Works by Kar, Nicole C A J van de

Results: 38

Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01350

By:

Michels, Marloes A. H. M.;
van de Kar, Nicole C. A. J.;
van den Bos, Ramon M.;
van der Velden, Thea J. A. M.;
van Kraaij, Sanne A. W.;
Sarlea, Sebastian A.;
Gracchi, Valentina;
Oosterveld, Michiel J. S.;
Volokhina, Elena B.;
van den Heuvel, Lambertus P. W. J.

Publication type:

Article

Outcome of atypical haemolytic uraemic syndrome relapse after eculizumab withdrawal.

Published in:

Clinical Kidney Journal, 2021, v. 14, n. 8, p. 1939, doi. 10.1093/ckj/sfaa241

By:

Duineveld, Caroline;
Bouwmeester, Romy;
Heijden, Joost W van der;
Berger, Stefan P;
Kar, Nicole C A J van de;
Wetzels, Jack F M;
Group, the Dutch aHUS Working

Publication type:

Article

The genetics of atypical hemolytic uremic syndrome.

Published in:

Medizinische Genetik, 2018, v. 30, n. 4, p. 400, doi. 10.1007/s11825-018-0216-0

By:

Feitz, Wouter J. C.;
van de Kar, Nicole C. A. J.;
Orth-Höller, Dorothea;
van den Heuvel, Lambert P. J. W.;
Licht, Christoph

Publication type:

Article

Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1279612

By:

Gerogianni, Alexandra;
Baas, Laura M.;
Sjöström, Dick J.;
van de Kar, Nicole C. A. J.;
Pullen, Marit;
van de Peppel, Siem J.;
Nilsson, Per H.;
van den Heuvel, Lambertus P.

Publication type:

Article

Modeling complement activation on human glomerular microvascular endothelial cells.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1206409

By:

Stevens, Kes H.;
Baas, Laura M.;
van der Velden, Thea J. A. M.;
Bouwmeester, Romy N.;
van Dillen, Niels;
Dorresteijn, Eiske M.;
van Zuilen, Arjan D.;
Wetzels, Jack F. M.;
Michels, Marloes A. H. M.;
van de Kar, Nicole C. A. J.;
van den Heuvel, Lambertus P.

Publication type:

Article

Primary Human Derived Blood Outgrowth Endothelial Cells: An Appropriate In Vitro Model to Study Shiga Toxin Mediated Damage of Endothelial Cells.

Published in:

Toxins, 2020, v. 12, n. 8, p. 483, doi. 10.3390/toxins12080483

By:

Feitz, Wouter J. C.;
van de Kar, Nicole C. A. J.;
Cheong, Ian;
van der Velden, Thea J. A. M.;
Ortiz-Sandoval, Carolina G.;
Orth-Höller, Dorothea;
van den Heuvel, Lambert P. J. W.;
Licht, Christoph

Publication type:

Article

Shiga Toxin Selectively Upregulates Expression of Syndecan-4 and Adhesion Molecule ICAM-1 in Human Glomerular Microvascular Endothelium.

Published in:

Toxins, 2020, v. 12, n. 7, p. 435, doi. 10.3390/toxins12070435

By:

Volokhina, Elena B.;
Feitz, Wouter J. C.;
Elders, Lonneke M.;
van der Velden, Thea J. A. M.;
van de Kar, Nicole C. A. J.;
van den Heuvel, Lambertus P. W. J.

Publication type:

Article

Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases.

Published in:

Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00612

By:

Michels, Marloes A. H. M.;
van de Kar, Nicole C. A. J.;
Okrój, Marcin;
Blom, Anna M.;
van Kraaij, Sanne A. W.;
Volokhina, Elena B.;
van den Heuvel, Lambertus P. W. J.

Publication type:

Article

Atypical hemolytic uremic syndrome and genetic aberrations in the complement factor H-related 5 gene.

Published in:

Journal of Human Genetics, 2012, v. 57, n. 7, p. 459, doi. 10.1038/jhg.2012.57

By:

Westra, Dineke;
Vernon, Katherine A;
Volokhina, Elena B;
Pickering, Matthew C;
van de Kar, Nicole C A J;
van den Heuvel, Lambert P

Publication type:

Article

Drug-Drug Interactions in Treatment Using Azole Antifungal Agents.

Published in:

2016

By:

Schreuder, Michiel F.;
van de Kar, Nicole C. A. J.;
Brüggemann, Roger J. M.

Publication type:

commentary

Shiga Toxin 2a Induces NETosis via NOX-Dependent Pathway.

