Works matching AU Kanai, Motomu

Results: 112

Supramolecular Ligands for Histone Tails by Employing a Multivalent Display of Trisulfonated Calix[4]arenes.

Published in:

ChemBioChem, 2015, v. 16, n. 18, p. 2599, doi. 10.1002/cbic.201500448

By:

Kimura, Yasuaki;
Saito, Nae;
Hanada, Kayo;
Liu, Jiaan;
Okabe, Takayoshi;
Kawashima, Shigehiro A.;
Yamatsugu, Kenzo;
Kanai, Motomu

Publication type:

Article

A Cyclic KLVFF-Derived Peptide Aggregation Inhibitor Induces the Formation of Less-Toxic Off-Pathway Amyloid-β Oligomers.

Published in:

ChemBioChem, 2014, v. 15, n. 17, p. 2577, doi. 10.1002/cbic.201402430

By:

Arai, Tadamasa;
Sasaki, Daisuke;
Araya, Takushi;
Sato, Takeshi;
Sohma, Youhei;
Kanai, Motomu

Publication type:

Article

Rhodium-Catalyzed Cross-Aldol Reaction: In Situ Aldehyde-Enolate Formation from Allyloxyboranes and Primary Allylic Alcohols.

Published in:

Angewandte Chemie, 2012, v. 124, n. 41, p. 10421, doi. 10.1002/ange.201205680

By:

Lin, Luqing;
Yamamoto, Kumiko;
Matsunaga, Shigeki;
Kanai, Motomu

Publication type:

Article

Catalytic Asymmetric Synthesis of Spirooxindoles by a Mannich-Type Reaction of Isothiocyanato Oxindoles.

Published in:

Angewandte Chemie, 2012, v. 124, n. 28, p. 7113, doi. 10.1002/ange.201203005

By:

Kato, Shota;
Yoshino, Tatsuhiko;
Shibasaki, Masakatsu;
Kanai, Motomu;
Matsunaga, Shigeki

Publication type:

Article

Catalytic Asymmetric Total Synthesis of Chimonanthine, Folicanthine, and Calycanthine through Double Michael Reaction of Bisoxindole.

Published in:

Angewandte Chemie, 2012, v. 124, n. 21, p. 5307, doi. 10.1002/ange.201201132

By:

Mitsunuma, Harunobu;
Shibasaki, Masakatsu;
Kanai, Motomu;
Matsunaga, Shigeki

Publication type:

Article

Asymmetric Synthesis of Dihydropyranones from Ynones by Sequential Copper(I)-Catalyzed Direct Aldol and Silver(I)-Catalyzed Oxy-Michael Reactions.

Published in:

Angewandte Chemie, 2012, v. 124, n. 16, p. 3998, doi. 10.1002/ange.201109209

By:

Shi, Shi-Liang;
Kanai, Motomu;
Shibasaki, Masakatsu

Publication type:

Article

A Facile Pathway to Enantiomerically Enriched 3-Hydroxy-2-Oxindoles: Asymmetric Intramolecular Arylation of α-Keto Amides Catalyzed by a Palladium-DifluorPhos Complex.

Published in:

Angewandte Chemie, 2011, v. 123, n. 33, p. 7762, doi. 10.1002/ange.201102158

By:

Yin, Liang;
Kanai, Motomu;
Shibasaki, Masakatsu

Publication type:

Article

Catalytic Asymmetric Total Synthesis of ent-Hyperforin.

Published in:

Angewandte Chemie, 2010, v. 122, n. 6, p. 1121, doi. 10.1002/ange.200906678

By:

Shimizu, Yohei;
Shi, Shi-Liang;
Usuda, Hiroyuki;
Kanai, Motomu;
Shibasaki, Masakatsu

Publication type:

Article

Identifying Specific Conformations by Using a Carbohydrate Scaffold: Discovery of Subtype-Selective LPA-Receptor Agonists and an Antagonist ( This project was supported by a 21st Century Center of Excellence (COE) grant. ).

