Works by Kakuda, Thomas N.

Results: 41

Population Pharmacokinetics of AL-335 and Its Two Main Metabolites (ALS-022399, ALS-022227) in Monotherapy and in Combination with Odalasvir and/or Simeprevir.

Published in:

AAPS Journal, 2019, v. 21, n. 1, p. 1, doi. 10.1208/s12248-018-0272-z

By:

Valade, Elodie;
Kakuda, Thomas N.;
McClure, Matthew W.;
Westland, Christopher;
Valenzuela, Belén;
Ouwerkerk-Mahadevan, Sivi;
Perez-Ruixo, Juan José;
Ackaert, Oliver

Publication type:

Article

Characterizing the Pharmacokinetic Interaction Between Simeprevir and Odalasvir in Healthy Volunteers Using a Population Modeling Approach.

Published in:

AAPS Journal, 2018, v. 20, n. 6, p. 1, doi. 10.1208/s12248-018-0271-0

By:

Valade, Elodie;
Valenzuela, Belén;
Kakuda, Thomas N.;
Westland, Christopher;
McClure, Matthew W.;
Ouwerkerk-Mahadevan, Sivi;
Perez-Ruixo, Juan José;
Ackaert, Oliver

Publication type:

Article

Pharmacokinetics, Safety, and Tolerability of the siRNA JNJ‐73763989 in Healthy Chinese Adult Participants.

Published in:

Clinical Pharmacology in Drug Development, 2023, v. 12, n. 2, p. 175, doi. 10.1002/cpdd.1197

By:

Li, Haiyan;
Niu, Xiaoye;
Zhang, Yu;
Zhang, Danning;
Zhang, Yanqing;
Wang, Liqun;
Miao, Yongqing;
Jiang, Yanxin;
Ji, Jia;
Chen, Qiaoqiao;
Wu, Xiaoyun;
Ediage, Emmanuel Njumbe;
Kakuda, Thomas N.;
Biermer, Michael

Publication type:

Article

Drug‐Drug Interactions With the Hepatitis B Virus Capsid Assembly Modulator JNJ‐56136379 (Bersacapavir).

Published in:

Clinical Pharmacology in Drug Development, 2022, v. 11, n. 12, p. 1419, doi. 10.1002/cpdd.1164

By:

Vandenbossche, Joris;
Yogaratnam, Jeysen;
Hillewaert, Vera;
Rasschaert, Freya;
Talloen, Willem;
Biewenga, Jeike;
Snoeys, Jan;
Kakuda, Thomas N.;
Palmer, Martyn;
Nangosyah, Julius;
Biermer, Michael

Publication type:

Article

Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0204974

By:

McClure, Matthew W.;
Berliba, Elina;
Tsertsvadze, Tengiz;
Streinu-Cercel, Adrian;
Vijgen, Leen;
Astruc, Béatrice;
Patat, Alain;
Westland, Christopher;
Chanda, Sushmita;
Zhang, Qingling;
Kakuda, Thomas N.;
Vuong, Jennifer;
Khorlin, Nick;
Beigelman, Leonid;
Blatt, Lawrence M.;
Fry, John

Publication type:

Article

Pharmacokinetics of JNJ‐73763989 and JNJ‐56136379 (Bersacapavir) in Participants With Moderate Hepatic Impairment.

Published in:

Journal of Clinical Pharmacology, 2023, v. 63, n. 6, p. 732, doi. 10.1002/jcph.2214

By:

Kakuda, Thomas N.;
Halabi, Atef;
Klein, Gernot;
Sanga, Madhu;
Guinard‐Azadian, Carine;
Kowalik, Monika;
Nedoschinsky, Katja;
Nangosyah, Julius;
Ediage, Emmanuel Njumbe;
Hillewaert, Vera;
Verboven, Peter;
Goris, Ivo;
Snoeys, Jan;
Palmer, Martyn;
Biermer, Michael

Publication type:

Article

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Relationships of Etravirine in HIV-1-Infected, Treatment-Experienced Children and Adolescents in PIANO.

Published in:

Journal of Clinical Pharmacology, 2016, v. 56, n. 11, p. 1395, doi. 10.1002/jcph.746

By:

Kakuda, Thomas N.;
Brochot, Anne;
Green, Bruce;
Nijs, Steven;
Vis, Peter;
Opsomer, Magda;
Tomaka, Frank L.;
Hoetelmans, Richard M. W.

Publication type:

Article

Pharmacokinetics of darunavir in fixed-dose combination with cobicistat compared with coadministration of darunavir and ritonavir as single agents in healthy volunteers.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 8, p. 949, doi. 10.1002/jcph.290

By:

Kakuda, Thomas N.;
Opsomer, Magda;
Timmers, Maarten;
Iterbeke, Koen;
Van De Casteele, Tom;
Hillewaert, Vera;
Petrovic, Romana;
Hoetelmans, Richard M. W.

Publication type:

Article

Pharmacokinetic interaction between etravirine or rilpivirine and telaprevir in healthy volunteers: A randomized, two-way crossover trial.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 5, p. 563, doi. 10.1002/jcph.245

By:

Kakuda, Thomas N.;
Leopold, Lorant;
Nijs, Steven;
Vandevoorde, Ann;
Crauwels, Herta M.;
Bertelsen, Kirk M.;
Stevens, Marita;
Witek, James;
van Delft, Yvon;
Tomaka, Frank;
Hoetelmans, Richard M.W.

Publication type:

Article

The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 4, p. 422, doi. 10.1002/jcph.214

By:

Kakuda, Thomas N.;
Van Solingen ‐ Ristea, Rodica M.;
Onkelinx, Joelle;
Stevens, Tanja;
Aharchi, Fatima;
De Smedt, Goedele;
Peeters, Monika;
Leopold, Lorant;
Hoetelmans, Richard M.W.

Publication type:

Article

Steady-State Pharmacokinetics of Etravirine and Lopinavir/Ritonavir Melt Extrusion Formulation, Alone and in Combination, in Healthy HIV-Negative Volunteers.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 2, p. 202, doi. 10.1177/0091270012445205

By:

Schöller‐Gyüre, Monika;
Kakuda, Thomas N.;
Witek, James;
Akuma, Sophie H.;
Smedt, Goedele De;
Spittaels, Kurt;
Vyncke, Veerle;
Hoetelmans, Richard M.W.

Publication type:

Article

Pharmacokinetics and Short-Term Safety of Etravirine in Combination With Fluconazole or Voriconazole in HIV-Negative Volunteers.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 1, p. 41, doi. 10.1177/0091270011433329

By:

Kakuda, Thomas N.;
Van Solingen‐Ristea, Rodica;
Aharchi, Fatima;
Smedt, Goedele De;
Witek, James;
Nijs, Steven;
Vyncke, Veerle;
Hoetelmans, Richard M. W.

Publication type:

Article

JNJ-73763989 pharmacokinetics and safety: Liver-targeted siRNAs against hepatitis B virus, in Japanese and non-Japanese healthy adults, and combined with JNJ-56136379 and a nucleos(t)ide analogue in patients with chronic hepatitis B.

Published in:

Antiviral Therapy, 2022, v. 27, n. 3, p. 1, doi. 10.1177/13596535221093856

By:

Gane, Ed;
Yuen, Man-Fung;
Kakuda, Thomas N;
Ogawa, Tetsuro;
Takahashi, Yasushi;
Goeyvaerts, Nele;
Lonjon-Domanec, Isabelle;
Vaughan, Tamisha;
Schluep, Thomas;
Hamilton, James;
Njumbe Ediage, Emmanuel;
Hillewaert, Vera;
Snoeys, Jan;
Lenz, Oliver;
Talloen, Willem;
Biermer, Michael

Publication type:

Article

Pharmacokinetics and pharmacodynamics of boosted once-daily darunavir.

Published in:

2014

By:

Kakuda, Thomas N;
Brochot, Anne;
Tomaka, Frank L;
Vangeneugden, Tony;
Van De Casteele, Tom;
Hoetelmans, Richard M W

Publication type:

Journal Article

Pharmacokinetics and pharmacodynamics of boosted once-daily darunavir.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 10, p. 2591, doi. 10.1093/jac/dku193

By:

Kakuda, Thomas N.;
Brochot, Anne;
Tomaka, Frank L.;
Vangeneugden, Tony;
Van De Casteele, Tom;
Hoetelmans, Richard M. W.

