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Cell Biological Responses after Shiga Toxin-1 Exposure to Primary Human Glomerular Microvascular Endothelial Cells from Pediatric and Adult Origin.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 11, p. 5615, doi. 10.3390/ijms22115615
By:
- Feitz, Wouter J. C.;
- van Setten, Petra A.;
- van der Velden, Thea J. A. M.;
- Licht, Christoph;
- van den Heuvel, Lambert P. J. W.;
- van de Kar, Nicole C. A. J.
Publication type:
Article
Proposal for individualized dosing of eculizumab in atypical haemolytic uraemic syndrome: patient friendly and cost-effective.
Published in:
Nephrology Dialysis Transplantation, 2023, v. 38, n. 2, p. 362, doi. 10.1093/ndt/gfac056
By:
- Avest, Mendy ter;
- Bouwmeester, Romy N;
- Duineveld, Caroline;
- Wijnsma, Kioa L;
- Volokhina, Elena B;
- Heuvel, Lambertus P W J van den;
- Burger, David M;
- Wetzels, Jack F M;
- Kar, Nicole C A J van de;
- Heine, Rob ter;
- group, CUREiHUS study
Publication type:
Article
COVID-19 vaccination and Atypical hemolytic uremic syndrome.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.1056153
By:
- Bouwmeester, Romy N.;
- Bormans, Esther M. G.;
- Duineveld, Caroline;
- van Zuilen, Arjan D.;
- van de Logt, Anne-Els;
- Wetzels, Jack F. M.;
- van de Kar, Nicole C. A. J.
Publication type:
Article
Atypical hemolytic uremic syndrome and genetic aberrations in the complement factor H-related 5 gene.
Published in:
Journal of Human Genetics, 2012, v. 57, n. 7, p. 459, doi. 10.1038/jhg.2012.57
By:
- Westra, Dineke;
- Vernon, Katherine A;
- Volokhina, Elena B;
- Pickering, Matthew C;
- van de Kar, Nicole C A J;
- van den Heuvel, Lambert P
Publication type:
Article
Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases.
Published in:
Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00612
By:
- Michels, Marloes A. H. M.;
- van de Kar, Nicole C. A. J.;
- Okrój, Marcin;
- Blom, Anna M.;
- van Kraaij, Sanne A. W.;
- Volokhina, Elena B.;
- van den Heuvel, Lambertus P. W. J.
Publication type:
Article
Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease.
Published in:
2016
By:
- van der Maten, Erika;
- Westra, Dineke;
- van Selm, Saskia;
- Langereis, Jeroen D.;
- Bootsma, Hester J.;
- van Opzeeland, Fred J. H.;
- de Groot, Ronald;
- Ruseva, Marieta M.;
- Pickering, Matthew C.;
- van den Heuvel, Lambert P. W. J.;
- van de Kar, Nicole C. A. J.;
- de Jonge, Marien I.;
- van der Flier, Michiel
Publication type:
journal article
Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy.
Published in:
Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01350
By:
- Michels, Marloes A. H. M.;
- van de Kar, Nicole C. A. J.;
- van den Bos, Ramon M.;
- van der Velden, Thea J. A. M.;
- van Kraaij, Sanne A. W.;
- Sarlea, Sebastian A.;
- Gracchi, Valentina;
- Oosterveld, Michiel J. S.;
- Volokhina, Elena B.;
- van den Heuvel, Lambertus P. W. J.
Publication type:
Article
Dose optimalization of subcutaneous ravulizumab is predicted to yield significant savings and to improve patient friendliness.
Published in:
British Journal of Clinical Pharmacology, 2023, v. 89, n. 3, p. 1211, doi. 10.1111/bcp.15602
By:
- ter Avest, Mendy;
- Langemeijer, Saskia M. C.;
- Blijlevens, Nicole M. A.;
- van de Kar, Nicole C. A. J.;
- ter Heine, Rob
Publication type:
Article
Long-term follow-up including extensive complement analysis of a pediatric C3 glomerulopathy cohort.
