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Sex dimorphism and tissue specificity of gene expression changes in aging mice.
Published in:
Biology of Sex Differences, 2024, v. 15, n. 1, p. 1, doi. 10.1186/s13293-024-00666-4
By:
- Zhu, Dantong;
- Arnold, Matt;
- Samuelson, Brady A.;
- Wu, Judy Z.;
- Mueller, Amber;
- Sinclair, David A.;
- Kane, Alice E.
Publication type:
Article
Animal Models Relevant for Geroscience: Current Trends and Future Perspectives in Biomarkers, and Measures of Biological Aging.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2024, v. 79, n. 9, p. 1, doi. 10.1093/gerona/glae135
By:
- Bartolomucci, Alessandro;
- Kane, Alice E;
- Gaydosh, Lauren;
- Razzoli, Maria;
- McCoy, Brianah M;
- Ehninger, Dan;
- Chen, Brian H;
- Howlett, Susan E;
- Snyder-Mackler, Noah
Publication type:
Article
Is Sex as a Biological Variable Still Being Ignored in Preclinical Aging Research?
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2022, v. 77, n. 11, p. 2177, doi. 10.1093/gerona/glac042
By:
- Carmody, Colleen;
- Duesing, Charlotte G;
- Kane, Alice E;
- Mitchell, Sarah J
Publication type:
Article
Applying the AFRAID and FRIGHT Clocks to Novel Preclinical Mouse Models of Polypharmacy.
Published in:
2022
By:
- Mach, John;
- Kane, Alice E;
- Howlett, Susan E;
- Sinclair, David A;
- Hilmer, Sarah N
Publication type:
journal article
Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged Mice.
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2021, v. 76, n. 6, p. 1010, doi. 10.1093/gerona/glaa060
By:
- Mach, John;
- Gemikonakli, Gizem;
- Logan, Caitlin;
- Wyk, Brent Vander;
- Allore, Heather;
- Ekambareshwar, Swathi;
- Kane, Alice E;
- Howlett, Susan E;
- Cabo, Rafael de;
- Couteur, David G Le;
- Hilmer, Sarah N
Publication type:
Article
Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged Mice.
Published in:
2021
By:
- Mach, John;
- Gemikonakli, Gizem;
- Logan, Caitlin;
- Wyk, Brent Vander;
- Allore, Heather;
- Ekambareshwar, Swathi;
- Kane, Alice E;
- Howlett, Susan E;
- Cabo, Rafael de;
- Couteur, David G Le;
- Hilmer, Sarah N;
- Vander Wyk, Brent;
- de Cabo, Rafael;
- Le Couteur, David G
Publication type:
journal article
Maladaptive Changes Associated With Cardiac Aging Are Sex-Specific and Graded by Frailty and Inflammation in C57BL/6 Mice.
Published in:
2021
By:
- Kane, Alice E;
- Bisset, Elise S;
- Heinze-Milne, Stefan;
- Keller, Kaitlyn M;
- Grandy, Scott A;
- Howlett, Susan E
Publication type:
journal article
A Murine Frailty Index Based on Clinical and Laboratory Measurements: Links Between Frailty and Pro-inflammatory Cytokines Differ in a Sex-Specific Manner.
Published in:
2019
By:
- Kane, Alice E;
- Keller, Kaitlyn M;
- Heinze-Milne, Stefan;
- Grandy, Scott A;
- Howlett, Susan E
Publication type:
journal article
Advances in Preclinical Models of Frailty.
Published in:
2017
By:
- Kane, Alice E.;
- Howlett, Susan E.
Publication type:
journal article
A Comparison of Two Mouse Frailty Assessment Tools.
Published in:
2017
By:
- Kane, Alice E.;
- Huizer-Pajkos, Aniko;
- Mach, John;
- Mitchell, Sarah J.;
- de Cabo, Rafael;
- Le Couteur, David G.;
- Howlett, Susan E.;
- Hilmer, Sarah N.
Publication type:
journal article
Development of a Rat Clinical Frailty Index.
Published in:
2017
By:
- Yorke, Amy;
- Kane, Alice E.;
- Hancock Friesen, Camille L.;
- Howlett, Susan E.;
- O'Blenes, Stacy
Publication type:
journal article
Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging.
Published in:
2016
By:
- Huizer-Pajkos, Aniko;
- Kane, Alice E.;
- Howlett, Susan E.;
- Mach, John;
- Mitchell, Sarah J.;
- de Cabo, Rafael;
- Le Couteur, David G.;
- Hilmer, Sarah N.
Publication type:
journal article
Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index.
Published in:
2016
By:
- Kane, Alice E.;
- Hilmer, Sarah N.;
- Boyer, Dawn;
- Gavin, Kristan;
- Nines, Dawn;
- Howlett, Susan E.;
- de Cabo, Rafael;
- Mitchell, Sarah J.
Publication type:
journal article
Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index.
Published in:
2015
By:
- Kane, Alice E;
- Hilmer, Sarah N;
- Huizer-Pajkos, Aniko;
- Mach, John;
- Nines, Dawn;
- Boyer, Dawn;
- Gavin, Kristan;
- Mitchell, Sarah J;
- de Cabo, Rafael
Publication type:
commentary
Novel cardioprotection strategies for the aged heart: evidence from pre-clinical studies.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2016, v. 43, n. 12, p. 1251, doi. 10.1111/1440-1681.12668
By:
- Kane, Alice E;
- Howlett, Susan E
Publication type:
Article
Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol.
