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Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products.
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- Bioengineering (Basel), 2022, v. 9, n. 3, p. 92, doi. 10.3390/bioengineering9030092
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Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products.
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- Bioengineering (Basel), 2020, v. 7, n. 2, p. 1, doi. 10.3390/bioengineering7020031
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Challenges and opportunities in downstream separation processes for mesenchymal stromal cells cultured in microcarrier‐based stirred suspension bioreactors.
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- Biotechnology & Bioengineering, 2022, v. 119, n. 11, p. 3062, doi. 10.1002/bit.28210
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Large‐scale expansion of feeder‐free mouse embryonic stem cells serially passaged in stirred suspension bioreactors at low inoculation densities directly from cryopreservation.
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- Biotechnology & Bioengineering, 2020, v. 117, n. 5, p. 1316, doi. 10.1002/bit.27279
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Non‐Newtonian rheology in suspension cell cultures significantly impacts bioreactor shear stress quantification.
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- Biotechnology & Bioengineering, 2018, v. 115, n. 8, p. 2101, doi. 10.1002/bit.26723
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Large-scale expansion of human skin-derived precursor cells (hSKPs) in stirred suspension bioreactors.
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- Biotechnology & Bioengineering, 2016, v. 113, n. 12, p. 2725, doi. 10.1002/bit.26040
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Inter-Microcarrier Transfer and Phenotypic Stability of Stem Cell-Derived Schwann Cells in Stirred Suspension Bioreactor Culture.
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- Biotechnology & Bioengineering, 2016, v. 113, n. 2, p. 393, doi. 10.1002/bit.25813
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Serum-free scaled up expansion and differentiation of murine embryonic stem cells to osteoblasts in suspension bioreactors.
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- Biotechnology & Bioengineering, 2010, v. 106, n. 5, p. 829, doi. 10.1002/bit.22727
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Bioreactor expansion of human neural precursor cells in serum-free media retains neurogenic potential.
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- Biotechnology & Bioengineering, 2010, v. 105, n. 4, p. 823, doi. 10.1002/bit.22590
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Scaled-up production of mammalian neural precursor cell aggregates in computer-controlled suspension bioreactors.
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- Biotechnology & Bioengineering, 2006, v. 94, n. 4, p. 783, doi. 10.1002/bit.20900
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Characterization of human islet-like structures generated from pancreatic precursor cells in culture.
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- Biotechnology & Bioengineering, 2006, v. 93, n. 5, p. 980, doi. 10.1002/bit.20801
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Cell cycle kinetics of expanding populations of neural stem and progenitor cells in vitro.
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- Biotechnology & Bioengineering, 2004, v. 88, n. 3, p. 332, doi. 10.1002/bit.20246
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Preface to the special issue honouring Professor Leo A. Behie.
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- Canadian Journal of Chemical Engineering, 2021, v. 99, n. 11, p. 2259, doi. 10.1002/cjce.24274
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Computational fluid dynamic characterization of vertical‐wheel bioreactors used for effective scale‐up of human induced pluripotent stem cell aggregate culture.
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- Canadian Journal of Chemical Engineering, 2021, v. 99, n. 11, p. 2536, doi. 10.1002/cjce.24253
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Research contributions of Leo A. Behie to chemical and biomedical engineering.
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- Canadian Journal of Chemical Engineering, 2021, v. 99, n. 11, p. 2262, doi. 10.1002/cjce.24192
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- Article
A new kinetic model for pyrolysis of Athabasca bitumen.
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- Canadian Journal of Chemical Engineering, 2013, v. 91, n. 5, p. 889, doi. 10.1002/cjce.21732
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A new reaction model for aquathermolysis of Athabasca bitumen.
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- Canadian Journal of Chemical Engineering, 2013, v. 91, n. 3, p. 475, doi. 10.1002/cjce.21662
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Measurement of intrinsic rates for homogeneous gas-phase reactions at high temperatures.
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- Canadian Journal of Chemical Engineering, 2002, v. 80, n. 3, p. 513, doi. 10.1002/cjce.5450800323
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A Multi-Stage Bioprocess for the Expansion of Rodent Skin-Derived Schwann Cells in Computer-Controlled Bioreactors.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5152, doi. 10.3390/ijms24065152
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Efficient suspension bioreactor expansion of murine embryonic stem cells on microcarriers in serum-free medium.
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- Biotechnology Progress, 2011, v. 27, n. 3, p. 811, doi. 10.1002/btpr.591
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Production of Islet-Like Structures from Neonatal Porcine Pancreatic Tissue in Suspension Bioreactors.
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- Biotechnology Progress, 2006, v. 22, n. 2, p. 561, doi. 10.1021/bp050261i
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Passaging Protocols for Mammalian Neural Stem Cells in Suspension Bioreactors.