Published in:

Biomedicines, 2021, v. 9, n. 12, p. 1807, doi. 10.3390/biomedicines9121807

By:

Feitz, Wouter J. C.;
Suntharalingham, Samuel;
Khan, Meraj;
Ortiz-Sandoval, Carolina G.;
Palaniyar, Nades;
van den Heuvel, Lambert P.;
van de Kar, Nicole C. A. J.;
Licht, Christoph

Publication type:

Article

Validity of the Patient Experiences and Satisfaction with Medications (PESaM) Questionnaire.

Published in:

Patient, 2019, v. 12, n. 1, p. 149, doi. 10.1007/s40271-018-0340-6

By:

Kimman, Merel L.;
Wijsenbeek, Marlies S.;
van Kuijk, Sander M. J.;
Wijnsma, Kioa L.;
van de Kar, Nicole C. A. J.;
Storm, Marjolein;
van Jaarsveld, Xana;
Dirksen, Carmen D.;
PESaM Collaborating Group

Publication type:

Article

Safety and effectiveness of restrictive eculizumab treatment in atypical haemolytic uremic syndrome.

Published in:

Nephrology Dialysis Transplantation, 2018, v. 33, n. 4, p. 635, doi. 10.1093/ndt/gfx196

By:

Wijnsma, Kioa L.;
Duineveld, Caroline;
Volokhina, Elena B.;
van den Heuvel, Lambertus P.;
van de Kar, Nicole C. A. J.;
Wetzels, Jack F. M.

Publication type:

Article

The Shiga Toxin Receptor Globotriaosylceramide as Therapeutic Target in Shiga Toxin E. coli Mediated HUS.

Published in:

Microorganisms, 2021, v. 9, n. 10, p. 2157, doi. 10.3390/microorganisms9102157

By:

Feitz, Wouter J. C.;
Bouwmeester, Romy;
van der Velden, Thea J. A. M.;
Goorden, Susan;
Licht, Christoph;
van den Heuvel, Lambert P. J. W.;
van de Kar, Nicole C. A. J.

Publication type:

Article

Case Report: Variable Pharmacokinetic Profile of Eculizumab in an aHUS Patient.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.612706

By:

Bouwmeester, Romy N.;
Ter Avest, Mendy;
Wijnsma, Kioa L.;
Duineveld, Caroline;
ter Heine, Rob;
Volokhina, Elena B.;
Van Den Heuvel, Lambertus P. W. J.;
Wetzels, Jack F. M.;
van de Kar, Nicole C. A. J.

Publication type:

Article

Heme as Possible Contributing Factor in the Evolvement of Shiga-Toxin Escherichia coli Induced Hemolytic-Uremic Syndrome.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.547406

By:

Wijnsma, Kioa L.;
Veissi, Susan T.;
de Wijs, Sem;
van der Velden, Thea;
Volokhina, Elena B.;
Wagener, Frank A. D. T. G.;
van de Kar, Nicole. C. A. J.;
van den Heuvel, L. P.

Publication type:

Article

Model-informed repurposing of eliglustat for treatment and prophylaxis of Shiga toxin-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) in children.

Published in:

Pediatric Nephrology, 2025, v. 40, n. 6, p. 2009, doi. 10.1007/s00467-025-06688-3

By:

Wolthuis, David F. G. J.;
Freriksen, Jolien J. M.;
ter Avest, Mendy;
Kartha, Reena V.;
de Wildt, Saskia N.;
Wijnsma, Kioa;
van de Kar, Nicole C. A. J.;
ter Heine, Rob

Publication type:

Article

Long-term follow-up including extensive complement analysis of a pediatric C3 glomerulopathy cohort.

Published in:

Pediatric Nephrology, 2022, v. 37, n. 3, p. 601, doi. 10.1007/s00467-021-05221-6

By:

Michels, Marloes A. H. M.;
Wijnsma, Kioa L.;
Kurvers, Roel A. J.;
Westra, Dineke;
Schreuder, Michiel F.;
van Wijk, Joanna A. E.;
Bouts, Antonia H. M.;
Gracchi, Valentina;
Engels, Flore A. P. T.;
Keijzer-Veen, Mandy G.;
Dorresteijn, Eiske M.;
Volokhina, Elena B.;
van den Heuvel, Lambertus P. W. J.;
van de Kar, Nicole C. A. J.

Publication type:

Article

Treatment-resistant nephrotic syndrome in dense deposit disease: complement-mediated glomerular capillary wall injury?

Published in:

Pediatric Nephrology, 2020, v. 35, n. 9, p. 1791, doi. 10.1007/s00467-020-04600-9

By:

Duineveld, Caroline;
Steenbergen, Eric J.;
Bomback, Andrew S.;
van de Kar, Nicole C. A. J.;
Wetzels, Jack F. M.

Publication type:

Article

Eculizumab in atypical hemolytic uremic syndrome: strategies toward restrictive use.

