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Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23.
Published in:
2015
By:
- Smeets, Cleo J. L. M.;
- Jezierska, Justyna;
- Hiroyuki Watanabe;
- Duarri, Anna;
- Fokkens, Michiel R.;
- Meijer, Michel;
- Qin Zhou;
- Yakovleva, Tania;
- Boddeke, Erik;
- den Dunnen, Wilfred;
- van Deursen, Jan;
- Bakalkin, Georgy;
- Kampinga, Harm H.;
- van de Sluis, Bart;
- Verbeek, Dineke S.
Publication type:
journal article
Heat-shock protein expression in cisplatin-sensitive and -resistant human tumor cells.
Published in:
International Journal of Cancer, 1996, v. 67, n. 6, p. 800, doi. 10.1002/(SICI)1097-0215(19960917)67:6<800::AID-IJC8>3.0.CO;2-V
By:
- Hettinga, Judith V. E.;
- Lemstra, Willy;
- Meijer, Coby;
- Los, Gerrit;
- de Vries, Elisabeth G. E.;
- Konings, Antonius W. T.;
- Kampinga, Harm H.
Publication type:
Article
Sensitization to cisplatin action by step-down heating in cddp-sensitive and -resistant cells.
Published in:
International Journal of Cancer, 1995, v. 61, n. 5, p. 722, doi. 10.1002/ijc.2910610521
By:
- Hettinga, Judith V. E.;
- Lemstra, Willy;
- De Vries, Elisabeth G. E.;
- Konings, Antonius W. T.;
- Kampinga, Harm H.
Publication type:
Article
Keratinocyte Growth Factor Prevents Radiation Damage to Salivary Glands by Expansion of the Stem/Progenitor Pool.
Published in:
Stem Cells, 2008, v. 26, n. 10, p. 2595, doi. 10.1634/stemcells.2007-1034
By:
- Lombaert, Isabelle M. A.;
- Brunsting, Jeanette F.;
- Wierenga, Pieter K.;
- Kampinga, Harm H.;
- de Haan, Gerald;
- Coppes, Robert P.
Publication type:
Article
The HSP70 chaperone machinery: J proteins as drivers of functional specificity.
Published in:
2010
By:
- Kampinga, Harm H.;
- Craig, Elizabeth A.
Publication type:
Correction Notice
The HSP70 chaperone machinery: J proteins as drivers of functional specificity.
Published in:
Nature Reviews Molecular Cell Biology, 2010, v. 11, n. 8, p. 579, doi. 10.1038/nrm2941
By:
- Kampinga, Harm H.;
- Craig, Elizabeth A.
Publication type:
Article
Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G.
Published in:
Scientific Reports, 2016, p. 34830, doi. 10.1038/srep34830
By:
- Kakkar, Vaishali;
- Kuiper, E. F. Elsiena;
- Pandey, Abhinav;
- Braakman, Ineke;
- Kampinga, Harm H.
Publication type:
Article
RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response.
Published in:
PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0133553
By:
- Meijering, Roelien A. M.;
- Wiersma, Marit;
- van Marion, Denise M. S.;
- Zhang, Deli;
- Hoogstra-Berends, Femke;
- Dijkhuis, Anne-Jan;
- Schmidt, Martina;
- Wieland, Thomas;
- Kampinga, Harm H.;
- Henning, Robert H.;
- Brundel, Bianca J. J. M.
Publication type:
Article
Rescue of αB Crystallin (HSPB5) Mutants Associated Protein Aggregation by Co-Expression of HSPB5 Partners.
Published in:
PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0126761
By:
- Hussein, Rasha M.;
- Benjamin, Ivor J.;
- Kampinga, Harm H.
Publication type:
Article
The Copper Metabolism MURR1 Domain Protein 1 (COMMD1) Modulates the Aggregation of Misfolded Protein Species in a Client-Specific Manner.
Published in:
PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0092408
By:
- Vonk, Willianne I. M.;
- Kakkar, Vaishali;
- Bartuzi, Paulina;
- Jaarsma, Dick;
- Berger, Ruud;
- Hofker, Marten H.;
- Klomp, Leo W. J.;
- Wijmenga, Cisca;
- Kampinga, Harm H.;
- van de Sluis, Bart
Publication type:
Article
ΔNp73 Enhances Promoter Activity of TGF-β Induced Genes.