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- Biotechnology Progress, 2002, v. 18, n. 2, p. 337, doi. 10.1021/bp010150t
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Improved expansion of equine cord blood derived mesenchymal stromal cells by using microcarriers in stirred suspension bioreactors.
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- Journal of Biological Engineering, 2019, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13036-019-0153-8
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Mass Transfer Limitations in Embryoid Bodies during Human Embryonic Stem Cell Differentiation.
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- Cells Tissues Organs, 2012, v. 196, n. 2, p. 34, doi. 10.1159/000330691
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Control of dissolved oxygen significantly increases the yield of skin‐derived Schwann cells during expansion in stirred suspension bioreactors.
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- Engineering Reports, 2021, v. 3, n. 12, p. 1, doi. 10.1002/eng2.12421
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Serum-free bioprocessing of adult human and rodent skin-derived Schwann cells: implications for cell therapy in nervous system injury.
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- Journal of Tissue Engineering & Regenerative Medicine, 2017, v. 11, n. 12, p. 3385, doi. 10.1002/term.2252
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Shear stress influences the pluripotency of murine embryonic stem cells in stirred suspension bioreactors.
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- Journal of Tissue Engineering & Regenerative Medicine, 2014, v. 8, n. 4, p. 268, doi. 10.1002/term.1518
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Improved expansion of human bone marrow-derived mesenchymal stem cells in microcarrier-based suspension culture.
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- Journal of Tissue Engineering & Regenerative Medicine, 2014, v. 8, n. 3, p. 210, doi. 10.1002/term.1515
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Expansion and long-term maintenance of induced pluripotent stem cells in stirred suspension bioreactors.
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- Journal of Tissue Engineering & Regenerative Medicine, 2012, v. 6, n. 6, p. 462, doi. 10.1002/term.450
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Fluid shear stress promotes embryonic stem cell pluripotency via interplay between β‐catenin and vinculin in bioreactor culture.
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- Stem Cells, 2021, v. 39, n. 9, p. 1166, doi. 10.1002/stem.3382
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Optimizing gelling parameters of gellan gum for fibrocartilage tissue engineering.
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- Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2011, v. 98B, n. 2, p. 238, doi. 10.1002/jbm.b.31845
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Extended serial passaging of mammalian neural stem cells in suspension bioreactors.
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- Biotechnology & Bioengineering, 1999, v. 65, n. 5, p. 589, doi. 10.1002/(SICI)1097-0290(19991205)65:5<589::AID-BIT12>3.0.CO;2-S
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Inoculation and growth conditions for high-cell-density expansion of mammalian neural stem cells in suspension bioreactors.
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- Biotechnology & Bioengineering, 1999, v. 63, n. 4, p. 473, doi. 10.1002/(SICI)1097-0290(19990520)63:4<473::AID-BIT11>3.0.CO;2-C
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Stirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells.
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- Communications Biology, 2020, v. 3, n. 1, p. N.PAG, doi. 10.1038/s42003-020-01218-3
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Optimized serial expansion of human induced pluripotent stem cells using low‐density inoculation to generate clinically relevant quantities in vertical‐wheel bioreactors.
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- Stem Cells Translational Medicine, 2020, v. 9, n. 9, p. 1036, doi. 10.1002/sctm.19-0406
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Enhanced Expansion and Sustained Inductive Function of Skin-Derived Precursor Cells in Computer-Controlled Stirred Suspension Bioreactors.
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- Stem Cells Translational Medicine, 2017, v. 6, n. 2, p. 434, doi. 10.5966/sctm.2016-0133
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Robust bioprocess design and evaluation of commercial media for the serial expansion of human induced pluripotent stem cell aggregate cultures in vertical-wheel bioreactors.
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- Stem Cell Research & Therapy, 2024, v. 15, n. 1, p. 1, doi. 10.1186/s13287-024-03819-9
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Suspension culture improves iPSC expansion and pluripotency phenotype.
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- Stem Cell Research & Therapy, 2023, v. 14, n. 1, p. 1, doi. 10.1186/s13287-023-03382-9
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Bioprocess development for cord blood mesenchymal stromal cells on microcarriers in Vertical‐Wheel bioreactors.
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- Biotechnology & Bioengineering, 2024, v. 121, n. 1, p. 192, doi. 10.1002/bit.28557
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Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors.
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- Stem Cell Research & Therapy, 2021, v. 12, n. 1, p. 1, doi. 10.1186/s13287-020-02109-4
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Suicide gene‐enabled cell therapy: A novel approach to scalable human pluripotent stem cell quality control.
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- BioEssays, 2023, v. 45, n. 11, p. 1, doi. 10.1002/bies.202300037
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- Article