Published in:
Pediatric Nephrology, 2022, v. 37, n. 3, p. 601, doi. 10.1007/s00467-021-05221-6
By:
- Michels, Marloes A. H. M.;
- Wijnsma, Kioa L.;
- Kurvers, Roel A. J.;
- Westra, Dineke;
- Schreuder, Michiel F.;
- van Wijk, Joanna A. E.;
- Bouts, Antonia H. M.;
- Gracchi, Valentina;
- Engels, Flore A. P. T.;
- Keijzer-Veen, Mandy G.;
- Dorresteijn, Eiske M.;
- Volokhina, Elena B.;
- van den Heuvel, Lambertus P. W. J.;
- van de Kar, Nicole C. A. J.
Publication type:
Article
Validity of the Patient Experiences and Satisfaction with Medications (PESaM) Questionnaire.
Published in:
Patient, 2019, v. 12, n. 1, p. 149, doi. 10.1007/s40271-018-0340-6
By:
- Kimman, Merel L.;
- Wijsenbeek, Marlies S.;
- van Kuijk, Sander M. J.;
- Wijnsma, Kioa L.;
- van de Kar, Nicole C. A. J.;
- Storm, Marjolein;
- van Jaarsveld, Xana;
- Dirksen, Carmen D.;
- PESaM Collaborating Group
Publication type:
Article
The genetics of atypical hemolytic uremic syndrome.
Published in:
Medizinische Genetik, 2018, v. 30, n. 4, p. 400, doi. 10.1007/s11825-018-0216-0
By:
- Feitz, Wouter J. C.;
- van de Kar, Nicole C. A. J.;
- Orth-Höller, Dorothea;
- van den Heuvel, Lambert P. J. W.;
- Licht, Christoph
Publication type:
Article
The Shiga Toxin Receptor Globotriaosylceramide as Therapeutic Target in Shiga Toxin E. coli Mediated HUS.
Published in:
Microorganisms, 2021, v. 9, n. 10, p. 2157, doi. 10.3390/microorganisms9102157
By:
- Feitz, Wouter J. C.;
- Bouwmeester, Romy;
- van der Velden, Thea J. A. M.;
- Goorden, Susan;
- Licht, Christoph;
- van den Heuvel, Lambert P. J. W.;
- van de Kar, Nicole C. A. J.
Publication type:
Article
Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE.
Published in:
Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1279612
By:
- Gerogianni, Alexandra;
- Baas, Laura M.;
- Sjöström, Dick J.;
- van de Kar, Nicole C. A. J.;
- Pullen, Marit;
- van de Peppel, Siem J.;
- Nilsson, Per H.;
- van den Heuvel, Lambertus P.
Publication type:
Article
Modeling complement activation on human glomerular microvascular endothelial cells.
Published in:
Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1206409
By:
- Stevens, Kes H.;
- Baas, Laura M.;
- van der Velden, Thea J. A. M.;
- Bouwmeester, Romy N.;
- van Dillen, Niels;
- Dorresteijn, Eiske M.;
- van Zuilen, Arjan D.;
- Wetzels, Jack F. M.;
- Michels, Marloes A. H. M.;
- van de Kar, Nicole C. A. J.;
- van den Heuvel, Lambertus P.
Publication type:
Article
Advances and challenges in the management of complement-mediated thrombotic microangiopathies.
Published in:
Therapeutic Advances in Hematology, 2015, v. 6, n. 4, p. 171, doi. 10.1177/2040620715577613
By:
- Davin, Jean-Claude;
- van de Kar, Nicole C. A. J.
Publication type:
Article
Refractory thrombotic thrombocytopenic purpura in a 16-year-old girl: successful treatment with bortezomib.
Published in:
European Journal of Haematology, 2014, v. 92, n. 1, p. 80, doi. 10.1111/ejh.12206
By:
- Balen, Tessa;
- Schreuder, Michiel F.;
- Jong, Huib;
- Kar, Nicole C. A. J.