Published in:
Current Gerontology & Geratrics Research, 2011, p. 1, doi. 10.1155/2011/624156
By:
- Mitchell, Sarah J.;
- Kane, Alice E.;
- Hilmer, Sarah N.
Publication type:
Article
Novel feature selection methods for construction of accurate epigenetic clocks.
Published in:
PLoS Computational Biology, 2022, v. 18, n. 8, p. 1, doi. 10.1371/journal.pcbi.1009938
By:
- Li, Adam;
- Mueller, Amber;
- English, Brad;
- Arena, Anthony;
- Vera, Daniel;
- Kane, Alice E.;
- Sinclair, David A.
Publication type:
Article
Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer's Disease.
Published in:
Frontiers in Aging Neuroscience, 2018, p. 1, doi. 10.3389/fnagi.2018.00172
By:
- Kane, Alice E.;
- Sooyoun Shin;
- Wong, Aimee A.;
- Fertan, Emre;
- Faustova, Natalia S.;
- Howlett, Susan E.;
- Brown, Richard E.
Publication type:
Article
Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments.
Published in:
Cellular & Molecular Life Sciences, 2023, v. 80, n. 1, p. 1, doi. 10.1007/s00018-022-04666-8
By:
- Alaghband, Yasaman;
- Klein, Peter M.;
- Kramár, Eniko A.;
- Cranston, Michael N.;
- Perry, Bayley C.;
- Shelerud, Lukas M.;
- Kane, Alice E.;
- Doan, Ngoc-Lien;
- Ru, Ning;
- Acharya, Munjal M.;
- Wood, Marcelo A.;
- Sinclair, David A.;
- Dickstein, Dara L.;
- Soltesz, Ivan;
- Limoli, Charles L.;
- Baulch, Janet E.
Publication type:
Article
Measurements of damage and repair of binary health attributes in aging mice and humans reveal that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by interventions.
Published in:
eLife, 2022, p. 1, doi. 10.7554/eLife.77632
By:
- Farrell, Spencer;
- Kane, Alice E.;
- Bisset, Elise;
- Howlett, Susan E.;
- Rutenberg, Andrew D.
Publication type:
Article
Age, Sex and Overall Health, Measured As Frailty, Modify Myofilament Proteins in Hearts From Naturally Aging Mice.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-66903-z
By:
- Kane, Alice E.;
- Bisset, Elise S.;
- Keller, Kaitlyn M.;
- Ghimire, Anjali;
- Pyle, W. Glen;
- Howlett, Susan E.
Publication type:
Article
Implementation of the mouse frailty index.
Published in:
Canadian Journal of Physiology & Pharmacology, 2017, v. 95, n. 10, p. 1149, doi. 10.1139/cjpp-2017-0025
By:
- Kane, Alice E.;
- Ayaz, Omar;
- Ghimire, Anjali;
- Feridooni, Hirad A.;
- Howlett, Susan E.
Publication type:
Article
Animal models of frailty: current applications in clinical research.
Published in:
Clinical Interventions in Aging, 2016, v. 11, p. 1519, doi. 10.2147/CIA.S105714
By:
- Kane, Alice E.;
- Howlett, Susan E.;
- Hilmer, Sarah N.;
- Mach, John;
- Mitchell, Sarah J.;
- de Cabo, Rafael
Publication type:
Article
Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty.
Published in:
2020
By:
- Schultz, Michael B.;
- Kane, Alice E.;
- Mitchell, Sarah J.;
- MacArthur, Michael R.;
- Warner, Elisa;
- Vogel, David S.;
- Mitchell, James R.;
- Howlett, Susan E.;
- Bonkowski, Michael S.;
- Sinclair, David A.
Publication type:
Correction Notice
Age and life expectancy clocks based on machine learning analysis of mouse frailty.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18446-0
By:
- Schultz, Michael B.;
- Kane, Alice E.;
- Mitchell, Sarah J.;
- MacArthur, Michael R.;
- Warner, Elisa;
- Vogel, David S.;
- Mitchell, James R.;
- Howlett, Susan E.;
- Bonkowski, Michael S.;
- Sinclair, David A.
Publication type:
Article
Age and life expectancy clocks based on machine learning analysis of mouse frailty.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18446-0
By:
- Schultz, Michael B.;
- Kane, Alice E.;
- Mitchell, Sarah J.;
- MacArthur, Michael R.;
- Warner, Elisa;
- Vogel, David S.;
- Mitchell, James R.;
- Howlett, Susan E.;
- Bonkowski, Michael S.;
- Sinclair, David A.
Publication type:
Article
Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice.
Published in:
Nutrients, 2021, v. 13, n. 9, p. 3290, doi. 10.3390/nu13093290
By:
- Ke, Shanlin;
- Mitchell, Sarah J.;
- MacArthur, Michael R.;
- Kane, Alice E.;
- Sinclair, David A.;
- Venable, Emily M.;
- Chadaideh, Katia S.;
- Carmody, Rachel N.;
- Grodstein, Francine;
- Mitchell, James R.;
- Liu, Yangyu
Publication type:
Article

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