Published in:

Pediatric Nephrology, 2019, v. 34, n. 11, p. 2261, doi. 10.1007/s00467-018-4091-3

By:

Wijnsma, Kioa L.;
Duineveld, Caroline;
Wetzels, Jack F. M.;
van de Kar, Nicole C. A. J.

Publication type:

Article

The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy?

Published in:

Pediatric Nephrology, 2019, v. 34, n. 8, p. 1349, doi. 10.1007/s00467-018-4042-z

By:

Michels, Marloes A. H. M.;
Volokhina, Elena B.;
van de Kar, Nicole C. A. J.;
van den Heuvel, Lambertus P. W. J.

Publication type:

Article

Correction to: Eculizumab in atypical hemolytic uremic syndrome: strategies toward restrictive use.

Published in:

Pediatric Nephrology, 2019, v. 34, n. 4, p. 741, doi. 10.1007/s00467-018-4186-x

By:

Wijnsma, Kioa L.;
Duineveld, Caroline;
Wetzels, Jack F. M.;
van de Kar, Nicole C. A. J.

Publication type:

Article

Glyco-iELISA: a highly sensitive and unambiguous serological method to diagnose STEC-HUS caused by serotype O157.

Published in:

Pediatric Nephrology, 2019, v. 34, n. 4, p. 631, doi. 10.1007/s00467-018-4118-9

By:

Wijnsma, Kioa L.;
Veissi, Susan T.;
van Bommel, Sheila A. M.;
Heuver, Rik;
Volokhina, Elena B.;
Comerci, Diego J.;
Ugalde, Juan E.;
van de Kar, Nicole C. A. J.;
van den Heuvel, Lambertus P. W. J.

Publication type:

Article

Clinical and genetic analyses of a Dutch cohort of 40 patients with a nephronophthisis-related ciliopathy.

Published in:

Pediatric Nephrology, 2018, v. 33, n. 10, p. 1701, doi. 10.1007/s00467-018-3958-7

By:

Stokman, Marijn F.;
van der Zwaag, Bert;
van de Kar, Nicole C. A. J.;
van Haelst, Mieke M.;
van Eerde, Albertien M.;
van der Heijden, Joost W.;
Kroes, Hester Y.;
Ippel, Elly;
Schulp, Annelien J. A.;
van Gassen, Koen L.;
van Rooij, Iris A. L. M.;
Giles, Rachel H.;
Beales, Philip L.;
Roepman, Ronald;
Arts, Heleen H.;
Bongers, Ernie M. H. F.;
Renkema, Kirsten Y.;
Knoers, Nine V. A. M.;
van Reeuwijk, Jeroen;
Lilien, Marc R.

Publication type:

Article

Advances and challenges in the management of complement-mediated thrombotic microangiopathies.

Published in:

Therapeutic Advances in Hematology, 2015, v. 6, n. 4, p. 171, doi. 10.1177/2040620715577613

By:

Davin, Jean-Claude;
van de Kar, Nicole C. A. J.

Publication type:

Article

Dose optimalization of subcutaneous ravulizumab is predicted to yield significant savings and to improve patient friendliness.

Published in:

British Journal of Clinical Pharmacology, 2023, v. 89, n. 3, p. 1211, doi. 10.1111/bcp.15602

By:

ter Avest, Mendy;
Langemeijer, Saskia M. C.;
Blijlevens, Nicole M. A.;
van de Kar, Nicole C. A. J.;
ter Heine, Rob

Publication type:

Article

Effects of TNFα on verocytotoxin cytotoxicity in purified human glomerular microvascular endothelial cells.

Published in:

Kidney International, 1997, v. 51, n. 4, p. 1245, doi. 10.1038/ki.1997.170

By:

van Setten, Petra A.;
van Hinsbergh, Victor W. M.;
van der Velden, Thea J. A. N.;
van de Kar, Nicole C. A. J.;
Vermeer, Mario;
Mahan, John D.;
Assmann, Karel J. M.;
van den Heugel, Lambertus P. W. J.;
Monnens, Leo A. H.

Publication type:

Article

Refractory severe intestinal vasculitis due to Henoch-Schönlein Purpura: successful treatment with plasmapheresis.

Published in:

Acta Paediatrica, 2006, v. 95, n. 5, p. 622, doi. 10.1080/08035250500509180

By:

Wortmann, Saskia B.;
Fiselier, Theo J. W.;
Van De Kar, Nicole C. A. J.;
Aarts, Ruud A. H. M.;
Warris, Adilia;
Draaisma, Jos M. Th.

Publication type:

Article

Mutations in Genes Encoding Subunits of the RNA Exosome as a Potential Novel Cause of Thrombotic Microangiopathy.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 14, p. 7604, doi. 10.3390/ijms25147604

By:

Wijnsma, Kioa L.;
Schijvens, Anne M.;
Bouwmeester, Romy N.;
Aarts, Lonneke A. M.;
van den Heuvel, Lambertus P.;
Haaxma, Charlotte A.;
van de Kar, Nicole C. A. J.

Publication type:

Article

Cell Biological Responses after Shiga Toxin-1 Exposure to Primary Human Glomerular Microvascular Endothelial Cells from Pediatric and Adult Origin.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 11, p. 5615, doi. 10.3390/ijms22115615

By:

Feitz, Wouter J. C.;
van Setten, Petra A.;
van der Velden, Thea J. A. M.;
Licht, Christoph;
van den Heuvel, Lambert P. J. W.;
van de Kar, Nicole C. A. J.

Publication type:

Article

COVID-19 vaccination and Atypical hemolytic uremic syndrome.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.1056153

By:

Bouwmeester, Romy N.;
Bormans, Esther M. G.;
Duineveld, Caroline;
van Zuilen, Arjan D.;
van de Logt, Anne-Els;
Wetzels, Jack F. M.;
van de Kar, Nicole C. A. J.

Publication type:

Article

Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease.

Published in:

2016

By:

van der Maten, Erika;
Westra, Dineke;
van Selm, Saskia;
Langereis, Jeroen D.;
Bootsma, Hester J.;
van Opzeeland, Fred J. H.;
de Groot, Ronald;
Ruseva, Marieta M.;
Pickering, Matthew C.;
van den Heuvel, Lambert P. W. J.;
van de Kar, Nicole C. A. J.;
de Jonge, Marien I.;
van der Flier, Michiel

Publication type:

journal article

Prospective validation of initial eculizumab dosing in adults with atypical hemolytic uremic syndrome.

Published in:

Nephrology Dialysis Transplantation, 2025, v. 40, p. 598, doi. 10.1093/ndt/gfae244

By:

Avest, Mendy ter;
Duineveld, Caroline;
Bouwmeester, Romy N;
Baas, Laura M;
Heuvel, Lambertus P W J van den;
Langemeijer, Saskia M C;
Wetzels, Jack F M;
Kar, Nicole C A J van de;
Heine, Rob ter;
group, for the CUREiHUS study

Publication type:

Article

Prospective validation of initial eculizumab dosing in adults with atypical hemolytic uremic syndrome.

Published in:

Nephrology Dialysis Transplantation, 2025, v. 40, n. 3, p. 598, doi. 10.1093/ndt/gfae244

By:

Avest, Mendy ter;
Duineveld, Caroline;
Bouwmeester, Romy N;
Baas, Laura M;
Heuvel, Lambertus P W J van den;
Langemeijer, Saskia M C;
Wetzels, Jack F M;
Kar, Nicole C A J van de;
Heine, Rob ter;
group, for the CUREiHUS study

Publication type:

Article

Proposal for individualized dosing of eculizumab in atypical haemolytic uraemic syndrome: patient friendly and cost-effective.

Published in:

Nephrology Dialysis Transplantation, 2023, v. 38, n. 2, p. 362, doi. 10.1093/ndt/gfac056

By:

Avest, Mendy ter;
Bouwmeester, Romy N;
Duineveld, Caroline;
Wijnsma, Kioa L;
Volokhina, Elena B;
Heuvel, Lambertus P W J van den;
Burger, David M;
Wetzels, Jack F M;
Kar, Nicole C A J van de;
Heine, Rob ter;
group, CUREiHUS study

Publication type:

Article

Different Aspects of Classical Pathway Overactivation in Patients With C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis.

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.715704

By:

Michels, Marloes A. H. M.;
van de Kar, Nicole C. A. J.;
van Kraaij, Sanne A. W.;
Sarlea, Sebastian A.;
Gracchi, Valentina;
Engels, Flore A. P. T.;
Dorresteijn, Eiske M.;
van der Deure, Johannes;
Duineveld, Caroline;
Wetzels, Jack F. M.;
van den Heuvel, Lambertus P. W. J.;
Volokhina, Elena B.

Publication type:

Article

Author's Reply to Liu et al.: "Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab".

Published in:

2020

By:

Wijnsma, Kioa Lente;
ter Heine, Rob;
Wetzels, Jack F. M.;
van de Kar, Nicole C. A. J.;
Brüggemann, Roger J.

Publication type:

Letter

Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab.

Published in:

2019

By:

Wijnsma, Kioa Lente;
ter Heine, Rob;
Moes, Dirk Jan A. R.;
Langemeijer, Saskia;
Schols, Saskia E. M.;
Volokhina, Elena. B.;
van den Heuvel, Lambertus P.;
Wetzels, Jack F. M.;
van de Kar, Nicole C. A. J.;
Brüggemann, Roger J.

Publication type:

journal article