Publication type:
Article
Different Aspects of Classical Pathway Overactivation in Patients With C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis.
Published in:
Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.715704
By:
- Michels, Marloes A. H. M.;
- van de Kar, Nicole C. A. J.;
- van Kraaij, Sanne A. W.;
- Sarlea, Sebastian A.;
- Gracchi, Valentina;
- Engels, Flore A. P. T.;
- Dorresteijn, Eiske M.;
- van der Deure, Johannes;
- Duineveld, Caroline;
- Wetzels, Jack F. M.;
- van den Heuvel, Lambertus P. W. J.;
- Volokhina, Elena B.
Publication type:
Article
Case Report: Variable Pharmacokinetic Profile of Eculizumab in an aHUS Patient.
Published in:
Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.612706
By:
- Bouwmeester, Romy N.;
- Ter Avest, Mendy;
- Wijnsma, Kioa L.;
- Duineveld, Caroline;
- ter Heine, Rob;
- Volokhina, Elena B.;
- Van Den Heuvel, Lambertus P. W. J.;
- Wetzels, Jack F. M.;
- van de Kar, Nicole C. A. J.
Publication type:
Article
Heme as Possible Contributing Factor in the Evolvement of Shiga-Toxin Escherichia coli Induced Hemolytic-Uremic Syndrome.
Published in:
Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.547406
By:
- Wijnsma, Kioa L.;
- Veissi, Susan T.;
- de Wijs, Sem;
- van der Velden, Thea;
- Volokhina, Elena B.;
- Wagener, Frank A. D. T. G.;
- van de Kar, Nicole. C. A. J.;
- van den Heuvel, L. P.
Publication type:
Article
Outcome of atypical haemolytic uraemic syndrome relapse after eculizumab withdrawal.
Published in:
Clinical Kidney Journal, 2021, v. 14, n. 8, p. 1939, doi. 10.1093/ckj/sfaa241
By:
- Duineveld, Caroline;
- Bouwmeester, Romy;
- Heijden, Joost W van der;
- Berger, Stefan P;
- Kar, Nicole C A J van de;
- Wetzels, Jack F M;
- Group, the Dutch aHUS Working
Publication type:
Article
Primary Human Derived Blood Outgrowth Endothelial Cells: An Appropriate In Vitro Model to Study Shiga Toxin Mediated Damage of Endothelial Cells.
Published in:
Toxins, 2020, v. 12, n. 8, p. 483, doi. 10.3390/toxins12080483
By:
- Feitz, Wouter J. C.;
- van de Kar, Nicole C. A. J.;
- Cheong, Ian;
- van der Velden, Thea J. A. M.;
- Ortiz-Sandoval, Carolina G.;
- Orth-Höller, Dorothea;
- van den Heuvel, Lambert P. J. W.;
- Licht, Christoph
Publication type:
Article
Shiga Toxin Selectively Upregulates Expression of Syndecan-4 and Adhesion Molecule ICAM-1 in Human Glomerular Microvascular Endothelium.
Published in:
Toxins, 2020, v. 12, n. 7, p. 435, doi. 10.3390/toxins12070435
By:
- Volokhina, Elena B.;
- Feitz, Wouter J. C.;
- Elders, Lonneke M.;
- van der Velden, Thea J. A. M.;
- van de Kar, Nicole C. A. J.;
- van den Heuvel, Lambertus P. W. J.
Publication type:
Article
Treatment-resistant nephrotic syndrome in dense deposit disease: complement-mediated glomerular capillary wall injury?
Published in:
Pediatric Nephrology, 2020, v. 35, n. 9, p. 1791, doi. 10.1007/s00467-020-04600-9
By:
- Duineveld, Caroline;
- Steenbergen, Eric J.;
- Bomback, Andrew S.;
- van de Kar, Nicole C. A. J.;
- Wetzels, Jack F. M.