Published in:

Angewandte Chemie, 2004, v. 116, n. 21, p. 2894, doi. 10.1002/ange.200454065

By:

Yoko Tamaruya;
Masato Suzuki;
Goshu Kamura;
Motomu Kanai;
Kotaro Hama;
Kumiko Shimizu;
Junken Aoki;
Hiroyuki Arai;
Masakatsu Shibasaki

Publication type:

Article

Multicenter Strategy for the Development of Catalytic Enantioselective Nucleophilic Alkylation of Ketones: Me2Zn Addition to α-Ketoesters ( Financial support was provided by RFTF of the Japan Society for the Promotion of Science (JSPS) and PRESTO of the Japan Science and Technology Corporation (JST). K.F. thanks JSPS Research Fellowships for Young Scientists. M.J. is an Alexander von Humboldt FoundationJSPS fellow. )

Published in:

Angewandte Chemie, 2003, v. 115, n. 44, p. 5647, doi. 10.1002/ange.200351650

By:

Ken Funabashi;
Markus Jachmann;
Motomu Kanai;
Masakatsu Shibasaki

Publication type:

Article

Titelbild: Multicenter Strategy for the Development of Catalytic Enantioselective Nucleophilic Alkylation of Ketones: Me2Zn Addition to α-Ketoesters (Angew. Chem. 44/2003).

Published in:

Angewandte Chemie, 2003, v. 115, n. 44, p. 5529, doi. 10.1002/ange.200390642

By:

Ken Funabashi;
Markus Jachmann;
Motomu Kanai;
Masakatsu Shibasaki

Publication type:

Article

Recent Development in Synthetic Strategies for Oseltamivir Phosphate.

Published in:

Israel Journal of Chemistry, 2011, v. 51, n. 3/4, p. 316, doi. 10.1002/ijch.201100001

By:

Shibasaki, Masakatsu;
Kanai, Motomu;
Yamatsugu, Kenzo

Publication type:

Article

Chemical catalyst manipulating cancer epigenome and transcription.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56204-2

By:

Yamanashi, Yuki;
Takamaru, Shinpei;
Okabe, Atsushi;
Kaito, Satoshi;
Azumaya, Yuto;
Kamimura, Yugo R.;
Yamatsugu, Kenzo;
Kujirai, Tomoya;
Kurumizaka, Hitoshi;
Iwama, Atsushi;
Kaneda, Atsushi;
Kawashima, Shigehiro A.;
Kanai, Motomu

Publication type:

Article

Catalytic acceptorless complete dehydrogenation of cycloalkanes.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-024-55460-y

By:

Jagtap, Rahul A.;
Nishioka, Yuki;
Geddis, Stephen M.;
Irie, Yu;
Takanashi, Tsukasa;
Adachi, Rintaro;
Yamakata, Akira;
Fuki, Masaaki;
Kobori, Yasuhiro;
Mitsunuma, Harunobu;
Kanai, Motomu

Publication type:

Article

Developmental Changes in P-Glycoprotein Function in the Blood--Brain Barrier of Nonhuman Primates: PET Study with R-11C-Verapamil and 11C-Oseltamivir.

Published in:

Journal of Nuclear Medicine, 2011, v. 52, n. 6, p. 950, doi. 10.2967/jnumed.110.083949

By:

Takashima, Tadayuki;
Yokoyama, Chihiro;
Mizuma, Hiroshi;
Yamanaka, Hajime;
Wada, Yasuhiro;
Onoe, Kayo;
Nagata, Hiroko;
Tazawa, Shusaku;
Doi, Hisashi;
Takahashi, Kazuhiro;
Morita, Masataka;
Kanai, Motomu;
Shibasaki, Masakatsu;
Kusuhara, Hiroyuki;
Sugiyama, Yuichi;
Onoe, Hirotaka;
Watanabe, Yasuyoshi

Publication type:

Article

Photo-oxygenation of histidine residue inhibits α-synuclein aggregation.

