Works by Küçükler, Sefa

Results: 46

The Protective Effects of Chrysin on Acrylamide‐Induced Hepatotoxicity: Insights Into Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histological Evaluation in Rats.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 6, p. 1, doi. 10.1002/jbt.70334

By:

Gencer, Selman;
Akaras, Nurhan;
Şimşek, Hasan;
Gür, Cihan;
İleritürk, Mustafa;
Küçükler, Sefa;
Kandemir, Fatih Mehmet

Publication type:

Article

The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 pathways.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 10, p. 1, doi. 10.1002/jbt.23863

By:

Gencer, Selman;
Gür, Cihan;
İleritürk, Mustafa;
Küçükler, Sefa;
Akaras, Nurhan;
Şimşek, Hasan;
Kandemir, Fatih M.

Publication type:

Article

Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 7, p. 1, doi. 10.1002/jbt.23751

By:

Kankılıç, Nazım Abdülkadir;
Küçükler, Sefa;
Gür, Cihan;
Akarsu, Serkan Ali;
Akaras, Nurhan;
Şimşek, Hasan;
İleritürk, Mustafa;
Kandemir, Fatih Mehmet

Publication type:

Article

Protective effects of naringin on colistin‐induced damage in rat testicular tissue: Modulating the levels of Nrf‐2/HO‐1, AKT‐2/FOXO1A, Bax/Bcl2/Caspase‐3, and Beclin‐1/LC3A/LC3B signaling pathways.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 2, p. 1, doi. 10.1002/jbt.23643

By:

Kankılıç, Nazım Abdülkadir;
Şimşek, Hasan;
Akaras, Nurhan;
Gür, Cihan;
İleritürk, Mustafa;
Küçükler, Sefa;
Akarsu, Serkan A.;
Kandemir, Fatih M.

Publication type:

Article

Beneficial effects of quercetin on vincristine‐induced liver injury in rats: Modulating the levels of Nrf2/HO‐1, NF‐kB/STAT3, and SIRT1/PGC‐1α.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 5, p. 1, doi. 10.1002/jbt.23326

By:

Çomaklı, Selim;
Özdemir, Selçuk;
Küçükler, Sefa;
Kandemir, Fatih M.

Publication type:

Article

Palliative effect of curcumin on doxorubicin‐induced testicular damage in male rats.

Published in:

Journal of Biochemical & Molecular Toxicology, 2019, v. 33, n. 10, p. N.PAG, doi. 10.1002/jbt.22384

By:

Aksu, Emrah Hicazi;
Kandemir, Fatih Mehmet;
Yıldırım, Serkan;
Küçükler, Sefa;
Dörtbudak, Muhammed Baheeddin;
Çağlayan, Cüneyt;
Benzer, Fulya

Publication type:

Article

The effects of zingerone against vancomycin‐induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes.

Published in:

Journal of Biochemical & Molecular Toxicology, 2019, v. 33, n. 10, p. N.PAG, doi. 10.1002/jbt.22381

By:

Çağlayan, Cüneyt;
Taslimi, Parham;
Demir, Yeliz;
Küçükler, Sefa;
Kandemir, Fatih Mehmet;
Gulçin, İlhami

Publication type:

Article

Improvement in colistin‐induced reproductive damage, apoptosis, and autophagy in testes via reducing oxidative stress by chrysin.

Published in:

Journal of Biochemical & Molecular Toxicology, 2018, v. 32, n. 11, p. N.PAG, doi. 10.1002/jbt.22201

By:

Aksu, Emrah Hicazi;
Kandemir, Fatih Mehmet;
Küçükler, Sefa;
Mahamadu, Amdia

Publication type:

Article

Ameliorative Effect of Carvacrol on Cisplatin-Induced Reproductive Damage in Male Rats.

Published in:

Journal of Biochemical & Molecular Toxicology, 2016, v. 30, n. 10, p. 513, doi. 10.1002/jbt.21816

By:

Aksu, Emrah Hicazi;
Kandemir, Fatih Mehmet;
Altun, Serdar;
Küçükler, Sefa;
Çomaklı, Selim;
Ömür, Ali Doğan

Publication type:

Article

Naringin protects against colistin-induced sciatic nerve damage by reducing oxidative stress, apoptosis and inflammation damage.