Publication type:
Article
Eculizumab in atypical hemolytic uremic syndrome: strategies toward restrictive use.
Published in:
Pediatric Nephrology, 2019, v. 34, n. 11, p. 2261, doi. 10.1007/s00467-018-4091-3
By:
- Wijnsma, Kioa L.;
- Duineveld, Caroline;
- Wetzels, Jack F. M.;
- van de Kar, Nicole C. A. J.
Publication type:
Article
The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy?
Published in:
Pediatric Nephrology, 2019, v. 34, n. 8, p. 1349, doi. 10.1007/s00467-018-4042-z
By:
- Michels, Marloes A. H. M.;
- Volokhina, Elena B.;
- van de Kar, Nicole C. A. J.;
- van den Heuvel, Lambertus P. W. J.
Publication type:
Article
Correction to: Eculizumab in atypical hemolytic uremic syndrome: strategies toward restrictive use.
Published in:
Pediatric Nephrology, 2019, v. 34, n. 4, p. 741, doi. 10.1007/s00467-018-4186-x
By:
- Wijnsma, Kioa L.;
- Duineveld, Caroline;
- Wetzels, Jack F. M.;
- van de Kar, Nicole C. A. J.
Publication type:
Article
Glyco-iELISA: a highly sensitive and unambiguous serological method to diagnose STEC-HUS caused by serotype O157.
Published in:
Pediatric Nephrology, 2019, v. 34, n. 4, p. 631, doi. 10.1007/s00467-018-4118-9
By:
- Wijnsma, Kioa L.;
- Veissi, Susan T.;
- van Bommel, Sheila A. M.;
- Heuver, Rik;
- Volokhina, Elena B.;
- Comerci, Diego J.;
- Ugalde, Juan E.;
- van de Kar, Nicole C. A. J.;
- van den Heuvel, Lambertus P. W. J.
Publication type:
Article
Clinical and genetic analyses of a Dutch cohort of 40 patients with a nephronophthisis-related ciliopathy.
Published in:
Pediatric Nephrology, 2018, v. 33, n. 10, p. 1701, doi. 10.1007/s00467-018-3958-7
By:
- Stokman, Marijn F.;
- van der Zwaag, Bert;
- van de Kar, Nicole C. A. J.;
- van Haelst, Mieke M.;
- van Eerde, Albertien M.;
- van der Heijden, Joost W.;
- Kroes, Hester Y.;
- Ippel, Elly;
- Schulp, Annelien J. A.;
- van Gassen, Koen L.;
- van Rooij, Iris A. L. M.;
- Giles, Rachel H.;
- Beales, Philip L.;
- Roepman, Ronald;
- Arts, Heleen H.;
- Bongers, Ernie M. H. F.;
- Renkema, Kirsten Y.;
- Knoers, Nine V. A. M.;
- van Reeuwijk, Jeroen;
- Lilien, Marc R.
Publication type:
Article
Effect of rare coding variants in the CFI gene on Factor I expression levels.
Published in:
Human Molecular Genetics, 2020, v. 29, n. 14, p. 2313, doi. 10.1093/hmg/ddaa114
By:
- Jong, Sarah de;
- Volokhina, Elena B;
- Breuk, Anita de;
- Nilsson, Sara C;
- Jong, Eiko K de;
- Kar, Nicole C A J van der;
- Bakker, Bjorn;
- Hoyng, Carel B;
- Heuvel, Lambert P van den;
- Blom, Anna M;
- Hollander, Anneke I den
Publication type:
Article
Shiga Toxin 2a Induces NETosis via NOX-Dependent Pathway.
Published in:
Biomedicines, 2021, v. 9, n. 12, p. 1807, doi. 10.3390/biomedicines9121807
By:
- Feitz, Wouter J. C.;
- Suntharalingham, Samuel;
- Khan, Meraj;
- Ortiz-Sandoval, Carolina G.;
- Palaniyar, Nades;
- van den Heuvel, Lambert P.;
- van de Kar, Nicole C. A. J.;
- Licht, Christoph
Publication type:
Article
Author's Reply to Liu et al.: "Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab".