Published in:
PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0050815
By:
- Niemantsverdriet, Maarten;
- Nagle, Peter;
- Chiu, Roland K.;
- Langendijk, Johannes A.;
- Kampinga, Harm H.;
- Coppes, Robert P.
Publication type:
Article
HSPB1, HSPB6, HSPB7 and HSPB8 Protect against RhoA GTPase-Induced Remodeling in Tachypaced Atrial Myocytes.
Published in:
PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0020395
By:
- Lei Ke;
- Meijering, Roelien A. M.;
- Hoogstra-Berend, Femke;
- Mackovicova, Katarina;
- Vos, Michel J.;
- Van Gelder, Isabelle C.;
- Henning, Robert H.;
- Kampinga, Harm H.;
- Brundel, Bianca J. J. M.
Publication type:
Article
BAG3 Directly Interacts with Mutated alphaB-Crystallin to Suppress Its Aggregation and Toxicity.
Published in:
PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0016828
By:
- Hishiya, Akinori;
- Salman, Mortada Najem;
- Carra, Serena;
- Kampinga, Harm H.;
- Takayama, Shinichi
Publication type:
Article
Rescue of Salivary Gland Function after Stem Cell Transplantation in Irradiated Glands.
Published in:
PLoS ONE, 2008, v. 3, n. 4, p. 1, doi. 10.1371/journal.pone.0002063
By:
- Lombaert, Isabelle M. A.;
- Brunsting, Jeanette F.;
- Wierenga, Pieter K.;
- Faber, Hette;
- Stokman, Monique A.;
- Kok, Tineke;
- Visser, Willy H.;
- Kampinga, Harm H.;
- de Haan, Gerald;
- Coppes, Robert P.
Publication type:
Article
Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome.
Published in:
eLife, 2022, p. 1, doi. 10.7554/eLife.70726
By:
- Huiting, Wouter;
- Dekker, Suzanne L.;
- van der Lienden, Joris C. J.;
- Mergener, Rafaella;
- Musskopf, Maiara K.;
- Furtado, Gabriel V.;
- Gerrits, Emma;
- Coit, David;
- Oghbaie, Mehrnoosh;
- Di Stefano, Luciano H.;
- Schepers, Hein;
- van Waarde-Verhagen, Maria A. W. H.;
- Couzijn, Suzanne;
- Barazzuol, Lara;
- LaCava, John;
- Kampinga, Harm H.;
- Bergink, Steven
Publication type:
Article
Dysfunctional BRCA1 is only indirectly linked to multiple centrosomes.
Published in:
Oncogene, 2005, v. 24, n. 51, p. 7619, doi. 10.1038/sj.onc.1208859
By:
- Hut, Henderika M. J.;
- Rembacz, Krzysztof P.;
- van Waarde, Maria A. W. H.;
- Lemstra, Willy;
- van Cappellen, Wiggert A.;
- Kampinga, Harm H.;
- Sibon, Ody C. M.
Publication type:
Article
Heat shock proteins as molecular targets for intervention in atrial fibrillation.
Published in:
Cardiovascular Research, 2008, v. 78, n. 3, p. 422, doi. 10.1093/cvr/cvn060
By:
- Brundel, Bianca J. J. M.;
- Lei Ke;
- Dijkhuis, Anne-Jan;
- Xiao Yan Qi;
- Shiroshita-Takeshita, Akiko;
- Nattel, Stanley;
- Henning, Robert H.;
- Kampinga, Harm H.
Publication type:
Article
Calpain inhibition prevents pacing-induced cellular remodeling in a HL-1 myocyte model for atrial fibrillation
Published in:
Cardiovascular Research, 2004, v. 62, n. 3, p. 521, doi. 10.1016/j.cardiores.2004.02.007
By:
- Brundel, Bianca J.J.M.;
- Kampinga, Harm H.;
- Henning, Robert H.
Publication type:
Article
Molecular mechanisms of remodeling in human atrial fibrillation
Published in:
Cardiovascular Research, 2002, v. 54, n. 2, p. 315, doi. 10.1016/S0008-6363(02)00222-5
By:
- Brundel, Bianca J.J.M.;
- Henning, Robert H.;
- Kampinga, Harm H.;
- Van Gelder, Isabelle C.;
- Crijns, Harry J.G.M.
Publication type:
Article
Role of membrane lipid composition in the cytotoxicity of the sesquiterpene lactone eupatoriopicrin.
