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Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy.
Published in:
Nature Medicine, 2013, v. 19, n. 8, p. 1039, doi. 10.1038/nm.3213
By:
- Woldt, Estelle;
- Sebti, Yasmine;
- Solt, Laura A;
- Duhem, Christian;
- Lancel, Steve;
- Eeckhoute, Jérôme;
- Hesselink, Matthijs K C;
- Paquet, Charlotte;
- Delhaye, Stéphane;
- Shin, Youseung;
- Kamenecka, Theodore M;
- Schaart, Gert;
- Lefebvre, Philippe;
- Nevière, Rémi;
- Burris, Thomas P;
- Schrauwen, Patrick;
- Staels, Bart;
- Duez, Hélène
Publication type:
Article
Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.
Published in:
PLoS Biology, 2018, v. 16, n. 6, p. 1, doi. 10.1371/journal.pbio.2004663
By:
- Zhao, Jing;
- Zhang, Lei;
- Mu, Xiaodong;
- Doebelin, Christelle;
- Nguyen, William;
- Wallace, Callen;
- Reay, Daniel P.;
- McGowan, Sara J.;
- Corbo, Lana;
- Clemens, Paula R.;
- Wilson, Gabriela Mustata;
- Watkins, Simon C.;
- Solt, Laura A.;
- Cameron, Michael D.;
- Huard, Johnny;
- Niedernhofer, Laura J.;
- Kamenecka, Theodore M.;
- Robbins, Paul D.
Publication type:
Article
LXR-Mediated Inhibition of CD4+ T Helper Cells.
Published in:
PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0046615
By:
- Solt, Laura A.;
- Kamenecka, Theodore M.;
- Burris, Thomas P.;
- Cooney, Austin John
Publication type:
Article
A structural mechanism for directing corepressor-selective inverse agonism of PPARγ.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07133-w
By:
- Brust, Richard;
- Shang, Jinsai;
- Fuhrmann, Jakob;
- Mosure, Sarah A.;
- Bass, Jared;
- Cano, Andrew;
- Heidari, Zahra;
- Chrisman, Ian M.;
- Nemetchek, Michelle D.;
- Blayo, Anne-Laure;
- Griffin, Patrick R.;
- Kamenecka, Theodore M.;
- Hughes, Travis S.;
- Kojetin, Douglas J.
Publication type:
Article
Studies in the Total Synthesis of Himastatin: A Revision of the Stereochemical Assignment.
Published in:
Angewandte Chemie International Edition, 1998, v. 37, n. 21, p. 2993, doi. 10.1002/(SICI)1521-3773(19981116)37:21<2993::AID-ANIE2993>3.0.CO;2-I
By:
- Kamenecka, Theodore M.;
- Danishefsky, Samuel J.
Publication type:
Article
Total Synthesis of Himastatin: Confirmation of the Revised Stereostructure.
Published in:
Angewandte Chemie International Edition, 1998, v. 37, n. 21, p. 2995, doi. 10.1002/(SICI)1521-3773(19981116)37:21<2995::AID-ANIE2995>3.0.CO;2-6
By:
- Kamenecka, Theodore M.;
- Danishefsky, Samuel J.
Publication type:
Article
Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation.
Published in:
Nature, 2011, v. 477, n. 7365, p. 477, doi. 10.1038/nature10383
By:
- Jang Hyun Choi;
- Banks, Alexander S.;
- Kamenecka, Theodore M.;
- Busby, Scott A.;
- Chalmers, Michael J.;
- Kumar, Naresh;
- Kuruvilla, Dana S.;
- Youseung Shin;
- Yuanjun He;
- Bruning, John B.;
- Marciano, David P.;
- Cameron, Michael D.;
- Laznik, Dina;
- Jurczak, Michael J.;
- Schürer, Stephan C.;
- Vidović, Dušica;
- Shulman, Gerald I.;
- Spiegelman, Bruce M.;
- Griffin, Patrick R.
Publication type:
Article
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
Published in:
Nature, 2011, v. 472, n. 7344, p. 491, doi. 10.1038/nature10075
By:
- Solt, Laura A.;
- Kumar, Naresh;
- Nuhant, Philippe;
- Yongjun Wang;
- Lauer, Janelle L.;
- Jin Liu;
- Istrate, Monica A.;
- Kamenecka, Theodore M.;
- Roush, William R.;
- Vidović, Dušica;
- Schürer, Stephan C.;
- Jihong Xu;
- Wagoner, Gail;
- Drew, Paul D.;
- Griffin, Patrick R.;
- Burris, Thomas P.
Publication type:
Article
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5.
Published in:
Nature, 2010, v. 466, n. 7305, p. 451, doi. 10.1038/nature09291
By:
- Jang Hyun Choi;
- Banks, Alexander S.;
- Estall, Jennifer L.;
- Kajimura, Shingo;
- Boström, Pontus;
- Laznik, Dina;
- Ruas, Jorge L.;
- Chalmers, Michael J.;
- Kamenecka, Theodore M.;
- Blüher, Matthias;
- Griffin, Patrick R.;