Published in:

FASEB Journal, 2023, v. 37, n. 12, p. 1, doi. 10.1096/fj.202301533R

By:

Reito Nakamura;
Ikumi Tomizawa;
Atsushi Iwai;
Tetsuo Ikeda;
Kota Hirayama;
Yung Wen Chiu;
Takanobu Suzuki;
Airi Tarutani;
Tatsuo Mano;
Atsushi Iwata;
Tatsushi Toda;
Youhei Sohma;
Motomu Kanai;
Yukiko Hori;
Taisuke Tomita

Publication type:

Article

Pathological complete remission of relapsed tumor by photo‐activating antibody–mimetic drug conjugate treatment.

Published in:

Cancer Science, 2022, v. 113, n. 12, p. 4350, doi. 10.1111/cas.15565

By:

Kaneko, Yudai;
Yamatsugu, Kenzo;
Yamashita, Takefumi;
Takahashi, Kazuki;
Tanaka, Toshiya;
Aki, Sho;
Tatsumi, Toshifumi;
Kawamura, Takeshi;
Miura, Mai;
Ishii, Masazumi;
Ohkubo, Kei;
Osawa, Tsuyoshi;
Kodama, Tatsuhiko;
Ishikawa, Shumpei;
Tsukagoshi, Masanobu;
Chansler, Michael;
Sugiyama, Akira;
Kanai, Motomu;
Katoh, Hiroto

Publication type:

Article

Siloxy Esters as Traceless Activators of Carboxylic Acids: Boron‐Catalyzed Chemoselective Asymmetric Aldol Reaction**.

Published in:

Angewandte Chemie, 2021, v. 133, n. 46, p. 24803, doi. 10.1002/ange.202109788

By:

Fujita, Taiki;
Yamane, Mina;
Sameera, W. M. C.;
Mitsunuma, Harunobu;
Kanai, Motomu

Publication type:

Article

Histidine Photooxygenation Chemistry: Mechanistic Evidence and Elucidation.

Published in:

Chemical Record, 2023, v. 23, n. 11, p. 1, doi. 10.1002/tcr.202300198

By:

Matsukawa, Ryota;
Yamane, Mina;
Kanai, Motomu

Publication type:

Article

Boron‐Catalyzed α‐Functionalizations of Carboxylic Acids.

Published in:

Chemical Record, 2023, v. 23, n. 7, p. 1, doi. 10.1002/tcr.202200273

By:

Shimizu, Yohei;
Kanai, Motomu

Publication type:

Article

Catalytic migratory oxidative coupling of nitrones through an outer-sphere C( sp3)-H activation process.

Published in:

Chemical Record, 2011, v. 11, n. 5, p. 236, doi. 10.1002/tcr.201100024

By:

Hashizume, Shogo;
Oisaki, Kounosuke;
Kanai, Motomu

Publication type:

Article

Linear‐Selective Allylation of Aldehydes with Simple Alkenes Mediated by Quadruple Hybrid Catalysis.

Published in:

Advanced Synthesis & Catalysis, 2022, v. 364, n. 19, p. 3378, doi. 10.1002/adsc.202200704

By:

Irie, Yu;
Chen, Hongyu;
Fuse, Hiromu;
Mitsunuma, Harunobu;
Kanai, Motomu

Publication type:

Article

Identification of Bond‐Weakening Spirosilane Catalyst for Photoredox α‐C−H Alkylation of Alcohols.

Published in:

Advanced Synthesis & Catalysis, 2020, v. 362, n. 2, p. 337, doi. 10.1002/adsc.201901253

By:

Sakai, Kentaro;
Oisaki, Kounosuke;
Kanai, Motomu

Publication type:

Article

A Cationic High-Valent Cp*CoIII Complex for the Catalytic Generation of Nucleophilic Organometallic Species: Directed CH Bond Activation.