Published in:
Phytotherapy Research, 1993, v. 7, n. 2, p. 128, doi. 10.1002/ptr.2650070207
By:
- Van Der Linde, Joost C. C.;
- Woerdenbag, Herman J.;
- Malingré, Theo M.;
- Kampinga, Harm H.;
- Konings, Antonius W. T.
Publication type:
Article
Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch.
Published in:
Frontiers in Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fnins.2017.00145
By:
- Kuiper, E. F. E.;
- de Mattos, Eduardo P.;
- Jardim, Laura B.;
- Kampinga, Harm H.;
- Bergink, Steven
Publication type:
Article
Cytotoxicity of Artemisinin, a Dimer of Dihydroartemisinin, Artemisitene and Eupatoriopicrin as Evaluated by the MTT and Clonogenic Assay.
Published in:
Phytotherapy Research, 1996, v. 10, n. 2, p. 140, doi. 10.1002/(SICI)1099-1573(199603)10:2<140::AID-PTR792>3.0.CO;2-D
By:
- Beekman, Aäron C.;
- Woerdenbag, Herman J.;
- Kampinga, Harm H.;
- Konings, Antonius W. T.
Publication type:
Article
Heat-shock-protein-27(HSP27) expression in ovarian carcinoma: Relation in response to chemotherapy and prognosis.
Published in:
International Journal of Cancer, 1999, v. 84, n. 3, p. 234, doi. 10.1002/(SICI)1097-0215(19990621)84:3<234::AID-IJC6>3.0.CO;2-9
By:
- Arts, Henriette J.G.;
- Hollema, Harry;
- Lemstra, Willy;
- Willemse, Pax H.B.;
- De Vries, Elisabeth G.E.;
- Kampinga, Harm H.;
- Van der Zee, Ate G.J.
Publication type:
Article
CAG Repeat Size Influences the Progression Rate of Spinocerebellar Ataxia Type 3.
Published in:
Annals of Neurology, 2021, v. 89, n. 1, p. 66, doi. 10.1002/ana.25919
By:
- Leotti, Vanessa B.;
- Vries, Jeroen J.;
- Oliveira, Camila M.;
- Mattos, Eduardo P.;
- Te Meerman, Gerard J.;
- Brunt, Ewout R.;
- Kampinga, Harm H.;
- Jardim, Laura B.;
- Verbeek, Dineke S.
Publication type:
Article
Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19.
Published in:
Annals of Neurology, 2012, v. 72, n. 6, p. 870, doi. 10.1002/ana.23700
By:
- Duarri, Anna;
- Jezierska, Justyna;
- Fokkens, Michiel;
- Meijer, Michel;
- Schelhaas, Helenius J.;
- den Dunnen, Wilfred F. A.;
- van Dijk, Freerk;
- Verschuuren-Bemelmans, Corien;
- Hageman, Gerard;
- van de Vlies, Pieter;
- Küsters, Benno;
- van de Warrenburg, Bart P.;
- Kremer, Berry;
- Wijmenga, Cisca;
- Sinke, Richard J.;
- Swertz, Morris A.;
- Kampinga, Harm H.;
- Boddeke, Erik;
- Verbeek, Dineke S.
Publication type:
Article
SCA14 mutation V138E leads to partly unfolded PKCγ associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization.
Published in:
Journal of Neurochemistry, 2014, v. 128, n. 5, p. 741, doi. 10.1111/jnc.12491
By:
- Jezierska, Justyna;
- Goedhart, Joachim;
- Kampinga, Harm H.;
- Reits, Eric A.;
- Verbeek, Dineke S.
Publication type:
Article
FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation.
Published in:
Human Molecular Genetics, 2021, v. 30, n. 11, p. 996, doi. 10.1093/hmg/ddab095
By:
- Furtado, Gabriel Vasata;
- Yang, Jing;
- Wu, Di;
- Papagiannopoulos, Christos I;
- Terpstra, Hanna M;
- Kuiper, E F Elsiena;
- Krauss, Sybille;
- Zhu, Wei-Guo;
- Kampinga, Harm H;
- Bergink, Steven
Publication type:
Article
Brain death induces renal expression of heme oxygenase-1 and heat shock protein 70.