- Spiegelman, Bruce M.
Publication type:
Article
RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis.
Published in:
FASEB Journal, 2017, v. 31, n. 10, p. 4492, doi. 10.1096/fj.201700172R
By:
- Ye Sun;
- Chi-Hsiu Liu;
- Zhongxiao Wang;
- Meng, Steven S.;
- Burnim, Samuel B.;
- SanGiovanni, John Paul;
- Kamenecka, Theodore M.;
- Solt, Laura A.;
- Jing Chen
Publication type:
Article
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.
Published in:
2016
By:
- Qingzhang Zhu;
- Ghoshal, Sarbani;
- Rodrigues, Ana;
- Su Gao;
- Asterian, Alice;
- Kamenecka, Theodore M.;
- Barrow, James C.;
- Chakraborty, Anutosh;
- Zhu, Qingzhang;
- Gao, Su
Publication type:
journal article
Site‐Selective γ‐C(sp3)−H and γ‐C(sp2)−H Arylation of Free Amino Esters Promoted by a Catalytic Transient Directing Group.
Published in:
Chemistry - A European Journal, 2018, v. 24, n. 38, p. 9535, doi. 10.1002/chem.201802465
By:
- Lin, Hua;
- Wang, Chao;
- Bannister, Thomas D.;
- Kamenecka, Theodore M.
Publication type:
Article
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.
Published in:
Nature Communications, 2015, v. 6, n. 8, p. 8013, doi. 10.1038/ncomms9013
By:
- Kojetin, Douglas J.;
- Matta-Camacho, Edna;
- Hughes, Travis S.;
- Srinivasan, Sathish;
- Nwachukwu, Jerome C.;
- Cavett, Valerie;
- Nowak, Jason;
- Chalmers, Michael J.;
- Marciano, David P.;
- Kamenecka, Theodore M.;
- Shulman, Andrew I.;
- Rance, Mark;
- Griffin, Patrick R.;
- Bruning, John B.;
- Nettles, Kendall W.
Publication type:
Article
Pharmacological repression of PPARγ promotes osteogenesis.
Published in:
Nature Communications, 2015, v. 6, n. 6, p. 7443, doi. 10.1038/ncomms8443
By:
- Marciano, David P.;
- Kuruvilla, Dana S.;
- Boregowda, Siddaraju V.;
- Asteian, Alice;
- Hughes, Travis S.;
- Garcia-Ordonez, Ruben;
- Corzo, Cesar A.;
- Khan, Tanya M.;
- Novick, Scott J.;
- Park, HaJeung;
- Kojetin, Douglas J.;
- Phinney, Donald G.;
- Bruning, John B.;
- Kamenecka, Theodore M.;
- Griffin, Patrick R.
Publication type:
Article
Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour.
Published in:
Nature Communications, 2014, v. 5, n. 12, p. 5759, doi. 10.1038/ncomms6759
By:
- Banerjee, Subhashis;
- Wang, Yongjun;
- Solt, Laura A.;
- Griffett, Kristine;
- Kazantzis, Melissa;
- Amador, Ariadna;
- El-Gendy, Bahaa M.;
- Huitron-Resendiz, Salvador;
- Roberts, Amanda J.;
- Shin, Youseung;
- Kamenecka, Theodore M.;
- Burris, Thomas P.
Publication type:
Article
An alternate binding site for PPARγ ligands.
Published in:
Nature Communications, 2014, v. 5, n. 4, p. 3571, doi. 10.1038/ncomms4571
By:
- Hughes, Travis S.;
- Giri, Pankaj Kumar;
- de Vera, Ian Mitchelle S.;
- Marciano, David P.;
- Kuruvilla, Dana S.;
- Shin, Youseung;
- Blayo, Anne-Laure;
- Kamenecka, Theodore M.;
- Burris, Thomas P.;
- Griffin, Patrick R.;
- Kojetin, Douglas J.
Publication type:
Article
Discovery through Total Synthesis: A Retrospective on the Himastatin Problem.
Published in:
Chemistry - A European Journal, 2001, v. 7, n. 1, p. 41, doi. 10.1002/1521-3765(20010105)7:1<41::AID-CHEM41>3.0.CO;2-D
By:
- Kamenecka, Theodore M.;
- Danishefsky, Samuel J.
Publication type:
Article
Cover Picture.
Published in:
Chemistry - A European Journal, 2001, v. 7, n. 1, p. 1, doi. 10.1002/1521-3765(20010105)7:1<1::AID-CHEM1>3.0.CO;2-0
By:
- Kamenecka, Theodore M.;
- Danishefsky, Samuel J.
Publication type:
Article
Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation.
Published in:
PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0162452
By:
- Amador, Ariadna;
- Huitron-Resendiz, Salvador;
- Roberts, Amanda J.;
- Kamenecka, Theodore M.;
- Solt, Laura A.;
- Burris, Thomas P.
Publication type:
Article
Correction: Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression.
Published in:
2016
By:
- Amador, Ariadna;
- Wang, Yongjun;
- Banerjee, Subhashis;