Published in:

Angewandte Chemie International Edition, 2013, v. 52, n. 8, p. 2207, doi. 10.1002/anie.201209226

By:

Yoshino, Tatsuhiko;
Ikemoto, Hideya;
Matsunaga, Shigeki;
Kanai, Motomu

Publication type:

Article

Rhodium-Catalyzed Cross-Aldol Reaction: In Situ Aldehyde-Enolate Formation from Allyloxyboranes and Primary Allylic Alcohols.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 41, p. 10275, doi. 10.1002/anie.201205680

By:

Lin, Luqing;
Yamamoto, Kumiko;
Matsunaga, Shigeki;
Kanai, Motomu

Publication type:

Article

Catalytic Asymmetric Synthesis of Spirooxindoles by a Mannich-Type Reaction of Isothiocyanato Oxindoles.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 28, p. 7007, doi. 10.1002/anie.201203005

By:

Kato, Shota;
Yoshino, Tatsuhiko;
Shibasaki, Masakatsu;
Kanai, Motomu;
Matsunaga, Shigeki

Publication type:

Article

Catalytic Asymmetric Total Synthesis of Chimonanthine, Folicanthine, and Calycanthine through Double Michael Reaction of Bisoxindole.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 21, p. 5217, doi. 10.1002/anie.201201132

By:

Mitsunuma, Harunobu;
Shibasaki, Masakatsu;
Kanai, Motomu;
Matsunaga, Shigeki

Publication type:

Article

Asymmetric Synthesis of Dihydropyranones from Ynones by Sequential Copper(I)-Catalyzed Direct Aldol and Silver(I)-Catalyzed Oxy-Michael Reactions.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 16, p. 3932, doi. 10.1002/anie.201109209

By:

Shi, Shi-Liang;
Kanai, Motomu;
Shibasaki, Masakatsu

Publication type:

Article

A Facile Pathway to Enantiomerically Enriched 3-Hydroxy-2-Oxindoles: Asymmetric Intramolecular Arylation of α-Keto Amides Catalyzed by a Palladium-DifluorPhos Complex.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 33, p. 7620, doi. 10.1002/anie.201102158

By:

Yin, Liang;
Kanai, Motomu;
Shibasaki, Masakatsu

Publication type:

Article

Catalytic Asymmetric Total Synthesis of ent-Hyperforin.

Published in:

Angewandte Chemie International Edition, 2010, v. 49, n. 6, p. 1103, doi. 10.1002/anie.200906678

By:

Shimizu, Yohei;
Shi, Shi-Liang;
Usuda, Hiroyuki;
Kanai, Motomu;
Shibasaki, Masakatsu

Publication type:

Article

A Synthesis of Tamiflu by Using a Barium-Catalyzed Asymmetric Diels-Alder-Type Reaction.

Published in:

Angewandte Chemie International Edition, 2009, v. 48, n. 6, p. 1070, doi. 10.1002/anie.200804777

By:

Yamatsugu, Kenzo;
Yin, Liang;
Kamijo, Shin;
Kimura, Yasuaki;
Kanai, Motomu;
Shibasaki, Masakatsu

Publication type:

Article

Total synthesis of (+)-lysergic acid.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 240, doi. 10.1038/ja.2017.80

By:

Kanno, Rentaro;
Yokoshima, Satoshi;
Kanai, Motomu;
Fukuyama, Tohru

Publication type:

Article

Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 2, p. 203, doi. 10.1038/ja.2013.137

By:

Paudel, Atmika;
Kaneko, Keiichi;
Watanabe, Ayako;
Shigeki, Matsunaga;
Motomu, Kanai;
Hamamoto, Hiroshi;
Sekimizu, Kazuhisa

Publication type:

Article

Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents.

Published in:

Journal of Antibiotics, 2013, v. 66, n. 11, p. 663, doi. 10.1038/ja.2013.69

By:

Paudel, Atmika;
Kaneko, Keiichi;
Watanabe, Ayako;
Shigeki, Matsunaga;
Motomu, Kanai;
Hamamoto, Hiroshi;
Sekimizu, Kazuhisa

Publication type:

Article

Zirconium Alkoxides in Catalysis.

Published in:

Chemistry - A European Journal, 2001, v. 7, n. 19, p. 4066, doi. 10.1002/1521-3765(20011001)7:19<4066::AID-CHEM4066>3.0.CO;2-K

By:

Yamasaki, Shingo;
Kanai, Motomu;
Shibasaki, Masakatsu

Publication type:

Article

A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus.