Published in:
Journal of Translational Medicine, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1479-5876-11-22
By:
- van Dullemen, Leon F. A.;
- Bos, Eelke M.;
- Schuurs, Theo A.;
- Kampinga, Harm H.;
- Ploeg, Rutger J.;
- van Goor, Harry;
- Leuvenink, Henri G. D.
Publication type:
Article
Polarised Asymmetric Inheritance of Accumulated Protein Damage in Higher Eukaryotes.
Published in:
PLoS Biology, 2006, v. 4, n. 12, p. 2325, doi. 10.1371/journal.pbio.0040417
By:
- Rujano, María A.;
- Bosveld, Floris;
- Salomons, Florian A.;
- Dijk, Freark;
- van Waarde, Maria A. W. H.;
- van der Want, Johannes J. L.;
- de Vos, Rob A. I.;
- Brunt, Ewout R.;
- Sibon, Ody C. M.;
- Kampinga, Harm H.
Publication type:
Article
Overexpression of Cystathionine γ-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3.
Published in:
Molecular Medicine, 2015, v. 21, n. 1, p. 758, doi. 10.2119/molmed.2015.00221
By:
- Snijder, Pauline M.;
- Baratashvili, Madina;
- Grzeschik, Nicola A.;
- Leuvenink, Henri G. D.;
- Kuijpers, Lucas;
- Huitema, Sippie;
- Schaap, Onno;
- Giepmans, Ben N. G.;
- Kuipers, Jeroen;
- Miljkovic, Jan Lj;
- Mitrovic, Aleksandra;
- Bos, Eelke M.;
- Szabó, Csaba;
- Kampinga, Harm H.;
- Dijkers, Pascale F.;
- den Dunnen, Wilfred F. A.;
- Filipovic, Milos R.;
- van Goor, Harry;
- Sibon, Ody C. M.
Publication type:
Article
Axonal inclusions in spinocerebellar ataxia type 3.
Published in:
Acta Neuropathologica, 2010, v. 120, n. 4, p. 449, doi. 10.1007/s00401-010-0717-7
By:
- Seidel, Kay;
- den Dunnen, Wilfred F. A.;
- Schultz, Christian;
- Paulson, Henry;
- Frank, Stefanie;
- de Vos, Rob A.;
- Brunt, Ewout R.;
- Deller, Thomas;
- Kampinga, Harm H.;
- Rüb, Udo
Publication type:
Article
Molecular biology: It takes two to untangle.
Published in:
Nature, 2015, v. 524, n. 7564, p. 169, doi. 10.1038/nature14640
By:
- Kampinga, Harm H.
Publication type:
Article
Purging of acute myeloid leukaemia cells from stem cell grafts by hyperthermia: enhancement of the therapeutic index by the tetrapeptide AcSDKP and the alkyl-lysophospholipid ET-18-OCH<sub>3</sub>.
Published in:
British Journal of Haematology, 2000, v. 111, n. 4, p. 1145, doi. 10.1046/j.1365-2141.2000.02469.x
By:
- Wierenga, Pieter K.;
- Setroikromo, Rita;
- Vellenga, Edo;
- Kampinga, Harm H.
Publication type:
Article
HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 23, p. 4677, doi. 10.1093/hmg/ddq398
By:
- Vos, Michel J.;
- Zijlstra, Marianne P.;
- Kanon, Bart;
- van Waarde-Verhagen, Maria A.W.H.;
- Brunt, Ewout R.P.;
- Oosterveld-Hut, Hendrika M.J.;
- Carra, Serena;
- Sibon, Ody C.M.;
- Kampinga, Harm H.
Publication type:
Article
De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system.
Published in:
Human Molecular Genetics, 2008, v. 17, n. 13, p. 2058, doi. 10.1093/hmg/ddn105
By:
- Bosveld, Floris;
- Rana, Anil;
- van der Wouden, Petra E.;
- Lemstra, Willy;
- Ritsema, Martha;
- Kampinga, Harm H.;
- Sibon, Ody C. M.
Publication type:
Article
Specific protein homeostatic functions of small heat-shock proteins increase lifespan.
Published in:
Aging Cell, 2016, v. 15, n. 2, p. 217, doi. 10.1111/acel.12422
By:
- Vos, Michel J.;
- Carra, Serena;
- Kanon, Bart;
- Bosveld, Floris;
- Klauke, Karin;
- Sibon, Ody C. M.;
- Kampinga, Harm H.
Publication type:
Article

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