, p. 1, doi. 10.1371/journal.pgen.1004758
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- Publication type:
- Article
The <i>PSEN1</i>, p.E318G Variant Increases the Risk of Alzheimer's Disease in <i>APOE</i>-ε4 Carriers.
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- PLoS Genetics, 2013, v. 9, n. 8, p. 1, doi. 10.1371/journal.pgen.1003685
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- Publication type:
- Article
Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
- Published in:
- 2018
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- Publication type:
- journal article
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
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- 2018
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- Publication type:
- journal article
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
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- 2017
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- Publication type:
- journal article
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
- Published in:
- eLife, 2016, p. 1, doi. 10.7554/eLife.20391
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- Publication type:
- Article
Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration.
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- Translational Psychiatry, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41398-022-02274-5
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- Publication type:
- Article
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia.
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- Nature Protocols, 2023, v. 18, n. 6, p. 1893, doi. 10.1038/s41596-023-00814-x
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- Publication type:
- Article
Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice.
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- PLoS ONE, 2023, v. 18, n. 11, p. 1, doi. 10.1371/journal.pone.0294731
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- Publication type:
- Article
Ascertaining perturbations in microglial expression profiles using single‐nuclei RNA‐seq from human brains: Genetics/genetic factors of Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.046024
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- Publication type:
- Article
Cross‐modal associations between traditional and emerging CSF biomarkers and grey matter network disruption in autosomal dominant Alzheimer disease: Neuroimaging / Multi‐modal comparisons.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045905
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- Publication type:
- Article
Multiomics approaches reveal a link between the MS4A gene loci, TREM2, and microglia function: Genetics/omics and systems biology.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043592
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- Publication type:
- Article
Single‐nuclei RNA‐seq of brains carriers of high‐risk variants and Mendelian mutations: Genetics: Genetics and omics of AD I.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043125
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- Publication type:
- Article
Protective genetic variants in the MS4A gene cluster modulate microglial activity: Imaging and biomarker correlates of genetic variants protective against AD.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.039431
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- Article
Global system segregation enhances reserve in normal aging and Alzheimer's disease: Reserve and resilience: Opportunities and mechanisms for dementia prevention.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.037930
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- Article
Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1504, doi. 10.1002/alz.12150
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- Article
Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease‐informed machine‐learning.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 3, p. 501, doi. 10.1002/alz.12032
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- Publication type:
- Article
P3‐200: TAU‐MEDIATED CELL DEATH MECHANISMS IN MAPT V337M IPSC‐DERIVED HUMAN NEURONS.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1006, doi. 10.1016/j.jalz.2019.06.3229
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- Publication type:
- Article
O3‐13‐06: THE MS4A GENE CLUSTER IS A KEY MODULATOR OF SOLUBLE TREM2 AND ALZHEIMER DISEASE RISK.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P922, doi. 10.1016/j.jalz.2019.06.4701
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- Publication type:
- Article
O3‐07‐02: LYSOSOMAL DYSFUNCTION IN STEM CELL MODELS OF TAUOPATHY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P897, doi. 10.1016/j.jalz.2019.06.4661
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- Publication type:
- Article
O5‐04‐03: IDENTIFICATION OF DIFFERENTIALLY EXPRESSED GENES AND POTENTIALLY NOVEL DRUGS FOR FRONTOTEMPORAL LOBAR DEMENTIA WITH TAU INCLUSIONS BY A DEPENDABLE ANALYSIS APPROACH.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1651, doi. 10.1016/j.jalz.2018.06.3015
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- Publication type:
- Article
P3‐125: NUCLEOSKELETON DYSREGULATION IS MEDIATED BY LMNA IN ALZHEIMER'S DISEASE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1115, doi. 10.1016/j.jalz.2018.06.1482
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- Publication type:
- Article
O3‐01‐03: TAU KINETICS IN NEURONS AND IN THE HUMAN CNS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1008, doi. 10.1016/j.jalz.2018.06.2772
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- Publication type:
- Article
O2‐12‐01: LYSOSOMAL DYSFUNCTION AND ALTERED TAU METABOLISM IN STEM CELL MODELS OF AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P650, doi. 10.1016/j.jalz.2018.06.2706
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- Publication type:
- Article
PHOSPHOLIPASE D3 CONTRIBUTES TO ALZHEIMER’S DISEASE RISK VIA DISRUPTION OF Aβ CLEARANCE THROUGH THE LYSOSOME.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P602, doi. 10.1016/j.jalz.2017.07.248
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- Publication type:
- Article
LINKAGE AND WHOLE GENOME SEQUENCE ANALYSIS OF ALZHEIMER'S DISEASE RESILIENCE AND RISK.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P675, doi. 10.1016/j.jalz.2016.06.1325
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- Publication type:
- Article
Phospholipase d3 contributes to Alzheimer’s disease risk via disruption in app trafficking and Aβ generation.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P163, doi. 10.1016/j.jalz.2015.07.106
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- Publication type:
- Article
Modeling tauopathies in human pluripotent stem cells.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P138, doi. 10.1016/j.jalz.2015.07.057
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- Publication type:
- Article
Novel coding variants in trem2 increase risk for alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P136, doi. 10.1016/j.jalz.2014.04.078
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- Publication type:
- Article
Alzheimer's disease risk variants in phospholipase d3 alter app metabolism by gamma-dependent and gamma-independent mechanisms.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P192, doi. 10.1016/j.jalz.2014.04.225
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- Publication type:
- Article