Published in:

Journal of Experimental & Clinical Medicine / Deneysel ve Klinik Tip Dergisi, 2024, v. 41, n. 1, p. 53, doi. 10.52142/omujecm.41.1.9

By:

YILMAZ, Selçuk;
KÜÇÜKLER, Sefa;
ŞİMŞEK, Hasan;
AYGÖRMEZ, Serpil;
KANDEMİR, Fatih Mehmet

Publication type:

Article

Kurşun Kaynaklı Oluşan Dalak Toksisitesine Karşı Sinapik Asidin Etkilerinin İncelenmesi.

Published in:

Journal of Laboratory Animal Science & Practices / Laboratuvar Hayvanlari Bilimi ve Uygulamalari Dergisi, 2024, v. 4, n. 2, p. 72, doi. 10.62425/jlasp.1418923

By:

DALKILINÇ, Elif;
KÜÇÜKLER, Sefa;
AYDIN, Şeyma

Publication type:

Article

E. coli ve Rotavirusların Neden Olduğu Neonatal Dönem Buzağı İshallerinde Klinik, Hematolojik ve IL-8 Düzeyi Üzerine Bir Araştırma.

Published in:

Firat Universitesi Saglik Bilimleri Veteriner Dergisi, 2024, v. 38, n. 2, p. 95

By:

EROĞLU, Muhammed Sertaç;
HANEDAN, Başak;
EREN, Emre;
KÜÇÜKLER, Sefa;
AKTAŞ, Mustafa Sinan

Publication type:

Article

Sıçan Dalak Dokusunda Akrilamidin İndüklediği Oksidatif Stres, İnflamasyona ve Apoptoza Karşı Morinin Koruyucu Etkileri: Biyokimyasal ve Histopatolojik Bir Yaklaşım.

Published in:

Firat Universitesi Saglik Bilimleri Veteriner Dergisi, 2023, v. 37, n. 3, p. 188

By:

AKARAS, Nurhan;
KANDEMİR, Fatih Mehmet;
ŞİMŞEK, Hasan;
KÜÇÜKLER, Sefa;
OĞUZ KABAYEL, Rabia

Publication type:

Article

Ameliorating Effects of Rutin on Nephrotoxicity Caused by Cisplatin in Rats.

Published in:

Firat Universitesi Saglik Bilimleri Veteriner Dergisi, 2020, v. 34, n. 3, p. 147

By:

KANDEMİR, Fatih Mehmet;
HANEDAN, Başak;
AKTAŞ, Mustafa Sinan;
KÜÇÜKLER, Sefa;
ÇAĞLAYAN, Cüneyt

Publication type:

Article

Ratlarda Dosetaksel Kaynaklı Testis Toksisitesi Üzerine Silimarinin Etkileri: Biyokimyasal, Moleküler ve Histopatolojik Değerlendirme.

Published in:

Firat Universitesi Saglik Bilimleri Veteriner Dergisi, 2020, v. 34, n. 1, p. 13

By:

KÜÇÜKLER, Sefa;
ÇOMAKLI, Selim;
ÖZDEMİR, Selçuk;
KANDEMİR, Fatih Mehmet

Publication type:

Article

Protective Effect of Naringin on Methotrexate-Induced Testicular Apoptosis and Autophagy Via Reducing Oxidative Stress in Male Rats.

Published in:

Firat Universitesi Saglik Bilimleri Veteriner Dergisi, 2018, v. 32, n. 3, p. 179

By:

AKSU, Emrah Hicazi;
KANDEMİR, Fatih Mehmet;
KÜÇÜKLER, Sefa

Publication type:

Article

Research on Hematology, Inflammatory and Antimicrobial Peptide Levels according to Clinical Scoring in Calves with Bovine Respiratory Disease (BRD).

Published in:

Van Veterinary Journal, 2024, v. 35, n. 3, p. 196, doi. 10.36483/vanvetj.1543947

By:

AKTAŞ, Mustafa Sinan;
EREN, Emre;
AYDIN, Ömer;
YANAR, Kerim Emre;
KÜÇÜKLER, Sefa;
EROĞLU, Muhammed Sertaç;
DEĞİRMENÇAY, Şükrü;
İLGÜN, Murat

Publication type:

Article

Integrative Analysis of Dog Serum‐Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis.

Published in:

Veterinary Medicine & Science, 2025, v. 11, n. 3, p. 1, doi. 10.1002/vms3.70344

By:

Değirmençay, Şükrü;
Özdemir, Selçuk;
Küçükler, Sefa;
Bayat, Reyhane;
Kadak, Muhammed

Publication type:

Article

Protective effects of sinapic acid against lead acetate-induced nephrotoxicity: a multi-biomarker approach.

Published in:

Environmental Science & Pollution Research, 2023, v. 30, n. 45, p. 101208, doi. 10.1007/s11356-023-29410-y

By:

Şimşek, Hasan;
Küçükler, Sefa;
Gür, Cihan;
Akaras, Nurhan;
Kandemir, Fatih Mehmet

Publication type:

Article

Carvacrol Reduces Mercuric Chloride-Induced Testicular Toxicity by Regulating Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histopathological Changes.

Published in:

Biological Trace Element Research, 2024, v. 202, n. 10, p. 4605, doi. 10.1007/s12011-023-04022-2

By:

Şimşek, Hasan;
Gür, Cihan;
Küçükler, Sefa;
İleritürk, Mustafa;
Akaras, Nurhan;
Öz, Mehmet;
Kandemir, Fatih Mehmet

Publication type:

Article

The effects of hesperidin on colistin‐induced reproductive damage, autophagy, and apoptosis by reducing oxidative stress.

Published in:

Andrologia, 2021, v. 53, n. 2, p. 1, doi. 10.1111/and.13900

By:

Aksu, Emrah Hicazi;
Kandemir, Fatih Mehmet;
Küçükler, Sefa

Publication type:

Article

Effect of chrysin on methotrexate‐induced testicular damage in rats.

Published in:

Andrologia, 2019, v. 51, n. 1, p. N.PAG, doi. 10.1111/and.13145

By:

Belhan, Saadet;
Çomaklı, Selim;
Yıldırım, Serkan;
Küçükler, Sefa;
Gülyüz, Fetih;
Yener, Zabit

Publication type:

Article

Contribution of Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress and Autophagy Pathways to the Ameliorative Effects of Hesperidin in NaF‐Induced Testicular Toxicity.

Published in:

Chemistry & Biodiversity, 2023, v. 20, n. 3, p. 1, doi. 10.1002/cbdv.202200982

By:

Emre Kızıl, Hamit;
Gür, Cihan;
Ayna, Adnan;
Darendelioğlu, Ekrem;
Küçükler, Sefa;
Sağ, Sevda

Publication type:

Article

Effects of In-Ovo Chrysin Injection to Quail Eggs on Hatchability, Production Parameters, and Immunity.

Published in:

Kafkas Universitesi Veteriner Fakultesi Dergisi, 2025, v. 31, n. 3, p. 392, doi. 10.9775/kvfd.2025.33658

By:

ÖZENTÜRK, Uğur;
GENÇ, Murat;
KÜÇÜKLER, Sefa

Publication type:

Article

Protective effects of gallic acid on doxorubicin-induced cardiotoxicity; an experimantal study.

Published in:

Archives of Physiology & Biochemistry, 2021, v. 127, n. 3, p. 258, doi. 10.1080/13813455.2019.1630652

By:

Ekinci Akdemir, Fazile Nur;
Yildirim, Serkan;
Kandemir, Fatih Mehmet;
Tanyeli, Ayhan;
Küçükler, Sefa;
Bahaeddin Dortbudak, Muhammed

Publication type:

Article

Preventive effects of hesperidin on diabetic nephropathy induced by streptozotocin via modulating TGF-β1 and oxidative DNA damage.

Published in:

Toxin Reviews, 2018, v. 37, n. 4, p. 287, doi. 10.1080/15569543.2017.1364268

By:

Kandemir, Fatih Mehmet;
Ozkaraca, Mustafa;
Küçükler, Sefa;
Caglayan, Cuneyt;
Hanedan, Basak

Publication type:

Article

Ratlarda Methotrexate Kaynaklı Karaciğer Toksisitesine Karşı Silymarin ve Naringin'in Yararlı Etkileri.

Published in:

Ataturk University Journal of Veterinary Sciences, 2017, v. 12, n. 2, p. 167, doi. 10.17094/ataunivbd.347970

By:

KANDEMİR, Fatih Mehmet;
KÜÇÜKLER, Sefa;
ÇAĞLAYAN, Cüneyt

Publication type:

Article

Ameliorative effect of hesperidin on streptozotocin‐diabetes mellitus‐induced testicular DNA damage and sperm quality degradation in Sprague–Dawley rats.

Published in:

Journal of Food Biochemistry, 2021, v. 45, n. 10, p. 1, doi. 10.1111/jfbc.13938

By:

Aksu, Emrah Hicazi;
Kandemir, Fatih Mehmet;
Küçükler, Sefa

Publication type:

Article

Protective Effects of Baicalein and Bergenin Against Gentamicin‐Induced Hepatic and Renal Injuries in Rats: An Immunohistochemical and Biochemical Study.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2025, v. 136, n. 1, p. 1, doi. 10.1111/bcpt.14121

By:

Ekinci Akdemir, Fazile Nur;
Yildirim, Serkan;
Kandemir, Fatih Mehmet;
Küçükler, Sefa;
Eraslan, Ersen;
Güler, Mustafa Can

Publication type:

Article

Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways.

Published in:

Iranian Journal of Basic Medical Sciences, 2025, v. 28, n. 4, p. 507, doi. 10.22038/ijbms.2025.79735.17270

By:

Şimşek, Hasan;
Akaras, Nurhan;
Gür, Cihan;
Küçükler, Sefa;
İleritürk, Mustafa;
Kandemir, Fatih Mehmet

Publication type:

Article

Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach.

Published in:

Iranian Journal of Basic Medical Sciences, 2023, v. 26, n. 9, p. 1098, doi. 10.22038/IJBMS.2023.71905.15623

By:

Şimşek, Hasan;
Küçükler, Sefa;
Gür, Cihan;
İleritürk, Mustafa;
Aygörmez, Serpil;
Kandemir, Fatih Mehmet

Publication type:

Article

The investigation of the effect of fraxin on hepatotoxicity induced by cisplatin in rats.

Published in:

Iranian Journal of Basic Medical Sciences, 2020, v. 23, n. 11, p. 1382, doi. 10.22038/ijbms.2020.38773.9200

By:

Ekinci-Akdemir, Fazile Nur;
Bingöl, Çiğdem;
Yıldırım, Serkan;
Kandemir, Fatih Mehmet;
Küçükler, Sefa;
Sağlam, Yavuz Selim

Publication type:

Article

The effects of casticin and myricetin on liver damage induced by methotrexate in rats.

Published in:

Iranian Journal of Basic Medical Sciences, 2018, v. 21, n. 12, p. 1281, doi. 10.22038/ijbms.2018.29922.7217

By:

Ekinci-Akdemir, Fazile Nur;
Yildirim, Serkan;
Kandemir, Fatih Mehmet;
Gülçin, İlhami;
Küçükler, Sefa;
Sağlam, Yavuz Selim;
Yakan, Selvinaz

Publication type:

Article

Effects of chrysin in cadmium-induced testicular toxicity in the rat; role of multi-pathway regulation.

Published in:

Molecular Biology Reports, 2023, v. 50, n. 10, p. 8305, doi. 10.1007/s11033-023-08715-8

By:

Tuncer, Sibel Çiğdem;
Küçükler, Sefa;
Gür, Cihan;
Aygörmez, Serpil;
Kandemir, Fatih Mehmet

Publication type:

Article

Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways.

Published in:

Molecular Biology Reports, 2023, v. 50, n. 4, p. 3479, doi. 10.1007/s11033-023-08286-8

By:

Kızıl, Hamit Emre;
Caglayan, Cuneyt;
Darendelioğlu, Ekrem;
Ayna, Adnan;
Gür, Cihan;
Kandemir, Fatih Mehmet;
Küçükler, Sefa

Publication type:

Article

Neuroprotective potential of carvacrol: restoration of oxidative balance and mitigation of brain injury markers in isoproterenol-induced rats.

Published in:

Metabolic Brain Disease, 2025, v. 40, n. 5, p. 1, doi. 10.1007/s11011-025-01634-6

By:

Bağcı, Betül;
Aydın, Şeyma;
Dalkılınç, Elif;
Çomaklı, Selim;
Küçükler, Sefa;
Özdemir, Selçuk

Publication type:

Article

Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats.

Published in:

Metabolic Brain Disease, 2024, v. 39, n. 4, p. 509, doi. 10.1007/s11011-023-01339-8

By:

Küçükler, Sefa;
Caglayan, Cuneyt;
Özdemir, Selçuk;
Çomaklı, Selim;
Kandemir, Fatih Mehmet

Publication type:

Article

Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway.

Published in:

Metabolic Brain Disease, 2022, v. 37, n. 6, p. 1931, doi. 10.1007/s11011-022-01027-z

By:

Caglayan, Cuneyt;
Kandemir, Fatih Mehmet;
Ayna, Adnan;
Gür, Cihan;
Küçükler, Sefa;
Darendelioğlu, Ekrem

Publication type:

Article

Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation.

Published in:

Biotechnic & Histochemistry, 2022, v. 97, n. 7, p. 490, doi. 10.1080/10520295.2021.2014569

By:

Küçükler, Sefa;
Kandemir, Fatih Mehmet;
Yıldırım, Serkan

Publication type:

Article

Morin mitigates ifosfamide induced nephrotoxicity by regulation of NF-kappaB/p53 and Bcl-2 expression.

Published in:

Biotechnic & Histochemistry, 2022, v. 97, n. 6, p. 423, doi. 10.1080/10520295.2021.2021449

By:

Çomaklı, Selim;
Kandemir, Fatih Mehmet;
Küçükler, Sefa;
Özdemir, Selçuk

Publication type:

Article

Protective Effects of Syringic Acid Against Oxidative Damage, Apoptosis, Autophagy, Inflammation, Testicular Histopathologic Disorders, and Impaired Sperm Quality in the Testicular Tissue of Rats Induced by Mercuric Chloride.

Published in:

Environmental Toxicology, 2024, v. 39, n. 10, p. 4803, doi. 10.1002/tox.24395

By:

Akarsu, Serkan Ali;
Gür, Cihan;
Küçükler, Sefa;
Akaras, Nurhan;
İleritürk, Mustafa;
Kandemir, Fatih Mehmet

Publication type:

Article

Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue.

Published in:

Environmental Toxicology, 2023, v. 38, n. 11, p. 2656, doi. 10.1002/tox.23900

By:

Tuncer, Sibel Çiğdem;
Akarsu, Serkan Ali;
Küçükler, Sefa;
Gür, Cihan;
Kandemir, Fatih Mehmet

Publication type:

Article

Hesperidin protects against the chlorpyrifos‐induced chronic hepato‐renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up‐regulation of PARP‐1/VEGF.

Published in:

Environmental Toxicology, 2021, v. 36, n. 8, p. 1600, doi. 10.1002/tox.23156

By:

Küçükler, Sefa;
Çomaklı, Selim;
Özdemir, Selçuk;
Çağlayan, Cüneyt;
Kandemir, Fatih Mehmet

Publication type:

Article

Protective effects of rutin against deltamethrin-induced hepatotoxicity and nephrotoxicity in rats via regulation of oxidative stress, inflammation, and apoptosis.

Published in:

Environmental Science & Pollution Research, 2021, v. 28, n. 44, p. 62975, doi. 10.1007/s11356-021-15190-w

By:

Küçükler, Sefa;
Kandemir, Fatih Mehmet;
Özdemir, Selçuk;
Çomaklı, Selim;
Caglayan, Cuneyt

Publication type:

Article

Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin.

Published in:

Environmental Science & Pollution Research, 2021, v. 28, n. 9, p. 10818, doi. 10.1007/s11356-020-11327-5

By:

Kuzu, Müslüm;
Kandemir, Fatih Mehmet;
Yıldırım, Serkan;
Çağlayan, Cüneyt;
Küçükler, Sefa

Publication type:

Article

Effects of Vitis vinifera L. cv. "Merlot" Seed Extract Against Thallium (I) Sulfate-Induced Reproductive Damage in Male Rats.

Published in:

Veterinary Sciences & Practices, 2023, v. 18, n. 3, p. 90, doi. 10.5152/VetSciPract.2023.23120

By:

ÖMÜR, Ali Doğan;
APAYDIN YILDIRIM, Betül;
MOKHTARE, Behzad;
KÜÇÜKLER, Sefa;
MENDİL, Ali Sefa;
GEZER, Arzu;
AKARSU, Serkan Ali

Publication type:

Article