Published in:
2020
By:
- Wijnsma, Kioa Lente;
- ter Heine, Rob;
- Wetzels, Jack F. M.;
- van de Kar, Nicole C. A. J.;
- Brüggemann, Roger J.
Publication type:
Letter
Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab.
Published in:
2019
By:
- Wijnsma, Kioa Lente;
- ter Heine, Rob;
- Moes, Dirk Jan A. R.;
- Langemeijer, Saskia;
- Schols, Saskia E. M.;
- Volokhina, Elena. B.;
- van den Heuvel, Lambertus P.;
- Wetzels, Jack F. M.;
- van de Kar, Nicole C. A. J.;
- Brüggemann, Roger J.
Publication type:
journal article
Safety and effectiveness of restrictive eculizumab treatment in atypical haemolytic uremic syndrome.
Published in:
Nephrology Dialysis Transplantation, 2018, v. 33, n. 4, p. 635, doi. 10.1093/ndt/gfx196
By:
- Wijnsma, Kioa L.;
- Duineveld, Caroline;
- Volokhina, Elena B.;
- van den Heuvel, Lambertus P.;
- van de Kar, Nicole C. A. J.;
- Wetzels, Jack F. M.
Publication type:
Article
Drug-Drug Interactions in Treatment Using Azole Antifungal Agents.
Published in:
2016
By:
- Schreuder, Michiel F.;
- van de Kar, Nicole C. A. J.;
- Brüggemann, Roger J. M.
Publication type:
commentary
Refractory severe intestinal vasculitis due to Henoch-Schönlein Purpura: successful treatment with plasmapheresis.
Published in:
Acta Paediatrica, 2006, v. 95, n. 5, p. 622, doi. 10.1080/08035250500509180
By:
- Wortmann, Saskia B.;
- Fiselier, Theo J. W.;
- Van De Kar, Nicole C. A. J.;
- Aarts, Ruud A. H. M.;
- Warris, Adilia;
- Draaisma, Jos M. Th.
Publication type:
Article
Mutations in Genes Encoding Subunits of the RNA Exosome as a Potential Novel Cause of Thrombotic Microangiopathy.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 14, p. 7604, doi. 10.3390/ijms25147604
By:
- Wijnsma, Kioa L.;
- Schijvens, Anne M.;
- Bouwmeester, Romy N.;
- Aarts, Lonneke A. M.;
- van den Heuvel, Lambertus P.;
- Haaxma, Charlotte A.;
- van de Kar, Nicole C. A. J.
Publication type:
Article
Preparing for a kidney transplant: Medical nephrectomy in children with nephrotic syndrome.
Published in:
Pediatric Transplantation, 2020, v. 24, n. 4, p. 1, doi. 10.1111/petr.13703
By:
- Vos, Eefke;
- Koster‐Kamphuis, Linda;
- Kar, Nicole C. A. J.;
- Bootsma‐Robroeks, Charlotte M. H. H. T.;
- Cornelissen, Elisabeth A. M.;
- Schreuder, Michiel F.
Publication type:
Article
Effects of TNFα on verocytotoxin cytotoxicity in purified human glomerular microvascular endothelial cells.
Published in:
Kidney International, 1997, v. 51, n. 4, p. 1245, doi. 10.1038/ki.1997.170
By:
- van Setten, Petra A.;
- van Hinsbergh, Victor W. M.;
- van der Velden, Thea J. A. N.;
- van de Kar, Nicole C. A. J.;
- Vermeer, Mario;
- Mahan, John D.;
- Assmann, Karel J. M.;
- van den Heugel, Lambertus P. W. J.;
- Monnens, Leo A. H.
Publication type:
Article

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