Published in:

Frontiers in Microbiology, 2017, v. 8, p. 1, doi. 10.3389/fmicb.2017.00712

By:

Paudel, Atmika;
Hiroshi Hamamoto;
Panthee, Suresh;
Keiichi Kaneko;
Shigeki Matsunaga;
Motomu Kanai;
Yutaka Suzuki;
Kazuhisa Sekimizu

Publication type:

Article

Inhibition of MAO-A and stimulation of behavioural activities in mice by the inactive prodrug form of the anti-influenza agent oseltamivir.

Published in:

2013

By:

Hiasa, Miki;
Isoda, Yumiko;
Kishimoto, Yasushi;
Saitoh, Kenta;
Kimura, Yasuaki;
Kanai, Motomu;
Shibasaki, Masakatsu;
Hatakeyama, Dai;
Kirino, Yutaka;
Kuzuhara, Takashi

Publication type:

journal article

Inhibition of MAO- A and stimulation of behavioural activities in mice by the inactive prodrug form of the anti-influenza agent oseltamivir.

Published in:

British Journal of Pharmacology, 2013, v. 169, n. 1, p. 115, doi. 10.1111/bph.12102

By:

Hiasa, Miki;
Isoda, Yumiko;
Kishimoto, Yasushi;
Saitoh, Kenta;
Kimura, Yasuaki;
Kanai, Motomu;
Shibasaki, Masakatsu;
Hatakeyama, Dai;
Kirino, Yutaka;
Kuzuhara, Takashi

Publication type:

Article

Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids.

Published in:

Angewandte Chemie International Edition, 2024, v. 63, n. 31, p. 1, doi. 10.1002/anie.202405605

By:

Umeda, Hiroki;
Suda, Kayo;
Yokogawa, Daisuke;
Azumaya, Yuto;
Kitada, Nobuo;
Maki, Shojiro A.;
Kawashima, Shigehiro A.;
Mitsunuma, Harunobu;
Yamanashi, Yuki;
Kanai, Motomu

Publication type:

Article

Siloxy Esters as Traceless Activators of Carboxylic Acids: Boron‐Catalyzed Chemoselective Asymmetric Aldol Reaction**.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 46, p. 24598, doi. 10.1002/anie.202109788

By:

Fujita, Taiki;
Yamane, Mina;
Sameera, W. M. C.;
Mitsunuma, Harunobu;
Kanai, Motomu

Publication type:

Article

A Method for Constructing Nucleosome Arrays with Spatially Defined Histone PTMs and DNA Damage.

Published in:

Angewandte Chemie, 2025, v. 137, n. 24, p. 1, doi. 10.1002/ange.202500162

By:

Liu, Ziyun;
Xi, Siqi;
McGregor, Lauren A.;
Yamatsugu, Kenzo;
Kawashima, Shigehiro A.;
Sczepanski, Jonathan T.;
Kanai, Motomu

Publication type:

Article

Ion‐Pair Hydrogen Atom Transfer Catalysis Enables Cr‐Catalyzed Allylation of Ketones Using Hydrocarbon Alkenes.

Published in:

Angewandte Chemie, 2025, v. 137, n. 21, p. 1, doi. 10.1002/ange.202503249

By:

Arii, Suguru;
Yu, Zonghan;
Chen, Hongyu;
Mitsunuma, Harunobu;
Kanai, Motomu

Publication type:

Article

Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids.

Published in:

Angewandte Chemie, 2024, v. 136, n. 31, p. 1, doi. 10.1002/ange.202405605

By:

Umeda, Hiroki;
Suda, Kayo;
Yokogawa, Daisuke;
Azumaya, Yuto;
Kitada, Nobuo;
Maki, Shojiro A.;
Kawashima, Shigehiro A.;
Mitsunuma, Harunobu;
Yamanashi, Yuki;
Kanai, Motomu

Publication type:

Article

Practical N-to-C peptide synthesis with minimal protecting groups.