- Kamenecka, Theodore M.;
- Solt, Laura A.;
- Burris, Thomas P.
Publication type:
Correction Notice
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.
Published in:
Nature, 2012, v. 485, n. 7396, p. 62, doi. 10.1038/nature11030
By:
- Solt, Laura A.;
- Wang, Yongjun;
- Banerjee, Subhashis;
- Hughes, Travis;
- Kojetin, Douglas J.;
- Lundasen, Thomas;
- Shin, Youseung;
- Liu, Jin;
- Cameron, Michael D.;
- Noel, Romain;
- Yoo, Seung-Hee;
- Takahashi, Joseph S.;
- Butler, Andrew A.;
- Kamenecka, Theodore M.;
- Burris, Thomas P.
Publication type:
Article
Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model.
Published in:
2014
By:
- Chang, Mi Ra;
- Lyda, Brent;
- Kamenecka, Theodore M.;
- Griffin, Patrick R.
Publication type:
Journal Article
Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model.
Published in:
Arthritis & Rheumatology, 2014, v. 66, n. 3, p. 579, doi. 10.1002/art.38272
By:
- Chang, Mi Ra;
- Lyda, Brent;
- Kamenecka, Theodore M.;
- Griffin, Patrick R.
Publication type:
Article
Defining a conformational ensemble that directs activation of PPARγ.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04176-x
By:
- Chrisman, Ian M.;
- Nemetchek, Michelle D.;
- S. de Vera, Ian Mitchelle;
- Jinsai Shang;
- Heidari, Zahra;
- Long, Yanan;
- Reyes-Caballero, Hermes;
- Galindo-Murillo, Rodrigo;
- Cheatham III, Thomas E.;
- Blayo, Anne-Laure;
- Youseung Shin;
- Fuhrmann, Jakob;
- Griffin, Patrick R.;
- Kamenecka, Theodore M.;
- Kojetin, Douglas J.;
- Hughes, Travis S.
Publication type:
Article
SR9883 is a novel small-molecule enhancer of α4β2* nicotinic acetylcholine receptor signaling that decreases intravenous nicotine self-administration in rats.
Published in:
Frontiers in Molecular Neuroscience, 2024, p. 1, doi. 10.3389/fnmol.2024.1459098
By:
- Braunscheidel, Kevin M.;
- Voren, George;
- Fowler, Christie D.;
- Qun Lu;
- Kuryatov, Alexander;
- Cameron, Michael D.;
- Ibañez-Tallon, Ines;
- Lindstrom, Jon M.;
- Kamenecka, Theodore M.;
- Kenny, Paul J.
Publication type:
Article
Methamphetamine Learning Induces Persistent and Selective Nonmuscle Myosin II-Dependent Spine Motility in the Basolateral Amygdala.
Published in:
Journal of Neuroscience, 2020, v. 40, n. 13, p. 2695, doi. 10.1523/jneurosci.2182-19.2020
By:
- Young, Erica J.;
- Hua Lin;
- Kamenecka, Theodore M.;
- Rumbaugh, Gavin;
- Miller, Courtney A.
Publication type:
Article
N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists.
Published in:
ChemMedChem, 2016, v. 11, n. 23, p. 2607, doi. 10.1002/cmdc.201600491
By:
- Doebelin, Christelle;
- Patouret, Rémi;
- Garcia‐Ordonez, Ruben D.;
- Chang, Mi Ra;
- Dharmarajan, Venkatasubramanian;
- Kuruvilla, Dana S.;
- Novick, Scott J.;
- Lin, Li;
- Cameron, Michael D.;
- Griffin, Patrick R.;
- Kamenecka, Theodore M.
Publication type:
Article
Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging.
Published in:
Aging Cell, 2021, v. 20, n. 12, p. 1, doi. 10.1111/acel.13486
By:
- Zhang, Lei;
- Zhao, Jing;
- Mu, Xiaodong;
- McGowan, Sara J.;
- Angelini, Luise;
- O'Kelly, Ryan D.;
- Yousefzadeh, Matthew J.;
- Sakamoto, Ayumi;
- Aversa, Zaira;
- LeBrasseur, Nathan K.;
- Suh, Yousin;
- Huard, Johnny;
- Kamenecka, Theodore M.;
- Niedernhofer, Laura J.;
- Robbins, Paul D.
Publication type:
Article
Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20385-9
By:
- Wang, Ran;
- Campbell, Sean;
- Amir, Mohammed;
- Mosure, Sarah A.;
- Bassette, Molly A.;
- Eliason, Amber;
- Sundrud, Mark S.;
- Kamenecka, Theodore M.;
- Solt, Laura A.
Publication type:
Article
Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-13768-0
By:
- Heidari, Zahra;
- Chrisman, Ian M.;
- Nemetchek, Michelle D.;
- Novick, Scott J.;
- Blayo, Anne-Laure;
- Patton, Trey;
- Mendes, Desiree E.;
- Diaz, Philippe;
- Kamenecka, Theodore M.;
- Griffin, Patrick R.;
- Hughes, Travis S.
Publication type:
Article