Publication type:

Article

Pharmacokinetic evaluation of the interaction between etravirine and rifabutin or clarithromycin in HIV-negative, healthy volunteers: results from two Phase 1 studies.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 3, p. 728, doi. 10.1093/jac/dkt421

By:

Kakuda, Thomas N.;
Woodfall, Brian;
De Marez, Tine;
Peeters, Monika;
Vandermeulen, Kati;
Aharchi, Fatima;
Hoetelmans, Richard M. W.

Publication type:

Article

Comment on: Suboptimal CD4 gains in HIV-infected patients receiving didanosine plus tenofovir.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2006, v. 58, n. 1, p. 220, doi. 10.1093/jac/dkl203

By:

Peter L. Anderson;
Thomas N. Kakuda

Publication type:

Article

Darunavir/cobicistat once daily for the treatment of HIV.

Published in:

Expert Review of Anti-infective Therapy, 2015, v. 13, n. 6, p. 691, doi. 10.1586/14787210.2015.1033400

By:

Kakuda, Thomas N;
Crauwels, Herta;
Opsomer, Magda;
Tomaka, Frank;
van de Casteele, Tom;
Vanveggel, Simon;
Iterbeke, Koen;
de Smedt, Goedele

Publication type:

Article

Effect of Food and Ranitidine on Saquinavir Pharmacokinetics and Gastric pH in Healthy Volunteers.

Published in:

Pharmacotherapy, 2006, v. 26, n. 8, p. 1060, doi. 10.1592/phco.26.8.1060

By:

Kakuda, Thomas N.;
Falcon, Ronald W.

Publication type:

Article

Evaluation of Concomitant Antiretrovirals and CYP2C9/CYP2C19 Polymorphisms on the Pharmacokinetics of Etravirine.

Published in:

2017

By:

Green, Bruce;
Crauwels, Herta;
Kakuda, Thomas;
Vanveggel, Simon;
Brochot, Anne;
Kakuda, Thomas N

Publication type:

journal article

Cobicistat-boosted darunavir in HIV-1-infected adults: week 48 results of a Phase IIIb, open-label single-arm trial.

Published in:

AIDS Research & Therapy, 2014, v. 11, p. 1, doi. 10.1186/1742-6405-11-39

By:

Tashima, Karen;
Crofoot, Gordon;
Tomaka, Frank L.;
Kakuda, Thomas N.;
Brochot, Anne;
van de Casteele, Tom;
Opsomer, Magda;
Garner, William;
Margot, Nicolas;
Custodio, Joseph M.;
Fordyce, Marshall W.;
Szwarcberg, Javier

Publication type:

Article

Efficacy, safety and pharmacokinetics of simeprevir and TMC647055/ritonavir with or without ribavirin and JNJ-56914845 in HCV genotype 1 infection.

Published in:

2017

By:

Bourgeois, Stefan;
Van Vlierberghe, Hans;
Moreno, Christophe;
Orlent, Hans;
Nevens, Frederik;
Arastéh, Keikawus;
Horsmans, Yves;
Schattenberg, Jörn M.;
Buggisch, Peter;
Francque, Sven;
Vijgen, Leen;
Kakuda, Thomas N.;
Hoeben, Eva;
Luo, Donghan;
Vandebosch, An;
Jacquemyn, Bert;
Van Remoortere, Pieter;
Verloes, René

Publication type:

journal article

Effects of Different Meal Compositions and Fasted State on the Oral Bioavailability of Etravirine.

Published in:

Pharmacotherapy, 2008, v. 28, n. 10, p. 1215

By:

Schöller-Gyüre, Monika;
Boffito, Marta;
Pozniak, Anton L.;
Leemans, Ruud;
Kakuda, Thomas N.;
Woodfall, Brian;
Vyncke, Veerle;
Peeters, Monika;
Vandermeulen, Kati;
Hoetelmans, Richard M. W.

Publication type:

Article

Safety, antiviral activity and pharmacokinetics of JNJ-64530440, a novel capsid assembly modulator, as 4 week monotherapy in treatment-naive patients with chronic hepatitis B virus infection.

Published in:

2022

By:

Gane, Ed J.;
Schwabe, Christian;
Berliba, Elina;
Tangkijvanich, Pisit;
Jucov, Alina;
Ghicavii, Nelea;
Verbinnen, Thierry;
Lenz, Oliver;
Talloen, Willem;
Kakuda, Thomas N.;
Westland, Chris;
Patel, Megha;
Yogaratnam, Jeysen Z.;
Dragone, Leonard;
Remoortere, Pieter Van;
Van Remoortere, Pieter

Publication type:

journal article

Single‐ and multiple‐dose pharmacokinetics and safety of pimodivir, a novel, non‐nucleoside polymerase basic protein 2 subunit inhibitor of the influenza A virus polymerase complex, and interaction with oseltamivir: a Phase 1 open‐label study in healthy volunteers.

Published in:

British Journal of Clinical Pharmacology, 2018, v. 84, n. 11, p. 2663, doi. 10.1111/bcp.13733

By:

Deleu, Sofie;
Kakuda, Thomas N.;
Spittaels, Kurt;
Vercauteren, Jurgen J.;
Hillewaert, Vera;
Lwin, Amy;
Leopold, Lorant;
Hoetelmans, Richard M. W.

Publication type:

Article

A pharmacokinetic study of etravirine (TMC125) co-administered with ranitidine and omeprazole in HIV–negative volunteers.

Published in:

British Journal of Clinical Pharmacology, 2008, v. 66, n. 4, p. 508, doi. 10.1111/j.1365-2125.2008.03214.x

By:

Schöller-Gyüre, Monika;
Kakuda, Thomas N.;
De Smedt, Goedele;
Vanaken, Hilde;
Bouche, Marie-Paule;
Peeters, Monika;
Woodfall, Brian;
Hoetelmans, Richard M. W.

Publication type:

Article

Pharmacokinetics, safety, and tolerability of the 2‐ and 3‐direct‐acting antiviral combination of AL‐335, odalasvir, and simeprevir in healthy subjects.

Published in:

Pharmacology Research & Perspectives, 2018, v. 6, n. 3, p. 1, doi. 10.1002/prp2.395

By:

Kakuda, Thomas N.;
McClure, Matthew W.;
Westland, Christopher;
Vuong, Jennifer;
Homery, Marie‐Claude;
Poizat, Gwendoline;
Viguerie, Laure;
Denot, Caroline;
Patat, Alain;
Zhang, Qingling;
Hui, James;
Apelian, David;
Smith, David B.;
Chanda, Sushmita M.;
Fry, John

Publication type:

Article

Pharmacokinetics of Etravirine Combined with Atazanavir/Ritonavir and a Nucleoside Reverse Transcriptase Inhibitor in Antiretroviral Treatment-Experienced, HIV-1-Infected Patients.

Published in:

AIDS Research & Treatment, 2015, v. 2015, p. 1, doi. 10.1155/2015/938628

By:

Orrell, Catherine;
Felizarta, Franco;
Nell, André;
Kakuda, Thomas N.;
Lavreys, Ludo;
Nijs, Steven;
Tambuyzer, Lotke;
Van Solingen-Ristea, Rodica;
Tomaka, Frank L.

Publication type:

Article

Phase IIIb, open-label single-arm trial of darunavir/cobicistat (DRV/COBI): Week 48 subgroup analysis of HIV-1-infected treatment-nave adults.

Published in:

Journal of the International AIDS Society, 2014, v. 17, p. n/a, doi. 10.7448/IAS.17.4.19772

By:

Tashima, Karen;
Crofoot, Gordon;
Tomaka, Frank L;
Kakuda, Thomas N;
Brochot, Anne;
Vanveggel, Simon;
Opsomer, Magda;
Garner, William;
Margot, Nicolas;
Custodio, Joseph M;
Fordyce, Marshall W;
Szwarcberg, Javier

Publication type:

Article

Bioavailability and bioequivalence of a darunavir 800-mg tablet formulation compared with the 400-mg tablet formulation.

Published in:

International Journal of Clinical Pharmacology & Therapeutics, 2014, v. 52, n. 9, p. 805, doi. 10.5414/CP202066

By:

Kakuda, Thomas N.;
Leopold, Lorant;
Timmers, Maarten;
Van De Casteele, Tom;
Hillewaert, Vera;
Tomaka, Frank L.;
Hoetelmans, Richard M. W.

Publication type:

Article

Single-dose pharmacokinetics of pediatric and adult formulations of etravirine and swallowability of the 200-mg tablet: results from three Phase 1 studies.