Published in:

Communications Chemistry, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42004-023-01030-0

By:

Tatsumi, Toshifumi;
Sasamoto, Koki;
Matsumoto, Takuya;
Hirano, Ryo;
Oikawa, Kazuki;
Nakano, Masato;
Yoshida, Masaru;
Oisaki, Kounosuke;
Kanai, Motomu

Publication type:

Article

Molecular mechanism of lysophosphatidic acid-induced hypertensive response.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-39041-4

By:

Kano, Kuniyuki;
Matsumoto, Hirotaka;
Inoue, Asuka;
Yukiura, Hiroshi;
Kanai, Motomu;
Chun, Jerold;
Ishii, Satoshi;
Shimizu, Takao;
Aoki, Junken

Publication type:

Article

Structure-based design of a streptavidin mutant specific for an artificial biotin analogue.

Published in:

Journal of Biochemistry, 2015, v. 157, n. 6, p. 467, doi. 10.1093/jb/mvv004

By:

Tatsuya Kawato;
Eiichi Mizohata;
Yohei Shimizu;
Tomohiro Meshizuka;
Tomohiro Yamamoto;
Noriaki Takasu;
Masahiro Matsuoka;
Hiroyoshi Matsumura;
Tatsuhiko Kodama;
Motomu Kanai;
Hirofumi Doi;
Tsuyoshi Inoue;
Akira Sugiyama

Publication type:

Article

Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood.

Published in:

Journal of Biochemistry, 2009, v. 146, n. 2, p. 283, doi. 10.1093/jb/mvp068

By:

Endo, Tomoko;
Kano, Kuniyuki;
Motoki, Rie;
Hama, Kotaro;
Okudaira, Shinichi;
Ishida, Mayuko;
Ogiso, Hideo;
Tanaka, Masayuki;
Matsuki, Norio;
Taguchi, Ryo;
Kanai, Motomu;
Shibasaki, Masakatsu;
Arai, Hiroyuki;
Aoki, Junken

Publication type:

Article

Cupid and Psyche system for the diagnosis and treatment of advanced cancer.

Published in:

Proceedings of the Japan Academy, Series B Physical & biological sciences, 2019, v. 95, n. 10, p. 602, doi. 10.2183/pjab.95.041

By:

Akira SUGIYAMA;
Takeshi KAWAMURA;
Toshiya TANAKA;
Hirofumi DOI;
Takefumi YAMASHITA;
Keiko SHINODA;
Hideaki FUJITANI;
Kenzo YAMATSUGU;
Yohei SHIMIZU;
Toshifumi TATSUMI;
Kazuki TAKAHASHI;
Motomu KANAI;
Eiichi MIZOHATA;
Tatsuya KAWATO;
Takefumi DOI;
Tsuyoshi INOUE;
Tatsuhiko KODAMA

Publication type:

Article

Structure-based design and synthesis of a bivalent iminobiotin analog showing strong affinity toward a low immunogenic streptavidin mutant.

Published in:

Bioscience, Biotechnology & Biochemistry, 2015, v. 79, n. 4, p. 640, doi. 10.1080/09168451.2014.991692

By:

Tatsuya Kawato;
Eiichi Mizohata;
Yohei Shimizu;
Tomohiro Meshizuka;
Tomohiro Yamamoto;
Noriaki Takasu;
Masahiro Matsuoka;
Hiroyoshi Matsumura;
Tatsuhiko Kodama;
Motomu Kanai;
Hirofumi Doi;
Tsuyoshi Inoue;
Akira Sugiyama

Publication type:

Article

Cover Feature: C(sp3)−H Cyanation Promoted by Visible‐Light Photoredox/Phosphate Hybrid Catalysis (Chem. Eur. J. 32/2018).

Published in:

2018

By:

Wakaki, Takayuki;
Sakai, Kentaro;
Enomoto, Takafumi;
Kondo, Mio;
Masaoka, Shigeyuki;
Oisaki, Kounosuke;
Kanai, Motomu

Publication type:

Cover Art