Found: 30

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy.

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.

LXR-Mediated Inhibition of CD4<sup>+</sup> T Helper Cells.

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ.

Studies in the Total Synthesis of Himastatin: A Revision of the Stereochemical Assignment.

Total Synthesis of Himastatin: Confirmation of the Revised Stereostructure.

Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation.

Suppression of T<sub>H</sub>17 differentiation and autoimmunity by a synthetic ROR ligand.

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5.

RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis.

Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.

Site‐Selective γ‐C(sp<sup>3</sup>)−H and γ‐C(sp<sup>2</sup>)−H Arylation of Free Amino Esters Promoted by a Catalytic Transient Directing Group.

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.

Pharmacological repression of PPARγ promotes osteogenesis.

Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour.

An alternate binding site for PPARγ ligands.

Discovery through Total Synthesis: A Retrospective on the Himastatin Problem.

Cover Picture.

Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation.

Correction: Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression.

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.

Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model.

Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model.

Defining a conformational ensemble that directs activation of PPARγ.

SR9883 is a novel small-molecule enhancer of α4β2* nicotinic acetylcholine receptor signaling that decreases intravenous nicotine self-administration in rats.

Methamphetamine Learning Induces Persistent and Selective Nonmuscle Myosin II-Dependent Spine Motility in the Basolateral Amygdala.

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists.

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging.

Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders.

Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ.