Works matching AU Kao, Aimee W.

Results: 17

Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2025, v. 21, n. 6, p. 1, doi. 10.1002/alz.70320

By:

Lane‐Donovan, Courtney;
Smith, Andrew W.;
Saloner, Rowan;
Miller, Bruce L.;
Casaletto, Kaitlin B.;
Kao, Aimee W.

Publication type:

Article

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-58585-w

By:

Acosta Ingram, Diana;
Turkes, Emir;
Kim, Tae Yeon;
Vo, Sheeny;
Sweeney, Nicholas;
Bonte, Marie-Amandine;
Rutherford, Ryan;
Julian, Dominic L.;
Pan, Meixia;
Marsh, Jacob;
Argouarch, Andrea R.;
Wu, Min;
Scharre, Douglas W.;
Bell, Erica H.;
Honig, Lawrence S.;
Vonsattel, Jean Paul;
Serrano, Geidy E.;
Beach, Thomas G.;
Karch, Celeste M.;
Kao, Aimee W.

Publication type:

Article

Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics.

Published in:

Frontiers in Neuroscience, 2020, v. 11, p. N.PAG, doi. 10.3389/fnins.2020.602235

By:

Gururaj, Sushmitha;
Sampognaro, Paul J.;
Argouarch, Andrea R.;
Kao, Aimee W.

Publication type:

Article

The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 25, p. 9315, doi. 10.1523/JNEUROSCI.4808-14.2015

By:

Salazar, Dominique A.;
Butler, Victoria J.;
Argouarch, Andrea R.;
Tsung-Yuan Hsu;
Mason, Amanda;
Ayumi Nakamura;
McCurdy, Helen;
Cox, David;
Ng, Rachel;
Pan, Gloria;
Seeley, William W.;
Miller, Bruce L.;
Kao, Aimee W.

Publication type:

Article

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.

Published in:

PLoS Genetics, 2019, v. 15, n. 8, p. 1, doi. 10.1371/journal.pgen.1008295

By:

Butler, Victoria J.;
Gao, Fuying;
Corrales, Christian I.;
Cortopassi, Wilian A.;
Caballero, Benjamin;
Vohra, Mihir;
Ashrafi, Kaveh;
Cuervo, Ana Maria;
Jacobson, Matthew P.;
Coppola, Giovanni;
Kao, Aimee W.

Publication type:

Article

Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia.

Published in:

JAMA Neurology, 2020, v. 77, n. 3, p. 358, doi. 10.1001/jamaneurol.2019.4284

By:

Liu, Andy J.;
Staffaroni, Adam M.;
Rojas-Martinez, Julio C.;
Olney, Nicholas T.;
Alquezar-Burillo, Carolina;
Ljubenkov, Peter A.;
La Joie, Renaud;
Fong, Jamie C.;
Taylor, Joanne;
Karydas, Anna;
Ramos, Eliana Marisa;
Coppola, Giovanni;
Boxer, Adam L.;
Rabinovici, Gil D.;
Miller, Bruce L.;
Kao, Aimee W.

Publication type:

Article

A Shift to Organismal Stress Resistance in Programmed Cell Death Mutants.

Published in:

PLoS Genetics, 2013, v. 9, n. 9, p. 1, doi. 10.1371/journal.pgen.1003714

By:

Judy, Meredith E.;
Nakamura, Ayumi;
Huang, Anne;
Grant, Harli;
McCurdy, Helen;
Weiberth, Kurt F.;
Gao, Fuying;
Coppola, Giovanni;
Kenyon, Cynthia;
Kao, Aimee W.

Publication type:

Article

The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness.

Published in:

Human Molecular Genetics, 2024, v. 33, n. 3, p. 245, doi. 10.1093/hmg/ddad184

By:

Wang, Austin L;
Mambou, Edwina A;
Kao, Aimee W

Publication type:

Article

Tuberous sclerosis complex is associated with a novel human tauopathy.

Published in:

Acta Neuropathologica, 2023, v. 145, n. 1, p. 1, doi. 10.1007/s00401-022-02521-5

By:

Hwang, Ji-Hye L.;
Perloff, Olga S.;
Gaus, Stephanie E.;
Benitez, Camila;
Alquezar, Carolina;
Cosme, Celica Q.;
Nana, Alissa L.;
Vatsavayai, Sarat C.;
Ramos, Eliana M.;
Geschwind, Daniel H.;
Miller, Bruce L.;
Kao, Aimee W.;
Seeley, William W.

Publication type:

Article

Clinicopathological correlations in behavioural variant frontotemporal dementia.

Published in:

2017

By:

Perry, David C.;
Brown, Jesse A.;
Possin, Katherine L.;
Datta, Samir;
Trujillo, Andrew;
Radke, Anneliese;
Karydas, Anna;
Kornak, John;
Sias, Ana C.;
Rabinovici, Gil D.;
Gorno-Tempini, Maria Luisa;
Boxer, Adam L.;
De May, Mary;
Rankin, Katherine P.;
Sturm, Virginia E.;
Lee, Suzee E.;
Matthews, Brandy R.;
Kao, Aimee W.;
Vossel, Keith A.;
Tartaglia, Maria Carmela

Publication type:

journal article

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation.

Published in:

Frontiers in Neurology, 2021, v. 11, p. N.PAG, doi. 10.3389/fneur.2020.595532

By:

Alquezar, Carolina;
Arya, Shruti;
Kao, Aimee W.

Publication type:

Article

Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Published in:

2023

By:

Sampognaro, Paul J.;
Arya, Shruti;
Knudsen, Giselle M.;
Gunderson, Emma L.;
Sandoval-Perez, Angelica;
Hodul, Molly;
Bowles, Kathryn;
Craik, Charles S.;
Jacobson, Matthew P.;
Kao, Aimee W.

Publication type:

Correction Notice

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Published in:

Molecular Neurodegeneration, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13024-023-00621-8

By:

Sampognaro, Paul J.;
Arya, Shruti;
Knudsen, Giselle M.;
Gunderson, Emma L.;
Sandoval-Perez, Angelica;
Hodul, Molly;
Bowles, Katherine;
Craik, Charles S.;
Jacobson, Matthew P.;
Kao, Aimee W.

Publication type:

Article

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.

Published in:

Molecular Neurodegeneration, 2021, v. 16, n. 1, p. 1, doi. 10.1186/s13024-021-00472-1

By:

Mohan, Swetha;
Sampognaro, Paul J.;
Argouarch, Andrea R.;
Maynard, Jason C.;
Welch, Mackenzie;
Patwardhan, Anand;
Courtney, Emma C.;
Zhang, Jiasheng;
Mason, Amanda;
Li, Kathy H.;
Huang, Eric J.;
Seeley, William W.;
Miller, Bruce L.;
Burlingame, Alma;
Jacobson, Mathew P.;
Kao, Aimee W.

Publication type:

Article

Protons in small spaces: Discrete simulations of vesicle acidification.

Published in:

PLoS Computational Biology, 2019, v. 15, n. 12, p. N.PAG, doi. 10.1371/journal.pcbi.1007539

By:

Singh, Apeksha;
Marcoline, Frank V.;
Veshaguri, Salome;
Kao, Aimee W.;
Bruchez, Marcel;
Mindell, Joseph A.;
Stamou, Dimitrios;
Grabe, Michael

Publication type:

Article

Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.

Published in:

Human Molecular Genetics, 2019, v. 28, n. 9, p. 1498, doi. 10.1093/hmg/ddy442

By:

Butler, Victoria J;
Salazar, Dominique A;
Soriano-Castell, David;
Alves-Ferreira, Miguel;
Dennissen, Frank J A;
Vohra, Mihir;
Oses-Prieto, Juan A;
Li, Kathy H;
Wang, Austin L;
Jing, Beibei;
Li, Biao;
Groisman, Alex;
Gutierrez, Edgar;
Mooney, Sean;
Burlingame, Alma L;
Ashrafi, Kaveh;
Mandelkow, Eva-Maria;
Encalada, Sandra E;
Kao, Aimee W

Publication type:

Article

Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 22, p. 3951, doi. 10.1093/hmg/ddy297

By:

Yuan, Shauna H;
Hiramatsu, Nobuhiko;
Liu, Qing;
Sun, Xuehan Victoria;
Lenh, David;
Chan, Priscilla;
Chiang, Karen;
Koo, Edward H;
Kao, Aimee W;
Litvan, Irene

Publication type:

Article