Published in:

International Journal of Clinical Pharmacology & Therapeutics, 2013, v. 51, n. 9, p. 725, doi. 10.5414/CP201770

By:

Kakuda, Thomas N.;
Berckmans, Cindy;
dele De Smedt, Goe;
Leemans, Ruud;
Leopold, Lorant;
Peeters, Monika;
Nijs, Steven;
Vyncke, Veerle;
van Solingen-Ristea, Rodica;
Hoetelmans, Richard M. W.

Publication type:

Article

CD4 response is correlated with peak plasma concentrations of indinavir in adults with undetectable human immunodeficiency virus ribonucleic acid<sup>*</sup>.

Published in:

Clinical Pharmacology & Therapeutics, 2002, v. 71, n. 4, p. 280, doi. 10.1067/mcp.2002.121910

By:

Anderson, Peter L.;
Brundage, Richard C.;
Kakuda, Thomas N.;
Fletcher, Courtney V.

Publication type:

Article

Pharmacokinetics of darunavir after administration of an oral suspension with low-dose ritonavir and with or without food.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 346, doi. 10.1002/cpdd.88

By:

Kakuda, Thomas N.;
Sekar, Vanitha;
Lavreys, Ludo;
De Paepe, Els;
Stevens, Tanja;
Vanstockem, Marc;
Vangeneugden, Tony;
Hoetelmans, Richard M.W.

Publication type:

Article

Drug Interactions with New and Investigational Antiretrovirals.

Published in:

2010

By:

Crauwels, Herta M.;
Kakuda, Thomas N.

Publication type:

Letter

Clinical pharmacokinetics and pharmacodynamics of etravirine.

Published in:

2009

By:

Schöller-Gyüre M;
Kakuda TN;
Raoof A;
De Smedt G;
Hoetelmans RM;
Schöller-Gyüre, Monika;
Kakuda, Thomas N;
Raoof, Araz;
De Smedt, Goedele;
Hoetelmans, Richard M W

Publication type:

journal article

Clinical Pharmacokinetics and Pharmacodynamics of Etravirine.

Published in:

Clinical Pharmacokinetics, 2009, v. 48, n. 9, p. 561

By:

Schöller-Gyüre, Monika;
Kakuda, Thomas N.;
Raoof, Araz;
de Smedt, Goedele;
Hoetelmans, Richard M. W.

Publication type:

Article

Drug Interactions between HIV Protease Inhibitors and Acid-Reducing Agents.

Published in:

Clinical Pharmacokinetics, 2008, v. 47, n. 2, p. 75, doi. 10.2165/00003088-200847020-00001

By:

Falcon, Ronald W.;
Kakuda, Thomas N.

Publication type:

Article

Intracellular Pharmacology of Emtricitabine and Tenofovir.

Published in:

2004

By:

Anderson, Peter L.;
Kakuda, Thomas N.;
Lichtenstein, Kenneth A.

Publication type:

Letter

The Cellular Pharmacology of Nucleoside- and Nucleotide-Analogue Reverse-Transcriptase Inhibitors and Its Relationship to Clinical Toxicities.

Published in:

Clinical Infectious Diseases, 2004, v. 38, n. 5, p. 743, doi. 10.1086/381678

By:

Anderson, Peter L.;
Kakuda, Thomas N.;
Lichtenstein, Kenneth A.

Publication type:

Article

Pharmacodynamics of Human Immunodeficiency Virus Type 1 Protease Inhibitors.

Published in:

Clinical Infectious Diseases, 2000, v. 30, p. S151, doi. 10.1086/313852

By:

Acosta, Edward P.;
Kakuda, Thomas N.;
Brundage, Richard C.;
Anderson, Peter L.;
Fletcher, Courtney V.

Publication type:

Article

Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study.

Published in:

2019

By:

Yogaratnam, Jeysen;
Rito, Jennifer;
Kakuda, Thomas N;
Fennema, Hein;
Gupta, Kusum;
Jekle, C Andreas;
Mitchell, Toni;
Boyce, Malcolm;
Sahgal, Omair;
Balaratnam, Ganesh;
Chanda, Sushmita;
Remoortere, Pieter Van;
Symons, Julian A;
Fry, John;
Van Remoortere, Pieter

Publication type:

journal article